메뉴 건너뛰기




Volumn 13, Issue 6, 2013, Pages 385-396

Progesterone signalling in breast cancer: A neglected hormone coming into the limelight

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA6 INTEGRIN; AMPHIREGULIN; BETA1 INTEGRIN; CALCITONIN; CYCLIN D1; EPIDERMAL GROWTH FACTOR; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; FIBROBLAST GROWTH FACTOR; MEDROXYPROGESTERONE ACETATE; OSTEOCLAST DIFFERENTIATION FACTOR; PROGESTERONE; PROGESTERONE RECEPTOR; SMAD2 PROTEIN; SMAD3 PROTEIN; TAMOXIFEN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; WNT4 PROTEIN;

EID: 84878258729     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc3518     Document Type: Review
Times cited : (203)

References (100)
  • 2
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Cancer Genome Atlas Network
    • Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature 490, 61-70 (2012).
    • (2012) Nature , vol.490 , pp. 61-70
  • 3
    • 84862523863 scopus 로고    scopus 로고
    • Sequence analysis of mutations and translocations across breast cancer subtypes
    • Banerji, S. et al. Sequence analysis of mutations and translocations across breast cancer subtypes. Nature 486, 405-409 (2012).
    • (2012) Nature , vol.486 , pp. 405-409
    • Banerji, S.1
  • 4
    • 84860214990 scopus 로고    scopus 로고
    • Intra-tumour heterogeneity: A looking glass for cancer? Nature Rev
    • Marusyk, A., Almendro, V. & Polyak, K. Intra-tumour heterogeneity: a looking glass for cancer? Nature Rev. Cancer 12, 323-334 (2012).
    • (2012) Cancer , vol.12 , pp. 323-334
    • Marusyk, A.1    Almendro, V.2    Polyak, K.3
  • 5
    • 84875884456 scopus 로고    scopus 로고
    • Cellular heterogeneity and molecular evolution in cancer
    • Almendro, V., Marusyk, A. & Polyak, K. Cellular heterogeneity and molecular evolution in cancer. Annu. Rev. Pathol. 8, 277-302 (2012).
    • (2012) Annu. Rev. Pathol. , vol.8 , pp. 277-302
    • Almendro, V.1    Marusyk, A.2    Polyak, K.3
  • 6
    • 0023589208 scopus 로고
    • Breast cancer and atypia among young and middle-aged women: A study of 110 medicolegal autopsies
    • Nielsen, M., Thomsen, J. L., Primdahl, S., Dyreborg, U. & Andersen, J. A. Breast cancer and atypia among young and middle-aged women: a study of 110 medicolegal autopsies. Br. J. Cancer 56, 814-819 (1987).
    • (1987) Br. J. Cancer , vol.56 , pp. 814-819
    • Nielsen, M.1    Thomsen, J.L.2    Primdahl, S.3    Dyreborg, U.4    Andersen, J.A.5
  • 7
    • 0032980789 scopus 로고    scopus 로고
    • Comparative genomic hybridization of ductal carcinoma in situ of the breast-evidence of multiple genetic pathways
    • Buerger, H. et al. Comparative genomic hybridization of ductal carcinoma in situ of the breast-evidence of multiple genetic pathways. J. Pathol. 187, 396-402 (1999).
    • (1999) J. Pathol. , vol.187 , pp. 396-402
    • Buerger, H.1
  • 8
    • 0001522593 scopus 로고
    • Endocrine control of mammary-gland development in the C3H/He Crgl mouse
    • Nandi, S. Endocrine control of mammary-gland development in the C3H/He Crgl mouse. J. Natl Cancer Inst. 21, 1039-1063 (1958).
    • (1958) J. Natl Cancer Inst. , vol.21 , pp. 1039-1063
    • Nandi, S.1
  • 9
    • 70449255204 scopus 로고
    • Hormonal synergism in mammary growth
    • Lyons, W. R. Hormonal synergism in mammary growth. Proc. R. Soc. Lond. B Biol. Sci. 149, 303-325 (1958).
    • (1958) Proc. R. Soc. Lond. B Biol. Sci. , vol.149 , pp. 303-325
    • Lyons, W.R.1
  • 10
    • 0014900473 scopus 로고
    • Age at first birth and breast cancer risk
    • MacMahon, B. et al. Age at first birth and breast cancer risk. Bull. World Health Organ. 43, 209-221 (1970).
    • (1970) Bull. World Health Organ. , vol.43 , pp. 209-221
    • MacMahon, B.1
  • 11
    • 1342327388 scopus 로고    scopus 로고
    • Risk factors for breast cancer according to estrogen and progesterone receptor status
    • Colditz, G. A., Rosner, B. A., Chen, W. Y., Holmes, M. D. & Hankinson, S. E. Risk factors for breast cancer according to estrogen and progesterone receptor status. J. Natl Cancer Inst. 96, 218-228 (2004).
    • (2004) J. Natl Cancer Inst. , vol.96 , pp. 218-228
    • Colditz, G.A.1    Rosner, B.A.2    Chen, W.Y.3    Holmes, M.D.4    Hankinson, S.E.5
  • 12
    • 0020576133 scopus 로고
    • 'Hormonal' risk factors, 'breast tissue age' and the age-incidence of breast cancer
    • Pike, M. C. Krailo, M. D., Henderson, B. E., Casagrande, J.T. & Hoel, D. G. 'Hormonal' risk factors, 'breast tissue age' and the age-incidence of breast cancer. Nature 303, 767-770 (1983).
    • (1983) Nature , vol.303 , pp. 767-770
    • Pike, M.C.1    Krailo, M.D.2    Henderson, B.E.3    Casagrande, J.T.4    Hoel, D.G.5
  • 13
    • 0017664370 scopus 로고
    • Cyclic Variation of DNA synthesis in human breast epithelium
    • Masters, J. R., Drife, J. O. & Scarisbrick, J. J. Cyclic Variation of DNA synthesis in human breast epithelium. J. Natl Cancer Inst. 58, 1263-1265 (1977).
    • (1977) J. Natl Cancer Inst. , vol.58 , pp. 1263-1265
    • Masters, J.R.1    Drife, J.O.2    Scarisbrick, J.J.3
  • 14
    • 0022508303 scopus 로고
    • A correlative morphologic study of human breast and endometrium in the menstrual cycle
    • Longacre, T. A. & Bartow, S. A. A correlative morphologic study of human breast and endometrium in the menstrual cycle. Am. J. Surg. Pathol. 10, 382-393 (1986).
    • (1986) Am. J. Surg. Pathol. , vol.10 , pp. 382-393
    • Longacre, T.A.1    Bartow, S.A.2
  • 15
    • 0015873713 scopus 로고
    • On the origin and progression of ductal carcinoma in the human breast
    • Wellings, S. R. & Jensen, H. M. On the origin and progression of ductal carcinoma in the human breast. J. Natl Cancer Inst. 50, 1111-1118 (1973).
    • (1973) J. Natl Cancer Inst. , vol.50 , pp. 1111-1118
    • Wellings, S.R.1    Jensen, H.M.2
  • 16
    • 50549123220 scopus 로고
    • On the treatment of inoperable cases of carcinoma of the mamma: Suggestions for a new method of treatment, with illustrative cases
    • Beatson, G. T. On the treatment of inoperable cases of carcinoma of the mamma: suggestions for a new method of treatment, with illustrative cases. Lancet, 104-107 (1896).
    • (1896) Lancet , pp. 104-107
    • Beatson, G.T.1
  • 17
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG).
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 365, 1687-1717 (2005).
    • (2005) Lancet , vol.365 , pp. 1687-1717
  • 18
    • 0242390079 scopus 로고    scopus 로고
    • Breast cancer and hormonal contraceptives: Collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies
    • Collaborative Group on Hormonal Factors in Breast Cancer.
    • Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and hormonal contraceptives: collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies. Lancet 347, 1713-1727 (1996).
    • (1996) Lancet , vol.347 , pp. 1713-1727
  • 19
    • 84860474009 scopus 로고    scopus 로고
    • Conjugated equine oestrogen and breast cancer incidence and mortality in postmenopausal women with hysterectomy: Extended follow-up of the Women's Health Initiative randomised placebo-controlled trial
    • Anderson, G. L. et al. Conjugated equine oestrogen and breast cancer incidence and mortality in postmenopausal women with hysterectomy: extended follow-up of the Women's Health Initiative randomised placebo-controlled trial. Lancet Oncol. 13, 476-486 (2012).
    • (2012) Lancet Oncol. , vol.13 , pp. 476-486
    • Anderson, G.L.1
  • 20
    • 0042018741 scopus 로고    scopus 로고
    • Breast cancer and hormone-replacement therapy in the Million Women Study
    • Beral, V. Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet 362, 419-427 (2003).
    • (2003) Lancet , vol.362 , pp. 419-427
    • Beral, V.1
  • 21
    • 77958138780 scopus 로고    scopus 로고
    • Estrogen plus progestin and breast cancer incidence and mortality in postmenopausal women
    • Chlebowski, R. T. et al. Estrogen plus progestin and breast cancer incidence and mortality in postmenopausal women. JAMA 304, 1684-1692 (2010).
    • (2010) JAMA , vol.304 , pp. 1684-1692
    • Chlebowski, R.T.1
  • 22
    • 0037125379 scopus 로고    scopus 로고
    • Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial
    • Rossouw, J. E. et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 288, 321-333 (2002).
    • (2002) JAMA , vol.288 , pp. 321-333
    • Rossouw, J.E.1
  • 23
    • 0033305673 scopus 로고    scopus 로고
    • Hormone replacement therapy with estrogen or estrogen plus medroxyprogesterone acetate is associated with increased epithelial proliferation in the normal postmenopausal breast
    • Hofseth, L. J. et al. Hormone replacement therapy with estrogen or estrogen plus medroxyprogesterone acetate is associated with increased epithelial proliferation in the normal postmenopausal breast. J. Clin. Endocrinol. Metab. 84, 4559-4565 (1999).
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 4559-4565
    • Hofseth, L.J.1
  • 24
    • 36549076409 scopus 로고    scopus 로고
    • Unequal risks for breast cancer associated with different hormone replacement therapies: Results from the E3N cohort study
    • Fournier, A., Berrino, F. & Clavel-Chapelon, F. Unequal risks for breast cancer associated with different hormone replacement therapies: results from the E3N cohort study. Breast Cancer Res. Treat. 107, 103-111 (2008).
    • (2008) Breast Cancer Res. Treat. , vol.107 , pp. 103-111
    • Fournier, A.1    Berrino, F.2    Clavel-Chapelon, F.3
  • 25
    • 14044266896 scopus 로고    scopus 로고
    • Breast cancer risk in relation to different types of hormone replacement therapy in the E3N-EPIC cohort
    • Fournier, A., Berrino, F., Riboli, E., Avenel, V. & Clavel-Chapelon, F. Breast cancer risk in relation to different types of hormone replacement therapy in the E3N-EPIC cohort. Int. J. Cancer 114, 448-454 (2005).
    • (2005) Int. J. Cancer , vol.114 , pp. 448-454
    • Fournier, A.1    Berrino, F.2    Riboli, E.3    Avenel, V.4    Clavel-Chapelon, F.5
  • 26
    • 1942439064 scopus 로고    scopus 로고
    • Pharmacological profile of progestins
    • Sitruk-Ware, R. Pharmacological profile of progestins. Maturitas 47, 277-283 (2004).
    • (2004) Maturitas , vol.47 , pp. 277-283
    • Sitruk-Ware, R.1
  • 27
    • 79951884699 scopus 로고    scopus 로고
    • Changes in invasive breast cancer and ductal carcinoma in situ rates in relation to the decline in hormone therapy use
    • Farhat, G. N., Walker, R., Buist, D. S., Onega, T. & Kerlikowske, K. Changes in invasive breast cancer and ductal carcinoma in situ rates in relation to the decline in hormone therapy use. J. Clin. Oncol. 28, 5140-5146 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 5140-5146
    • Farhat, G.N.1    Walker, R.2    Buist, D.S.3    Onega, T.4    Kerlikowske, K.5
  • 28
    • 59749098583 scopus 로고    scopus 로고
    • Breast cancer after use of estrogen plus progestin in postmenopausal women
    • Chlebowski, R. T. et al. Breast cancer after use of estrogen plus progestin in postmenopausal women. N. Engl. J. Med. 360, 573-587 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , pp. 573-587
    • Chlebowski, R.T.1
  • 29
    • 33745683831 scopus 로고    scopus 로고
    • Breast density and parenchymal patterns as markers of breast cancer risk: A meta-analysis
    • McCormack, V. A. & dos Santos Silva, I. Breast density and parenchymal patterns as markers of breast cancer risk: a meta-analysis. Cancer Epidemiol. Biomarkers Prev. 15, 1159-1169 (2006).
    • (2006) Cancer Epidemiol. Biomarkers Prev. , vol.15 , pp. 1159-1169
    • McCormack, V.A.1    Dos Santos Silva, I.2
  • 30
    • 33846407655 scopus 로고    scopus 로고
    • Mammographic density and the risk and detection of breast cancer
    • Boyd, N. F. et al. Mammographic density and the risk and detection of breast cancer. N. Engl. J. Med. 356, 227-236 (2007).
    • (2007) N. Engl. J. Med. , vol.356 , pp. 227-236
    • Boyd, N.F.1
  • 31
    • 0036264710 scopus 로고    scopus 로고
    • Effects of tibolone and continuous combined hormone replacement therapy on mammographic breast density
    • Lundstrom, E. et al. Effects of tibolone and continuous combined hormone replacement therapy on mammographic breast density. Am. J. Obstet. Gynecol. 186, 717-722 (2002).
    • (2002) Am. J. Obstet. Gynecol. , vol.186 , pp. 717-722
    • Lundstrom, E.1
  • 32
    • 0036847605 scopus 로고    scopus 로고
    • Case-control study of increased mammographic breast density response to hormone replacement therapy
    • Vachon, C. M., Sellers, T. A., Vierkant, R. A., Wu, F. F. & Brandt, K. R. Case-control study of increased mammographic breast density response to hormone replacement therapy. Cancer Epidemiol. Biomarkers Prev. 11, 1382-1388 (2002).
    • (2002) Cancer Epidemiol. Biomarkers Prev. , vol.11 , pp. 1382-1388
    • Vachon, C.M.1    Sellers, T.A.2    Vierkant, R.A.3    Wu, F.F.4    Brandt, K.R.5
  • 33
    • 0037245313 scopus 로고    scopus 로고
    • Postmenopausal hormone therapy and change in mammographic density
    • Greendale, G. A. et al. Postmenopausal hormone therapy and change in mammographic density. J. Natl Cancer Inst. 95, 30-37 (2003).
    • (2003) J. Natl Cancer Inst. , vol.95 , pp. 30-37
    • Greendale, G.A.1
  • 34
    • 0023577680 scopus 로고
    • Direct action of 17 β-estradiol on mouse mammary ducts analyzed by sustained release implants and steroid autoradiography
    • Daniel, C. W., Silberstein, G. B. & Strickland, P. Direct action of 17 β-estradiol on mouse mammary ducts analyzed by sustained release implants and steroid autoradiography. Cancer Res. 47, 6052-6057 (1987).
    • (1987) Cancer Res. , vol.47 , pp. 6052-6057
    • Daniel, C.W.1    Silberstein, G.B.2    Strickland, P.3
  • 35
    • 77649259667 scopus 로고    scopus 로고
    • Tw o distinct mechanisms underlie progesterone-induced proliferation in the mammary gland
    • Beleut, M. et al. Tw o distinct mechanisms underlie progesterone-induced proliferation in the mammary gland. Proc. Natl Acad. Sci. USA 107, 2989-2994 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 2989-2994
    • Beleut, M.1
  • 36
    • 0025066468 scopus 로고
    • Progesterone action in normal mouse mammary gland
    • Wang, S., Counterman, L. J. & Haslam, S. Z. Progesterone action in normal mouse mammary gland. Endocrinology 127, 2183-2189 (1990).
    • (1990) Endocrinology , vol.127 , pp. 2183-2189
    • Wang, S.1    Counterman, L.J.2    Haslam, S.Z.3
  • 37
    • 0018597824 scopus 로고
    • Effect of oestradiol on progesterone receptors in normal mammary glands and its relationship with lactation
    • Haslam, S. Z. & Shyamala, G. Effect of oestradiol on progesterone receptors in normal mammary glands and its relationship with lactation. Biochem. J. 182, 127-131 (1979).
    • (1979) Biochem. J. , vol.182 , pp. 127-131
    • Haslam, S.Z.1    Shyamala, G.2
  • 38
    • 34249800111 scopus 로고    scopus 로고
    • Differential hormonal regulation and function of progesterone receptor isoforms in normal adult mouse mammary gland
    • Aupperlee, M. D. & Haslam, S. Z. Differential hormonal regulation and function of progesterone receptor isoforms in normal adult mouse mammary gland. Endocrinology 148, 2290-2300 (2007).
    • (2007) Endocrinology , vol.148 , pp. 2290-2300
    • Aupperlee, M.D.1    Haslam, S.Z.2
  • 39
    • 0029115517 scopus 로고
    • Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities
    • Lydon, J. et al. Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev 9, 2266-2278 (1995).
    • (1995) Genes Dev , vol.9 , pp. 2266-2278
    • Lydon, J.1
  • 40
    • 0033767836 scopus 로고    scopus 로고
    • Effect of single and compound knockouts of estrogen receptors α (ERα) and β (ERβ) on mouse reproductive phenotypes
    • Dupont, S. et al. Effect of single and compound knockouts of estrogen receptors α (ERα) and β (ERβ) on mouse reproductive phenotypes. Development 127, 4277-4291 (2000).
    • (2000) Development , vol.127 , pp. 4277-4291
    • Dupont, S.1
  • 41
    • 33144474647 scopus 로고    scopus 로고
    • Paracrine signaling through the epithelial estrogen receptor α is required for proliferation and morphogenesis in the mammary gland
    • Mallepell, S., Krust, A., Chambon, P. & Brisken, C. Paracrine signaling through the epithelial estrogen receptor α is required for proliferation and morphogenesis in the mammary gland. Proc. Natl Acad. Sci. USA 103, 2196-2201 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 2196-2201
    • Mallepell, S.1    Krust, A.2    Chambon, P.3    Brisken, C.4
  • 42
    • 0032574830 scopus 로고    scopus 로고
    • A paracrine role for the epithelial progesterone receptor in mammary gland development
    • Brisken, C. et al. A paracrine role for the epithelial progesterone receptor in mammary gland development. Proc. Natl Acad. Sci. USA 95, 5076-5081 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 5076-5081
    • Brisken, C.1
  • 44
    • 0026808841 scopus 로고
    • Lactoferrin expression in the mouse reproductive tract during the natural estrous cycle: Correlation with circulating estradiol and progesterone
    • Walmer, D. K., Wrona, M. A., Hughes, C. L. & Nelson, K. G. Lactoferrin expression in the mouse reproductive tract during the natural estrous cycle: correlation with circulating estradiol and progesterone. Endocrinology 131, 1458-1466 (1992).
    • (1992) Endocrinology , vol.131 , pp. 1458-1466
    • Walmer, D.K.1    Wrona, M.A.2    Hughes, C.L.3    Nelson, K.G.4
  • 45
    • 67651113440 scopus 로고    scopus 로고
    • Assessing reproductive status/stages in mice
    • Appendix 4I
    • Caligioni, C. S. Assessing reproductive status/stages in mice. Curr. Protoc. Neurosci. 4, Appendix 4I (2009).
    • (2009) Curr. Protoc. Neurosci. , vol.4
    • Caligioni, C.S.1
  • 46
    • 67349274102 scopus 로고    scopus 로고
    • Alternative 5′-untranslated first exons of the mouse Cyp19A1 (aromatase) gene
    • Chow, J. D., Simpson, E. R. & Boon, W. C. Alternative 5′-untranslated first exons of the mouse Cyp19A1 (aromatase) gene. J. Steroid Biochem. Mol. Biol. 115, 115-125 (2009).
    • (2009) J. Steroid Biochem. Mol. Biol. , vol.115 , pp. 115-125
    • Chow, J.D.1    Simpson, E.R.2    Boon, W.C.3
  • 47
    • 84877748040 scopus 로고    scopus 로고
    • Progesterone/RANKL is a major regulatory axis in the human breast
    • Tanos, T. et al. Progesterone/RANKL is a major regulatory axis in the human breast. Sci. Transl. Med. 5, 182ra55 (2013).
    • (2013) Sci. Transl. Med. , vol.5
    • Tanos, T.1
  • 48
    • 0030670385 scopus 로고    scopus 로고
    • Dissociation between steroid receptor expression and cell proliferation in the human breast
    • Clarke, R. B., Howell, A., Potten, C. S. & Anderson, E. Dissociation between steroid receptor expression and cell proliferation in the human breast. Cancer Res. 57, 4987-4991 (1997).
    • (1997) Cancer Res. , vol.57 , pp. 4987-4991
    • Clarke, R.B.1    Howell, A.2    Potten, C.S.3    Anderson, E.4
  • 49
    • 12244294465 scopus 로고    scopus 로고
    • Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development
    • Grimm, S. L. et al. Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development. Mol. Endocrinol. 16, 2675-2691 (2002).
    • (2002) Mol. Endocrinol. , vol.16 , pp. 2675-2691
    • Grimm, S.L.1
  • 50
    • 0034335414 scopus 로고    scopus 로고
    • C/EBPβ (CCAAT/enhancer binding protein) controls cell fate determination during mammary gland development
    • Seagroves, T. N., Lydon, J. P., Hovey, R. C, Vonderhaar, B. K. & Rosen, J. M. C/EBPβ (CCAAT/enhancer binding protein) controls cell fate determination during mammary gland development. Mol. Endocrinol. 14, 359-368 (2000).
    • (2000) Mol. Endocrinol. , vol.14 , pp. 359-368
    • Seagroves, T.N.1    Lydon, J.P.2    Hovey, R.C.3    Vonderhaar, B.K.4    Rosen, J.M.5
  • 51
    • 0032925166 scopus 로고    scopus 로고
    • Pattern of distribution of cells positive for estrogen receptor a and progesterone receptor in relation to proliferating cells in the mammary gland [In Process Citation]
    • Russo, J., Ao, X., Grill, C. & Russo, I. H. Pattern of distribution of cells positive for estrogen receptor a and progesterone receptor in relation to proliferating cells in the mammary gland [In Process Citation]. Breast Cancer Res. Treat. 53, 217-227 (1999).
    • (1999) Breast Cancer Res. Treat. , vol.53 , pp. 217-227
    • Russo, J.1    Ao, X.2    Grill, C.3    Russo, I.H.4
  • 52
    • 25144457206 scopus 로고    scopus 로고
    • Proliferation of estrogen receptor-A-positive mammary epithelial cells is restrained by transforming growth factor-β1 in adult mice
    • Ewan, K. B. et al. Proliferation of estrogen receptor-a-positive mammary epithelial cells is restrained by transforming growth factor-β1 in adult mice. Am. J. Pathol. 167, 409-417 (2005).
    • (2005) Am. J. Pathol. , vol.167 , pp. 409-417
    • Ewan, K.B.1
  • 53
    • 34248353890 scopus 로고    scopus 로고
    • Amphiregulin is an essential mediator of estrogen receptor a function in mammary gland development
    • Ciarloni, L, Mallepell, S. & Brisken, C. Amphiregulin is an essential mediator of estrogen receptor a function in mammary gland development. Proc. Natl Acad. Sci. USA 104, 5455-5460 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 5455-5460
    • Ciarloni, L.1    Mallepell, S.2    Brisken, C.3
  • 54
    • 78650208471 scopus 로고    scopus 로고
    • Amphiregulin mediates estrogen, progesterone, and EGFR signaling in the normal rat mammary gland and in hormone-dependent rat mammary cancers
    • Kariagina, A., Xie, J., Leipprandt, J. R. & Haslam, S. Z. Amphiregulin mediates estrogen, progesterone, and EGFR signaling in the normal rat mammary gland and in hormone-dependent rat mammary cancers. Horm. Cancer 1, 229-244 (2010).
    • (2010) Horm. Cancer , vol.1 , pp. 229-244
    • Kariagina, A.1    Xie, J.2    Leipprandt, J.R.3    Haslam, S.Z.4
  • 55
    • 0034730327 scopus 로고    scopus 로고
    • The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development
    • Fata, J. E. et al. The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell 103, 41-50 (2000).
    • (2000) Cell , vol.103 , pp. 41-50
    • Fata, J.E.1
  • 56
    • 0034653649 scopus 로고    scopus 로고
    • Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling
    • Brisken, C. et al. Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes Dev 14, 650-654 (2000).
    • (2000) Genes Dev , vol.14 , pp. 650-654
    • Brisken, C.1
  • 57
    • 0037351881 scopus 로고    scopus 로고
    • Cyclic, proteasome-mediated turnover of unliganded and liganded ERa on responsive promoters is an integral feature of estrogen signaling
    • Reid, G. et al. Cyclic, proteasome-mediated turnover of unliganded and liganded ERa on responsive promoters is an integral feature of estrogen signaling. Mol. Cell 11, 695-707 (2003).
    • (2003) Mol. Cell , vol.11 , pp. 695-707
    • Reid, G.1
  • 58
    • 33750470097 scopus 로고    scopus 로고
    • CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells
    • Sleeman, K. E., Kendrick, H., Ashworth, A., Isacke, C. M. & Smalley, M. J. CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells. Breast Cancer Res. 8, R7 (2006).
    • (2006) Breast Cancer Res. , vol.8
    • Sleeman, K.E.1    Kendrick, H.2    Ashworth, A.3    Isacke, C.M.4    Smalley, M.J.5
  • 59
    • 33845982922 scopus 로고    scopus 로고
    • Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland
    • Sleeman, K. E. et al. Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland. J. Cell Biol. 176, 19-26 (2007).
    • (2007) J. Cell Biol. , vol.176 , pp. 19-26
    • Sleeman, K.E.1
  • 60
    • 58949085251 scopus 로고    scopus 로고
    • Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate
    • Kendrick, H. et al. Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate. BMC Genomics 9, 591 (2008).
    • (2008) BMC Genomics , vol.9 , pp. 591
    • Kendrick, H.1
  • 61
    • 40249108932 scopus 로고    scopus 로고
    • The Ets transcription factor Elf5 specifies mammary alveolar cell fate
    • Oakes, S. R. et al. The Ets transcription factor Elf5 specifies mammary alveolar cell fate. Genes Dev. 22, 581-586 (2008).
    • (2008) Genes Dev. , vol.22 , pp. 581-586
    • Oakes, S.R.1
  • 62
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou, C. M. et al. Molecular portraits of human breast tumours. Nature 406, 747-752 (2000).
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1
  • 63
    • 66249109653 scopus 로고    scopus 로고
    • Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics
    • Hennessy, B. T. et al. Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics. Cancer Res. 69, 4116-4124 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 4116-4124
    • Hennessy, B.T.1
  • 64
    • 22744448864 scopus 로고    scopus 로고
    • Identification of molecular apocrine breast tumours by microarray analysis
    • Farmer, P. et al. Identification of molecular apocrine breast tumours by microarray analysis. Oncogene 24, 4660-4671 (2005).
    • (2005) Oncogene , vol.24 , pp. 4660-4671
    • Farmer, P.1
  • 65
    • 77953697676 scopus 로고    scopus 로고
    • High CCND1 amplification identifies a group of poor prognosis women with estrogen receptor positive breast cancer
    • Roy, P. G. et al. High CCND1 amplification identifies a group of poor prognosis women with estrogen receptor positive breast cancer. Int. J. Cancer 127, 355-360 (2010).
    • (2010) Int. J. Cancer , vol.127 , pp. 355-360
    • Roy, P.G.1
  • 66
    • 0032771839 scopus 로고    scopus 로고
    • Overexpression of cyclin D1 messenger RNA predicts for poor prognosis in estrogen receptor-positive breast cancer
    • Kenny, F S. et al. Overexpression of cyclin D1 messenger RNA predicts for poor prognosis in estrogen receptor-positive breast cancer. Clin. Cancer Res. 5, 2069-2076 (1999).
    • (1999) Clin. Cancer Res. , vol.5 , pp. 2069-2076
    • Kenny, F.S.1
  • 67
    • 41549097895 scopus 로고    scopus 로고
    • Cyclin D1 expression in breast cancer patients receiving adjuvant tamoxifen-based therapy Clin
    • Rudas, M. et al. Cyclin D1 expression in breast cancer patients receiving adjuvant tamoxifen-based therapy Clin. Cancer Res. 14, 1767-1774 (2008).
    • (2008) Cancer Res. , vol.14 , pp. 1767-1774
    • Rudas, M.1
  • 68
    • 2942533005 scopus 로고    scopus 로고
    • Cyclin D1 overexpression is a negative predictive factor for tamoxifen response in postmenopausal breast cancer patients
    • Stendahl, M. et al. Cyclin D1 overexpression is a negative predictive factor for tamoxifen response in postmenopausal breast cancer patients. Br. J. Cancer 90, 1942-1948 (2004).
    • (2004) Br. J. Cancer , vol.90 , pp. 1942-1948
    • Stendahl, M.1
  • 69
    • 9444236895 scopus 로고    scopus 로고
    • Minireview: Cyclin D1: Normal and abnormal functions
    • Fu, M., Wang, C, Li, Z., Sakamaki, T & Pestell, R. G. Minireview: Cyclin D1: normal and abnormal functions. Endocrinology 145, 5439-5447 (2004).
    • (2004) Endocrinology , vol.145 , pp. 5439-5447
    • Fu, M.1    Wang, C.2    Li, Z.3    Sakamaki, T.4    Pestell, R.G.5
  • 70
    • 0033611467 scopus 로고    scopus 로고
    • OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
    • Kong, Y. Y. et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397, 315-323 (1999).
    • (1999) Nature , vol.397 , pp. 315-323
    • Kong, Y.Y.1
  • 71
    • 0035861314 scopus 로고    scopus 로고
    • IKKa provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development
    • Cao, Y et al. IKKa provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell 107, 763-775 (2001).
    • (2001) Cell , vol.107 , pp. 763-775
    • Cao, Y.1
  • 72
    • 0036898588 scopus 로고    scopus 로고
    • IGF-2 is a mediator of prolactin-induced morphogenesis in the breast
    • Brisken, C. et al. IGF-2 is a mediator of prolactin-induced morphogenesis in the breast. Dev. Cell 3, 877-887 (2002).
    • (2002) Dev. Cell , vol.3 , pp. 877-887
    • Brisken, C.1
  • 73
    • 0042693019 scopus 로고    scopus 로고
    • Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform
    • Mulac-Jericevic, B., Lydon, J. P., DeMayo, F J. & Conneely, O. M. Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform. Proc. Natl Acad. Sci. USA 100, 9744-9749 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 9744-9749
    • Mulac-Jericevic, B.1    Lydon, J.P.2    Demayo, F.J.3    Conneely, O.M.4
  • 74
    • 78649821635 scopus 로고    scopus 로고
    • Targeting RANKL to a specific subset of murine mammary epithelial cells induces ordered branching morphogenesis and alveologenesis in the absence of progesterone receptor expression
    • Mukherjee, A. et al. Targeting RANKL to a specific subset of murine mammary epithelial cells induces ordered branching morphogenesis and alveologenesis in the absence of progesterone receptor expression. FASEB J. 24, 4408-4419 (2010).
    • (2010) FASEB J. , vol.24 , pp. 4408-4419
    • Mukherjee, A.1
  • 75
    • 77953388315 scopus 로고    scopus 로고
    • Progesterone induces adult mammary stem cell expansion
    • Joshi, P. A. et al. Progesterone induces adult mammary stem cell expansion. Nature 465, 803-807 (2010).
    • (2010) Nature , vol.465 , pp. 803-807
    • Joshi, P.A.1
  • 76
    • 77953384898 scopus 로고    scopus 로고
    • Control of mammary stem cell function by steroid hormone signalling
    • Asselin-Labat, M. L. et al. Control of mammary stem cell function by steroid hormone signalling. Nature 465, 798-802 (2010).
    • (2010) Nature , vol.465 , pp. 798-802
    • Asselin-Labat, M.L.1
  • 77
    • 78149284013 scopus 로고    scopus 로고
    • Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer
    • Schramek, D. et al. Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature 468, 98-102 (2010).
    • (2010) Nature , vol.468 , pp. 98-102
    • Schramek, D.1
  • 78
    • 80855130470 scopus 로고    scopus 로고
    • Distinct stem cells contribute to mammary gland development and maintenance
    • Van Keymeulen, A. et al. Distinct stem cells contribute to mammary gland development and maintenance. Nature 479, 189-193 (2011).
    • (2011) Nature , vol.479 , pp. 189-193
    • Van Keymeulen, A.1
  • 79
    • 84866114887 scopus 로고    scopus 로고
    • Developmental stage and time dictate the fate of Wnt/β-catenin- responsive stem cells in the mammary gland
    • van Amerongen, R., Bowman, A. N. & Nusse, R. Developmental stage and time dictate the fate of Wnt/β-catenin-responsive stem cells in the mammary gland. Cell Stem Cell 11, 387-400 (2012).
    • (2012) Cell Stem Cell , vol.11 , pp. 387-400
    • Van Amerongen, R.1    Bowman, A.N.2    Nusse, R.3
  • 80
    • 84555179609 scopus 로고    scopus 로고
    • Extracellular matrix degradation and remodeling in development and disease
    • Lu, P., Takai, K., Weaver, V. M. & Werb, Z. Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harb. Perspect. Biol. 3, a005058 (2011).
    • (2011) Cold Spring Harb. Perspect. Biol. , vol.3
    • Lu, P.1    Takai Weaver K, V.M.2    Werb, Z.3
  • 81
    • 33845354896 scopus 로고    scopus 로고
    • W Macrophages promote collagen fibrillogenesis around terminal end buds of the developing mammary gland
    • Ingman, W V., Wyckoff, J., Gouon-Evans, V., Condeelis, J. & Pollard, J. W Macrophages promote collagen fibrillogenesis around terminal end buds of the developing mammary gland. Dev. Dyn. 235, 3222-3229 (2006).
    • (2006) Dev. Dyn. , vol.235 , pp. 3222-3229
    • Ingman, W.V.1    Wyckoff, J.2    Gouon-Evans, V.3    Condeelis, J.4    Pollard, J.5
  • 82
    • 80755152942 scopus 로고    scopus 로고
    • ID4 regulates mammary gland development by suppressing p38MAPK activity
    • Dong, J. et al. ID4 regulates mammary gland development by suppressing p38MAPK activity. Development 138, 5247-5256 (2011).
    • (2011) Development , vol.138 , pp. 5247-5256
    • Dong, J.1
  • 83
    • 57349095397 scopus 로고    scopus 로고
    • Transcriptional response of the murine mammary gland to acute progesterone exposure
    • Fernandez-Valdivia, R. et al. Transcriptional response of the murine mammary gland to acute progesterone exposure. Endocrinology 149, 6236-6250 (2008).
    • (2008) Endocrinology , vol.149 , pp. 6236-6250
    • Fernandez-Valdivia, R.1
  • 84
    • 0029791362 scopus 로고    scopus 로고
    • Medroxyprogesterone acetate accelerates the development and increases the incidence of mouse mammary tumors induced by dimethylbenzanthracene
    • Aldaz, C. M., Liao, Q. Y., LaBate, M. & Johnston, D. A. Medroxyprogesterone acetate accelerates the development and increases the incidence of mouse mammary tumors induced by dimethylbenzanthracene. Carcinogenesis 17, 2069-2072 (1996).
    • (1996) Carcinogenesis , vol.17 , pp. 2069-2072
    • Aldaz, C.M.1    Liao, Q.Y.2    Labate, M.3    Johnston, D.A.4
  • 85
    • 78149284767 scopus 로고    scopus 로고
    • RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis
    • Gonzalez-Suarez, E. et al. RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis. Nature 468, 103-107 (2010).
    • (2010) Nature , vol.468 , pp. 103-107
    • Gonzalez-Suarez, E.1
  • 86
    • 33846911452 scopus 로고    scopus 로고
    • RANK overexpression in transgenic mice with mouse mammary tumor virus promoter-controlled RANK increases proliferation and impairs alveolar differentiation in the mammary epithelia and disrupts lumen formation in cultured epithelial acini
    • Gonzalez-Suarez, E. et al. RANK overexpression in transgenic mice with mouse mammary tumor virus promoter-controlled RANK increases proliferation and impairs alveolar differentiation in the mammary epithelia and disrupts lumen formation in cultured epithelial acini. Mol. Cell. Biol. 27, 1442-1454 (2007).
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 1442-1454
    • Gonzalez-Suarez, E.1
  • 87
    • 0020216124 scopus 로고
    • Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
    • Nusse, R. & Varmus, H. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell 31, 99-109 (1982).
    • (1982) Cell , vol.31 , pp. 99-109
    • Nusse, R.1    Varmus, H.2
  • 88
    • 0024162530 scopus 로고
    • Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice
    • Tsukamoto, A., Grosschedl, R., Guzman, R., Parslow, T. & Varmus, H. Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell 55, 619-625 (1988).
    • (1988) Cell , vol.55 , pp. 619-625
    • Tsukamoto, A.1    Grosschedl, R.2    Guzman, R.3    Parslow, T.4    Varmus, H.5
  • 89
    • 84871846692 scopus 로고    scopus 로고
    • WNT signalling pathways as therapeutic targets in cancer
    • Anastas, J. N. & Moon, R. T. WNT signalling pathways as therapeutic targets in cancer. Nature Rev. Cancer 13, 11-26 (2012).
    • (2012) Nature Rev. Cancer , vol.13 , pp. 11-26
    • Anastas, J.N.1    Moon, R.T.2
  • 90
    • 79952193038 scopus 로고    scopus 로고
    • Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling
    • Tan, W. et al. Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling. Nature 470, 548-553 (2011).
    • (2011) Nature , vol.470 , pp. 548-553
    • Tan, W.1
  • 91
    • 84961043177 scopus 로고
    • Rapid induction of mammary carcinoma in the rat and the influence of hormones on the tumors
    • Huggins, C., Briziarelli, G. & Sutton, H. Jr. Rapid induction of mammary carcinoma in the rat and the influence of hormones on the tumors. J. Exp. Med. 109, 25-42 (1959).
    • (1959) J. Exp. Med. , vol.109 , pp. 25-42
    • Huggins, C.1    Briziarelli, G.2    Sutton Jr., H.3
  • 92
    • 0042127169 scopus 로고    scopus 로고
    • An expression study of hormone receptors in spontaneously developed, carcinogen-induced and hormone-induced mammary tumors in female Noble rats
    • Cheung, S. Y. et al. An expression study of hormone receptors in spontaneously developed, carcinogen-induced and hormone-induced mammary tumors in female Noble rats. Int. J. Oncol. 22, 1383-1395 (2003).
    • (2003) Int. J. Oncol. , vol.22 , pp. 1383-1395
    • Cheung, S.Y.1
  • 93
    • 27644482809 scopus 로고    scopus 로고
    • Altered progesterone receptor isoform expression remodels progestin responsiveness of breast cancer cells
    • Graham, J. D. et al. Altered progesterone receptor isoform expression remodels progestin responsiveness of breast cancer cells. Mol. Endocrinol. 19, 2713-2735 (2005).
    • (2005) Mol. Endocrinol. , vol.19 , pp. 2713-2735
    • Graham, J.D.1
  • 94
    • 0034622974 scopus 로고    scopus 로고
    • Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform
    • Mulac-Jericevic, B., Mullinax, R. A., DeMayo, F. J., Lydon, J. P. & Conneely, O. M. Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform. Science 289, 1751-1754 (2000).
    • (2000) Science , vol.289 , pp. 1751-1754
    • Mulac-Jericevic, B.1    Mullinax, R.A.2    Demayo, F.J.3    Lydon, J.P.4    Conneely, O.M.5
  • 95
    • 0037085303 scopus 로고    scopus 로고
    • Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells
    • Richer, J. K. et al. Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells. J. Biol. Chem. 277, 5209-5218 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 5209-5218
    • Richer, J.K.1
  • 96
    • 23044500236 scopus 로고    scopus 로고
    • Progesterone receptor isoforms A and B: Temporal and spatial differences in expression during murine mammary gland development
    • Aupperlee, M. D., Smith, K. T., Kariagina, A. & Haslam, S. Z. Progesterone receptor isoforms A and B: temporal and spatial differences in expression during murine mammary gland development. Endocrinology 146, 3577-3588 (2005).
    • (2005) Endocrinology , vol.146 , pp. 3577-3588
    • Aupperlee, M.D.1    Smith, K.T.2    Kariagina, A.3    Haslam, S.Z.4
  • 97
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon, E. R. & Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell 61, 759-767 (1990).
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 98
    • 34547700854 scopus 로고    scopus 로고
    • Alterations of gene expression in the development of early hyperplastic precursors of breast cancer
    • Lee, S. et al. Alterations of gene expression in the development of early hyperplastic precursors of breast cancer. Am. J. Pathol. 171, 252-262 (2007).
    • (2007) Am. J. Pathol. , vol.171 , pp. 252-262
    • Lee, S.1
  • 99
    • 84861854171 scopus 로고    scopus 로고
    • RANK induces epithelial-mesenchymal transition and stemness in human mammary epithelial cells and promotes tumorigenesis and metastasis
    • Palafox, M. et al. RANK induces epithelial-mesenchymal transition and stemness in human mammary epithelial cells and promotes tumorigenesis and metastasis. Cancer Res. 72, 2879-2888 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 2879-2888
    • Palafox, M.1
  • 100
    • 84865152210 scopus 로고    scopus 로고
    • Id4 protein is highly expressed in triple-negative breast carcinomas: Possible implications for BRCA1 downregulation
    • Wen, Y. H. et al. Id4 protein is highly expressed in triple-negative breast carcinomas: possible implications for BRCA1 downregulation. Breast Cancer Res. Treat. 135, 93-102 (2012).
    • (2012) Breast Cancer Res. Treat. , vol.135 , pp. 93-102
    • Wen, Y.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.