Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM Structures

Journal of Molecular Biology

Volumn 429, Issue 5, 2017, Pages 633-646

  Kellogg, Elizabeth H ^a   Hejab, Nisreen M A ^b   Howes, Stuart ^b,e   Northcote, Peter ^c   Miller, John H ^c   Díaz, J Fernando ^d   Downing, Kenneth H ^a   Nogales, Eva ^a,b  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VICTORIA UNIVERSITY OF WELLINGTON   (New Zealand)

^d CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^e LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

cryo EM; microtubule; microtubule stabilizing agents; peloruside; Taxol; zampanolide

Indexed keywords

BETA TUBULIN; PACLITAXEL; PELORUSIDE; STABILIZING AGENT; UNCLASSIFIED DRUG; ZAMPANOLIDE; ANTINEOPLASTIC AGENT; BRIDGED COMPOUND; MACROLIDE; PROTEIN; TAXANE; TAXOID; TUBULIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL HETEROGENEITY; COMPARATIVE STUDY; CONFORMATION; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; DRUG STRUCTURE; HYDROGEN BOND; MICROTUBULE; POLYMERIZATION; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY; CHEMISTRY; IMAGE PROCESSING;

ANTINEOPLASTIC AGENTS; BINDING SITES; BRIDGED-RING COMPOUNDS; CRYOELECTRON MICROSCOPY; IMAGE PROCESSING, COMPUTER-ASSISTED; MACROLIDES; MICROTUBULES; PACLITAXEL; PROTEINS; TAXOIDS; TUBULIN;

EID: 85010217900     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2017.01.001     Document Type: Article

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