Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system

Journal of Neuroscience

Volumn 35, Issue 2, 2015, Pages 518-526

  Plog, Benjamin A ^a   Dashnaw, Matthew L ^a   Hitomi, Emi ^a   Peng, Weiguo ^a   Liao, Yonghong ^a   Lou, Nanhong ^a   Deane, Rashid ^a   Nedergaard, Maiken ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Biomarker; Clearance; CSF; Lymphatic; Traumatic brain injury

Indexed keywords

14C INULIN; 3H DEXTRAN; TRACER; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 3; BIOLOGICAL MARKER; GLIAL FIBRILLARY ACIDIC PROTEIN; PROTEIN S100B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN DECOMPRESSION; CEREBROSPINAL FLUID FLOW; CERVICAL LYMPH NODE; CISTERNA MAGNA; CISTERNOTOMY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIFLUORESCENCE MICROSCOPY; FEMALE; FLUORESCENCE IMAGING; INJURY SEVERITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SLEEP DEPRIVATION; TRAUMATIC BRAIN INJURY; ANIMAL; BLOOD; BLOOD BRAIN BARRIER; BRAIN INJURY; C57BL MOUSE; CEREBROSPINAL FLUID; EXTRACELLULAR FLUID; GLIA; METABOLIC CLEARANCE RATE; METABOLISM;

ANIMALS; BIOMARKERS; BLOOD-BRAIN BARRIER; BRAIN INJURIES; EXTRACELLULAR FLUID; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; METABOLIC CLEARANCE RATE; MICE; MICE, INBRED C57BL; NEUROGLIA; S100 CALCIUM BINDING PROTEIN BETA SUBUNIT; SLEEP DEPRIVATION;

EID: 84920973035     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3742-14.2015     Document Type: Article

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