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Volumn 56, Issue , 2011, Pages 481-493

GABAA receptor binding and ion channel function in primary neuronal cultures for neuropharmacology/neurotoxicity testing

Author keywords

Allosteric modulation; Chloride uptake; Flunitrazepam binding; GABAA receptor; Muscimol binding; Primary neuronal cultures; TBPS binding

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR; ALCOHOL; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE; CHLORAL HYDRATE; DIAZEPAM; FLUNITRAZEPAM; ION CHANNEL; MUSCIMOL; NEUROSTEROID; PHENOBARBITAL; PICROTOXININ; THYMOL;

EID: 79952609034     PISSN: 08932336     EISSN: 19406045     Source Type: Book Series    
DOI: 10.1007/978-1-61779-077-5_25     Document Type: Article
Times cited : (5)

References (21)
  • 1
    • 0033931959 scopus 로고    scopus 로고
    • Neuroreceptors and ion channels as the basis for drug action: Past, present, and future
    • Narahashi T (2000) Neuroreceptors and ion channels as the basis for drug action: Past, present, and future. J Pharmacol Exp Ther 294:1-26 (Pubitemid 30434665)
    • (2000) Journal of Pharmacology and Experimental Therapeutics , vol.294 , Issue.1 , pp. 1-26
    • Narahashi, T.1
  • 3
    • 0242660375 scopus 로고    scopus 로고
    • Inhibition of γ-aminobutyric acid uptake: Anatomy, physiology and effects against epileptic seizures
    • DOI 10.1016/j.ejphar.2003.08.063
    • Dalby NO (2003) Inhibition of gammaaminobutyric acid uptake: Anatomy, physiology and effects against epileptic seizures. Eur J Pharmacol 479:127-137 (Pubitemid 37377882)
    • (2003) European Journal of Pharmacology , vol.479 , Issue.1-3 , pp. 127-137
    • Dalby, N.O.1
  • 5
    • 0038178996 scopus 로고    scopus 로고
    • GABA-A receptor subtypes in the brain: A paradigm for CNS drug discovery?
    • DOI 10.1016/S1359-6446(03)02703-X, PII S135964460302703X
    • Whiting PJ (2003) GABAA receptor subtypes in the brain: A paradigm for CNS drug discovery? Drug Discov Today 8:445-450 (Pubitemid 36686731)
    • (2003) Drug Discovery Today , vol.8 , Issue.10 , pp. 445-450
    • Whiting, P.J.1
  • 6
    • 33845301644 scopus 로고    scopus 로고
    • Mapping convulsants' binding to the GABA-A receptor chloride ionophore: A proposed model for channel binding sites
    • DOI 10.1016/j.neuint.2006.07.004, PII S0197018606002397
    • Kalueff AV (2007) Mapping convulsants' binding to the GABAA receptor chloride ionophore: A proposed model for channel binding sites. Neurochem Int 50:61-68 (Pubitemid 44879662)
    • (2007) Neurochemistry International , vol.50 , Issue.1 , pp. 61-68
    • Kalueff, A.V.1
  • 7
    • 54049137689 scopus 로고    scopus 로고
    • International Union of Pharmacology. LXX. Subtypes of g-aminobutric acidA receptors: Classification on the basis of subunit composition, pharmacology, and function. Update
    • Olsen RW, Sieghart W (2008) International Union of Pharmacology. LXX. Subtypes of g-aminobutric acidA receptors: Classification on the basis of subunit composition, pharmacology, and function. Update. Pharmacol Rev 60:243-260
    • (2008) Pharmacol Rev , vol.60 , pp. 243-260
    • Olsen, R.W.1    Sieghart, W.2
  • 8
    • 0028211208 scopus 로고
    • Dual action of the cyclodiene insecticide dieldrin on the γ-aminobutyric acid receptor-chloride channel complex of rat dorsal root ganglion neurons
    • Nagata K, Narahashi T (1994) Dual action of the cyclodiene insecticide dieldrin on the a-aminobutyric acid receptor-chloride channel complex of rat dorsal root ganglion neurons. J Pharmacol Exp Ther 269:164-171 (Pubitemid 24143249)
    • (1994) Journal of Pharmacology and Experimental Therapeutics , vol.269 , Issue.1 , pp. 164-171
    • Nagata, K.1    Narahashi, T.2
  • 9
    • 0027967665 scopus 로고
    • Disruption of GABA-dependent chloride flux by cyclodienes and hexachlorocyclohexanes in primary cultures of cortical neurons
    • Pomés A, Rodríguez-Farré E, Suñol C (1994) Disruption of GABA-dependent chloride flux by cyclodienes and hexachlorocyclohexanes in primary cultures of cortical neurons. J Pharmacol Exp Ther 271:1616-1623 (Pubitemid 24382678)
    • (1994) Journal of Pharmacology and Experimental Therapeutics , vol.271 , Issue.3 , pp. 1616-1623
    • Pomes, A.1    Rodriguez-Farre, E.2    Sunol, C.3
  • 11
    • 30344454228 scopus 로고    scopus 로고
    • A receptor in primary cultures of mouse cortical neurons
    • DOI 10.1016/j.neuropharm.2005.07.009, PII S0028390805002716
    • García DA, Bujons J, Vale C, Suñol C (2006) Allosteric positive interaction of thymol with the GABAA receptor in primary cultures of mouse cortical neurons. Neuropharmacology 50:25-35 (Pubitemid 43069769)
    • (2006) Neuropharmacology , vol.50 , Issue.1 , pp. 25-35
    • Garcia, D.A.1    Bujons, J.2    Vale, C.3    Sunol, C.4
  • 12
    • 73649094450 scopus 로고    scopus 로고
    • GABAA receptor and cell membrane potential as functional endpoints in cultured neurons to evaluate chemicals for human acute toxicity
    • Galofré M, Babot Z, García DA, Iraola S, Rodríguez-Farré E, Forsby A, Suñol C (2010) GABAA receptor and cell membrane potential as functional endpoints in cultured neurons to evaluate chemicals for human acute toxicity. Neurotoxicol Teratol 32:52-61
    • (2010) Neurotoxicol Teratol , vol.32 , pp. 52-61
    • Galofré, M.1    Babot, Z.2    García, D.A.3    Iraola, S.4    Rodríguez-Farré, E.5    Forsby, A.6    Sunol, C.7
  • 14
    • 44749090948 scopus 로고    scopus 로고
    • Studies with neuronal cells: From basic studies of mechanisms of neurotoxicity to the prediction of chemical toxicity
    • Suñol C, Babot Z, Fonfría E, Galofré M, García D, Herrera N, Iraola S, Vendrell I (2008) Studies with neuronal cells: From basic studies of mechanisms of neurotoxicity to the prediction of chemical toxicity. Toxicol In Vitro 22(5):1350-1355
    • (2008) Toxicol In Vitro , vol.22 , Issue.5 , pp. 1350-1355
    • Suñol, C.1    Babot, Z.2    Fonfría, E.3    Galofré, M.4    García, D.5    Herrera, N.6    Iraola, S.7    Vendrell, I.8
  • 15
    • 0030614595 scopus 로고    scopus 로고
    • Evidence that GABA(A) receptor subunit mRNA expression during development is regulated by GABA(A) receptor stimulation
    • Poulter MO, Ohannesian L, Larmet Y, Feltz P (1997) Evidence that GABAA receptor subunit mRNA expression during development is regulated by GABAA receptor stimulation. J Neurochem 68:631-639 (Pubitemid 27044724)
    • (1997) Journal of Neurochemistry , vol.68 , Issue.2 , pp. 631-639
    • Poulter, M.O.1    Ohannesian, L.2    Larmet, Y.3    Feltz, P.4
  • 16
    • 0034962851 scopus 로고    scopus 로고
    • A receptor partial agonists in primary cultures of cerebellar granule neurons and cerebral cortical neurons reflect different receptor subunit compositions
    • Hansen SL, Ebert B, Fjalland B, Kristiansen B (2001) Effects of GABAA receptor partial agonists in primary cultures of cerebellar granule neurons and cerebral cortical neurons reflect different receptor subunit compositions. Br J Pharmacol 133:539-549 (Pubitemid 32591920)
    • (2001) British Journal of Pharmacology , vol.133 , Issue.4 , pp. 539-549
    • Hansen, S.L.1    Ebert, B.2    Fjalland, B.3    Kristiansen, U.4
  • 17
    • 0027251589 scopus 로고
    • 35S]butylbicyclophosphorothionate binding by convulsant agents in primary cultures of cerebellar neurons
    • DOI 10.1016/0165-3806(93)90049-G
    • Pomés A, Rodriguez-Farré E, Suñol C (1993) Inhibition of t-(35S]butylbicyclophosphorothionate binding by convulsant agents in primary cultures of cerebellar neurons. Dev Brain Res 73:85-90 (Pubitemid 23144609)
    • (1993) Developmental Brain Research , vol.73 , Issue.1 , pp. 85-90
    • Pomes, A.1    Rodriguez-Farre, E.2    Sunol, C.3
  • 18
    • 55949083383 scopus 로고    scopus 로고
    • GABA released from cultured cortical neurons influences the modulation of t-[35S] butylbicyclophosphorothionate binding at the GABAA receptor. Effects of thymol
    • García DA, Vendrell I, Galofre M, Suñol C (2008) GABA released from cultured cortical neurons influences the modulation of t-[35S] butylbicyclophosphorothionate binding at the GABAA receptor. Effects of thymol. Eur J Pharmacol 600:26-31
    • (2008) Eur J Pharmacol , vol.600 , pp. 26-31
    • García, D.A.1    Vendrell, I.2    Galofre, M.3    Sunol, C.4
  • 19
    • 0031027379 scopus 로고    scopus 로고
    • Allosteric interactions between γ-aminobutyric acid, benzodiazepine and picrotoxinin binding sites in primary cultures of cerebellar granule cells. Differential effects induced by γ- and δ-hexachlorocyclohexane
    • DOI 10.1016/S0014-2999(96)00866-7, PII S0014299996008667
    • Vale C, Pomés A, Rodríguez-Farré E, Suñol C (1997) Allosteric interactions between g-aminobutyric acid, benzodiazepine and picrotoxinin binding sites in primary cultures of cerebellar granule cells. Differential effects induced by g- and d-hexachlorocyclohexanes. Eur J Neurosci 319:343-353 (Pubitemid 27056058)
    • (1997) European Journal of Pharmacology , vol.319 , Issue.2-3 , pp. 343-353
    • Vale, C.1    Pomes, A.2    Rodriguez-Farre, E.3    Sunol, C.4
  • 20
    • 0037459802 scopus 로고    scopus 로고
    • A and glycine-gated chloride channels in primary cultures of cerebellar granule cells
    • DOI 10.1016/S0306-4522(02)00875-8
    • Vale C, Fonfría E, Bujons J, Messeguer A, Rodríguez- Farré E, Suñol C (2003) The organochlorine pesticides gamma-hexachlorocyclohexane (lindane), alpha-endosulfan and dieldrin differentially interact with GABAA and glycine-gated chloride channels in primary cultures of cerebellar granule cells. Neuroscience 117:397-403 (Pubitemid 36259754)
    • (2003) Neuroscience , vol.117 , Issue.2 , pp. 397-403
    • Vale, C.1    Fonfria, E.2    Bujons, J.3    Messeguer, A.4    Rodriguez-Farre, E.5    Sunol, C.6
  • 21
    • 0034773538 scopus 로고    scopus 로고
    • A receptor modulates the benzodiazepine binding site in primary cultures of mouse cerebellar granule cells
    • DOI 10.1016/S0028-3908(01)00130-7, PII S0028390801001307
    • Fonfría E, Rodríguez-Farré E, Suñol C (2001) Mercury interaction with the GABAA receptor modulates the benzodiazepine binding site in primary cultures of cerebellar granule cells. Neuropharmacology 41:819-833 (Pubitemid 33001416)
    • (2001) Neuropharmacology , vol.41 , Issue.7 , pp. 819-833
    • Fonfria, E.1    Rodriguez-Farre, E.2    Sunol3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.