Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury

Journal of Neuroscience

Volumn 34, Issue 49, 2014, Pages 16180-16193

  Iliff, Jeffrey J ^a,b   Chen, Michael J ^a   Plog, Benjamin A ^a   Zeppenfeld, Douglas M ^b   Soltero, Melissa ^b   Yang, Lijun ^a   Singh, Itender ^a   Deane, Rashid ^a   Nedergaard, Maiken ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

AQP4; Aquaporin 4; Cerebrospinal fluid; Neurodegeneration; Tauopathy; Traumatic brain injury

Indexed keywords

ALLOGRAFT INFLAMMATORY FACTOR 1; TAU PROTEIN; AQUAPORIN 4;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUAPORIN 4 GENE; ARTICLE; BARNES MAZE TEST; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; GENE; GENE DELETION; GENE EXPRESSION; GLYMPHATIC CLEARANCE; GLYMPHATIC PATHWAY; IMMUNOFLUORESCENCE; IMMUNOREACTIVITY; LOCOMOTION; MALE; MOUSE; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NEUROFIBRILLARY TANGLE; NEUROPROTECTION; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; OPEN FIELD TEST; PARENCHYMA; PROTEIN PHOSPHORYLATION; ROTAROD TEST; SIGNAL TRANSDUCTION; TAUOPATHY; TRAUMATIC BRAIN INJURY; WESTERN BLOTTING; ANIMAL; BRAIN INJURY; C57BL MOUSE; CEREBROSPINAL FLUID; COMPLICATION; EXTRACELLULAR FLUID; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY;

ANIMALS; AQUAPORIN 4; BRAIN INJURIES; CEREBROSPINAL FLUID; EXTRACELLULAR FLUID; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NERVE DEGENERATION; NEUROFIBRILLARY TANGLES; TAU PROTEINS;

EID: 84914691722     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3020-14.2014     Document Type: Article

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