Taxol allosterically alters the dynamics of the tubulin dimer and increases the flexibility of microtubules

Biophysical Journal

Volumn 95, Issue 7, 2008, Pages 3252-3258

  Mitra, Arpita ^a,b   Sept, David ^a,b  

^a WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

^b WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA TUBULIN; DIMER; MONOMER; NUCLEOTIDE; PACLITAXEL; TUBULIN; ANTINEOPLASTIC AGENT;

ARTICLE; CONFORMATIONAL TRANSITION; DRUG PROTEIN BINDING; HYDROLYSIS; MICROTUBULE; MOLECULAR DYNAMICS; PROTEIN INTERACTION; SIMULATION; ALLOSTERISM; ANIMAL; BINDING SITE; CATTLE; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; DRUG EFFECT; METABOLISM; PROTEIN QUATERNARY STRUCTURE;

ALLOSTERIC REGULATION; ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; CATTLE; DIMERIZATION; MICROTUBULES; MODELS, MOLECULAR; PACLITAXEL; PROTEIN STRUCTURE, QUATERNARY; TUBULIN;

EID: 55949090064     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1529/biophysj.108.133884     Document Type: Article

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