A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: The case of NPC1 deficiency

Scientific Reports

Volumn 7, Issue , 2017, Pages

  Tharkeshwar, Arun Kumar ^a,b,c   Trekker, Jesse ^b,d   Vermeire, Wendy ^a   Pauwels, Jarne ^c   Sannerud, Ragna ^a   Priestman, David A ^e   Te Vruchte, Danielle ^e   Vints, Katlijn ^f   Baatsen, Pieter ^f   Decuypere, Jean Paul ^a   Lu, Huiqi ^a   Martin, Shaun ^g   Vangheluwe, Peter ^g   Swinnen, Johannes V ^h   Lagae, Liesbet ^a,b   Impens, Francis ^c,f   Platt, Frances M ^e   Gevaert, Kris ^c   Annaert, Wim ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b IMEC   (Belgium)

^c GHENT UNIVERSITY   (Belgium)

^d DEPARTMENT OF IMAGING AND PATHOLOGY   (Belgium)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^g LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

^h University of Leuven   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; DEXTRAN; MAGNETITE NANOPARTICLE; MEMBRANE PROTEIN; NANOPARTICLE; NPC1 PROTEIN, HUMAN; PROTEOME; STEROL; SUPERPARAMAGNETIC IRON OXIDE;

AUTOPHAGOSOME; CELL FRACTIONATION; CELL MEMBRANE; CHEMISTRY; DEFICIENCY; ENDOSOME; GENE KNOCKOUT; HELA CELL LINE; HUMAN; LIPID METABOLISM; LYSOSOME; METABOLISM; PATHOLOGY; PROTEOMICS; ULTRASTRUCTURE;

AUTOPHAGOSOMES; CARRIER PROTEINS; CELL MEMBRANE; DEXTRANS; ENDOSOMES; GENE KNOCKOUT TECHNIQUES; HELA CELLS; HUMANS; LIPID METABOLISM; LYSOSOMES; MAGNETITE NANOPARTICLES; MEMBRANE GLYCOPROTEINS; NANOPARTICLES; PROTEOME; PROTEOMICS; STEROLS; SUBCELLULAR FRACTIONS;

EID: 85011284116     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep41408     Document Type: Article

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