Mitochondrial perturbation, oxidative stress and lysosomal destabilization are involved in 7β-hydroxysitosterol and 7β-hydroxycholesterol triggered apoptosis in human colon cancer cells

Apoptosis

Volumn 12, Issue 1, 2007, Pages 87-96

  Roussi, Stamatiki ^a,d   Gossé, Francine ^a   Aoudé Werner, Dalal ^b   Zhang, Xin ^c   Marchioni, Eric ^c   Geoffroy, Philippe ^c   Miesch, Michel ^c   Raul, Francis ^a  

^a INSERM   (France)

^b Aérial ^*  (France)

^c CNRS   (France)

^d IRCAD   (France)

Author keywords

7 hydroxycholesterol; 7 hydroxysitosterol; Apoptosis; Caco 2 cells; Lysosomes; Mitochondria

Indexed keywords

7BETA HYDROXYCHOLESTEROL; 7BETA HYDROXYSITOSTEROL; ASCORBIC ACID; CASPASE; ENDONUCLEASE G; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SITOSTEROL DERIVATIVE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CELL DEATH; CELL MEMBRANE PERMEABILITY; CELL MEMBRANE POTENTIAL; CELL STRAIN CACO 2; CHEMICAL STRUCTURE; COLON CANCER; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIPOPHILICITY; MITOCHONDRIAL MEMBRANE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

APOPTOSIS; ASCORBIC ACID; BCL-2-ASSOCIATED X PROTEIN; CACO-2 CELLS; COLONIC NEOPLASMS; CYTOCHROMES C; ENDODEOXYRIBONUCLEASES; HUMANS; HYDROXYCHOLESTEROLS; LYSOSOMES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SITOSTEROLS;

EID: 33845733075     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-006-0485-y     Document Type: Article

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