A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability

Nature Communications

Volumn 8, Issue , 2017, Pages

  Liu, Jiang ^a   Wang, Ying ^a   Song, Lizhi ^a   Zeng, Linghua ^a   Yi, Weiwei ^a   Liu, Ting ^a   Chen, Huanzhen ^b   Wang, Miao ^a   Ju, Zhenyu ^a   Cong, Yu Sheng ^a  

^a HANGZHOU NORMAL UNIVERSITY   (China)

^b SHANXI MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CASPASE 3; DDRGK DOMAIN CONTAINING PROTEIN 1; DR5 PROTEIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HEAT SHOCK COGNATE PROTEIN 70; INITIATION FACTOR 2ALPHA; MESSENGER RNA; PKR LIKE ENDOPLASMIC RETICULUM KINASE; PROTEIN; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; PROTEIN IRE1; PROTEIN IRE1ALPHA; PROTEIN KINASE; PROTEIN NOXA; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA; THAPSIGARGIN; TUNICAMYCIN; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; CARRIER PROTEIN; DDRGK1 PROTEIN, HUMAN; ERN1 PROTEIN, HUMAN; ERN1 PROTEIN, MOUSE; PROTEIN SERINE THREONINE KINASE; RIBONUCLEASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SMALL INTERFERING RNA; UFM1 PROTEIN, HUMAN; UFM1-BINDING PROTEIN 1 CONTAINING A PCI DOMAIN, MOUSE; XBP1 PROTEIN, HUMAN;

APOPTOSIS; CANCER; CELLS AND CELL COMPONENTS; ENZYME ACTIVITY; GENE EXPRESSION; HOMEOSTASIS; PROTEIN; SURVIVAL;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL; CELL DEATH; CELL SURVIVAL; COMPARATIVE STUDY; CONTROLLED STUDY; ECTOPIC EXPRESSION; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELL; HOMEOSTASIS; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; IN VITRO STUDY; MOUSE; MTT ASSAY; NONHUMAN; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; ANIMAL; GENE KNOCKDOWN; GENETICS; HEK293 CELL LINE; HEP-G2 CELL LINE; HUMAN; MCF-7 CELL LINE; METABOLISM; PHYSIOLOGY; PROTEIN DOMAIN; UNFOLDED PROTEIN RESPONSE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; CARRIER PROTEINS; CELL SURVIVAL; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HEP G2 CELLS; HUMANS; MCF-7 CELLS; MICE; PROTEIN DOMAINS; PROTEIN STABILITY; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; X-BOX BINDING PROTEIN 1;

EID: 85010869357     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms14186     Document Type: Article

References (33)

1. Brown, M. K. & Naidoo, N. The endoplasmic reticulum stress response in aging and age-related diseases. Front. Physiol. 3, 263 (2012).
2. Hetz, C. The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat. Rev. Mol Cell Biol. 13, 89-102 (2012).
3. Xu, C., Bailly-Maitre, B. & Reed, J. C. Endoplasmic reticulum stress: cell life and death decisions. J. Clin. Investig. 115, 2656-2664 (2005).
4. Rutkowski, D. T. & Kaufman, R. J. A trip to the ER: coping with stress. Trends Cell Biol. 14, 20-28 (2004).
5. Tabas, I. & Ron, D. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat. Cell Biol. 13, 184-190 (2011).
6. Jing, G., Wang, J. J. & Zhang, S. X. ER stress and apoptosis: a new mechanism for retinal cell death. Exp. Diab. Res. 2012, 589589 (2012).
7. Lin, J. H. et al. IRE1 signaling affects cell fate during the unfolded protein response. Science 318, 944-949 (2007).
8. Chen, Y. & Brandizzi, F. IRE1: ER stress sensor and cell fate executor. Trends Cell Biol. 23, 547-555 (2013).
9. Chen, L. et al. Cab45S inhibits the ER stress-induced IRE1-JNK pathway and apoptosis via GRP78/BiP. Cell Death Dis. 5, e1219 (2014).
10. Urano, F. et al. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287, 664-666 (2000).
11. Oslowski, C. M. & Urano, F. Measuring ER stress and the unfolded protein response using mammalian tissue culture system. Methods Enzymol. 490, 71-92 (2011).
12. Lemaire, K. et al. Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis. PLoS ONE 6, e18517 (2011).
13. Hofmann, K. & Bucher, P. The PCI domain: a common theme in three multiprotein complexes. Trends Biochem. Sci. 23, 204-205 (1998).
14. Wu, J., Lei, G., Mei, M., Tang, Y. & Li, H. A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling. J. Biol. Chem. 285, 15126-15136 (2010).
15. Tatsumi, K. et al. A novel type of E3 ligase for the Ufm1 conjugation system. J Biol. Chem. 285, 5417-5427 (2010).
16. Kwon, J. et al. A novel LZAP-binding protein, NLBP, inhibits cell invasion. J. Biol. Chem. 285, 12232-12240 (2010).
17. Azfer, A., Niu, J., Rogers, L. M., Adamski, F. M. & Kolattukudy, P. E. Activation of endoplasmic reticulum stress response during the development of ischemic heart disease. Am. J. Physiol. Heart Circ. Physiol. 291, H1411-H1420 (2006).
18. Lu, H., Yang, Y., Allister, E. M., Wijesekara, N. & Wheeler, M. B. The identification of potential factors associated with the development of type 2 diabetes: a quantitative proteomics approach. Mol. Cell. Proteom. 7, 1434-1451 (2008).
19. Zhang, Y., Zhang, M., Wu, J., Lei, G. & Li, H. Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking. PLoS ONE 7, e48587 (2012).
20. Yoo, H. M. et al. Modification of ASC1 by UFM1 is crucial for ERalpha transactivation and breast cancer development. Mol. Cell 56, 261-274 (2014).
21. Xi, P., Ding, D., Zhou, J., Wang, M. & Cong, Y. S. DDRGK1 regulates NF-kappaB activity by modulating IkappaBalpha stability. PLoS ONE 8, e64231 (2013).
22. Janicke, R. U. MCF-7 breast carcinoma cells do not express caspase-3. Breast Cancer Res. Treat. 117, 219-221 (2009).
23. Zhang, K. et al. The unfolded protein response transducer IRE1alpha prevents ER stress-induced hepatic steatosis. EMBO J. 30, 1357-1375 (2011).
24. Sun, S. et al. IRE1alpha is an endogenous substrate of endoplasmic-reticulumassociated degradation. Nat. Cell Biol. 17, 1546-1555 (2015).
25. Komatsu, M. et al. A novel protein-conjugating system for Ufm1, a ubiquitinfold modifier. EMBO J. 23, 1977-1986 (2004).
26. van Galen, P. et al. The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress. Nature 510, 268-272 (2014).
27. Hetz, C., Martinon, F., Rodriguez, D. & Glimcher, L. H. The unfolded protein response: integrating stress signals through the stress sensor IRE1alpha. Physiol. Rev. 91, 1219-1243 (2011).
28. Walter, P. & Ron, D. The unfolded protein response: from stress pathway to homeostatic regulation. Science 334, 1081-1086 (2011).
29. Merksamer, P. I. & Papa, F. R. The UPR and cell fate at a glance. J. Cell Sci. 123, 1003-1006 (2010).
30. Zhang, M. et al. RCAD/Ufl1, a Ufm1 E3 ligase, is essential for hematopoietic stem cell function and murine hematopoiesis. Cell Death Diff. 22, 1922-1934 (2015).
31. Tatsumi, K. et al. The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice. Nat. Commun. 2, 181 (2011).
32. Cai, Y. et al. UFBP1, a key component of the Ufm1 conjugation system, is essential for ufmylation-mediated regulation of erythroid development. PLoS Genet. 11, e1005643 (2015).
33. Chen, Z. et al. Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways. Nat. Commun. 6, 6808 (2015).