In vitro models for methylmercury neurotoxicity: Effects on glutamatergic cerebellar granule neurons

Methylmercury and Neurotoxicity

Volumn , Issue , 2012, Pages 259-270

  Sunol, Cristina ^a   Rodríguez Farré, Eduard ^a  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85009194050     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4614-2383-6_14     Document Type: Chapter

References (55)

1. Allen JW, Mutkus LA, Aschner M. Methylmercury-mediated inhibition of 3H-D-aspartate transport in cultured astrocytes is reversed by the antioxidant catalase. Brain Res. 2001;902: 92-100.
2. Aschner M, Du YL, Gannon M, Kimelberg HK. Methylmercury-induced alterations in excitatory amino acid transport in rat primary astrocyte cultures. Brain Res. 1993;602:181-6.
3. a receptors and niflu- mic acid-sensitive chloride channels. Eur J Neurosci. 2005;21:103-12.
4. a and NMDA receptor function in primary cultures of mouse cerebellar granule cells. J Neurosci Res. 2007;85: 3687-95.
5. Basu N, Scheuhammer AM, Rouvinen-Watt K, Evans RD, Trudeau VL, Chan LHM. In vitro and whole animal evidence that methylmercury disrupts GABAergic systems in discrete brain regions in captive mink. Comp Biochem Physiol C. 2010;151:379-85.
6. Branco V, Canário J, Holmgren A, Carvalho C. Inhibition of the thioredoxin system in the brain and liver of zebra-seabreams exposed to waterborne methylmercury. Toxicol Appl Pharmacol. 2011;251:95-103.
7. Briz V, Sunol C. Homeostatic regulation of glutamate neurotransmission in primary neuronal cultures (Chap. 17). In: Costa LG, Giordano G, Guizzetti M, editors. In vitro neurotoxicology. Methods and protocols, Methods in molecular biology, vol. 758. 2011. pp. 253-65.
8. Briz V, Molina-Molina JM, Sánchez-Redondo S, Fernandez MF, Grimait JO, Olea N, Rodríguez- Farré E, Sunol C. Differential estrogenic effects of the persistent organochlorine pesticides dieldrin, endosulfan and lindane in primary neuronal cultures. Toxicol Sci. 2011;120:413-27.
9. Carvalho MC, Franco JL, Ghizoni H, Kobus K, Nazari EM, Rocha JBT, Nogueira CW, Dafre AL, Müller YML, Farina M. Effects of 2, 3-dimercapto-1-propanesulfonic acid (DMPS) on methylmercury-induced locomotor deficits and cerebellar toxicity in mice. Toxicology. 2007;239:195-203.
10. Carvalho CML, Chew EH, Hashemy SI, Lu J, Holmgren A. Inhibition of the human thioredoxin system. A molecular mechanism of mercury toxicity. J Biol Chem. 2008;283:11913-23.
11. Castoldi AF, Barni S, Turin I, Gandini C, Manzo L. Early acute necrosis, delayed apoptosis and cytoskeletal breakdown in cultured cerebellar granule neurons exposed to methylmercury. J Neurosci Res. 2000;59:775-87.
12. Castoldi AF, Coccini T, Manzo L. Neurotoxic and molecular effects of methylmercury in humans. Rev Environ Health. 2003;18:19-31.
13. Choi BH, Lapham LW, Amin-Zaki L, Saleem T. Abnormal neuronal migration, deranged cerebral cortical organization, and diffuse white matter astrocytosis of human fetal brain: a major effect of methylmercury poisoning in utero. J Neuropathol Exp Neurol. 1978;37:719-33.
14. Chua BT, Volbracht C, Tan KO, Li R, Yu VC, Li P. Mitochondrial translocation of cofilin is an early step in apoptosis induction. Nat Cell Biol. 2003;5:1083-9.
15. Clarkson TW, Magos L, Myers GJ. The toxicology of mercury-current exposures and clinical manifestations. New Engl J Med. 2003;349:1731-7.
16. Edwards JR, Marty MS, Atchison WD. Comparative sensitivity of rat cerebellar neurons to dysregulation of divalent cation homeostasis and cytotoxicity caused by methylmercury. Toxicol Appl Pharmacol. 2005;208:222-32.
17. Ekino S, Susa M, Ninomiya T, Imamura K, Kitamura T. Minamata disease revisited: an update on the acute and chronic manifestations of methyl mercury poisoning. J Neurol Sci. 2007;262: 131-44.
18. Eto K, Marumoto M, Takeya M. The pathology of methylmercury poisoning (Minamata disease). Neuropathology. 2010;30:471-9.
19. Farina M, Campos F, Vendrell I, Berenguer J, Barzi M, Pons S, Sunol C. Probucol increases glutathione peroxidase-1 activity and displays long-lasting protection against methylmercury toxicity in cerebellar granule cells. Toxicol Sci. 2009;112:416-26.
20. a receptor modulates the benzodiazepine binding site in primary cultures of cerebellar granule cells. Neuropharmacology. 2001;41:819-33.
21. Fonfría E, Dare E, Benelli M, Sunol C, Ceccatelli S. Translocation of apoptosis inducing factor in cerebellar granule cells exposed to neurotoxic agents inducing oxidative stress. Eur J Neurosci. 2002;16:2013-6.
22. Fonfría E, Vilaró MT, Babot Z, Rodríguez-Farré E, Sunol C. Mercury compounds disrupt neuronal glutamate transport in cultured mouse cerebellar granule cells. J Neurosci Res. 2005;79: 545-53.
23. Fujimura M, Usuki F, Sawada M, Rostene W, Godefroy D, Takashima A. Methylmercury exposure downregulates the expression of Racl and leads to neuritic degeneration and ultimately apoptosis in cerebrocortical neurons. Neurotoxicology. 2009;30:16-22.
24. Fujimura M, Usuki F, Kawamura M, Izumo S. Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure. Toxicol Appl Pharmacol. 2011;250:1-9.
25. 2+ pathway blockers differentially protect against methylmercury and mercuric chloride neurotoxicity. J Neurosci Res. 2001;66:135-45.
26. Gegelashvili G, Robinson MB, Trotti D, Rauen T. Regulation of glutamate transporters in health and disease. Prog Brain Res. 2001;32:267-86.
27. Grandjean P, Landrigan PJ. Developmental neurotoxicity of industrial chemicals. Lancet 2006; 368:2167-78.
28. Grandjean P. Methylmercury toxicity and functional programming. Reprod Toxicol. 2007;23: 414-20.
29. Herden CJ, Pardo NE, Hajela RK, Yuan Y, Atchison WD. Differential effects of methylmercury on gamma-aminobutyric acid type A receptor currents in rat cerebellar granule and cerebral cortical neurons in culture. J Pharmacol Exper Ther. 2008;324:517-28.
30. Hogberg HT, Kinsner-Ovaskainen A, Coecke S, Hartung T, Bal-Price AK. mRNA expression is a relevant tool to identify developmental neurotoxicants using an in vitro approach. Toxicol Sci. 2010;113:95-115.
31. Joels M, Yoolt AJ, Gruol DL. Unique properties of non-N-methyl-D-aspartate excitatory responses in cultured Purkinje neurons. Proc Natl Acad Sci USA. 1989;86:3404-8.
32. Korogi Y, Takahashi M, Okajima T, Eto K. MR findings of Minamata disease-organic mercury poisoning. J Magn Reson Imaging. 1998;8:308-16.
33. Lipton SA, Choi YB, Takahashi H, Zhang D, Li W, Godzik A, Bankston LA. Cysteine regulation of protein function-as exemplified by NMDA-receptor modulation. Trends Neurosci. 2002;25:474-80.
34. Murata K, Grandjean P, Dakeishi M. Neurophysiological evidence of methylmercury neurotoxicity. Am J Ind Med. 2007;50:765-71.
35. Narahashi T, Ma JY, Arakawa O, Reuveny E, Nakahiro M. GABA receptor-channel complex as a target site of mercury, copper, zinc, and lanthanides. Cell Mol Neurobiol. 1994;14:599-621.
36. 35S]butylbicyclophosphorothionate binding by convulsant agents in primary cultures of cerebellar neurons. Brain Res Dev Brain Res. 1993;73:85-90.
37. Ramón R, Murcia M, Ballester F, Rebagliato M, Lacasana M, Vioque J, Llop S, Amurrio A, Aguinagalde X, Marco A, León G, Ibarluzea J, Ribas-Fitó N. Prenatal exposure to mercury in a prospective mother-infant cohort study in a Mediterranean area, Valencia, Spain. Sci Total Environ. 2008;392(1):69-78.
38. Sanfeliu C, Sebastià J, Cristòfol R, Rodríguez-Farré E. Neurotoxicity of organomercurial compounds. Neurotox Res. 2003;5:283-305.
39. Solà C, Cristòfol R, Sunol C, Sanfeliu C. Primary cultures for neurotoxicity testing (Chap. 4). In: Aschner M, Sunol C, Bal-Price A, editors. Cell culture techniques, Neuromethods, vol. 56. 2011. pp. 87-103.
40. Stringari J, Nunes AKC, Franco JL, Bohrer D, Garcia SC, Dafre AL, Milatovic D, Souza DO, Rocha JBT, Aschner M, Farina M. Prenatal methylmercury exposure hampers glutathione antioxidant system ontogenesis and causes long-lasting oxidative stress in the mouse brain. Toxicol Appl Pharmacol. 2008;227:147-54.
41. Sugiura Y, Tamai Y, Tanaka H. Selenium protection against mercury toxicity; high binding affinity of methylmercury by selenium-containing ligands in comparison with sulfur-containing ligands. Bioinorg Chem. 1978;9:167-80.
42. A receptor binding and ion channel function in primary neuronal cultures for neuropharmacology/neurotoxicity testing (Chap. 25). In: Aschner M, Sunol C, Bal- Price A, editors. Cell culture techniques, Neuromethods, vol. 56. 2011. pp. 481-93.
43. Sunol C, Babot Z, Fonfría E, Galofré M, García D, Herrera N, Iraola S, Vendrell I. Studies with neuronal cells: from basic studies of mechanisms of neurotoxicity to the prediction of chemical toxicity. Toxicol In Vitro. 2008;22:1350-5.
44. Sunol C, Babot Z, Cristòfol R, Sonnewald U, Waagepetersen HS, Schousboe A. A possible role of the non-GAT1 GABA transporters in transfer of GABA from GABAergic to glutamatergic neurons in mouse cerebellar neuronal cultures. Neurochem Res. 2010;35:1384-90.
45. Szücs A, Angiello C, Salánki J, Carpenter DO. Effects of inorganic mercury and methylmercury on the ionic currents of cultured rat hippocampal neurons. Cell Mol Neurobiol. 1997;17:273-88.
46. Tamm C, Duckworth J, Hermanson O, Ceccatelli S. High susceptibility of neural stem cells to methylmercury toxicity: effects on cell survival and neuronal differentiation. J Neurochem. 2006;97:69-78.
47. US National Academy of Sciences. Toxicity Testing in the 21st Century: A Vision and a Strategy. Washington (USA): The National Acad. Press; 2007.
48. Usuki F, Yamashita A, Fujimura M. Post-transcriptional defects of antioxidant selenoenzymes cause oxidative stress under methylmercury exposure. J Biol Chem. 2011;286:6641-9.
49. Vale C, Pomés A, Rodríguez-Farré E, Sunol C. Allosteric interactions between GABA, benzodiazepine and picrotoxinin binding sites in primary cultures of cerebellar granule cells. Differential effects induced by g- and S-hexachlorocyclohexane. Eur J Pharmacol. 1997;319:343-53.
50. a and glycine- gated chloride channels in primary cultures of cerebellar granule cells. Neuroscience. 2003;117:397-402.
51. Vendrell I, Carrascal M, Vilaró MT, Abián J, Rodríguez-Farré E, Sunol C. Cell viability and pro- teomic analysis in cultured neurons exposed to methylmercury. Hum Exp Toxicol. 2007;26: 263-72.
52. Vendrell I, Carrascal M, Campos F, Abián J, Sunol C. Methylmercury disrupts the balance between phosphorylated and non-phosphorylated cofilin in primary cultures of mice cerebellar granule cells. A proteomic study. Toxicol Appl Pharmacol. 2010;242:109-18.
53. Wang X, Zaidi A, Pal R, Garrett AS, Braceras R, Chen X, Michaelis ML, Michaelis EK. Genomic and biochemical approaches in the discovery of mechanisms for selective neuronal vulnerability to oxidative stress. BMC Neurosci. 2009;10:12. doi:10.1186/1471-2202-10-12.
54. Yorifuji T, Tsuda T, Inoue S, Takao S, Harada M. Long-term exposure to methylmercury and psychiatric symptoms in residents of Minamata, Japan. Environ Int. 2011;37:907-13.
55. a receptor-mediated inhibitory synaptic transmission is primarily responsible for its early stimulatory effects on hippocampal CA1 excitatory synaptic transmission. J Pharmacol Exper Ther. 1997;282:64-73.