메뉴 건너뛰기




Volumn 18, Issue 1, 2003, Pages 19-31

Neurotoxic and molecular effects of methylmercury in humans

Author keywords

Brain; Calcium; Development; Excitotoxicity; Microtubules; Oxidative stress

Indexed keywords

METHYLMERCURY; METHYLMERCURY DERIVATIVE; NEUROTOXIN;

EID: 0141767166     PISSN: 00487554     EISSN: None     Source Type: Journal    
DOI: 10.1515/REVEH.2003.18.1.19     Document Type: Review
Times cited : (116)

References (69)
  • 2
    • 0010994298 scopus 로고    scopus 로고
    • EPA-823-F-01-011. Washington DC, USA: U.S. EPA
    • U.S. Environmental Protection Agency. Mercury Update: Impact on Fish Advisories. EPA-823-F-01-011. Washington DC, USA: U.S. EPA, 2001. http://www.epa.gov/ost/fishadvice/mercupd.pdf
    • (2001) Mercury Update: Impact on Fish Advisories
  • 4
    • 0024540448 scopus 로고
    • The effects of methylmercury on the developing brain
    • Choi BH. The effects of methylmercury on the developing brain. Prog Neurobiol 1989; 32: 447-470.
    • (1989) Prog Neurobiol , vol.32 , pp. 447-470
    • Choi, B.H.1
  • 5
    • 0020538256 scopus 로고
    • Mercury content of commercially important fish of the Seychelles, and hair mercury levels of a selected part of the population
    • Matthews AD. Mercury content of commercially important fish of the Seychelles, and hair mercury levels of a selected part of the population. Environ Res 1983; 30: 305-312.
    • (1983) Environ Res , vol.30 , pp. 305-312
    • Matthews, A.D.1
  • 6
    • 0003609171 scopus 로고
    • Geneva, Switzerland: United Nations Environment Programme, International Labour Organisation, and the World Health Organization
    • International Programme on Chemical Safety. Environmental Health Criteria Vol. 101. Methylmercury. Geneva, Switzerland: United Nations Environment Programme, International Labour Organisation, and the World Health Organization, 1990. http://www.inchem.org/documents/ehc/ehc/ehc101.htm
    • (1990) Environmental Health Criteria Vol. 101. Methylmercury , vol.101
  • 7
    • 0031858703 scopus 로고    scopus 로고
    • Prenatal methylmercury exposure and children: Neurologic, developmental, and behavioral research
    • Myers GJ, Davidson PW. Prenatal methylmercury exposure and children: neurologic, developmental, and behavioral research. Environ Health Perspect 1998; 106(suppl 3): 841-847.
    • (1998) Environ Health Perspect , vol.106 , Issue.SUPPL. 3 , pp. 841-847
    • Myers, G.J.1    Davidson, P.W.2
  • 8
    • 0036177730 scopus 로고    scopus 로고
    • The three modern faces of mercury
    • Clarkson TW. The three modern faces of mercury. Environ Health Perspect. 2002; 110 (Suppl 1): 11-23.
    • (2002) Environ Health Perspect , vol.110 , Issue.SUPPL. 1 , pp. 11-23
    • Clarkson, T.W.1
  • 9
    • 0026729394 scopus 로고
    • Methylmercury transport across the blood brain barrier by an amino acid carrier
    • Kerper LE, Ballatori N, Clarkson TW. Methylmercury transport across the blood brain barrier by an amino acid carrier. Am J Physiol 1992; 262(5 Pt 2): R761-765.
    • (1992) Am J Physiol , vol.262 , Issue.5 PART 2
    • Kerper, L.E.1    Ballatori, N.2    Clarkson, T.W.3
  • 11
    • 0029559030 scopus 로고
    • Monitoring methylmercury during pregnancy: Maternal hair predicts fetal brain exposure
    • Cernichiari E, Brewer R, Myers GJ, Marsh DO, Lapham LW, Cox C, et al. Monitoring methylmercury during pregnancy: maternal hair predicts fetal brain exposure. Neurotoxicology 1995; 16: 705-710.
    • (1995) Neurotoxicology , vol.16 , pp. 705-710
    • Cernichiari, E.1    Brewer, R.2    Myers, G.J.3    Marsh, D.O.4    Lapham, L.W.5    Cox, C.6
  • 12
  • 13
    • 0027252099 scopus 로고
    • Mercury major issues in environmental health
    • Clarkson TW. Mercury major issues in environmental health. Environ Health Perspect. 1993; 100: 31-38.
    • (1993) Environ Health Perspect , vol.100 , pp. 31-38
    • Clarkson, T.W.1
  • 14
    • 0028821638 scopus 로고
    • Minamata disease: Methylmercury poisoning in Japan caused by environmental pollution
    • Harada M. Minamata disease: methylmercury poisoning in Japan caused by environmental pollution. Crit Rev Toxicol 1995; 25: 1-24.
    • (1995) Crit Rev Toxicol , vol.25 , pp. 1-24
    • Harada, M.1
  • 15
    • 0000325893 scopus 로고
    • Methylmercury toxicity to the mature and developing nervous system: Possible mechanisms
    • Sarkar B, ed. New York, NY, USA: Raven Press
    • Clarkson T., Methylmercury toxicity to the mature and developing nervous system: Possible mechanisms. In: Sarkar B, ed. Biological Aspects of Metals and Metal-Related Diseases. New York, NY, USA: Raven Press, 183-197, 1983.
    • (1983) Biological Aspects of Metals and Metal-Related Diseases , pp. 183-197
    • Clarkson, T.1
  • 16
    • 0032569224 scopus 로고    scopus 로고
    • Methylmercury exposure and neurotoxicity
    • Mahaffey KR. Methylmercury exposure and neurotoxicity. JAMA 1998; 280: 737-738.
    • (1998) JAMA , vol.280 , pp. 737-738
    • Mahaffey, K.R.1
  • 17
    • 0141998295 scopus 로고
    • Pathogenetic mechanisms of the neurotoxicity of methylmercury
    • Prasad K, Vernadakis A, eds, New York, NY, USA: Raven Press
    • Chang LW. Pathogenetic mechanisms of the neurotoxicity of methylmercury. In: Prasad K, Vernadakis A, eds, Mechanisms of Neurotoxic Substances. New York, NY, USA: Raven Press, 1981; 51-66.
    • (1981) Mechanisms of Neurotoxic Substances , pp. 51-66
    • Chang, L.W.1
  • 18
    • 0008470180 scopus 로고
    • Methylmercury in fish: A toxicological-epidemiological evaluation of risks
    • Swedish Expert Group. Methylmercury in fish: a toxicological-epidemiological evaluation of risks. Nord Hyg Tidskr 1971; 32(Suppl 4): 1-333.
    • (1971) Nord Hyg Tidskr , vol.32 , Issue.SUPPL. 4 , pp. 1-333
  • 20
    • 0029954664 scopus 로고    scopus 로고
    • Human brain disturbance by methylmercury poisoning, focusing on the long-term effect on brain weight
    • Takeuchi T, Eto K, Kinjo Y, Tokunaga H. Human brain disturbance by methylmercury poisoning, focusing on the long-term effect on brain weight. Neurotoxicology 1996; 17: 187-190.
    • (1996) Neurotoxicology , vol.17 , pp. 187-190
    • Takeuchi, T.1    Eto, K.2    Kinjo, Y.3    Tokunaga, H.4
  • 21
    • 0020338425 scopus 로고
    • Pathology of Minamata disease. With special reference to its pathogenesis
    • Takeuchi T. Pathology of Minamata disease. With special reference to its pathogenesis. Acta Pathologica Japonica 1982; 32 Suppl 1: 73-99.
    • (1982) Acta Pathologica Japonica , vol.32 , Issue.SUPPL. 1 , pp. 73-99
    • Takeuchi, T.1
  • 22
    • 0032603820 scopus 로고    scopus 로고
    • Methylmercury-induced generation of free radicals: Biological implications
    • Sarafian TA. Methylmercury-induced generation of free radicals: biological implications. Met Ions Biol Syst 1999; 36: 415-444.
    • (1999) Met Ions Biol Syst , vol.36 , pp. 415-444
    • Sarafian, T.A.1
  • 23
    • 0030438419 scopus 로고    scopus 로고
    • Evidence for delayed neurotoxicity produced by methylmercury
    • Rice DC. Evidence for delayed neurotoxicity produced by methylmercury. Neurotoxicology 1996; 17: 583-596.
    • (1996) Neurotoxicology , vol.17 , pp. 583-596
    • Rice, D.C.1
  • 25
    • 0028353420 scopus 로고
    • Speciation of mercury in the primate blood and brain following long-term exposure to methyl mercury
    • Vahter M, Mottet NK, Friberg L, Lind B, Shen DD, Burbacher T. Speciation of mercury in the primate blood and brain following long-term exposure to methyl mercury. Toxicol Appl Pharmacol 1994; 124: 221-229.
    • (1994) Toxicol Appl Pharmacol , vol.124 , pp. 221-229
    • Vahter, M.1    Mottet, N.K.2    Friberg, L.3    Lind, B.4    Shen, D.D.5    Burbacher, T.6
  • 26
    • 0024935753 scopus 로고
    • Mercury level and histochemical distribution in a human brain with Minamata disease following a long-term clinical course of twenty-six years
    • Takeuchi T, Eto K, Tokunaga H. Mercury level and histochemical distribution in a human brain with Minamata disease following a long-term clinical course of twenty-six years. Neurotoxicology 1989; 10: 651-657.
    • (1989) Neurotoxicology , vol.10 , pp. 651-657
    • Takeuchi, T.1    Eto, K.2    Tokunaga, H.3
  • 27
    • 0002176340 scopus 로고
    • Congenital (or fetal) Minamata disease
    • Katsanuma M, ed. Japan: Study Group of Minamata Disease, Kunamoto University
    • Harada Y. Congenital (or fetal) Minamata disease. In: Katsanuma M, ed, Minamata Disease. Japan: Study Group of Minamata Disease, Kunamoto University, 1968; 93-117.
    • (1968) Minamata Disease , pp. 93-117
    • Harada, Y.1
  • 29
    • 0024364219 scopus 로고
    • Dose-response analysis of infants prenatally exposed to methyl mercury: An application of a single compartment model to single-strand hair analysis
    • Cox C, Clarkson TW, Marsh DO, Amin-Zaki L, Tikriti S, Myers GG. Dose-response analysis of infants prenatally exposed to methyl mercury: an application of a single compartment model to single-strand hair analysis. Environ Res 1989; 49: 318-332.
    • (1989) Environ Res , vol.49 , pp. 318-332
    • Cox, C.1    Clarkson, T.W.2    Marsh, D.O.3    Amin-Zaki, L.4    Tikriti, S.5    Myers, G.G.6
  • 30
    • 0033909580 scopus 로고    scopus 로고
    • Does methylmercury have a role in causing developmental disabilities in children?
    • Myers GJ, Davidson PW. Does methylmercury have a role in causing developmental disabilities in children? Environ Health Perspect 2000; 108 Suppl 3: 413-420.
    • (2000) Environ Health Perspect , vol.108 , Issue.SUPPL. 3 , pp. 413-420
    • Myers, G.J.1    Davidson, P.W.2
  • 31
    • 0038569135 scopus 로고    scopus 로고
    • EPA-823-F-02-007. Washington DC, USA: U.S. EPA
    • United States Environmental Protection Agency. Update: National Listing of Fish and Wildlife Advisories. EPA-823-F-02-007. Washington DC, USA: U.S. EPA, 2002. http://www.epa.gov/waterscience/fish/advisories/factsheet.pdf
    • (2002) Update: National Listing of Fish and Wildlife Advisories
  • 33
    • 0004011126 scopus 로고    scopus 로고
    • Atlanta, Georgia, USA: ATSDR
    • Agency for Toxic Substances and Disease Registry. Toxicological Profile for Mercury (Update). Atlanta, Georgia, USA: ATSDR, 1999.
    • (1999) Toxicological Profile for Mercury (Update)
  • 34
    • 0029620820 scopus 로고
    • Main neuro-developmental study of Seychellois children following in utero exposure to methylmercury from a maternal fish diet: Outcome at six months
    • Myers GJ, Marsh DO, Davidson PW, Cox C, Shamlaye CF, Tanner M, et al. Main neuro-developmental study of Seychellois children following in utero exposure to methylmercury from a maternal fish diet: outcome at six months. Neurotoxicology. 1995; 16: 653-664.
    • (1995) Neurotoxicology , vol.16 , pp. 653-664
    • Myers, G.J.1    Marsh, D.O.2    Davidson, P.W.3    Cox, C.4    Shamlaye, C.F.5    Tanner, M.6
  • 35
    • 0029415150 scopus 로고
    • Longitudinal neurodevelopmental study of Seychellois children following in utero exposure to methylmercury from maternal fish ingestion: Outcomes at 19 and 29 months
    • Davidson PW, Myers GJ, Cox C, Shamlaye CF, Marsh DO, Tanner MA, et al. Longitudinal neurodevelopmental study of Seychellois children following in utero exposure to methylmercury from maternal fish ingestion: outcomes at 19 and 29 months. Neurotoxicology. 1995; 16: 677-888.
    • (1995) Neurotoxicology , vol.16 , pp. 677-888
    • Davidson, P.W.1    Myers, G.J.2    Cox, C.3    Shamlaye, C.F.4    Marsh, D.O.5    Tanner, M.A.6
  • 36
    • 17644448642 scopus 로고    scopus 로고
    • Effects of prenatal and postnatal methylmercury exposure from fish consumption on neurodevelopment: Outcomes at 66 months of age in the Seychelles Child Development Study
    • Davidson PW, Myers GJ, Cox C, Axtell C, Shamiaye C, Sloane-Reeves J, et al. Effects of prenatal and postnatal methylmercury exposure from fish consumption on neurodevelopment: outcomes at 66 months of age in the Seychelles Child Development Study. JAMA. 1998; 280: 701-707.
    • (1998) JAMA , vol.280 , pp. 701-707
    • Davidson, P.W.1    Myers, G.J.2    Cox, C.3    Axtell, C.4    Shamiaye, C.5    Sloane-Reeves, J.6
  • 38
    • 0020555977 scopus 로고
    • Methyl mercury exposure in northern Quebec. II. Neurologic findings in children
    • McKeown-Eyssen GE, Ruedy J, Neims A. Methyl mercury exposure in northern Quebec. II. Neurologic findings in children. Am J Epidemiol. 1983; 118: 470-479.
    • (1983) Am J Epidemiol , vol.118 , pp. 470-479
    • McKeown-Eyssen, G.E.1    Ruedy, J.2    Neims, A.3
  • 45
    • 0023637052 scopus 로고
    • Trace elements intake in the Faroe Islands I. Element levels in edible parts of pilot whales (Globicephalus meleanus)
    • Julshamn K, Andersen A, Ringdal O, Morkore J. Trace elements intake in the Faroe Islands I. Element levels in edible parts of pilot whales (Globicephalus meleanus). Sci Total Environ 1987; 65: 53-62.
    • (1987) Sci Total Environ , vol.65 , pp. 53-62
    • Julshamn, K.1    Andersen, A.2    Ringdal, O.3    Morkore, J.4
  • 47
    • 0036087968 scopus 로고    scopus 로고
    • Benchmark dose calculations for methylmercury-associated delays on evoked potential latencies in two cohorts of children
    • Murata K, Budtz-Jorgensen E, Grandjean P. Benchmark dose calculations for methylmercury-associated delays on evoked potential latencies in two cohorts of children. Risk Anal. 2002; 22: 465-474.
    • (2002) Risk Anal , vol.22 , pp. 465-474
    • Murata, K.1    Budtz-Jorgensen, E.2    Grandjean, P.3
  • 48
    • 0034653355 scopus 로고    scopus 로고
    • Benchmark dose calculations of methylmercury-associated neurobehavioural deficits
    • Budtz-Jorgensen E, Grandjean P, Keiding N, White RF, Weihe P. Benchmark dose calculations of methylmercury-associated neurobehavioural deficits. Toxicol Lett 2000; 112-113: 193-199.
    • (2000) Toxicol Lett , vol.112-113 , pp. 193-199
    • Budtz-Jorgensen, E.1    Grandjean, P.2    Keiding, N.3    White, R.F.4    Weihe, P.5
  • 49
    • 0032438305 scopus 로고    scopus 로고
    • Influence of prenatal mercury exposure upon scholastic and psychological test performance: Benchmark analysis of a New Zealand cohort
    • Crump KS, Kjellstrom T, Shipp AM, Silvers A, Stewart A. Influence of prenatal mercury exposure upon scholastic and psychological test performance: benchmark analysis of a New Zealand cohort. Risk Analysis 1998; 18: 701-713.
    • (1998) Risk Analysis , vol.18 , pp. 701-713
    • Crump, K.S.1    Kjellstrom, T.2    Shipp, A.M.3    Silvers, A.4    Stewart, A.5
  • 51
  • 54
    • 0028206137 scopus 로고
    • Mechanism of methylmercury induced neurotoxicity
    • Atchison WD, Hare MF. Mechanism of methylmercury induced neurotoxicity. FASEB J 1994; 8: 622-629.
    • (1994) FASEB J , vol.8 , pp. 622-629
    • Atchison, W.D.1    Hare, M.F.2
  • 55
    • 6844241966 scopus 로고    scopus 로고
    • A review of experimental methylmercury toxicity in rats: Neuropathology and evidence for apoptosis
    • Nagashima K. A review of experimental methylmercury toxicity in rats: neuropathology and evidence for apoptosis. Toxicol Pathol 1997; 25: 624-631.
    • (1997) Toxicol Pathol , vol.25 , pp. 624-631
    • Nagashima, K.1
  • 56
    • 0030909239 scopus 로고    scopus 로고
    • Migration of granule neurons in cerebellar organotypic cultures is impaired by methylmercury
    • Kunimoto M, Suzuki T. Migration of granule neurons in cerebellar organotypic cultures is impaired by methylmercury. Neurosci Lett 1997; 226: 183-186.
    • (1997) Neurosci Lett , vol.226 , pp. 183-186
    • Kunimoto, M.1    Suzuki, T.2
  • 58
    • 0021344790 scopus 로고
    • Persistent, differential alterations in developing cerebellar cortex of male and female mice after methylmercury exposure
    • Sager PR, Aschner M, Rodier PM. Persistent, differential alterations in developing cerebellar cortex of male and female mice after methylmercury exposure. Brain Res 1984; 314: 1-11.
    • (1984) Brain Res , vol.314 , pp. 1-11
    • Sager, P.R.1    Aschner, M.2    Rodier, P.M.3
  • 59
    • 0019798947 scopus 로고
    • Effects of methylmercury on human fetal neurons and astrocytes in vitro: A time-lapse cinematographic, phase, and electron microscopic study
    • Choi BH, Cho KH, Lapham LW. Effects of methylmercury on human fetal neurons and astrocytes in vitro: a time-lapse cinematographic, phase, and electron microscopic study. Environ Res 1981; 24: 61-74.
    • (1981) Environ Res , vol.24 , pp. 61-74
    • Choi, B.H.1    Cho, K.H.2    Lapham, L.W.3
  • 60
    • 0034653128 scopus 로고    scopus 로고
    • Early acute necrosis, delayed apoptosis and cytoskeletal breakdown in cultured cerebellar granule neurons exposed to methylmercury
    • Castoldi AF, Barni S, Turin I, Gandini C, Manzo L. Early acute necrosis, delayed apoptosis and cytoskeletal breakdown in cultured cerebellar granule neurons exposed to methylmercury. J Neurosci Res 2000; 60: 775-787.
    • (2000) J Neurosci Res , vol.60 , pp. 775-787
    • Castoldi, A.F.1    Barni, S.2    Turin, I.3    Gandini, C.4    Manzo, L.5
  • 61
    • 0018195969 scopus 로고
    • Modification of methylmercury toxicity and metabolism by selenium and vitamin E: Possible mechanisms
    • Ganther HE. Modification of methylmercury toxicity and metabolism by selenium and vitamin E: possible mechanisms. Environ Health Perspect 1978; 25: 71-76.
    • (1978) Environ Health Perspect , vol.25 , pp. 71-76
    • Ganther, H.E.1
  • 62
    • 0026565594 scopus 로고
    • Deferoxamine inhibits methyl mercury-induced increases in reactive oxygen species formation in rat brain
    • LeBel CP, Ali SF, Bondy SC. Deferoxamine inhibits methyl mercury-induced increases in reactive oxygen species formation in rat brain. Toxicol Appl Pharmacol 1992; 112: 161-165.
    • (1992) Toxicol Appl Pharmacol , vol.112 , pp. 161-165
    • LeBel, C.P.1    Ali, S.F.2    Bondy, S.C.3
  • 63
    • 0026102123 scopus 로고
    • Oxidative mechanisms underlying methyl mercury neurotoxicity
    • Sarafian T, Verity MA. Oxidative mechanisms underlying methyl mercury neurotoxicity. Int J Devl Neurosci 1991; 9: 147-153.
    • (1991) Int J Devl Neurosci , vol.9 , pp. 147-153
    • Sarafian, T.1    Verity, M.A.2
  • 64
    • 0034668745 scopus 로고    scopus 로고
    • Antioxidants J811 and 17beta-estradiol protect cerebellar granule cells from methylmercury-induced apoptotic cell death
    • Daré E, Gotz ME, Zhivotovsky B, Manzo L, Ceccatelli S. Antioxidants J811 and 17beta-estradiol protect cerebellar granule cells from methylmercury-induced apoptotic cell death J Neurosci Res 2000; 62: 557-565.
    • (2000) J Neurosci Res , vol.62 , pp. 557-565
    • Daré, E.1    Gotz, M.E.2    Zhivotovsky, B.3    Manzo, L.4    Ceccatelli, S.5
  • 66
    • 0030010607 scopus 로고    scopus 로고
    • Methylmercury-induced neurotoxicity in cerebral neuron culture is blocked by antioxidants and NMDA receptor antagonists
    • Park ST, Lim KT, Chung YT, Kim SU. Methylmercury-induced neurotoxicity in cerebral neuron culture is blocked by antioxidants and NMDA receptor antagonists. Neurotoxicology 1996; 17: 37-45.
    • (1996) Neurotoxicology , vol.17 , pp. 37-45
    • Park, S.T.1    Lim, K.T.2    Chung, Y.T.3    Kim, S.U.4
  • 68
    • 0034256934 scopus 로고    scopus 로고
    • Methylmercury alters glutamate transport in astrocytes
    • Aschner M, Yao CP, Allen JW, Tan KH. Methylmercury alters glutamate transport in astrocytes. Neurochem Int 2000; 37: 199-206.
    • (2000) Neurochem Int , vol.37 , pp. 199-206
    • Aschner, M.1    Yao, C.P.2    Allen, J.W.3    Tan, K.H.4
  • 69
    • 0027093677 scopus 로고
    • In vitro evidence for the role of glutamate in the CNS toxicity of mercury
    • Brookes N. In vitro evidence for the role of glutamate in the CNS toxicity of mercury. Toxicology 1992; 76: 245-256.
    • (1992) Toxicology , vol.76 , pp. 245-256
    • Brookes, N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.