Magnetic nanoparticles in biomedicine: Synthesis, functionalization and applications

Nanomedicine

Volumn 5, Issue 9, 2010, Pages 1401-1414

  Frimpong, Reynolds A ^a   Hilt, J Zach ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

iron oxide; magnetic nanoparticles; stabilization; surface functionalization; synthesis

Indexed keywords

LIGAND; MAGNETIC NANOPARTICLE;

BIOMEDICINE; DRUG DELIVERY SYSTEM; HEATING; HUMAN; HYPERTHERMIC THERAPY; NUCLEAR MAGNETIC RESONANCE IMAGING; POLYMERIZATION; PRIORITY JOURNAL; REVIEW; SYNTHESIS;

DRUG DELIVERY SYSTEMS; HUMANS; MAGNETICS; MICROSCOPY, ELECTRON, TRANSMISSION; NANOMEDICINE; NANOPARTICLES;

EID: 78650070099     PISSN: 17435889     EISSN: None     Source Type: Journal    
DOI: 10.2217/nnm.10.114     Document Type: Review

References (102)

1. Jeong U, Teng X, Wang Y, Yang H, Xia Y: Superparamagnetic colloids: controlled synthesis and niche applications. Adv. Mater. 19, 33-60 (2007).
2. Lu A-H, Salabas EL, Schüth F: Magnetic nanoparticles: synthesis, protection, functionalization, and application. Angew. Chem. Int. Ed. 46, 1222-1244 (2007).
3. Yean S, Cong L, Yavuz CT et al.: Effect of magnetite particle size on adsorption and desorption of arsenite and arsenate. J. Mater. Res. 20, 3255-3264 (2005).
4. Gupta AK, Gupta M: Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 26, 3995-4021 (2005).
5. Sun C, Lee JSH, Zhang M: Magnetic nanoparticles in MR imaging and drug delivery. Adv. Drug Deliver. Rev. 60, 1252-1265 (2008).
6. Weissleder R, Elizondo G, Wittenberg J, Rabito CA, Bengele HH, Josephson L: Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging. Radiology 175, 489-493 (1990). (Pubitemid 20135290)
7. Jain TK, Morales MA, Sahoo SK, Leslie-Pelecky DL, Labhasetwar V: Iron oxide nanoparticles for sustained delivery of anticancer agents. Mol. Pharm. 2, 194-205 (2005).
8. Moroz P, Jones SK, Gray BN: Magnetically mediated hyperthermia: current status and future directions. Int. J. Hyperther. 18, 267-284 (2002).
9. Pankhurst QA, Connolly J, Jones SK, Dobson J: Applications of magnetic nanoparticles in biomedicine. J. Phys. D. Appl. Phys 36, R167-R181 (2003).
10. Neuberger T, Schöpf B, Hofmann H, Hofmann M, von Rechenberg, B: Superparamagnetic nanoparticles for biomedical applications: possibilities and limitations of a new drug delivery system. J. Magn. Magn. Mater. 293, 483-496 (2005).
11. Pankhurst QA, Thanh NKT, Jones SK, Dobson J: Progress in applications of magnetic nanoparticles in biomedicine. J. Phys. D. Appl. Phys 42, 224001 (2009).
12. Berry CC, Curtis ASG: Functionalization of magnetic nanoparticles for application in biomedicine. J. Phys. D. Appl. Phys. 36, R198-R206 (2003).
13. Gupta AK, Naregalkar RR, Vaidya VD, Gupta M: Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications. Nanomedicine 2, 23-29 (2007).
14. Huber DL: Synthesis, properties, and applications of iron nanoparticles. Small 5, 482-501 (2005).
15. Zeng Q, Baker I, Loudis JA, Liao Y, Hoopes PJ, Weaver JB: Fe/Fe oxide nanocomposite particles with large specifc absorption rate for hyperthermia. Appl. Phys. Lett. 90, 233112 (2007).
16. Bomati-Miguel O, Morales MP, Tartaj P et al.: Fe-based nanoparticulate metallic alloys as contrast agents for magnetic resonance imaging. Biomaterials 26, 5695-5703 (2005).
17. Veiseh O, Conroy S, Gunn J et al.: Optical and MRI multifunctional nanoprobe for targeting gliomas. Nano Lett. 5, 1003-1008 (2005).
18. Lee CM, Jeong HJ, Kim EM et al.: Superparamagnetic iron oxide nanoparticles as a dual imaging probe for targeting hepatocytes in vivo. Magn. Reson. Med. 62, 1440-1446 (2009).
19. Shubayev VI, Pisanic II TR, Jin S: Magnetic nanoparticles for theragnostics. Adv. Drug Deliver. Rev. 61, 467-477 (2009).
20. McCarthy JR, Weissleder R: Multifunctional magnetic nanoparticles for targeted imaging and therapy. Adv. Drug Deliver. Rev. 60, 1241-1251 (2008).
21. Gao J, Gu H, Xu B: Multifunctional magnetic nanoparticles: design, synthesis, and biomedical applications. Accounts Chem. Res. 42, 1097-1107 (2009).
22. Satarkar NS, Hilt JZ: Magnetic hydrogel nanocomposites for remote controlled pulsatile drug release. J. Control. Rel. 130, 246-251 (2008).
23. Hawkins A, Satarkar NS, Hilt JZ: Nanocomposite degradable hydrogels: demonstration of remote controlled degradation and drug release. Pharm. Res. 26, 667-673 (2009).
24. Babincova M, Novotny J, Rosenecker J, Babinec P: Remote radio-control of siRNA release from magnetite-hydrogel composite. Optoelectronics Adv. Materials Rapid Comm. 1, 644-647 (2007).
25. Babincova M, Leszczynska D, Sourivong P, Cicmanec P, Babinec P: Superparamagnetic gels as a novel material for electromagnetically induced hyperthermia. J. Magn. Magn. Mater. 225, 109-112 (2001).
26. Ramanujan R, Ang K, Venkatraman S: Magnetic-PNIPA hydrogels for bioengineering applications. J. Mater. Sci. 44, 1381-1387 (2009).
27. Frimpong RA, Dou J, Pechan M, Hilt JZ: Enhancing remote controlled heating characteristics in hydrophilic magnetite via facile co-precipitation. J. Magn. Magn. Mater. 322, 326-331 (2010).
28. Xu C, Xu K, Gu H: Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles. J. Am. Chem. Soc. 126, 9938-9939 (2004).
29. Hyeon T, Lee SS, Park J, Chung Y, Na HB: Synthesis of highly crystalline and monodisperse maghemite nanocrystallites without a size-selection process. J. Am. Chem. Soc. 123, 12798-12801 (2001).
30. Sun S, Zeng H: Size-controlled synthesis of magnetite nanoparticles. J. Am. Chem. Soc. 124, 8204-8205 (2002).
31. Bautista MC, Bomati-Miguel O, Morales MP, Serna CJ, Veintemillas-Verdauer S: Surface characterization of dextran-coated iron oxide nanoparticles prepared by laser pyrolysis and coprecipitation. J. Magn. Magn. Mater. 293, 20-27 (2005).
32. 4 nanoparticles for reduced non-specifc uptake by macrophage cells. Adv. Mater. 19, 3163-3166 (2007).
33. Chastellain M, Petri A, Hofmann H: Particle size investigation of a multistep synthesis of PVA coated superparamagnetic nanoparticles. J. Colloid Interf. Sci. 278, 353-360 (2004).
34. Bee A, Massart R, Neveu S: Synthesis of very fne maghemite particles. J. Magn. Magn. Mater. 149, 6-9 (1995).
35. Kim DK, Zhang Y, Voit W, Rao KV, Muhammed M: Synthesis and characterization of surfactant coated superparamagnetic monodispersed iron oxide nanoparticles. J. Magn. Magn. Mater. 225, 30-36 (2001). (Pubitemid 32335271)
36. Kim DK, Mikhaylova M, Zhang Y, Muhammed M: Protective coating of superparamagnetic iron oxide nanoparticles. Chem. Mater. 15, 1617-1627 (2003).
37. Rockenberger J, Scher EC, Alivisatos AP: A new nonhydrolytic single-precursor approach to surfactant-capped nanocrystals of transition metal oxides. J. Am. Chem. Soc. 121, 11595 (1999).
38. 4 (M = Fe, Co, Mn) nanoparticles. J. Am. Chem. Soc. 126, 273-279 (2004).
39. Li Z, Chen H, Bao H, Gao M: One-pot reaction to synthesize water-soluble magnetite nanocrystals. Chem. Mater. 16, 1391-1393 (2004).
40. 4. Angew. Chem. Int. Ed. 44, 123-126 (2005).
41. Li Z, Wei L, Gao M, Lei H: One-pot reaction to synthesize biocompatible magnetite nanoparticles. Adv. Mater. 17, 1001-1005 (2005).
42. Hu F, Wei L, Zhou Z, Ran Y, Li Z, Gao M: Preparation of biocompatible magnetite nanocrystals for in vivo magnetic resonance detection of cancer. Adv. Mater. 18, 2553-2556 (2006).
43. Wan J, Cai W, Meng X, Liu E: Monodisperse water-soluble magnetite nanoparticles prepared by polyol process for high performance magnetic resonance imaging. Chem. Commun. 5004-5006 (2007).
44. Jia X, Chen D, Jiao X, Zhai S: Environmentally-friendly preparation of water-dispersible magnetite nanoparticles. Chem. Commun. 968-970 (2009).
45. Hu F, MacRenaris K W, Waters EA et al.: Ultrasmall, water-soluble magnetite nanoparticles with high relaxivity for magnetic resonance imaging. J. Phys. Chem. C 113, 20855-20860 (2009).
46. 4 nanoparticles. Mater. Res. Bull. 41, 525-529 (2006).
47. Ge S, Shi X, Sun K et al.: Facile hydrothermal synthesis of iron oxide nanoparticles with tunable magnetic properties. J. Phys. Chem. C 113, 13593-13599 (2009).
48. Wang X, Zhuang J, Peng Q, Li Y: A general strategy for nanocrystal synthesis. Nature 437, 121-124 (2005).
49. Gupta AK, Wells S: Surface-modifed superparamagnetic nanoparticles for drug delivery: Preparation, characterization, and cytotoxicity studies. IEEE T. Nanobiosci. 3, 66-73 (2004).
50. Lee Y, Lee J, Bae CJ, Park JG et al.: Large scale synthesis of uniform and crystalline magnetite nanoparticles using reverse micelles as nanoreactors under refux conditions. Adv. Funct. Mater. 15, 503-509 (2005).
51. Esquivel J, Facundo IA, Treviño ME, López RG: A novel method to prepare magnetic nanoparticles: precipitation in bicontinuous microemulsions. J. Mater. Sci. 42, 9015-9020 (2007).
52. Loo AL, Pineda MG, Saade H, Treviño ME, López RG: Synthesis of magnetic nanoparticles in bicontinuous microemulsions. Effect of surfactant concentration. J. Mater. Sci. 43, 3649-3654 (2008).
53. Willard MA, Kurihara LK, Carpenter EE, Calvin S, Harris VG: Chemically prepared magnetic nanoparticles. Int. Mater. Rev. 49, 125-169 (2004).
54. Qiao R, Yang C, Gao M: Superparamagnetic iron oxide nanoparticles: from preparation to in vivo MRI applications. J. Mater. Chem. 19, 6274-6293 (2009).
55. Hu FX, Neoh KG, Cen L, Kang E-T: Cellular response to magnetic nanoparticles 'PEGylated' via surface-initiated atom transfer radical polymerization. Biomacromolecules 7, 809-816 (2006).
56. Lutz JF, Stiller S, Hoth A, Kaufner L, Pison U, Cartier R: One-pot synthesis of PEGylated ultrasmall iron oxide nanoparticles and their in vivo evaluation as magnetic resonance imaging contrast agent. Biomacromolecules 7, 3132-3138 (2006).
57. Gao L, Wu J, Lyle S, Zehr K, Cao L, Gao D: Magnetite nanoparticle-linked immunosorbent assay. J. Phys. Chem. C 112, 17357-17361(2008).
58. Gao LZ, Zhuang J, Nie L et al.: Intrinsic peroxidase-like activity of ferromagnetic nanoparticles. Nat. Nanotechnol. 2, 577-583 (2007).
59. Bucak S, Jones DA, Laibinis PE, Hatton TA: Protein separation using colloidal magnetic nanoparticles. Biotechnol. Progr. 19, 477-484 (2003).
60. Yang SY, Jian ZF, Horng HE et al.: Dual immobilization and magnetic manipulation of magnetic nanoparticles. J. Magn. Magn. Mater. 320, 2688-2691 (2008).
61. 34 Eng J. 42, 290-300 (2008).
62. Banerjee SS, Chen DH: Glucose-grafted gum arabic modifed magnetic nanoparticles: preparation and specifc interaction with concanavalin A. Chem. Mater. 19, 3667-3672 (2007).
63. Pellegrino T, Manna L, Kudera S et al.: Hydrophobic nanocrystals coated with an amphiphilic polymer shell: a general route to water soluble nanocrystals. Nano Lett. 4, 703-707 (2004).
64. Wang Y, Wong SF, Teng X, Lin XZ, Yang Y: Pulling nanoparticles into water: phase transfer of oleic acid stabilized monodisperse nanoparticle into aqueous solution of a-cyclodextrin. Nano Lett. 3, 1555-1559 (2003).
65. Xie J, Peng S, Brower N, Pourmand N, Wang SX, Sun S: One-pot synthesis of monodisperse iron oxide nanoparticles for potential biomedical applications. Pure Appl. Chem. 78, 1003-1014 (2006).
66. Sun B, Zhang Y, Gu KJ, Shen QD, Yang Y, Song H: Layer by layer assembly of conjugated polyelectrolytes on magnetic nanoparticle surfaces. Langmuir 25, 5969-5973 (2009).
67. 4/amino-silane core-shell nanoparticles via layer-by-layer method. Appl. Surf. Sci. 255, 7974-7980 (2009).
68. Al-Saadi A, Yu CH, Khutoryanskiy V V, Shih SJ, Crossley A, Tsang SC: Layer-by-layer electrostatic entrapment of protein molecules on superparamagnetic nanoparticles: a new strategy to enhance adsorption capacity and maintain biological activity. J. Phys. Chem. C 113, 15260-15265 (2009).
69. Jun Y, Huh YM, Choi JS et al.: Nanoscale size effect of magnetic nanocrystals and their utilization for cancer diagnosis via magnetic resonance imaging. J. Am. Chem. Soc. 127, 5732-5733 (2005).
70. Huh YM, Jun Y, Song HT et al.: In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals. J. Am. Chem. Soc. 127, 12387-12391 (2005).
71. Lattuada M, Hatton TA: Functionalization of monodisperse magnetic nanoparticles. Langmuir 23, 2158-2168 (2007).
72. De Palma R, Peeters S, Van Bael MJ et al.: Silane ligand exchange to make hydrophobic superparamagnetic nanoparticles water-dispersible. Chem. Mater. 19, 1821-1831 (2007).
73. Barrera C, Herrera AP, Rinaldi C: Colloid dispersion of monodisperse magnetite nanoparticles modifed with poly(ethylene glycol). J. Colloid Interface Sci. 329, 107-113 (2009).
74. Kohler N, Sun C, Wang J, Zhang M: Methotrexate-modifed superparamagnetic nanoparticles and their intracellular uptake into human cancer cells. Langmuir 21, 8858-8864 (2005).
75. Kohler N, Sun C, Fichtenholtz A, Gunn J, Fang C, Zhang M: Methotrexate-immobilized poly(ethylene glycol) magnetic nanoparticles for MR imaging and drug delivery. Small 2, 785-792 (2006).
76. Huang G, Zhang C, Li S et al.: A novel strategy for surface modifcation of superparamagnetic iron oxide nanoparticles for lung cancer imaging. J. Mater. Chem. 19, 6367-6372 (2009).
77. Duan H, Kuang M, Wang X, Wang A, Mao H, Nie S: Reexamining the effects of particle size and surface chemistry on magnetic properties of iron oxide nanocrystals: new insights into spin disorder and proton relaxivity. J. Phys. Chem. C 112, 8127-8131 (2008).
78. Tromsdorf UI, Bigall NC, Kaul MG et al.: Size and surface effects on the MRI relaxivity of manganese ferrite nanoparticle contrast agents. Nano Lett. 7, 2422-2427 (2007).
79. Lee JH, Huh YM, Jun YW et al.: Artifcially engineered magnetic nanoparticles for ultra-sensitive molecular imaging. Nature Med. 13, 95-99 (2007).
80. 34 novel magnetic resonance imaging contrast agent: an in vitro assessment. Adv. Funct. Mater. 19, 2615-2622 (2009).
81. Flesch C, Bourgeat-Lami E, Mornet S, Duguet E, Delaite C, Dumas P: Synthesis of colloidal superparamagnetic nanocomposites by grafting poly(e-caprolactone) from the surface of organosilane-modifed maghemite nanoparticles. J. Polym. Sci. A1 43, 3221-3231 (2005).
82. Biswas S, Belfeld KD, Das RK, Ghosh S, Hebard AF: Block copolymer-mediated formation of superparamagnetic nanocomposites. Chem. Mater. 21, 5644-5653 (2009).
83. Binder WH, Gloger D, Weinstabl H, Günther A, Pittenauer E: Telechelic poly (N-isopropyl acrylamide) via nitroxide-mediated controlled polymerization and 'click' chemistry: livingness and 'grafting-from' methodology. Macromolecules 40, 3097-3107 (2007).
84. Matsuno R, Yamamoto K, Otsuka H, Takahara A: Polystyrene-and poly(3-vinylpyridine)-grafted magnetite nanoparticles prepared through surface-initiated nitroxide-mediated radical polymerization. Macromolecules 37, 2203-2209 (2004).
85. Boyer C, Bulmus V, Priyanto P, Teoh WY, Amal R, Davis TP: The stabilization and bio-functionalization of iron oxide nanoparticles using heterotelechelic polymers. J. Mater. Chem. 19, 111-123 (2009).
86. Narain R, Gonzales M, Hoffman AS, Stayton PS, Krishnan KM: Synthesis of monodisperse biotinylated P(NIPAAm)-coated iron oxide magnetic nanoparticles and their bioconjugation to streptavidin. Langmuir 23, 6299-6304 (2007).
87. Kang SM, Choi IS, Lee KB, Kim Y: Bioconjugation of poly(poly(ethylene glycol) methacrylate)-coated iron oxide magnetic nanoparticles for magnetic capture of target proteins. Macromol. Res. 17, 259-264 (2009).
88. Zhou Y, Wang S, Ding B, Yang Z: Modifcation of magnetite nanoparticles via surface-initiated atom transfer radical polymerization (ATRP). Chem. Eng. J. 138, 578-585 (2008).
89. Frimpong RA, Hilt JZ: Poly(N-isopropylacrylamide)-based hydrogel coatings on magnetite nanoparticles via atom transfer radical polymerization. Nanotechnology 19, 175101-175107 (2008).
90. Edmondson S, Osborne VL, Huck WTS: Polymer brushes via surface-initiated polymerizations. Chem. Soc. Rev. 33, 14-22 (2004).
91. Pyun J, Matyjaszewski K: Synthesis of nanocomposite organic/inorganic hybrid materials using controlled/living radical polymerization. Chem. Mater. 13, 3436-3448 (2001).
92. Berry CC: Progress in functionalization of magnetic nanoparticles for applications in biomedicine. J. Phys. D. Appl. Phys. 42, 224003 (2009).
93. Villanueva A, Cañete M, Roca AG et al.: The infuence of surface functionalization on the enhanced internalization of magnetic nanoparticles in cancer cell. Nanotechnology 20, 115103 (2009).
94. Hergt R, Dutz S: Magnetic particle hyperthermia-biophysical limitation of a visionary tumor therapy. J. Magn. Magn. Mater. 311, 187-192 (2007).
95. Schmidt AM: Thermoresponsive magnetic colloids. Colloid Polym. Sci. 285, 953-966 (2007).
96. Zhang LY, Gu HC, Wang XM: Magnetite ferrofuid with high specifc absorption rate for application in hyperthermia. J. Magn. Magn. Mater. 311, 228-233 (2007).
97. Hergt R, Andra W, d'Ambly CG et al.: Physical limits of hyperthermia using magnetite fne particles. IEEE T. Magn. 34, 3745-3754 (1998).
98. 4 particles in AC magnetic feld. J. Magn. Magn. Mater. 268, 33-39 (2004).
99. Gonzales-Weimuller M, Zeisberger M, Krishnan KM: Size dependent heating rates of iron oxide nanoparticles for magnetic fuid hyperthermia. J. Magn. Magn. Mater. 321, 1947-1950 (2009).
100. Fortin JP, Wilheim C, Servais J, Menager C, Bacri JC, Gazeau F: Size sorted anionic iron oxide nanomagnets as colloidal mediators for magnetic hyperthermia. J. Am. Chem. Soc. 129, 2628-2635 (2007).
101. 4 nanoparticles: synthesis, characterization and cellular uptake. Biomaterials 28, 5426-5436 (2007).
102. Lai JJ, Hoffman JM, Ebara M et al.: Dual magnetic-/temperature responsive nanoparticles for microfuidic separation and assays. Langmuir 23, 7385-7391 (2007).