-
1
-
-
84895809519
-
Cancer as a metabolic disease: Implications for novel therapeutics
-
Seyfried, T. N., Flores, R. E., Poff, A. M. & DAgostino, D. P. Cancer as a metabolic disease: implications for novel therapeutics. Carcinogenesis 35, 515-527, doi: 10.1093/carcin/bgt480 (2014).
-
(2014)
Carcinogenesis
, vol.35
, pp. 515-527
-
-
Seyfried, T.N.1
Flores, R.E.2
Poff, A.M.3
Dagostino, D.P.4
-
2
-
-
12444279265
-
On the origin of cancer cells
-
Warburg, O. On the origin of cancer cells. Science 123, 309-314 (1956).
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
3
-
-
77955281020
-
Glutamine addiction: A new therapeutic target in cancer
-
Wise, D. R. & Thompson, C. B. Glutamine addiction: A new therapeutic target in cancer. Trends Biochem Sci 35, 427-433, doi: 10.1016/j.tibs.2010.05.003 (2010).
-
(2010)
Trends Biochem Sci
, vol.35
, pp. 427-433
-
-
Wise, D.R.1
Thompson, C.B.2
-
4
-
-
79953661070
-
Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect
-
Shlomi, T., Benyamini, T., Gottlieb, E., Sharan, R. & Ruppin, E. Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect. PLoS Comput Biol 7, e1002018, doi: 10.1371/journal.pcbi.1002018 (2011).
-
(2011)
PLoS Comput Biol
, vol.7
, pp. e1002018
-
-
Shlomi, T.1
Benyamini, T.2
Gottlieb, E.3
Sharan, R.4
Ruppin, E.5
-
5
-
-
79955476606
-
Metabolic trade-offs and the maintenance of the fittest and the flattest
-
Beardmore, R. E., Gudelj, I., Lipson, D. A. & Hurst, L. D. Metabolic trade-offs and the maintenance of the fittest and the flattest. Nature 472, 342-346, doi: 10.1038/nature09905 (2011).
-
(2011)
Nature
, vol.472
, pp. 342-346
-
-
Beardmore, R.E.1
Gudelj, I.2
Lipson, D.A.3
Hurst, L.D.4
-
6
-
-
84877140107
-
A proposed role for glutamine in cancer cell growth through acid resistance
-
Huang, W. et al. A proposed role for glutamine in cancer cell growth through acid resistance. Cell Res 23, 724-727, doi: 10.1038/cr.2013.15 (2013).
-
(2013)
Cell Res
, vol.23
, pp. 724-727
-
-
Huang, W.1
-
7
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
Vander Heiden, M. G., Cantley, L. C. & Thompson, C. B. Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science 324, 1029-1033, doi: 10.1126/science.1160809 (2009).
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
8
-
-
80054046029
-
Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation
-
Lunt, S. Y. & Vander Heiden, M. G. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol 27, 441-464, doi: 10.1146/annurev-cellbio-092910-154237 (2011).
-
(2011)
Annu Rev Cell Dev Biol
, vol.27
, pp. 441-464
-
-
Lunt, S.Y.1
Vander Heiden, M.G.2
-
9
-
-
80052242132
-
Targeting cancer metabolism: A therapeutic window opens
-
Vander Heiden, M. G. Targeting cancer metabolism: A therapeutic window opens. Nat Rev Drug Discov 10, 671-684, doi: 10.1038/nrd3504 (2011).
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 671-684
-
-
Vander, H.M.G.1
-
10
-
-
33749011163
-
The NCI60 human tumour cell line anticancer drug screen
-
nrc1951
-
Shoemaker, R. H. The NCI60 human tumour cell line anticancer drug screen. Nat Rev Cancer 6, 813-823, doi: nrc1951 (2006).
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 813-823
-
-
Shoemaker, R.H.1
-
11
-
-
84861420588
-
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation
-
Jain, M. et al. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science 336, 1040-1044, doi: 10.1126/science.1218595 (2012).
-
(2012)
Science
, vol.336
, pp. 1040-1044
-
-
Jain, M.1
-
12
-
-
84880861468
-
The exomes of the NCI-60 panel: A genomic resource for cancer biology and systems pharmacology
-
Abaan, O. D. et al. The exomes of the NCI-60 panel: A genomic resource for cancer biology and systems pharmacology. Cancer Res 73, 4372-4382, doi: 10.1158/0008-5472.CAN-12-3342 (2013).
-
(2013)
Cancer Res
, vol.73
, pp. 4372-4382
-
-
Abaan, O.D.1
-
13
-
-
84881613658
-
Global proteome analysis of the NCI-60 cell line panel
-
Moghaddas Gholami, A. et al. Global proteome analysis of the NCI-60 cell line panel. Cell reports 4, 609-620, doi: 10.1016/j. celrep.2013.07.018 (2013).
-
(2013)
Cell Reports
, vol.4
, pp. 609-620
-
-
Moghaddas Gholami, A.1
-
14
-
-
84897420143
-
The metabolic demands of cancer cells are coupled to their size and protein synthesis rates
-
Dolfi, S. C. et al. The metabolic demands of cancer cells are coupled to their size and protein synthesis rates. Cancer Metab 1, 20, doi: 10.1186/2049-3002-1-20 (2013).
-
(2013)
Cancer Metab
, vol.1
, pp. 20
-
-
Dolfi, S.C.1
-
15
-
-
0030865104
-
Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents
-
OConnor, P. M. et al. Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents. Cancer Res 57, 4285-4300 (1997).
-
(1997)
Cancer Res
, vol.57
, pp. 4285-4300
-
-
Oconnor, P.M.1
-
16
-
-
77749320898
-
What is flux balance analysis?
-
nbt.1614
-
Orth, J. D., Thiele, I. & Palsson, B. O. What is flux balance analysis? Nat Biotechnol 28, 245-248, doi: nbt.1614 (2010).
-
(2010)
Nat Biotechnol
, vol.28
, pp. 245-248
-
-
Orth, J.D.1
Thiele, I.2
Palsson, B.O.3
-
17
-
-
84872093417
-
Analysis of omics data with genome-scale models of metabolism
-
Hyduke, D. R., Lewis, N. E. & Palsson, B. O. Analysis of omics data with genome-scale models of metabolism. Mol Biosyst 9, 167-174, doi: 10.1039/c2mb25453k (2013).
-
(2013)
Mol Biosyst
, vol.9
, pp. 167-174
-
-
Hyduke, D.R.1
Lewis, N.E.2
Palsson, B.O.3
-
18
-
-
84858439602
-
Constraining the metabolic genotype-phenotype relationship using a phylogeny of in silico methods
-
Lewis, N. E., Nagarajan, H. & Palsson, B. O. Constraining the metabolic genotype-phenotype relationship using a phylogeny of in silico methods. Nat Rev Microbiol 10, 291-305, doi: 10.1038/nrmicro2737 (2012).
-
(2012)
Nat Rev Microbiol
, vol.10
, pp. 291-305
-
-
Lewis, N.E.1
Nagarajan, H.2
Palsson, B.O.3
-
19
-
-
84884565153
-
The evolution of genome-scale models of cancer metabolism
-
Lewis, N. E. & Abdel-Haleem, A. M. The evolution of genome-scale models of cancer metabolism. Front Physiol 4, 237, doi: 10.3389/fphys.2013.00237 (2013).
-
(2013)
Front Physiol
, vol.4
, pp. 237
-
-
Lewis, N.E.1
Abdel-Haleem, A.M.2
-
20
-
-
80052580351
-
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase
-
Frezza, C. et al. Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase. Nature 477, 225-228, doi: 10.1038/nature10363 (2011).
-
(2011)
Nature
, vol.477
, pp. 225-228
-
-
Frezza, C.1
-
21
-
-
84927786144
-
Alterations in cancer cell metabolism: The Warburg effect and metabolic adaptation
-
Asgari, Y., Zabihinpour, Z., Salehzadeh-Yazdi, A., Schreiber, F. & Masoudi-Nejad, A. Alterations in cancer cell metabolism: The Warburg effect and metabolic adaptation. Genomics 105, 275-281, doi: 10.1016/j.ygeno.2015.03.001 (2015).
-
(2015)
Genomics
, vol.105
, pp. 275-281
-
-
Asgari, Y.1
Zabihinpour, Z.2
Salehzadeh-Yazdi, A.3
Schreiber, F.4
Masoudi-Nejad, A.5
-
22
-
-
84877315835
-
A community-driven global reconstruction of human metabolism
-
Thiele, I. et al. A community-driven global reconstruction of human metabolism. Nat Biotechnol 31, 419-425, doi: 10.1038/nbt.2488 (2013).
-
(2013)
Nat Biotechnol
, vol.31
, pp. 419-425
-
-
Thiele, I.1
-
23
-
-
0347951257
-
Karyotypic complexity of the NCI-60 drug-screening panel
-
Roschke, A. V. et al. Karyotypic complexity of the NCI-60 drug-screening panel. Cancer Res 63, 8634-8647 (2003).
-
(2003)
Cancer Res
, vol.63
, pp. 8634-8647
-
-
Roschke, A.V.1
-
24
-
-
13544265458
-
Modeling hybridoma cell metabolism using a generic genome-scale metabolic model of Mus musculus
-
Sheikh, K., Forster, J. & Nielsen, L. K. Modeling hybridoma cell metabolism using a generic genome-scale metabolic model of Mus musculus. Biotechnol Prog 21, 112-121, doi: 10.1021/bp0498138 (2005).
-
(2005)
Biotechnol Prog
, vol.21
, pp. 112-121
-
-
Sheikh, K.1
Forster, J.2
Nielsen, L.K.3
-
25
-
-
0014517696
-
The energetics of mammalian cell growth
-
Kilburn, D. G., Lilly, M. D. & Webb, F. C. The energetics of mammalian cell growth. J Cell Sci 4, 645-654 (1969).
-
(1969)
J Cell Sci
, vol.4
, pp. 645-654
-
-
Kilburn, D.G.1
Lilly, M.D.2
Webb, F.C.3
-
26
-
-
77952886804
-
The biomass objective function
-
Feist, A. M. & Palsson, B. O. The biomass objective function. Curr Opin Microbiol 13, 344-349, doi: 10.1016/j.mib.2010.03.003 (2010).
-
(2010)
Curr Opin Microbiol
, vol.13
, pp. 344-349
-
-
Feist, A.M.1
Palsson, B.O.2
-
27
-
-
70449519259
-
Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells
-
Metallo, C. M., Walther, J. L. & Stephanopoulos, G. Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells. J Biotechnol 144, 167-174, doi: 10.1016/j.jbiotec.2009.07.010 (2009).
-
(2009)
J Biotechnol
, vol.144
, pp. 167-174
-
-
Metallo, C.M.1
Walther, J.L.2
Stephanopoulos, G.3
-
28
-
-
33749495312
-
Estradiol stimulates the biosynthetic pathways of breast cancer cells: Detection by metabolic flux analysis
-
S1096-7176(06) 00062-0
-
Forbes, N. S., Meadows, A. L., Clark, D. S. & Blanch, H. W. Estradiol stimulates the biosynthetic pathways of breast cancer cells: detection by metabolic flux analysis. Metab Eng 8, 639-652, doi: S1096-7176(06)00062-0 (2006).
-
(2006)
Metab Eng
, vol.8
, pp. 639-652
-
-
Forbes, N.S.1
Meadows, A.L.2
Clark, D.S.3
Blanch, H.W.4
-
29
-
-
79959942853
-
The rate of oxygen utilization by cells
-
Wagner, B. A., Venkataraman, S. & Buettner, G. R. The rate of oxygen utilization by cells. Free Radic Biol Med 51, 700-712, doi: 10.1016/j.freeradbiomed.2011.05.024 (2011).
-
(2011)
Free Radic Biol Med
, vol.51
, pp. 700-712
-
-
Wagner, B.A.1
Venkataraman, S.2
Buettner, G.R.3
-
30
-
-
0347694776
-
Cancer metabolism: Facts, fantasy, and fiction
-
Zu, X. L. & Guppy, M. Cancer metabolism: facts, fantasy, and fiction. Biochem Biophys Res Commun 313, 459-465, doi: S0006291X0302504X (2004).
-
(2004)
Biochem Biophys Res Commun
, vol.313
, pp. 459-465
-
-
Zu, X.L.1
Guppy, M.2
-
31
-
-
66149180567
-
Abnormalities in glucose uptake and metabolism in imatinib-resistant human BCR-ABL-positive cells
-
Kominsky, D. J. et al. Abnormalities in glucose uptake and metabolism in imatinib-resistant human BCR-ABL-positive cells. Clin Cancer Res 15, 3442-3450, doi: 10.1158/1078-0432.CCR-08-3291 (2009).
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3442-3450
-
-
Kominsky, D.J.1
-
32
-
-
0030255579
-
In human hepatocellular carcinoma cells the total membrane surface area of each major organelle is a particular allometric function of the cytoplasmic volume. A morphometric study
-
De Menezes, Y., De Faria, F. P. & Sesso, A. In human hepatocellular carcinoma cells the total membrane surface area of each major organelle is a particular allometric function of the cytoplasmic volume. A morphometric study. J Submicrosc Cytol Pathol 28, 573-582 (1996).
-
(1996)
J Submicrosc Cytol Pathol
, vol.28
, pp. 573-582
-
-
De Menezes, Y.1
De Faria, F.P.2
Sesso, A.3
-
33
-
-
84858717996
-
Redox balance is key to explaining full vs. Partial switching to low-yield metabolism
-
van Hoek, M. J. & Merks, R. M. Redox balance is key to explaining full vs. partial switching to low-yield metabolism. BMC Syst Biol 6, 22, doi: 10.1186/1752-0509-6-22 (2012).
-
(2012)
BMC Syst Biol
, vol.6
, pp. 22
-
-
Van Hoek, M.J.1
Merks, R.M.2
-
34
-
-
34347332311
-
A genome-scale metabolic reconstruction for Escherichia coli K-12 MG1655 that accounts for 1260 ORFs and thermodynamic information
-
msb4100155
-
Feist, A. M. et al. A genome-scale metabolic reconstruction for Escherichia coli K-12 MG1655 that accounts for 1260 ORFs and thermodynamic information. Mol Syst Biol 3, 121, doi: msb4100155 (2007).
-
(2007)
Mol Syst Biol
, vol.3
, pp. 121
-
-
Feist, A.M.1
-
35
-
-
77951803596
-
Catabolic efficiency of aerobic glycolysis: The Warburg effect revisited
-
Vazquez, A., Liu, J., Zhou, Y. & Oltvai, Z. N. Catabolic efficiency of aerobic glycolysis: The Warburg effect revisited. BMC Syst Biol 4, 58, doi: 10.1186/1752-0509-4-58 (2010).
-
(2010)
BMC Syst Biol
, vol.4
, pp. 58
-
-
Vazquez, A.1
Liu, J.2
Zhou, Y.3
Oltvai, Z.N.4
-
36
-
-
37449034854
-
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
-
0709747104
-
DeBerardinis, R. J. et al. Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci USA 104, 19345-19350, doi: 0709747104 (2007).
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 19345-19350
-
-
DeBerardinis, R.J.1
-
37
-
-
0034671521
-
ATP depletion + pyrimidine depletion can markedly enhance cancer therapy: Fresh insight for a new approach
-
Martin, D. S., Bertino, J. R. & Koutcher, J. A. ATP depletion + pyrimidine depletion can markedly enhance cancer therapy: fresh insight for a new approach. Cancer Res 60, 6776-6783 (2000).
-
(2000)
Cancer Res
, vol.60
, pp. 6776-6783
-
-
Martin, D.S.1
Bertino, J.R.2
Koutcher, J.A.3
-
38
-
-
33746879141
-
Glycolysis inhibition for anticancer treatment
-
Pelicano, H., Martin, D. S., Xu, R. H. & Huang, P. Glycolysis inhibition for anticancer treatment. Oncogene 25, 4633-4646, doi: 1209597 (2006).
-
(2006)
Oncogene
, vol.25
, pp. 4633-4646
-
-
Pelicano, H.1
Martin, D.S.2
Xu, R.H.3
Huang, P.4
-
39
-
-
84855363557
-
Intracellular ATP levels are a pivotal determinant of chemoresistance in colon cancer cells
-
Zhou, Y. et al. Intracellular ATP levels are a pivotal determinant of chemoresistance in colon cancer cells. Cancer Res 72, 304-314, doi: 10.1158/0008-5472.CAN-11-1674 (2012).
-
(2012)
Cancer Res
, vol.72
, pp. 304-314
-
-
Zhou, Y.1
-
40
-
-
84872596428
-
Activating oxidative phosphorylation by a pyruvate dehydrogenase kinase inhibitor overcomes sorafenib resistance of hepatocellular carcinoma
-
Shen, Y. C. et al. Activating oxidative phosphorylation by a pyruvate dehydrogenase kinase inhibitor overcomes sorafenib resistance of hepatocellular carcinoma. Br J Cancer 108, 72-81, doi: 10.1038/bjc.2012.559 (2013).
-
(2013)
Br J Cancer
, vol.108
, pp. 72-81
-
-
Shen, Y.C.1
-
41
-
-
84856111309
-
MiR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response
-
Mateescu, B. et al. miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response. Nat Med 17, 1627-1635, doi: 10.1038/nm.2512 (2011).
-
(2011)
Nat Med
, vol.17
, pp. 1627-1635
-
-
Mateescu, B.1
-
42
-
-
84945156659
-
Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death
-
Catanzaro, D. et al. Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death. Oncotarget 6, 30102-30114, doi: 10.18632/oncotarget.4945 (2015).
-
(2015)
Oncotarget
, vol.6
, pp. 30102-30114
-
-
Catanzaro, D.1
-
43
-
-
82755166890
-
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses
-
Anastasiou, D. et al. Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science 334, 1278-1283, doi: 10.1126/science.1211485 (2011).
-
(2011)
Science
, vol.334
, pp. 1278-1283
-
-
Anastasiou, D.1
-
44
-
-
84899925866
-
Constant growth rate can be supported by decreasing energy flux and increasing aerobic glycolysis
-
Slavov, N., Budnik, B. A., Schwab, D., Airoldi, E. M. & van Oudenaarden, A. Constant growth rate can be supported by decreasing energy flux and increasing aerobic glycolysis. Cell reports 7, 705-714, doi: 10.1016/j.celrep.2014.03.057 (2014).
-
(2014)
Cell Reports
, vol.7
, pp. 705-714
-
-
Slavov, N.1
Budnik, B.A.2
Schwab, D.3
Airoldi, E.M.4
Van Oudenaarden, A.5
-
45
-
-
54249141095
-
Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival
-
Maciver, N. J. et al. Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival. J Leukoc Biol 84, 949-957, doi: 10.1189/jlb.0108024 (2008).
-
(2008)
J Leukoc Biol
, vol.84
, pp. 949-957
-
-
Maciver, N.J.1
-
46
-
-
0023245202
-
Regulation of t-cell activation and t-cell growth factor (tcgf) production by hydrogen peroxide
-
Roth, S. & Droge, W. Regulation of T-cell activation and T-cell growth factor (TCGF) production by hydrogen peroxide. Cell Immunol 108, 417-424 (1987).
-
(1987)
Cell Immunol
, vol.108
, pp. 417-424
-
-
Roth, S.1
Droge, W.2
-
47
-
-
33846420629
-
A high glycolytic flux supports the proliferative potential of murine embryonic stem cells
-
Kondoh, H. et al. A high glycolytic flux supports the proliferative potential of murine embryonic stem cells. Antioxid Redox Signal 9, 293-299, doi: 10.1089/ars.2006.1467 (2007).
-
(2007)
Antioxid Redox Signal
, vol.9
, pp. 293-299
-
-
Kondoh, H.1
-
48
-
-
77952545479
-
Metabolic oxidation regulates embryonic stem cell differentiation
-
Yanes, O. et al. Metabolic oxidation regulates embryonic stem cell differentiation. Nat Chem Biol 6, 411-417, doi: 10.1038/nchembio.364 (2010).
-
(2010)
Nat Chem Biol
, vol.6
, pp. 411-417
-
-
Yanes, O.1
-
49
-
-
77953799148
-
Induction of the Warburg effect by Kaposis sarcoma herpesvirus is required for the maintenance of latently infected endothelial cells
-
Delgado, T. et al. Induction of the Warburg effect by Kaposis sarcoma herpesvirus is required for the maintenance of latently infected endothelial cells. Proc Natl Acad Sci U S A 107, 10696-10701, doi: 10.1073/pnas.1004882107 (2010).
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 10696-10701
-
-
Delgado, T.1
-
50
-
-
84973603509
-
Six hours after infection, the metabolic changes induced by wssv neutralize the hosts oxidative stress defenses
-
Chen, I. T. et al. Six Hours after Infection, the Metabolic Changes Induced by WSSV Neutralize the Hosts Oxidative Stress Defenses. Sci Rep 6, 27732, doi: 10.1038/srep27732 (2016).
-
(2016)
Sci Rep
, vol.6
, pp. 27732
-
-
Chen, I.T.1
-
51
-
-
78049269134
-
Correlation of brain amyloid with "aerobic glycolysis": A question of assumptions?
-
Phelps, M. E. & Barrio, J. R. Correlation of brain amyloid with "aerobic glycolysis": A question of assumptions? Proc Natl Acad Sci USA 107, 17459-17460, doi: 10.1073/pnas.1012684107 (2010).
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 17459-17460
-
-
Phelps, M.E.1
Barrio, J.R.2
-
52
-
-
84857814973
-
Patterns of amino acid metabolism by proliferating human mesenchymal stem cells
-
Higuera, G. A. et al. Patterns of amino acid metabolism by proliferating human mesenchymal stem cells. Tissue Eng Part A 18, 654-664, doi: 10.1089/ten.TEA.2011.0223 (2012).
-
(2012)
Tissue Eng Part A
, vol.18
, pp. 654-664
-
-
Higuera, G.A.1
-
53
-
-
84881475919
-
Pyrimidine homeostasis is accomplished by directed overflow metabolism
-
Reaves, M. L., Young, B. D., Hosios, A. M., Xu, Y. F. & Rabinowitz, J. D. Pyrimidine homeostasis is accomplished by directed overflow metabolism. Nature 500, 237-241, doi: 10.1038/nature12445 (2013).
-
(2013)
Nature
, vol.500
, pp. 237-241
-
-
Reaves, M.L.1
Young, B.D.2
Hosios, A.M.3
Xu, Y.F.4
Rabinowitz, J.D.5
-
54
-
-
84860793042
-
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation
-
Ye, J. et al. Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. Proc Natl Acad Sci USA 109, 6904-6909, doi: 10.1073/pnas.1204176109 (2012).
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 6904-6909
-
-
Ye, J.1
-
55
-
-
80051923932
-
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
-
Possemato, R. et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 476, 346-350, doi: 10.1038/nature10350 (2011).
-
(2011)
Nature
, vol.476
, pp. 346-350
-
-
Possemato, R.1
-
56
-
-
84958120328
-
Metabolic heterogeneity in human lung tumors
-
Hensley, C. T. et al. Metabolic Heterogeneity in Human Lung Tumors. Cell 164, 681-694, doi: 10.1016/j.cell.2015.12.034 (2016).
-
(2016)
Cell
, vol.164
, pp. 681-694
-
-
Hensley, C.T.1
-
57
-
-
84959524203
-
Mitochondria and cancer
-
Zong, W. X., Rabinowitz, J. D. & White, E. Mitochondria and Cancer. Mol Cell 61, 667-676, doi: 10.1016/j.molcel.2016.02.011 (2016).
-
(2016)
Mol Cell
, vol.61
, pp. 667-676
-
-
Zong, W.X.1
Rabinowitz, J.D.2
White, E.3
-
58
-
-
67650687092
-
CellMiner: A relational database and query tool for the NCI-60 cancer cell lines
-
Shankavaram, U. T. et al. CellMiner: A relational database and query tool for the NCI-60 cancer cell lines. BMC Genomics 10, 277, doi: 10.1186/1471-2164-10-277 (2009).
-
(2009)
BMC Genomics
, vol.10
, pp. 277
-
-
Shankavaram, U.T.1
-
59
-
-
0035543345
-
Analysis of CHO cells metabolic redistribution in a glutamate-based defined medium in continuous culture
-
bp0100981
-
Altamirano, C. et al. Analysis of CHO cells metabolic redistribution in a glutamate-based defined medium in continuous culture. Biotechnol Prog 17, 1032-1041, doi: bp0100981 (2001).
-
(2001)
Biotechnol Prog
, vol.17
, pp. 1032-1041
-
-
Altamirano, C.1
-
60
-
-
0030570128
-
Metabolic flux analysis of hybridoma cells in different culture media using mass balances
-
Bonarius, H. P. et al. Metabolic flux analysis of hybridoma cells in different culture media using mass balances. Biotechnol Bioeng 50, 299-318, doi: 10.1002/(SICI)1097-0290(19960505)50:3 3.0.CO;2-B (1996).
-
(1996)
Biotechnol Bioeng
, vol.50
, pp. 299-318
-
-
Bonarius, H.P.1
-
61
-
-
84879747337
-
Intracellular water exchange for measuring the dry mass, water mass and changes in chemical composition of living cells
-
Feijo Delgado, F. et al. Intracellular water exchange for measuring the dry mass, water mass and changes in chemical composition of living cells. PLoS One 8, e67590, doi: 10.1371/journal.pone.0067590 (2013).
-
(2013)
PLoS One
, vol.8
, pp. e67590
-
-
Feijo Delgado, F.1
-
62
-
-
70449245667
-
Metabolism and enzyme content of diploid and tetraploid lympnomas and carcinomas
-
Kit, S., Fiscus, J., Graham, O. L. & Gross, A. L. Metabolism and enzyme content of diploid and tetraploid lympnomas and carcinomas. Cancer Res 19, 201-206 (1959).
-
(1959)
Cancer Res
, vol.19
, pp. 201-206
-
-
Kit, S.1
Fiscus, J.2
Graham, O.L.3
Gross, A.L.4
-
63
-
-
34250131466
-
Volume and surface changes of smooth endoplasmic reticulum in crayfish retinula cells upon light-And dark-Adaptation
-
Frixione, E. & Porter, R. M. Volume and surface changes of smooth endoplasmic reticulum in crayfish retinula cells upon light-And dark-Adaptation. J. Comp. Physiol. 159, 667-674, doi: 10.1007/bf00612039 (1986).
-
(1986)
J. Comp Physiol
, vol.159
, pp. 667-674
-
-
Frixione, E.1
Porter, R.M.2
-
64
-
-
84892788440
-
Constraint-based models predict metabolic and associated cellular functions
-
Bordbar, A., Monk, J. M., King, Z. A. & Palsson, B. O. Constraint-based models predict metabolic and associated cellular functions. Nat Rev Genet 15, 107-120, doi: 10.1038/nrg3643 (2014).
-
(2014)
Nat Rev Genet
, vol.15
, pp. 107-120
-
-
Bordbar, A.1
Monk, J.M.2
King, Z.A.3
Palsson, B.O.4
-
65
-
-
79953072390
-
Building the process-drug-side effect network to discover the relationship between biological processes and side effects
-
Lee, S., Lee, K. H., Song, M. & Lee, D. Building the process-drug-side effect network to discover the relationship between biological processes and side effects. Bmc Bioinformatics 12 Suppl 2, S2, doi: 10.1186/1471-2105-12-S2-S2 (2011).
-
(2011)
Bmc Bioinformatics
, vol.2-12
-
-
Lee, S.1
Lee, K.H.2
Song, M.3
Lee, D.4
|