Protective effect of thymoquinone improves cardiovascular function, and attenuates oxidative stress, inflammation and apoptosis by mediating the PI3K/Akt pathway in diabetic rats

Molecular Medicine Reports

Volumn 13, Issue 3, 2016, Pages 2836-2842

  Liu, Hui ^a   Liu, Hong Yang ^a   Jiang, Yi Nong ^a   Li, Nan ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Cardiovascular functions; Diabetic cardiovascular disease; PI3K Akt; Thymoquinone

Indexed keywords

CASPASE 3; CYCLOOXYGENASE 2; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; INSULIN; INTERLEUKIN 6; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN; PROTEIN KINASE B; THYMOQUINONE; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; BENZOQUINONE DERIVATIVE; CARDIOTONIC AGENT; GLUCOSE BLOOD LEVEL; MALONALDEHYDE; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLOOD PRESSURE; BODY WEIGHT; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GLUCOSE BLOOD LEVEL; HEART; HEART RATE; INFLAMMATION; LIVER; LUNG; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ANIMAL; BLOOD; COMPLICATION; DIABETIC CARDIOMYOPATHIES; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; METABOLISM; PHOSPHORYLATION; PRECLINICAL STUDY; PROTEIN PROCESSING; WISTAR RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; BENZOQUINONES; BLOOD GLUCOSE; CARDIOTONIC AGENTS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC CARDIOMYOPATHIES; DRUG EVALUATION, PRECLINICAL; INFLAMMATION; MALE; MALONDIALDEHYDE; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; RATS, WISTAR; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84958719896     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2016.4823     Document Type: Article

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