Protective effect of antioxidants contained in milk-based fruit beverages against sterol oxidation products

Journal of Functional Foods

Volumn 30, Issue , 2017, Pages 81-89

  López García, Gabriel ^a   Cilla, Antonio ^a   Barberá, Reyes ^a   Alegría, Amparo ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Bioaccessible fractions; Caco 2 cells; Cholesterol oxidation products; Cytotoxic effect; Milk based fruit beverage; Phytosterol oxidation products

Indexed keywords

EID: 85009135972     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2016.12.028     Document Type: Article

References (37)

1. Alemany, L., Cilla, A., García-Llatas, G., Rodriguez-Estrada, M.T., Cardenia, V., Alegría, A., Effect of simulated gastrointestinal digestion on plant sterols and their oxides in enriched beverages. Food Research International 52 (2013), 1–7.
2. Alemany, L., Laparra, J., Barberá, R., Alegría, A., Evaluation of the cytotoxic effect of 7keto-stigmasterol and 7keto-cholesterol in human intestinal (Caco-2) cells. Food and Chemical Toxicology 50 (2012), 3106–3113.
3. Alemany-Costa, L., González-Larena, M., García-Llatas, G., Alegría, A., Barberá, R., Sánchez-Siles, L.M., Lagarda, M.J., Sterol stability in functional fruit beverages enriched with different plant sterol sources. Food Research International 48 (2012), 265–270.
4. AOAC International, Official methods of analysis of AOAC international. 17th ed., 2000, AOAC International, Washington, DC.
5. Barriuso, B., Ansorena, D., Astiasarán, I., Oxysterol formation: A review of a multifactorial process. Journal of Steroid Biochemistry & Molecular Biology, 2016, 10.1016/j.jsbmb.2016.02.027.q.
6. Biasi, F., Chiarpotto, E., Sottero, B., Maina, M., Mascia, C., Guina, T.,.. Poli, G., Evidence of cell damage induced by major components of a diet-compatible mixture of oxysterols in human colon cancer Caco-2 cell line. Biochimie 95 (2013), 632–640.
7. Biasi, F., Mascia, C., Astegiano, M., Chiarpotto, E., Nano, M., Vizio, B.,.. Poli, G., Pro-oxidant and proapoptotic effects of cholesterol oxidation products on human colonic epithelial cells: A potential mechanism of inflammatory bowel disease progression. Free Radical Biology and Medicine 47 (2009), 1731–1741.
8. Brzeska, M., Szymczyk, K., Szterk, A., Current knowledge about oxysterols: A review. Journal of Food Science 81 (2016), R2299–R2308.
9. Chalubinski, M., Wojdan, K., Gorzelak, P., Borowiec, M., Broncel, M., The effect of oxidized cholesterol on barrier functions and IL-10 mRNA expression in human intestinal epithelium co-cultured with dendritic cells in the transwell system. Food and Chemical Toxicology 69 (2014), 289–293.
10. +2 – and oxidative stress induced apoptosis. Journal of Functional Foods 12 (2015), 282–293.
11. Cilla, A., González-Sarrías, A., Tomás-Barberán, F.A., Espín, J.C., Barberá, R., Availability of polyphenols in fruit beverages subjected to in vitro gastrointestinal digestion and their effects on proliferation, cell-cycle and apoptosis in human colon cancer Caco-2 cells. Food Chemistry 114 (2009), 813–820.
12. Cilla, A., Perales, S., Lagarda, M.J., Barberá, R., Clemente, G., Farré, R., Influence of storage and in vitro gastrointestinal digestion on total antioxidant capacity of fruit beverages. Journal of Food Composition and Analysis 24 (2011), 87–94.
13. Conrad, M., Angeli, J.P., Vandenabeele, P., Stockwell, B.R., Regulated necrosis: Disease relevance and therapeutic opportunities. Nature Reviews Drug Discovery, 2016, 10.1038/nrd.2015.6.
14. Deiana, M., Loru, D., Incani, A., Rosa, A., Atzeri, A., Melis, M.P.,.. Dessì, A., Wine extracts from Sardinian grape varieties attenuate membrane oxidative damage in Caco-2 cell monolayers. Food Chemistry 134 (2012), 2105–2113.
15. Gao, J., Chen, S., Zhang, L., Cheng, B., Xu, A., Wu, L., Zhang, X., Evaluation of cytotoxic and apoptotic effects of individual and mixed 7-ketophytosterol oxides on human intestinal carcinoma cells. Journal of Agricultural and Food Chemistry 63 (2015), 1035–1041.
16. González-Larena, M., Cilla, A., García-Llatas, G., Barberá, R., Lagarda, M.J., Plant sterols and antioxidant parameters in enriched beverages: Storage stability. Journal of Agricultural and Food Chemistry 60 (2012), 4725–4734.
17. González-Larena, M., Garcia-Llatas, G., Clemente, G., Barberá, R., Lagarda, M.J., Plant sterol oxides in functional beverages: Influence of matrix and storage. Journal of Agricultural and Food Chemistry 173 (2015), 881–889.
18. Granado-Lorencio, F., Largarda, M.J., García-López, F.J., Sánchez-Siles, L.M., Blanco-Navarro, I., Alegría, A.,.. Barberá, R., Effect of β-cryptoxanthin plus phytosterols on cardiovascular risk and bone turnover markers in post-menopausal women: A randomized crossover trial. Nutrition, Metabolism & Cardiovascular Diseases 24 (2014), 1090–1096.
19. Guerra, A., Etienne-Mesmin, L., Livrelli, V., Denis, S., Blanquet-Diot, S., Alric, M., Relevance and challenges in modeling human gastric and small intestinal digestion. Trends in Biotechnology 30 (2012), 591–600.
20. Hernández-Alvarez, E., Blanco-Navarro, I., Pérez-Sacristán, B., Sánchez-Siles, L.M., Granado-Lorencio, F., In vitro digestion-assisted development of a β-cryptoxanthin-rich functional beverage; in vivo validation using systemic response and faecal content. Food Chemistry 208 (2016), 18–25.
21. Incani, A., Serra, G., Atzeri, A., Melis, M.P., Serreli, G., Bandino, G.,.. Deiana, M., Extra virgin olive oil phenolic extracts counteract the pro-oxidant effect of dietary oxidized lipids in human intestinal cells. Food and Chemical Toxicology 90 (2016), 171–180.
22. Katz, O., Reifen, R., Lerner, A., β-Carotene can reverse dysregulation of iron protein in an in vitro model of inflammation. Immunology Research 61 (2015), 70–78.
23. Laparra, J.M., Alfonso-García, A., Alegría, A., Barberá, R., Cilla, A., 7keto-stigmasterol and 7keto-cholesterol induce differential proteome changes to intestinal epithelial (Caco-2) cells. Food and Chemical Toxicology 84 (2015), 29–36.
24. Lin, Y., Knol, D., Trautwein, E.A., Phytosterol oxidation products (POP) in foods with added phytosterols and estimation of their daily intake: A literature review. European Journal of Lipids Science and Technology 118 (2016), 1423–1438.
25. Otaegui-Arrazola, A., Menéndez-Carreño, M., Ansorena, D., Astiasarán, I., Oxysterol: A world to explore. Food and Chemical Toxycology 48 (2010), 3289–3303.
26. Palozza, P., Serini, S., Verdecchia, S., Ameruso, M., Trombino, S., Picci, N.,.. Ranelleti, F.O., Redox regulation of 7-ketocholesterol-induced apoptosis by β-carotene in human macrophages. Free Radical Biology and Medicine 42 (2007), 1579–1590.
27. Palozza, P., Simone, R., Catalano, A., Boninsegna, A., Böhm, V., Fröhlich, K.,.. Ranelletti, F.O., Lycopene prevents 7-ketocholesterol-induced oxidative stress, cell cycle arrest and apoptosis in human macrophages. Journal of Nutritional Biochemistry 21 (2010), 34–46.
28. Ras, R.T., Schouw, T., Trautwein, E.A., Sioen, I., Dalmeijer, G.W., Zock, P.L., Beulens, J.W.J., Intake of phytosterols from natural sources and risk of cardiovascular disease in the European Prospective Investigation into Cancer and Nutrition-the Netherlands (EPIC-NL) population. European Journal of Preventive Cardiology 22:8 (2015), 1067–1075.
29. Rodríguez-Roque, M.J., Rojas-Graü, M.A., Elez-Martínez, P., Martín-Belloso, O., In vitro bioaccessibility of health-related compounds from a blended fruit juice-soymilk beverage: Influence of the food matrix. Journal of Functional Foods 7 (2014), 161–169.
30. Roussi, S., Gossé, F., Aoude-Werner, D., Zhang, X., Marchioni, E., Geoffroy, P.,.. Raul, F., Mitochondrial perturbation, oxidative stress and lysosomal destabilization are involved in 7β-hydroxycholesterol triggered apoptosis in human colon cancer cells. Apoptosis 12 (2007), 87–96.
31. Ryan, E., Chopra, J., McCarthy, F., Maguire, A.R., O'Brien, N.M., Qualitative and quantitative comparison of the cytotoxic and apoptotic potential of phytosterol oxidation products with their corresponding cholesterol oxidation products. British Journal of Nutrition 94 (2005), 443–451.
32. Ryan, L., O'Callaghan, Y.C., O'Brien, N.M., The role of the mitochondria in apoptosis induced by 7β-hydroxycholesterol and cholesterol-5b,6b-epoxide. British Journal of Nutrition 94 (2005), 519–525.
33. Scholz, B., Guth, S., Engel, K.-H., Steinberg, P., Phytosterol oxidation products in enriched foods: Occurrence, exposure, and biological effects. Molecular Nutrition & Food Research 59 (2015), 1339–1352.
34. Vanmierlo, T., Husche, C., Schött, H.F., Pettersson, H., Lütjohann, D., Plant sterol oxidation products – Analogs to cholesterol oxidation products from plant origin?. Biochimie 95 (2013), 464–472.
35. Vejux, A., Lizard, G., Cytotoxic effects of oxysterols associated with human diseases: Induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and phospholipidosis. Molecular Aspects of Medicine 30 (2009), 153–170.
36. Zulueta, A., Esteve, M.J., Frasquet, I., Frígola, A., Vitamin C, vitamin A, phenolic compounds and total antioxidant capacity of new fruit juice and skim milk mixture beverages marketed in Spain. Food Chemistry 103 (2007), 1365–1374.
37. Zulueta, A., Esteve, M.J., Frígola, A., Ascorbic acid in orange juice–milk beverage treated by high intensity pulsed electric fields and its stability during storage. Innovative Food Science and Emerging Technologies 11 (2010), 84–90.