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Volumn 31, Issue 1, 2017, Pages 282-293

Omega-3 polyunsaturated fatty acids promote amyloid-b clearance from the brain through mediating the function of the glymphatic system

Author keywords

AQP4 polarization; DHA; Extracellular solutes clearance; Fish oil; Perivascular pathways

Indexed keywords

ADRENIC ACID; AMYLOID BETA PROTEIN; AQUAPORIN 4; ARACHIDONIC ACID; DIHOMO GAMMA LINOLENIC ACID; DOCOSAPENTAENOIC ACID; LINOLEIC ACID; MONOUNSATURATED FATTY ACID; OMEGA 3 FATTY ACID;

EID: 85009809502     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.201600896     Document Type: Article
Times cited : (90)

References (51)
  • 1
    • 84922479473 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids and theirmetabolites in brain function and disease
    • Bazinet, R. P., and Laýe, S. (2014) Polyunsaturated fatty acids and theirmetabolites in brain function and disease. Nat. Rev. Neurosci. 15, 771-785.
    • (2014) Nat. Rev. Neurosci , vol.15 , pp. 771-785
    • Bazinet, R.P.1    Laýe, S.2
  • 4
    • 47749114025 scopus 로고    scopus 로고
    • The effects of omega-3 fatty acids monotherapy in Alzheimer's disease and mild cognitive impairment: A preliminary randomized double-blind placebo-controlled study
    • Chiu, C. C., Su, K. P., Cheng, T. C., Liu, H. C., Chang, C. J., Dewey, M. E., Stewart, R., and Huang, S. Y. (2008) The effects of omega-3 fatty acids monotherapy in Alzheimer's disease and mild cognitive impairment: a preliminary randomized double-blind placebo-controlled study. Prog. Neuropsychopharmacol. Biol. Psychiatry 32, 1538-1544.
    • (2008) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.32 , pp. 1538-1544
    • Chiu, C.C.1    Su, K.P.2    Cheng, T.C.3    Liu, H.C.4    Chang, C.J.5    Dewey, M.E.6    Stewart, R.7    Huang, S.Y.8
  • 6
    • 84873720956 scopus 로고    scopus 로고
    • Docosahexaenoic acid-concentrated fish oil supplementation in subjects withmild cognitive impairment(MCI): A 12-monthrandomised, double-blind, placebo-controlled trial
    • Berl
    • Lee, L. K., Shahar, S., Chin, A. V., and Yusoff, N. A. (2013) Docosahexaenoic acid-concentrated fish oil supplementation in subjects withmild cognitive impairment(MCI): a 12-monthrandomised, double-blind, placebo-controlled trial. Psychopharmacology (Berl.) 225, 605-612.
    • (2013) Psychopharmacology , vol.225 , pp. 605-612
    • Lee, L.K.1    Shahar, S.2    Chin, A.V.3    Yusoff, N.A.4
  • 7
    • 34147100004 scopus 로고    scopus 로고
    • Fish consumption, n-3 fatty acids, and subsequent 5-y cognitive decline in elderly men: The zutphen elderly study
    • Van Gelder, B.M., Tijhuis, M., Kalmijn, S., and Kromhout, D. (2007) Fish consumption, n-3 fatty acids, and subsequent 5-y cognitive decline in elderly men: the Zutphen Elderly Study. Am. J. Clin. Nutr. 85, 1142-1147.
    • (2007) Am. J. Clin., Nutr. , vol.85 , pp. 1142-1147
    • Van Gelder, B.M.1    Tijhuis, M.2    Kalmijn, S.3    Kromhout, D.4
  • 9
    • 16244416174 scopus 로고    scopus 로고
    • Adiet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimermousemodel
    • Lim, G. P., Calon, F., Morihara, T., Yang, F., Teter, B., Ubeda, O., Salem, N. Jr., Frautschy, S.A., andCole, G.M. (2005)Adiet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimermousemodel. J. Neurosci. 25, 3032-3040.
    • (2005) J. Neurosci , vol.25 , pp. 3032-3040
    • Lim, G.P.1    Calon, F.2    Morihara, T.3    Yang, F.4    Teter, B.5    Ubeda, O.6    Salem, N.7    Frautschy, S.A.8    AndCole, G.M.9
  • 10
    • 34247380762 scopus 로고    scopus 로고
    • Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels
    • Green, K. N., Martinez-Coria, H., Khashwji, H., Hall, E. B., Yurko-Mauro, K. A., Ellis, L., and LaFerla, F. M. (2007) Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels. J. Neurosci. 27, 4385-4395.
    • (2007) J. Neurosci , vol.27 , pp. 4385-4395
    • Green, K.N.1    Martinez-Coria, H.2    Khashwji, H.3    Hall, E.B.4    Yurko-Mauro, K.A.5    Ellis, L.6    LaFerla, F.M.7
  • 11
    • 33747180133 scopus 로고    scopus 로고
    • Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice
    • Oksman, M., Iivonen, H., Hogyes, E., Amtul, Z., Penke, B., Leenders, I., Broersen, L., Lutjohann, D., Hartmann, T., and Tanila, H. (2006) Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice. Neurobiol. Dis. 23, 563-572.
    • (2006) Neurobiol. Dis. , vol.23 , pp. 563-572
    • Oksman, M.1    Iivonen, H.2    Hogyes, E.3    Amtul, Z.4    Penke, B.5    Leenders, I.6    Broersen, L.7    Lutjohann, D.8    Hartmann, T.9    Tanila, H.10
  • 15
    • 70349311725 scopus 로고    scopus 로고
    • Mechanism of docosahexaenoic acid-induced inhibition of in vitro Abeta1-42 fibrillation and Abeta1-42-induced toxicity in SH-S5Y5 cells
    • Hossain, S., Hashimoto, M., Katakura, M., Miwa, K., Shimada, T., and Shido, O. (2009) Mechanism of docosahexaenoic acid-induced inhibition of in vitro Abeta1-42 fibrillation and Abeta1-42-induced toxicity in SH-S5Y5 cells. J. Neurochem. 111, 568-579.
    • (2009) J. Neurochem , vol.111 , pp. 568-579
    • Hossain, S.1    Hashimoto, M.2    Katakura, M.3    Miwa, K.4    Shimada, T.5    Shido, O.6
  • 17
    • 0037135111 scopus 로고    scopus 로고
    • Theamyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy, J., and Selkoe, D. J. (2002)Theamyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 18
    • 0033943469 scopus 로고    scopus 로고
    • Clearance of amyloid beta-peptide from brain: Transport or metabolism?
    • Zlokovic, B.V., Yamada, S., Holtzman, D., Ghiso, J., and Frangione, B. (2000) Clearance of amyloid beta-peptide from brain: transport or metabolism? Nat. Med. 6, 718-719.
    • (2000) Nat. Med , vol.6 , pp. 718-719
    • Zlokovic, B.V.1    Yamada, S.2    Holtzman, D.3    Ghiso, J.4    Frangione, B.5
  • 23
    • 84920973035 scopus 로고    scopus 로고
    • Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system
    • Plog, B. A., Dashnaw, M. L., Hitomi, E., Peng, W., Liao, Y., Lou, N., Deane, R., and Nedergaard, M. (2015)Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system. J. Neurosci. 35, 518-526.
    • (2015) J. Neurosci , vol.35 , pp. 518-526
    • Plog, B.A.1    Dashnaw, M.L.2    Hitomi, E.3    Peng, W.4    Liao, Y.5    Lou, N.6    Deane, R.7    Nedergaard, M.8
  • 24
    • 1142310943 scopus 로고    scopus 로고
    • Transgenicmice: Fat-1 mice convert n-6 to n-3 fatty acids
    • Kang, J. X., Wang, J., Wu, L., and Kang, Z. B. (2004)Transgenicmice: fat-1 mice convert n-6 to n-3 fatty acids. Nature 427, 504.
    • (2004) Nature , vol.427 , pp. 504
    • Kang, J.X.1    Wang, J.2    Wu, L.3    Kang, Z.B.4
  • 25
    • 84904019789 scopus 로고    scopus 로고
    • Enriched endogenous omega-3 fatty acids in mice protect against global ischemia injury
    • Luo, C., Ren, H., Wan, J. B., Yao, X., Zhang, X., He, C., So, K. F., Kang, J. X., Pei, Z., and Su, H. (2014) Enriched endogenous omega-3 fatty acids in mice protect against global ischemia injury. J. Lipid Res. 55, 1288-1297.
    • (2014) J. Lipid Res. , vol.55 , pp. 1288-1297
    • Luo, C.1    Ren, H.2    Wan, J.B.3    Yao, X.4    Zhang, X.5    He, C.6    So, K.F.7    Kang, J.X.8    Pei, Z.9    Su, H.10
  • 28
    • 84863446808 scopus 로고    scopus 로고
    • Two-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brain
    • S [published erratum in: J. Cereb. Blood Flow Metab. (2013) 2, 319].
    • Shih, A. Y., Driscoll, J. D., Drew, P. J., Nishimura, N., Schaffer, C. B., and Kleinfeld, D. (2012) Two-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brain [published erratum in: J. Cereb. Blood Flow Metab. (2013) 2, 319]. J. Cereb. Blood Flow Metab. 32, 1277-1309.
    • (2012) J Cereb. Blood Flow Metab , vol.32 , pp. 1277-1309
    • Hih, A.Y.1    Driscoll, J.D.2    Drew, P.J.3    Nishimura, N.4    Schaffer, C.B.5    Kleinfeld, D.6
  • 29
    • 84861914969 scopus 로고    scopus 로고
    • Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloidb1- 42 oligomers are revealed in vivo by using a novel animal model
    • Brouillette, J., Caillierez, R., Zommer, N., Alves-Pires, C., Benilova, I., Blum, D., De Strooper, B., and Búee, L. (2012) Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloidb1- 42 oligomers are revealed in vivo by using a novel animal model. J. Neurosci. 32, 7852-7861.
    • (2012) J. Neurosci , vol.32 , pp. 7852-7861
    • Brouillette, J.1    Caillierez, R.2    Zommer, N.3    Alves-Pires, C.4    Benilova, I.5    Blum, D.6    De Strooper, B.7    Búee, L.8
  • 30
    • 84879753759 scopus 로고    scopus 로고
    • CLARITY for mapping the nervous system
    • Chung, K., and Deisseroth, K. (2013) CLARITY for mapping the nervous system. Nat. Methods 10, 508-513.
    • (2013) Nat. Methods , vol.10 , pp. 508-513
    • Chung, K.1    Deisseroth, K.2
  • 31
    • 84946605557 scopus 로고    scopus 로고
    • Mapping neural circuits with CLARITY
    • Willard, A. M., and Gittis, A. H. (2015) Mapping neural circuits with CLARITY. eLife 4, e11409.
    • (2015) ELife , vol.4 , pp. e11409
    • Willard, A.M.1    Gittis, A.H.2
  • 32
    • 84924691925 scopus 로고    scopus 로고
    • Simplified CLARITY for visualizing immunofluorescence labeling in the developing rat brain
    • Zheng, H., and Rinaman, L. (2016) Simplified CLARITY for visualizing immunofluorescence labeling in the developing rat brain. Brain Struct. Funct. 221, 2375-2383.
    • (2016) Brain Struct. Funct. , vol.221 , pp. 2375-2383
    • Zheng, H.1    Rinaman, L.2
  • 34
    • 84865748485 scopus 로고    scopus 로고
    • 3, 69-Dithiothalidomide, a new TNF-a synthesis inhibitor, attenuates the effect of Ab1-42intracerebroventricular injection on hippocampal neurogenesis and memory deficit
    • Russo, I., Caracciolo, L., Tweedie, D., Choi, S. H., Greig, N. H., Barlati, S., and Bosetti, F. (2012) 3, 69-Dithiothalidomide, a new TNF-a synthesis inhibitor, attenuates the effect of Ab1-42intracerebroventricular injection on hippocampal neurogenesis and memory deficit. J. Neurochem. 122, 1181-1192.
    • (2012) J. Neurochem. , vol.122 , pp. 1181-1192
    • Russo, I.1    Caracciolo, L.2    Tweedie, D.3    Choi, S.H.4    Greig, N.H.5    Barlati, S.6    Bosetti, F.7
  • 39
    • 78149255128 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor-related protein-1: A serial clearance homeostatic mechanism controlling Alzheimer's amyloid b-peptide elimination from the brain
    • Zlokovic, B. V., Deane, R., Sagare, A. P., Bell, R. D., and Winkler, E. A. (2010) Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid b-peptide elimination from the brain. J. Neurochem. 115, 1077-1089.
    • (2010) J. Neurochem , vol.115 , pp. 1077-1089
    • Zlokovic, B.V.1    Deane, R.2    Sagare, A.P.3    Bell, R.D.4    Winkler, E.A.5
  • 41
    • 2942625603 scopus 로고    scopus 로고
    • Neuroprotectin D1: A docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells fromoxidative stress
    • Mukherjee, P. K., Marcheselli, V. L., Serhan, C. N., and Bazan, N. G. (2004) Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells fromoxidative stress. Proc. Natl. Acad. Sci. USA 101, 8491-8496.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 8491-8496
    • Mukherjee, P.K.1    Marcheselli, V.L.2    Serhan, C.N.3    Bazan, N.G.4
  • 42
    • 0034634590 scopus 로고    scopus 로고
    • Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3), Role of phosphatidylserine in antiapoptotic effect
    • Kim, H. Y., Akbar, M., Lau, A., and Edsall, L. (2000) Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J. Biol. Chem. 275, 35215-35223.
    • (2000) J. Biol. Chem. , vol.275 , pp. 35215-35223
    • Kim, H.Y.1    Akbar, M.2    Lau, A.3    Edsall, L.4
  • 43
    • 84878766313 scopus 로고    scopus 로고
    • N-Docosahexaenoylethanolamine is a potent neurogenic factor for neural stem cell differentiation
    • Rashid, M.A., Katakura, M., Kharebava, G., Kevala, K., and Kim, H. Y. (2013) N-Docosahexaenoylethanolamine is a potent neurogenic factor for neural stem cell differentiation. J. Neurochem. 125, 869-884.
    • (2013) J. Neurochem. , vol.125 , pp. 869-884
    • Rashid, M.A.1    Katakura, M.2    Kharebava, G.3    Kevala, K.4    Kim, H.Y.5
  • 44
    • 67650473883 scopus 로고    scopus 로고
    • Improved spatial learningperformance of fat-1mice is associatedwithenhanced neurogenesis and neuritogenesis by docosahexaenoic acid
    • He, C., Qu, X., Cui, L., Wang, J., and Kang, J. X. (2009) Improved spatial learningperformance of fat-1mice is associatedwithenhanced neurogenesis and neuritogenesis by docosahexaenoic acid. Proc.Natl. Acad. Sci. USA 106, 11370-11375.
    • (2009) Proc.Natl. Acad. Sci. USA , vol.106 , pp. 11370-11375
    • He, C.1    Qu, X.2    Cui, L.3    Wang, J.4    Kang, J.X.5
  • 45
    • 46749151032 scopus 로고    scopus 로고
    • The emerging role of docosahexaenoic acid in neuroinflammation
    • Orr, S. K., and Bazinet, R. P. (2008) The emerging role of docosahexaenoic acid in neuroinflammation. Curr. Opin. Investig. Drugs 9, 735-743.
    • (2008) Curr. Opin. Investig. Drugs , vol.9 , pp. 735-743
    • Orr, S.K.1    Bazinet, R.P.2
  • 46
    • 0030775948 scopus 로고    scopus 로고
    • Dietary fat intake and the risk of incident dementia in the Rotterdam Study
    • Kalmijn, S., Launer, L. J., Ott, A., Witteman, J. C., Hofman, A., and Breteler, M. M. (1997) Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Ann. Neurol. 42, 776-782.
    • (1997) Ann. Neurol , vol.42 , pp. 776-782
    • Kalmijn, S.1    Launer, L.J.2    Ott, A.3    Witteman, J.C.4    Hofman, A.5    Breteler, M.M.6
  • 48
    • 28944444905 scopus 로고    scopus 로고
    • Fish consumption and cognitive decline with age in a large community study
    • Morris, M. C., Evans, D. A., Tangney, C. C., Bienias, J. L., and Wilson, R. S. (2005) Fish consumption and cognitive decline with age in a large community study. Arch. Neurol. 62, 1849-1853.
    • (2005) Arch. Neurol , vol.62 , pp. 1849-1853
    • Morris, M.C.1    Evans, D.A.2    Tangney, C.C.3    Bienias, J.L.4    Wilson, R.S.5
  • 49
    • 55149109190 scopus 로고    scopus 로고
    • Parenchymal and vascular Abeta-deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease
    • Thal, D. R., Griffin, W. S., and Braak, H. (2008) Parenchymal and vascular Abeta-deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease. J. Cell. Mol. Med. 12 (5), 1848-1862.
    • (2008) J. Cell. Mol. Med , vol.12 , Issue.5 , pp. 1848-1862
    • Thal, D.R.1    Griffin, W.S.2    Braak, H.3
  • 50
    • 79952021693 scopus 로고    scopus 로고
    • DHA improves cognition and prevents dysfunction of entorhinal cortex neurons in 3xTg-AD mice
    • Arsenault, D., Julien, C., Tremblay, C., and Calon, F. (2011) DHA improves cognition and prevents dysfunction of entorhinal cortex neurons in 3xTg-AD mice. PLoS One 6, e17397.
    • (2011) PLoS One , vol.6 , pp. e17397
    • Arsenault, D.1    Julien, C.2    Tremblay, C.3    Calon, F.4
  • 51
    • 0031022918 scopus 로고    scopus 로고
    • Specialized membrane domains for water transport in glial cells: High-resolution immunogold cytochemistry of aquaporin-4 in rat brain
    • Nielsen, S., Nagelhus, E. A., Amiry-Moghaddam, M., Bourque, C., Agre, P., and Ottersen, O. P. (1997) Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain. J. Neurosci. 17, 171-180.
    • (1997) J. Neurosci. , vol.17 , pp. 171-180
    • Nielsen, S.1    Nagelhus, E.A.2    Amiry-Moghaddam, M.3    Bourque, C.4    Agre, P.5    Ottersen, O.P.6


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