Comparative systems toxicology analysis of cigarette smoke and aerosol from a candidate modified risk tobacco product in organotypic human gingival epithelial cultures: A 3-day repeated exposure study

Food and Chemical Toxicology

Volumn 101, Issue , 2017, Pages 15-35

  Zanetti, Filippo ^a   Titz, Bjoern ^a   Sewer, Alain ^a   Lo Sasso, Giuseppe ^a   Scotti, Elena ^a   Schlage, Walter K ^b   Mathis, Carole ^a   Leroy, Patrice ^a   Majeed, Shoaib ^a   Torres, Laura Ortega ^a   Keppler, Brian R ^c   Ashraf, Elamin ^a   Trivedi, Keyur ^a   Guedj, Emmanuel ^a   Martin, Florian ^a   Frentzel, Stefan ^a   Ivanov, Nikolai V ^a   Peitsch, Manuel C ^a   Hoeng, Julia ^a  

^a Philip Morris Products SA   (Switzerland)

^b Biology Consultant   (Germany)

^c METABOLON INC   (United States)

Author keywords

21st century toxicology; 3Rs; Air liquid interface aerosol exposure; Gingiva; Metabolomics; Tobacco heating system 2.2

Indexed keywords

CIGARETTE SMOKE; AEROSOL; SMOKE;

AEROSOL; ARTICLE; COMPARATIVE TOXICOLOGY; CYTOTOXICITY; EXPOSURE; GENERAL DEVICE; GINGIVA; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; METABOLITE; MODIFIED RISK TOBACCO PRODUCT; SMOKING; TOBACCO; TOBACCO HEATING SYSTEM; TRANSCRIPTOMICS; ADULT; ADVERSE EFFECTS; ANALYSIS; CELL CULTURE; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECTS; EPITHELIUM CELL; MALE; MIDDLE AGED; PROCEDURES; RISK FACTOR; SMOKE; TOXICITY TESTING;

ADULT; AEROSOLS; CELLS, CULTURED; EPITHELIAL CELLS; GINGIVA; HUMANS; MALE; MIDDLE AGED; RISK FACTORS; SMOKE; TOBACCO; TOBACCO PRODUCTS; TOXICITY TESTS;

EID: 85009138452     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2016.12.027     Document Type: Article

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