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Volumn 94, Issue , 2017, Pages 4-8

Aging leads to altered microglial function that reduces brain resiliency increasing vulnerability to neurodegenerative diseases

Author keywords

Microglia; Polyphenol

Indexed keywords

POLYPHENOL; ANTIINFLAMMATORY AGENT; AUTACOID; NEUROPROTECTIVE AGENT;

EID: 85011851555     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2017.01.027     Document Type: Review
Times cited : (28)

References (40)
  • 1
    • 78650016970 scopus 로고    scopus 로고
    • NT-020, a natural therapeutic approach to optimize spatial memory performance and increase neural progenitor cell proliferation and decrease inflammation in the aged rat
    • Acosta, S., Jernberg, J., Sanberg, C.D., Sanberg, P.R., Small, B.J., Gemma, C., Bickford, P.C., NT-020, a natural therapeutic approach to optimize spatial memory performance and increase neural progenitor cell proliferation and decrease inflammation in the aged rat. Rejuvenation Res. 13 (2010), 581–588.
    • (2010) Rejuvenation Res. , vol.13 , pp. 581-588
    • Acosta, S.1    Jernberg, J.2    Sanberg, C.D.3    Sanberg, P.R.4    Small, B.J.5    Gemma, C.6    Bickford, P.C.7
  • 3
    • 84879335548 scopus 로고    scopus 로고
    • Polyphenols: multipotent therapeutic agents in neurodegenerative diseases
    • Bhullar, K.S., Rupasinghe, H.P., Polyphenols: multipotent therapeutic agents in neurodegenerative diseases. Oxidative Med. Cell. Longev., 891748, 2013, 2013.
    • (2013) Oxidative Med. Cell. Longev. , vol.891748 , pp. 2013
    • Bhullar, K.S.1    Rupasinghe, H.P.2
  • 7
    • 13944261231 scopus 로고    scopus 로고
    • Rejuvenation of aged progenitor cells by exposure to a young systemic environment
    • Conboy, I.M., Conboy, M.J., Wagers, A.J., Girma, E.R., Weissman, I.L., Rando, T.A., Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 433 (2005), 760–764.
    • (2005) Nature , vol.433 , pp. 760-764
    • Conboy, I.M.1    Conboy, M.J.2    Wagers, A.J.3    Girma, E.R.4    Weissman, I.L.5    Rando, T.A.6
  • 8
    • 84861989218 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced interleukin (IL)-4 receptor-alpha expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice
    • Fenn, A.M., Henry, C.J., Huang, Y., Dugan, A., Godbout, J.P., Lipopolysaccharide-induced interleukin (IL)-4 receptor-alpha expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice. Brain Behav. Immun. 26 (2012), 766–777.
    • (2012) Brain Behav. Immun. , vol.26 , pp. 766-777
    • Fenn, A.M.1    Henry, C.J.2    Huang, Y.3    Dugan, A.4    Godbout, J.P.5
  • 9
    • 84903160194 scopus 로고    scopus 로고
    • IL-4 signaling drives a unique arginase +/IL-1beta + microglia phenotype and recruits macrophages to the inflammatory CNS: consequences of age-related deficits in IL-4Ralpha after traumatic spinal cord injury
    • Fenn, A.M., Hall, J.C., Gensel, J.C., Popovich, P.G., Godbout, J.P., IL-4 signaling drives a unique arginase +/IL-1beta + microglia phenotype and recruits macrophages to the inflammatory CNS: consequences of age-related deficits in IL-4Ralpha after traumatic spinal cord injury. J. Neurosci. 34 (2014), 8904–8917.
    • (2014) J. Neurosci. , vol.34 , pp. 8904-8917
    • Fenn, A.M.1    Hall, J.C.2    Gensel, J.C.3    Popovich, P.G.4    Godbout, J.P.5
  • 11
    • 0037101641 scopus 로고    scopus 로고
    • Diets enriched in foods with high antioxidant activity reverse age-induced decreases in cerebellar beta-adrenergic function and increases in proinflammatory cytokines
    • Gemma, C., Mesches, M.H., Sepesi, B., Choo, K., Holmes, D.B., Bickford, P.C., Diets enriched in foods with high antioxidant activity reverse age-induced decreases in cerebellar beta-adrenergic function and increases in proinflammatory cytokines. J. Neurosci. 22 (2002), 6114–6120.
    • (2002) J. Neurosci. , vol.22 , pp. 6114-6120
    • Gemma, C.1    Mesches, M.H.2    Sepesi, B.3    Choo, K.4    Holmes, D.B.5    Bickford, P.C.6
  • 12
    • 26944442371 scopus 로고    scopus 로고
    • Improvement of memory for context by inhibition of caspase-1 in aged rats
    • Gemma, C., Fister, M., Hudson, C., Bickford, P.C., Improvement of memory for context by inhibition of caspase-1 in aged rats. Eur. J. Neurosci. 22 (2005), 1751–1756.
    • (2005) Eur. J. Neurosci. , vol.22 , pp. 1751-1756
    • Gemma, C.1    Fister, M.2    Hudson, C.3    Bickford, P.C.4
  • 13
    • 0023231758 scopus 로고
    • Age-related changes in cerebellar noradrenergic pre- and postsynaptic mechanisms: intrinsic vs extrinsic determinants evaluated with brain grafts in oculo
    • Granholm, A.C., Gerhardt, G.A., Eriksdotter-Nilsson, M., Bickford-Wimer, P.C., Palmer, M.R., Seiger, A., Olson, L., Hoffer, B.J., Age-related changes in cerebellar noradrenergic pre- and postsynaptic mechanisms: intrinsic vs extrinsic determinants evaluated with brain grafts in oculo. Brain Res. 423 (1987), 71–78.
    • (1987) Brain Res. , vol.423 , pp. 71-78
    • Granholm, A.C.1    Gerhardt, G.A.2    Eriksdotter-Nilsson, M.3    Bickford-Wimer, P.C.4    Palmer, M.R.5    Seiger, A.6    Olson, L.7    Hoffer, B.J.8
  • 17
    • 84864023667 scopus 로고    scopus 로고
    • α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease
    • Lastres-Becker, I., Ulusoy, A., Innamorato, N.G., Sahin, G., Rábano, A., Kirik, D., Cuadrado, A., α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease. Hum. Mol. Genet. 21 (2012), 3173–3192.
    • (2012) Hum. Mol. Genet. , vol.21 , pp. 3173-3192
    • Lastres-Becker, I.1    Ulusoy, A.2    Innamorato, N.G.3    Sahin, G.4    Rábano, A.5    Kirik, D.6    Cuadrado, A.7
  • 19
    • 84872731930 scopus 로고    scopus 로고
    • Aging-induced Nrf2-ARE pathway disruption in the subventricular zone drives neurogenic impairment in parkinsonian mice via PI3K-Wnt/beta-catenin dysregulation
    • L'Episcopo, F., Tirolo, C., Testa, N., Caniglia, S., Morale, M.C., Impagnatiello, F., Pluchino, S., Marchetti, B., Aging-induced Nrf2-ARE pathway disruption in the subventricular zone drives neurogenic impairment in parkinsonian mice via PI3K-Wnt/beta-catenin dysregulation. J. Neurosci. 33 (2013), 1462–1485.
    • (2013) J. Neurosci. , vol.33 , pp. 1462-1485
    • L'Episcopo, F.1    Tirolo, C.2    Testa, N.3    Caniglia, S.4    Morale, M.C.5    Impagnatiello, F.6    Pluchino, S.7    Marchetti, B.8
  • 20
    • 75749090492 scopus 로고    scopus 로고
    • Systemic signals regulate ageing and rejuvenation of blood stem cell niches
    • Mayack, S.R., Shadrach, J.L., Kim, F.S., Wagers, A.J., Systemic signals regulate ageing and rejuvenation of blood stem cell niches. Nature 463 (2010), 495–500.
    • (2010) Nature , vol.463 , pp. 495-500
    • Mayack, S.R.1    Shadrach, J.L.2    Kim, F.S.3    Wagers, A.J.4
  • 22
    • 84899729969 scopus 로고    scopus 로고
    • Selective manipulation of aging: a novel strategy for the treatment of neurodegenerative disorders
    • Moll, L., El-Ami, T., Cohen, E., Selective manipulation of aging: a novel strategy for the treatment of neurodegenerative disorders. Swiss Med. Wkly., 144, 2014, w13917.
    • (2014) Swiss Med. Wkly. , vol.144 , pp. w13917
    • Moll, L.1    El-Ami, T.2    Cohen, E.3
  • 23
    • 0345189366 scopus 로고    scopus 로고
    • Inflammatory blockade restores adult hippocampal neurogenesis
    • Monje, M.L., Toda, H., Palmer, T.D., Inflammatory blockade restores adult hippocampal neurogenesis. Science 302 (2003), 1760–1765.
    • (2003) Science , vol.302 , pp. 1760-1765
    • Monje, M.L.1    Toda, H.2    Palmer, T.D.3
  • 24
    • 84958152299 scopus 로고    scopus 로고
    • Call off the dog(ma): M1/M2 polarization is concurrent following traumatic brain injury
    • Morganti, J.M., Riparip, L.K., Rosi, S., Call off the dog(ma): M1/M2 polarization is concurrent following traumatic brain injury. PLoS One, 11, 2016, e0148001.
    • (2016) PLoS One , vol.11
    • Morganti, J.M.1    Riparip, L.K.2    Rosi, S.3
  • 25
    • 84866183226 scopus 로고    scopus 로고
    • Ageing as a risk factor for disease
    • Niccoli, T., Partridge, L., Ageing as a risk factor for disease. Curr. Biol. 22 (2012), R741–R752.
    • (2012) Curr. Biol. , vol.22 , pp. R741-R752
    • Niccoli, T.1    Partridge, L.2
  • 26
    • 84930926658 scopus 로고    scopus 로고
    • Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease
    • Norden, D.M., Muccigrosso, M.M., Godbout, J.P., Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease. Neuropharmacology 96 (2015), 29–41.
    • (2015) Neuropharmacology , vol.96 , pp. 29-41
    • Norden, D.M.1    Muccigrosso, M.M.2    Godbout, J.P.3
  • 27
    • 84903369130 scopus 로고    scopus 로고
    • Neural stem and progenitor cells in the aged subependyma are activated by the young niche
    • Piccin, D., Tufford, A., Morshead, C.M., Neural stem and progenitor cells in the aged subependyma are activated by the young niche. Neurobiol. Aging 35 (2014), 1669–1679.
    • (2014) Neurobiol. Aging , vol.35 , pp. 1669-1679
    • Piccin, D.1    Tufford, A.2    Morshead, C.M.3
  • 32
    • 84863857726 scopus 로고    scopus 로고
    • Resveratrol and diabetic cardiac function: focus on recent in vitro and in vivo studies
    • Turan, B., Tuncay, E., Vassort, G., Resveratrol and diabetic cardiac function: focus on recent in vitro and in vivo studies. J. Bioenerg. Biomembr. 44 (2012), 281–296.
    • (2012) J. Bioenerg. Biomembr. , vol.44 , pp. 281-296
    • Turan, B.1    Tuncay, E.2    Vassort, G.3
  • 36
    • 84864936920 scopus 로고    scopus 로고
    • A changing perspective on the role of neuroinflammation in Alzheimer's disease
    • Wilcock, D.M., A changing perspective on the role of neuroinflammation in Alzheimer's disease. Int. J. Alzheimers Dis., 495243, 2012, 2012.
    • (2012) Int. J. Alzheimers Dis. , vol.495243 , pp. 2012
    • Wilcock, D.M.1
  • 37
    • 18744386136 scopus 로고    scopus 로고
    • Blueberry extract enhances survival of intraocular hippocampal transplants
    • Willis, L., Bickford, P., Zaman, V., Moore, A., Granholm, A.C., Blueberry extract enhances survival of intraocular hippocampal transplants. Cell Transplant. 14 (2005), 213–223.
    • (2005) Cell Transplant. , vol.14 , pp. 213-223
    • Willis, L.1    Bickford, P.2    Zaman, V.3    Moore, A.4    Granholm, A.C.5
  • 40
    • 84924540176 scopus 로고    scopus 로고
    • Cleaning up after ICH: the role of Nrf2 in modulating microglia function and hematoma clearance
    • Zhao, X., Sun, G., Ting, S.M., Song, S., Zhang, J., Edwards, N.J., Aronowski, J., Cleaning up after ICH: the role of Nrf2 in modulating microglia function and hematoma clearance. J. Neurochem., 2014, 10.1111/jnc.12974.
    • (2014) J. Neurochem.
    • Zhao, X.1    Sun, G.2    Ting, S.M.3    Song, S.4    Zhang, J.5    Edwards, N.J.6    Aronowski, J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.