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Volumn 29, Issue 4, 2016, Pages 210-219

Type 2 diabetes, cognition, and dementia in older adults: Toward a precision health approach

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INSULIN;

EID: 85009074847     PISSN: 10409165     EISSN: 19447353     Source Type: Journal    
DOI: 10.2337/ds16-0041     Document Type: Article
Times cited : (95)

References (96)
  • 1
    • 4043164114 scopus 로고    scopus 로고
    • Type 2 diabetes mellitus contributes to cognitive decline in old age: A longitudinal population-based study
    • Hassing LB, Grant MD, Hofer SM, et al. Type 2 diabetes mellitus contributes to cognitive decline in old age: a longitudinal population-based study. J Int Neuropsychol Soc 2004;10:599-607
    • (2004) J Int Neuropsychol Soc , vol.10 , pp. 599-607
    • Hassing, L.B.1    Grant, M.D.2    Hofer, S.M.3
  • 2
    • 78651076743 scopus 로고    scopus 로고
    • R. D. Lawrence Lecture 2010: The brain as a target organ in type 2 diabetes: Exploring the links with cognitive impairment and dementia
    • Strachan MW. R. D. Lawrence Lecture 2010: The brain as a target organ in type 2 diabetes: exploring the links with cognitive impairment and dementia. Diabet Med 2011;28:141-147
    • (2011) Diabet Med , vol.28 , pp. 141-147
    • Strachan, M.W.1
  • 4
    • 84954348867 scopus 로고    scopus 로고
    • Risk factors of cognitive impairment and brief cognitive tests to predict cognitive performance determined by a formal neuropsychological evaluation of primary health care patients
    • Shaik MA, Chan QL, Xu J, et al. Risk factors of cognitive impairment and brief cognitive tests to predict cognitive performance determined by a formal neuropsychological evaluation of primary health care patients. J Am Med Dir Assoc 2016;17:343-347
    • (2016) J Am Med Dir Assoc , vol.17 , pp. 343-347
    • Ma, S.1    Chan, Q.L.2    Xu, J.3
  • 6
    • 84867573020 scopus 로고    scopus 로고
    • Cognitive dysfunction profile and arterial stiffness in type 2 diabetes
    • Mehrabian S, Raycheva M, Gateva A, et al. Cognitive dysfunction profile and arterial stiffness in type 2 diabetes. J Neurol Sci 2012;322:152-156
    • (2012) J Neurol Sci , vol.322 , pp. 152-156
    • Mehrabian, S.1    Raycheva, M.2    Gateva, A.3
  • 7
    • 84862280143 scopus 로고    scopus 로고
    • Diabetes and cognitive dysfunction
    • McCrimmon RJ, Ryan CM, Frier BM. Diabetes and cognitive dysfunction. Lancet 2012;379:2291-2299
    • (2012) Lancet , vol.379 , pp. 2291-2299
    • McCrimmon, R.J.1    Ryan, C.M.2    Frier, B.M.3
  • 8
    • 84946041157 scopus 로고    scopus 로고
    • Alzheimer's genetic risk intensifies neurocognitive slowing associated with diabetes in non-demented older adults
    • McFall GP, Wiebe SA, Vergote D, Anstey KJ, Dixon RA. Alzheimer's genetic risk intensifies neurocognitive slowing associated with diabetes in non-demented older adults. Alzheimer's Dement 2015;1:395-402
    • (2015) Alzheimer's Dement , vol.1 , pp. 395-402
    • McFall, G.P.1    Wiebe, S.A.2    Vergote, D.3    Anstey, K.J.4    Dixon, R.A.5
  • 9
    • 84981276055 scopus 로고    scopus 로고
    • Longterm cognitive trajectories and mortality in older women
    • Yaffe K, Peltz CB, Ewing SK, et al. Longterm cognitive trajectories and mortality in older women. J Gerontol A Biol Sci Med Sci 2016;71:1074-1080
    • (2016) J Gerontol A Biol Sci Med Sci , vol.71 , pp. 1074-1080
    • Yaffe, K.1    Peltz, C.B.2    Ewing, S.K.3
  • 10
    • 85015598616 scopus 로고    scopus 로고
    • Predictors of optimal cognitive aging in 80+ women: The Women's Health Initiative Memory Study
    • Goveas JS, Rapp SR, Hogan PE, et al. Predictors of optimal cognitive aging in 80+ women: the Women's Health Initiative Memory Study. J Gerontol A Biol Sci Med Sci 2016;71(Suppl. 1):S62-S71
    • (2016) J Gerontol A Biol Sci Med Sci , Issue.71 , pp. S62-S71
    • Goveas, J.S.1    Rapp, S.R.2    Hogan, P.E.3
  • 11
    • 0031456345 scopus 로고    scopus 로고
    • Selective, physiological transport of insulin across the blood-brain barrier: Novel demonstration by species-specific radioimmunoassays
    • Banks WA, Jaspan JB, Kastin AJ. Selective, physiological transport of insulin across the blood-brain barrier: novel demonstration by species-specific radioimmunoassays. Peptides 1997;18:1257-1262
    • (1997) Peptides , vol.18 , pp. 1257-1262
    • Banks, W.A.1    Jaspan, J.B.2    Kastin, A.J.3
  • 12
    • 85007591728 scopus 로고    scopus 로고
    • Wnt3a upregulates brain-derived insulin by increasing NeuroD1 via Wnt/beta-catenin signaling in the hypothalamus
    • Lee J, Kim K, Yu SW, Kim EK. Wnt3a upregulates brain-derived insulin by increasing NeuroD1 via Wnt/beta-catenin signaling in the hypothalamus. Mol Brain 2016;9:24
    • (2016) Mol Brain , vol.9 , pp. 24
    • Lee, J.1    Kim, K.2    Yu, S.W.3    Kim, E.K.4
  • 14
    • 84926688499 scopus 로고    scopus 로고
    • Insulin improves memory and reduces chronic neuroinflammation in the hippocampus of young but not aged brains
    • Adzovic L, Lynn AE, D'Angelo HM, et al. Insulin improves memory and reduces chronic neuroinflammation in the hippocampus of young but not aged brains. J Neuroinflammation 2015;12:63
    • (2015) J Neuroinflammation , vol.12 , pp. 63
    • Adzovic, L.1    Lynn, A.E.2    D'Angelo, H.M.3
  • 15
    • 0034012731 scopus 로고    scopus 로고
    • Intracerebroventricular insulin enhances memory in a passive-avoidance task
    • Park CR, Seeley RJ, Craft S, Woods SC. Intracerebroventricular insulin enhances memory in a passive-avoidance task. Physiol Behav 2000;68:509-514
    • (2000) Physiol Behav , vol.68 , pp. 509-514
    • Park, C.R.1    Seeley, R.J.2    Craft, S.3    Woods, S.C.4
  • 16
    • 84880555817 scopus 로고    scopus 로고
    • Intranasal insulin as a treatment for Alzheimer's disease: A review of basic research and clinical evidence
    • Freiherr J, Hallschmid M, Frey WH 2nd, et al. Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence. CNS Drugs 2013;27:505-514
    • (2013) CNS Drugs , vol.27 , pp. 505-514
    • Freiherr, J.1    Hallschmid, M.2    Frey, W.H.3
  • 17
    • 0033521130 scopus 로고    scopus 로고
    • Brain insulin receptors and spatial memory: Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats
    • Zhao W, Chen H, Xu H, et al. Brain insulin receptors and spatial memory: correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats. J Biol Chem 1999;274:34893-34902
    • (1999) J Biol Chem , vol.274 , pp. 34893-34902
    • Zhao, W.1    Chen, H.2    Xu, H.3
  • 18
    • 0025279593 scopus 로고
    • Insulin binding to brain capillaries is reduced in genetically obese, hyperinsulinemic Zucker rats
    • Schwartz MW, Figlewicz DF, Kahn SE, Baskin DG, Greenwood MR, Porte D Jr. Insulin binding to brain capillaries is reduced in genetically obese, hyperinsulinemic Zucker rats. Peptides 1990;11:467-472
    • (1990) Peptides , vol.11 , pp. 467-472
    • Schwartz, M.W.1    Figlewicz, D.F.2    Kahn, S.E.3    Baskin, D.G.4    Greenwood, M.R.5    Porte, D.6
  • 19
    • 84891885282 scopus 로고    scopus 로고
    • Brain atrophy in type 2 diabetes: Regional distribution and influence on cognition
    • Moran C, Phan TG, Chen J, et al. Brain atrophy in type 2 diabetes: regional distribution and influence on cognition. Diabetes Care 2013;36:4036-4042
    • (2013) Diabetes Care , vol.36 , pp. 4036-4042
    • Moran, C.1    Phan, T.G.2    Chen, J.3
  • 21
    • 0031888289 scopus 로고    scopus 로고
    • Cognitive function in an elderly population with persistent impaired glucose tolerance
    • Vanhanen M, Koivisto K, Kuusisto J, et al. Cognitive function in an elderly population with persistent impaired glucose tolerance. Diabetes Care 1998;21:398-402
    • (1998) Diabetes Care , vol.21 , pp. 398-402
    • Vanhanen, M.1    Koivisto, K.2    Kuusisto, J.3
  • 22
    • 84888402101 scopus 로고    scopus 로고
    • Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies
    • Gudala K, Bansal D, Schifano F, Bhansali A. Diabetes mellitus and risk of dementia: a meta-analysis of prospective observational studies. J Diabetes Invest 2013;4:640-650
    • (2013) J Diabetes Invest , vol.4 , pp. 640-650
    • Gudala, K.1    Bansal, D.2    Schifano, F.3    Bhansali, A.4
  • 23
    • 84962376094 scopus 로고    scopus 로고
    • Risk of dementia in seniors with newly diagnosed diabetes: A population-based study
    • Haroon NN, Austin PC, Shah BR, Wu J, Gill SS, Booth GL. Risk of dementia in seniors with newly diagnosed diabetes: a population-based study. Diabetes Care 2015;38:1868-1875
    • (2015) Diabetes Care , vol.38 , pp. 1868-1875
    • Haroon, N.N.1    Austin, P.C.2    Shah, B.R.3    Wu, J.4    Gill, S.S.5    Booth, G.L.6
  • 24
    • 84956624721 scopus 로고    scopus 로고
    • Effect of vascular risk factors and diseases on mortality in individuals with dementia: A systematic review and meta-analysis
    • van de Vorst IE, Koek HL, de Vries R, Bots ML, Reitsma JB, Vaartjes I. Effect of vascular risk factors and diseases on mortality in individuals with dementia: a systematic review and meta-analysis. J Am Geriatr Soc 2016;64:37-46
    • (2016) J Am Geriatr Soc , vol.64 , pp. 37-46
    • Van De Vorst, I.E.1    Koek, H.L.2    De Vries, R.3    Bots, M.L.4    Reitsma, J.B.5    Vaartjes, I.6
  • 25
    • 85012839741 scopus 로고    scopus 로고
    • Shared links between type 2 diabetes mellitus and Alzheimer's disease: A review
    • pii:S1871-4021 Electronically published ahead of print (DOI: 10.1016/j.dsx.2016.01.021)
    • Mittal K, Katare DP. Shared links between type 2 diabetes mellitus and Alzheimer's disease: a review. Diabetes Metab Syndr 2016;pii:S1871-4021: 30070-9. Electronically published ahead of print (DOI: 10.1016/j.dsx.2016.01.021)
    • (2016) Diabetes Metab Syndr , pp. 30070-30079
    • Mittal, K.1    Katare, D.P.2
  • 27
    • 66249126971 scopus 로고    scopus 로고
    • Metabolic links between diabetes and Alzheimer's disease
    • Maher PA, Schubert DR. Metabolic links between diabetes and Alzheimer's disease. Expert Rev Neurother 2009;9:617-630
    • (2009) Expert Rev Neurother , vol.9 , pp. 617-630
    • Maher, P.A.1    Schubert, D.R.2
  • 29
    • 84936961448 scopus 로고    scopus 로고
    • Associations between potentially modifiable risk factors and Alzheimer disease: A Mendelian randomization study
    • discussion e1001841
    • Ostergaard SD, Mukherjee S, Sharp SJ, et al. Associations between potentially modifiable risk factors and Alzheimer disease: a Mendelian randomization study. PLoS Med 2015;12:e1001841; discussion e1001841
    • (2015) PLoS Med , vol.12 , pp. e1001841
    • Ostergaard, S.D.1    Mukherjee, S.2    Sharp, S.J.3
  • 30
    • 84955735405 scopus 로고    scopus 로고
    • Association of type 2 diabetes GWAS loci and the risk of Parkinson's and Alzheimer's diseases
    • Chung SJ, Kim MJ, Kim J, et al. Association of type 2 diabetes GWAS loci and the risk of Parkinson's and Alzheimer's diseases. Parkinsonism Relat Disord 2015;21:1435-1440
    • (2015) Parkinsonism Relat Disord , vol.21 , pp. 1435-1440
    • Chung, S.J.1    Kim, M.J.2    Kim, J.3
  • 31
    • 84960812445 scopus 로고    scopus 로고
    • Diabetic phenotypes and late-life dementia risk: A mechanism-specific Mendelian randomization study
    • Walter S, Marden JR, Kubzansky LD, et al. Diabetic phenotypes and late-life dementia risk: a mechanism-specific Mendelian randomization study. Alzheimer Dis Assoc Disord 2016;30:15-20
    • (2016) Alzheimer Dis Assoc Disord , vol.30 , pp. 15-20
    • Walter, S.1    Marden, J.R.2    Kubzansky, L.D.3
  • 32
    • 84943451142 scopus 로고    scopus 로고
    • Shared genetic etiology underlying Alzheimer's disease and type 2 diabetes
    • Hao K, Di Narzo AF, Ho L, et al. Shared genetic etiology underlying Alzheimer's disease and type 2 diabetes. Mol Aspects Med 2015;43-44,66-76
    • (2015) Mol Aspects Med , Issue.43-44 , pp. 66-76
    • Hao, K.1    Di Narzo, A.F.2    Ho, L.3
  • 33
    • 0035871641 scopus 로고    scopus 로고
    • Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling
    • Gasparini L, Gouras GK, Wang R, et al. Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling. J Neurosci 2001;21:2561-2570
    • (2001) J Neurosci , vol.21 , pp. 2561-2570
    • Gasparini, L.1    Gouras, G.K.2    Wang, R.3
  • 34
    • 84942505240 scopus 로고    scopus 로고
    • Linking insulin with Alzheimer's disease: Emergence as type III diabetes
    • Ahmed S, Mahmood Z, Zahid S. Linking insulin with Alzheimer's disease: emergence as type III diabetes. Neurol Sci 2015;36:1763-1769
    • (2015) Neurol Sci , vol.36 , pp. 1763-1769
    • Ahmed, S.1    Mahmood, Z.2    Zahid, S.3
  • 35
    • 36348935683 scopus 로고    scopus 로고
    • Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway
    • Townsend M, Mehta T, Selkoe DJ. Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. J Biol Chem 2007;282:33305-33312
    • (2007) J Biol Chem , vol.282 , pp. 33305-33312
    • Townsend, M.1    Mehta, T.2    Selkoe, D.J.3
  • 36
    • 60549084867 scopus 로고    scopus 로고
    • Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Abeta oligomers
    • De Felice FG, Vieira MN, Bomfim TR, et al. Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. Proc Natl Acad Sci U S A 2009;106:1971-1976
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 1971-1976
    • De Felice, F.G.1    Vieira, M.N.2    Bomfim, T.R.3
  • 37
    • 0030748390 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons
    • Hong M, Lee VM. Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons. J Biol Chem 1997;272:19547-19553
    • (1997) J Biol Chem , vol.272 , pp. 19547-19553
    • Hong, M.1    Lee, V.M.2
  • 38
    • 0043127453 scopus 로고    scopus 로고
    • Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation
    • Schubert M, Brazil DP, Burks DJ, et al. Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci 2003;23:7084-7092
    • (2003) J Neurosci , vol.23 , pp. 7084-7092
    • Schubert, M.1    Brazil, D.P.2    Burks, D.J.3
  • 39
    • 12144290448 scopus 로고    scopus 로고
    • Role for neuronal insulin resistance in neurodegenerative diseases
    • Schubert M, Gautam D, Surjo D, et al. Role for neuronal insulin resistance in neurodegenerative diseases. Proc Natl Acad Sci U S A 2004;101:3100-3105
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 3100-3105
    • Schubert, M.1    Gautam, D.2    Surjo, D.3
  • 40
    • 0036238441 scopus 로고    scopus 로고
    • Oxidative stress and programmed cell death in diabetic neuropathy
    • Vincent AM, Brownlee M, Russell JW. Oxidative stress and programmed cell death in diabetic neuropathy. Ann N Y Acad Sci 2002;959:368-383
    • (2002) Ann N y Acad Sci , vol.959 , pp. 368-383
    • Vincent, A.M.1    Brownlee, M.2    Russell, J.W.3
  • 41
    • 84939968557 scopus 로고    scopus 로고
    • Staging of cognitive deficits and neuropathological and ultrastructural changes in streptozotocin-induced rat model of Alzheimer's disease
    • Knezovic A, Osmanovic-Barilar J, Curlin M, et al. Staging of cognitive deficits and neuropathological and ultrastructural changes in streptozotocin-induced rat model of Alzheimer's disease. J Neural Transm 2015;122:577-592
    • (2015) J Neural Transm , vol.122 , pp. 577-592
    • Knezovic, A.1    Osmanovic-Barilar, J.2    Curlin, M.3
  • 42
    • 84901299033 scopus 로고    scopus 로고
    • Diabetes and elevated hemoglobin A1c levels are associated with brain hypometabolism but not amyloid accumulation
    • Roberts RO, Knopman DS, Cha RH, et al. Diabetes and elevated hemoglobin A1c levels are associated with brain hypometabolism but not amyloid accumulation. J Nuclear Med 2014;55:759-764
    • (2014) J Nuclear Med , vol.55 , pp. 759-764
    • Roberts, R.O.1    Knopman, D.S.2    Cha, R.H.3
  • 43
    • 84948978519 scopus 로고    scopus 로고
    • Alzheimer's Disease Neuroimaging I: Type 2 diabetes mellitus and biomarkers of neurodegeneration
    • Moran C, Beare R, Phan TG, Bruce DG, Callisaya ML, Srikanth V; Alzheimer's Disease Neuroimaging I: Type 2 diabetes mellitus and biomarkers of neurodegeneration. Neurology 2015;85:1123-1130
    • (2015) Neurology , vol.85 , pp. 1123-1130
    • Moran, C.1    Beare, R.2    Phan, T.G.3    Bruce, D.G.4    Callisaya, M.L.5    Srikanth, V.6
  • 44
    • 84954306767 scopus 로고    scopus 로고
    • Vascular contributions to cognitive impairment clinical Alzheimer's disease and dementia in older persons
    • Kapasi A, Schneider JA. Vascular contributions to cognitive impairment, clinical Alzheimer's disease, and dementia in older persons. Biochim Biophys Acta 2016;1862:878-886
    • (2016) Biochim Biophys Acta , vol.1862 , pp. 878-886
    • Kapasi, A.1    Schneider, J.A.2
  • 45
    • 84878249805 scopus 로고    scopus 로고
    • Disruption of the cerebral white matternetwork is related to slowing of information processing speed in patients with type 2 diabetes
    • Utrecht Vascular Cognitive Impairment Study Group
    • Reijmer YD, Leemans A, Brundel M, Kappelle LJ, Biessels GJ, Utrecht Vascular Cognitive Impairment Study Group. Disruption of the cerebral white matternetwork is related to slowing of information processing speed in patients with type 2 diabetes. Diabetes 2013;62:2112-2115
    • (2013) Diabetes , vol.62 , pp. 2112-2115
    • Reijmer, Y.D.1    Leemans, A.2    Brundel, M.3    Kappelle, L.J.4    Biessels, G.J.5
  • 46
    • 84872051258 scopus 로고    scopus 로고
    • Microstructural white matter abnormalities and cognitive functioning in type 2 diabetes: A diffusion tensor imaging study
    • Utrecht Vascular Cognitive Impairment Study Group
    • Reijmer YD, Brundel M, de Bresser J, Kappelle LJ, Leemans A, Biessels GJ, Utrecht Vascular Cognitive Impairment Study Group. Microstructural white matter abnormalities and cognitive functioning in type 2 diabetes: a diffusion tensor imaging study. Diabetes Care 2013;36:137-144
    • (2013) Diabetes Care , vol.36 , pp. 137-144
    • Reijmer, Y.D.1    Brundel, M.2    De Bresser, J.3    Kappelle, L.J.4    Leemans, A.5    Biessels, G.J.6
  • 47
    • 84975720730 scopus 로고    scopus 로고
    • Nepsilon-(carboxymethyl)-lysine, white matter, and cognitive function in diabetes patients
    • Zhang JH, Xu HZ, Shen QF, et al. Nepsilon-(carboxymethyl)-lysine, white matter, and cognitive function in diabetes patients. Can J Neurol Sci 2016:43:518-522
    • (2016) Can J Neurol Sci , vol.43 , pp. 518-522
    • Zhang, J.H.1    Xu, H.Z.2    Shen, Q.F.3
  • 48
    • 72149088442 scopus 로고    scopus 로고
    • Emotional and neutral declarative memory impairments and associated white matter microstructural abnormalities in adults with type 2 diabetes
    • Yau PL, Javier D, Tsui W, et al. Emotional and neutral declarative memory impairments and associated white matter microstructural abnormalities in adults with type 2 diabetes. Psychiatry Res 2009;174:223-230
    • (2009) Psychiatry Res , vol.174 , pp. 223-230
    • Yau, P.L.1    Javier, D.2    Tsui, W.3
  • 49
    • 84962128814 scopus 로고    scopus 로고
    • Type 2 diabetes as a risk factor for dementia in women compared with men: A pooled analysis of 2.3 million people comprising more than 100,000 cases of dementia
    • Chatterjee S, Peters SA, Woodward M, et al. Type 2 diabetes as a risk factor for dementia in women compared with men: a pooled analysis of 2.3 million people comprising more than 100,000 cases of dementia. Diabetes Care 2016;39:300-307
    • (2016) Diabetes Care , vol.39 , pp. 300-307
    • Chatterjee, S.1    Peters, S.A.2    Woodward, M.3
  • 50
    • 84941710038 scopus 로고    scopus 로고
    • Clinical-pathologic correlations in vascular cognitive impairment and dementia
    • Flanagan M, Larson EB, Latimer CS, et al. Clinical-pathologic correlations in vascular cognitive impairment and dementia. Biochim Biophys Acta 2016;1862:945-951
    • (2016) Biochim Biophys Acta , vol.1862 , pp. 945-951
    • Flanagan, M.1    Larson, E.B.2    Latimer, C.S.3
  • 51
    • 33644941776 scopus 로고    scopus 로고
    • Synaptic transmission changes in the pyramidal cells of the hippocampus in streptozotocin-induced diabetes mellitus in rats
    • Kamal A, Biessels GJ, Gispen WH, Ramakers GM. Synaptic transmission changes in the pyramidal cells of the hippocampus in streptozotocin-induced diabetes mellitus in rats. Brain Res 2006;1073-1074:276-280
    • (2006) Brain Res , vol.1073-1074 , pp. 276-280
    • Kamal, A.1    Biessels, G.J.2    Gispen, W.H.3    Ramakers, G.M.4
  • 52
    • 84966373163 scopus 로고    scopus 로고
    • Clinical features of incidental mild cognitive impairment and dementia in a population-based study
    • Electronically published ahead of print (DOI: 10.1111/ggi.12778)
    • Hishikawa N, Fukui Y, Sato K, Yamashita T, Ohta Y, Abe K. Clinical features of incidental mild cognitive impairment and dementia in a population-based study. Geriatr Gerontol Int 2016. Electronically published ahead of print (DOI: 10.1111/ggi.12778)
    • (2016) Geriatr Gerontol Int
    • Hishikawa, N.1    Fukui, Y.2    Sato, K.3    Yamashita, T.4    Ohta, Y.5    Abe, K.6
  • 53
    • 84956572611 scopus 로고    scopus 로고
    • Cognitive and affective functions in Alzheimer's disease patients with metabolic syndrome
    • Hishikawa N, Fukui Y, Sato K, et al. Cognitive and affective functions in Alzheimer's disease patients with metabolic syndrome. Eur J Neurol 2016;23:339-345
    • (2016) Eur J Neurol , vol.23 , pp. 339-345
    • Hishikawa, N.1    Fukui, Y.2    Sato, K.3
  • 54
    • 70349334173 scopus 로고    scopus 로고
    • Treatment of vascular risk factors is associated with slower decline in Alzheimer disease
    • Deschaintre Y, Richard F, Leys D, Pasquier F. Treatment of vascular risk factors is associated with slower decline in Alzheimer disease. Neurology 2009;73:674-680
    • (2009) Neurology , vol.73 , pp. 674-680
    • Deschaintre, Y.1    Richard, F.2    Leys, D.3    Pasquier, F.4
  • 55
    • 84959019693 scopus 로고    scopus 로고
    • Precision medicine: Clarity for the complexity of dementia
    • Cholerton B, Larson EB, Quinn JF, et al. Precision medicine: clarity for the complexity of dementia. Am J Pathol 2016;186:500-506
    • (2016) Am J Pathol , vol.186 , pp. 500-506
    • Cholerton, B.1    Larson, E.B.2    Quinn, J.F.3
  • 56
    • 84863723011 scopus 로고    scopus 로고
    • The neurobiology of Alzheimer disease defined by neuroimaging
    • Masdeu JC, Kreisl WC, Berman KF. The neurobiology of Alzheimer disease defined by neuroimaging. Curr Opin Neurol 2012;25:410-420
    • (2012) Curr Opin Neurol , vol.25 , pp. 410-420
    • Masdeu, J.C.1    Kreisl, W.C.2    Berman, K.F.3
  • 57
    • 79956098248 scopus 로고    scopus 로고
    • Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    • Sperling RA, Aisen PS, Beckett LA, et al. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's Dement 2011;7:280-292
    • (2011) Alzheimer's Dement , vol.7 , pp. 280-292
    • Sperling, R.A.1    Aisen, P.S.2    Beckett, L.A.3
  • 58
    • 84870922252 scopus 로고    scopus 로고
    • Midlife vascular risk factors and Alzheimer's disease: Evidence from epidemiological studies
    • Tolppanen AM, Solomon A, Soininen H, Kivipelto M. Midlife vascular risk factors and Alzheimer's disease: evidence from epidemiological studies. J Alzheimer's Dis 2012;32:531-540
    • (2012) J Alzheimer's Dis , vol.32 , pp. 531-540
    • Tolppanen, A.M.1    Solomon, A.2    Soininen, H.3    Kivipelto, M.4
  • 59
    • 84929295476 scopus 로고    scopus 로고
    • Insulin resistance predicts brain amyloid deposition in late middle-aged adults
    • Willette AA, Johnson SC, Birdsill AC, et al. Insulin resistance predicts brain amyloid deposition in late middle-aged adults. Alzheimer's Dement 2015;11:504-510
    • (2015) Alzheimer's Dement , vol.11 , pp. 504-510
    • Willette, A.A.1    Johnson, S.C.2    Birdsill, A.C.3
  • 60
    • 79955653924 scopus 로고    scopus 로고
    • Diet and Alzheimer's disease risk factors or prevention: The current evidence
    • Solfrizzi V, Panza F, Frisardi V, et al. Diet and Alzheimer's disease risk factors or prevention: the current evidence. Expert Rev Neurother 2011;11:677-708
    • (2011) Expert Rev Neurother , vol.11 , pp. 677-708
    • Solfrizzi, V.1    Panza, F.2    Frisardi, V.3
  • 61
    • 77956026310 scopus 로고    scopus 로고
    • Dietary manipulation and caloric restriction in the development of mouse models relevant to neurological diseases
    • Schroeder JE, Richardson JC, Virley DJ. Dietary manipulation and caloric restriction in the development of mouse models relevant to neurological diseases. Biochim Biophys Acta 2010;1802:840-846
    • (2010) Biochim Biophys Acta , vol.1802 , pp. 840-846
    • Schroeder, J.E.1    Richardson, J.C.2    Virley, D.J.3
  • 63
    • 77953736212 scopus 로고    scopus 로고
    • Diet and neurocognition: Review of evidence and methodological considerations
    • Smith PJ, Blumenthal JA. Diet and neurocognition: review of evidence and methodological considerations. Curr Aging Sci 2010;3:57-66
    • (2010) Curr Aging Sci , vol.3 , pp. 57-66
    • Smith, P.J.1    Blumenthal, J.A.2
  • 64
    • 79958707315 scopus 로고    scopus 로고
    • Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment
    • Bayer-Carter JL, Green PS, Montine TJ, et al. Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment. Arch Neurol 2011;68:743-752
    • (2011) Arch Neurol , vol.68 , pp. 743-752
    • Bayer-Carter, J.L.1    Green, P.S.2    Montine, T.J.3
  • 65
    • 79952093796 scopus 로고    scopus 로고
    • Physical exercise alleviates debilities of normal aging and Alzheimer's disease
    • Archer T. Physical exercise alleviates debilities of normal aging and Alzheimer's disease. Acta Neurol Scand 2011;123:221-238
    • (2011) Acta Neurol Scand , vol.123 , pp. 221-238
    • Archer, T.1
  • 66
    • 0033614960 scopus 로고    scopus 로고
    • Ageing, fitness and neurocognitive function
    • Kramer AF, Hahn S, Cohen NJ, et al. Ageing, fitness and neurocognitive function. Nature 1999;400:418-419
    • (1999) Nature , vol.400 , pp. 418-419
    • Kramer, A.F.1    Hahn, S.2    Cohen, N.J.3
  • 68
    • 78650827898 scopus 로고    scopus 로고
    • Aerobic exercise improves cognition for older adults with glucose intolerance, a risk factor for Alzheimer's disease
    • Baker LD, Frank LL, Foster-Schubert K, et al. Aerobic exercise improves cognition for older adults with glucose intolerance, a risk factor for Alzheimer's disease. J Alzheimer's Dis 2010;22:569-579
    • (2010) J Alzheimer's Dis , vol.22 , pp. 569-579
    • Baker, L.D.1    Frank, L.L.2    Foster-Schubert, K.3
  • 69
    • 50949110086 scopus 로고    scopus 로고
    • Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: A randomized trial
    • Lautenschlager NT, Cox KL, Flicker L, et al. Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. JAMA 2008;300:1027-1037
    • (2008) JAMA , vol.300 , pp. 1027-1037
    • Lautenschlager, N.T.1    Cox, K.L.2    Flicker, L.3
  • 70
    • 74949111301 scopus 로고    scopus 로고
    • Physical exercise, aging, and mild cognitive impairment: A population-based study
    • Geda YE, Roberts RO, Knopman DS, et al. Physical exercise, aging, and mild cognitive impairment: a population-based study. Arch Neurol 2010;67:80-86
    • (2010) Arch Neurol , vol.67 , pp. 80-86
    • Geda, Y.E.1    Roberts, R.O.2    Knopman, D.S.3
  • 72
    • 77956363424 scopus 로고    scopus 로고
    • Exercise and Alzheimer's disease biomarkers in cognitively normal older adults
    • Liang KY, Mintun MA, Fagan AM, et al. Exercise and Alzheimer's disease biomarkers in cognitively normal older adults. Ann Neurol 2010;68:311-318
    • (2010) Ann Neurol , vol.68 , pp. 311-318
    • Liang, K.Y.1    Ma, M.2    Fagan, A.M.3
  • 74
    • 56549112905 scopus 로고    scopus 로고
    • Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type i diabetic encephalopathy
    • Francis GJ, Martinez JA, Liu WQ, et al. Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy. Brain 2008;131:3311-3334
    • (2008) Brain , vol.131 , pp. 3311-3334
    • Francis, G.J.1    Martinez, J.A.2    Liu, W.Q.3
  • 75
    • 3242740239 scopus 로고    scopus 로고
    • Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration
    • Thorne RG, Pronk GJ, Padmanabhan V, Frey WH 2nd. Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 2004;127:481-496
    • (2004) Neuroscience , vol.127 , pp. 481-496
    • Thorne, R.G.1    Pronk, G.J.2    Padmanabhan, V.3    Frey, W.H.4
  • 77
    • 47849123972 scopus 로고    scopus 로고
    • Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults
    • Reger MA, Watson GS, Green PS, et al. Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults. J Alzheimer's Dis 2008;13:323-331
    • (2008) J Alzheimer's Dis , vol.13 , pp. 323-331
    • Ma, R.1    Watson, G.S.2    Green, P.S.3
  • 78
    • 31844434789 scopus 로고    scopus 로고
    • Effects of intranasal insulin on cognition in memory-impaired older adults: Modulation by APOE genotype
    • Reger MA, Watson GS, Frey WH 2nd, et al. Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype. Neurobiol Aging 2006;27:451-458
    • (2006) Neurobiol Aging , vol.27 , pp. 451-458
    • Ma, R.1    Watson, G.S.2    Frey, W.H.3
  • 79
    • 84922666525 scopus 로고    scopus 로고
    • Long-acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment or early-stage Alzheimer's disease dementia
    • Claxton A, Baker LD, Hanson A, et al. Long-acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment or early-stage Alzheimer's disease dementia. J Alzheimer's Dis 2015;44:897-906
    • (2015) J Alzheimer's Dis , vol.44 , pp. 897-906
    • Claxton, A.1    Baker, L.D.2    Hanson, A.3
  • 80
    • 84855613853 scopus 로고    scopus 로고
    • Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: A pilot clinical trial
    • Craft S, Baker LD, Montine TJ, et al. Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial. Arch Neurol 2012;69:29-38
    • (2012) Arch Neurol , vol.69 , pp. 29-38
    • Craft, S.1    Baker, L.D.2    Montine, T.J.3
  • 81
    • 40349091597 scopus 로고    scopus 로고
    • Intranasal insulin improves cognition and modulates beta-amyloid in early AD
    • Reger MA, Watson GS, Green PS, et al. Intranasal insulin improves cognition and modulates beta-amyloid in early AD. Neurology 2008;70:440-448
    • (2008) Neurology , vol.70 , pp. 440-448
    • Ma, R.1    Watson, G.S.2    Green, P.S.3
  • 82
    • 84902239478 scopus 로고    scopus 로고
    • Long-term metformin usage and cognitive function among older adults with diabetes
    • Ng TP, Feng L, Yap KB, Lee TS, Tan CH, Winblad B. Long-term metformin usage and cognitive function among older adults with diabetes. J Alzheimer's Dis 2014;41:61-68
    • (2014) J Alzheimer's Dis , vol.41 , pp. 61-68
    • Ng, T.P.1    Feng, L.2    Yap, K.B.3    Lee, T.S.4    Ch, T.5    Winblad, B.6
  • 83
    • 84964432741 scopus 로고    scopus 로고
    • Differential metformin dose-dependent effects on cognition in rats: Role of Akt
    • Mostafa DK, Ismail CA, Ghareeb DA. Differential metformin dose-dependent effects on cognition in rats: role of Akt. Psychopharmacology 2016;233:2513-2524
    • (2016) Psychopharmacology , vol.233 , pp. 2513-2524
    • Mostafa, D.K.1    Ismail, C.A.2    Ghareeb, D.A.3
  • 84
    • 84890094663 scopus 로고    scopus 로고
    • Increased risk of cognitive impairment in patients with diabetes is associated with metformin
    • Moore EM, Mander AG, Ames D, et al. Increased risk of cognitive impairment in patients with diabetes is associated with metformin. Diabetes Care 2013;36:2981-2987
    • (2013) Diabetes Care , vol.36 , pp. 2981-2987
    • Moore, E.M.1    Mander, A.G.2    Ames, D.3
  • 85
    • 62449286253 scopus 로고    scopus 로고
    • Different patterns of cerebral injury in dementia with or without diabetes
    • Sonnen JA, Larson EB, Brickell K, et al. Different patterns of cerebral injury in dementia with or without diabetes. Arch Neurol 2009;66:315-322
    • (2009) Arch Neurol , vol.66 , pp. 315-322
    • Sonnen, J.A.1    Larson, E.B.2    Brickell, K.3
  • 86
    • 84971382130 scopus 로고    scopus 로고
    • The effect of diabetes medication on cognitive function: Evidence from the PATH Through Life study
    • Herath PM, Cherbuin N, Eramudugolla R, Anstey KJ. The effect of diabetes medication on cognitive function: evidence from the PATH Through Life study. Biomed Res Int 2016;2016:7208429
    • (2016) Biomed Res Int , vol.2016 , pp. 7208429
    • Herath, P.M.1    Cherbuin, N.2    Eramudugolla, R.3    Anstey, K.J.4
  • 87
    • 84928080180 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma agonist pioglitazone ameliorates white matter lesion and cognitive impairment in hypertensive rats
    • Lan LF, Zheng L, Yang X, Ji XT, Fan YH, Zeng JS. Peroxisome proliferator-activated receptor-gamma agonist pioglitazone ameliorates white matter lesion and cognitive impairment in hypertensive rats. CNS Neurosci Ther 2015;21:410-416
    • (2015) CNS Neurosci Ther , vol.21 , pp. 410-416
    • Lan, L.F.1    Zheng, L.2    Yang, X.3    Ji, X.T.4    Fan, Y.H.5    Zeng, J.S.6
  • 88
    • 84923534350 scopus 로고    scopus 로고
    • Central activation of PPAR-gamma ameliorates diabetes induced cognitive dysfunction and improves BDNF expression
    • Kariharan T, Nanayakkara G, Parameshwaran K, et al. Central activation of PPAR-gamma ameliorates diabetes induced cognitive dysfunction and improves BDNF expression. Neurobiol Aging 2015;36:1451-1461
    • (2015) Neurobiol Aging , vol.36 , pp. 1451-1461
    • Kariharan, T.1    Nanayakkara, G.2    Parameshwaran, K.3
  • 89
    • 84877310015 scopus 로고    scopus 로고
    • Pioglitazone ameliorates memory deficits in streptozotocin-induced diabetic mice by reducing brain beta-amyloid through PPARgamma activation
    • Liu LP, Yan TH, Jiang LY, et al. Pioglitazone ameliorates memory deficits in streptozotocin-induced diabetic mice by reducing brain beta-amyloid through PPARgamma activation. Acta Pharmacol Sin 2013;34:455-463
    • (2013) Acta Pharmacol Sin , vol.34 , pp. 455-463
    • Liu, L.P.1    Yan, T.H.2    Jiang, L.Y.3
  • 90
    • 33644592598 scopus 로고    scopus 로고
    • Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: A preliminary study
    • Watson GS, Cholerton BA, Reger MA, et al. Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study. Am J Geriatr Psychiatry 2005;13:950-958
    • (2005) Am J Geriatr Psychiatry , vol.13 , pp. 950-958
    • Watson, G.S.1    Cholerton, B.A.2    Ma, R.3
  • 91
    • 79959974461 scopus 로고    scopus 로고
    • Rosiglitazone does not improve cognition or global function when used as adjunctive therapy to AChE inhibitors in mild-to-moderate Alzheimer's disease: Two phase 3 studies
    • Harrington C, Sawchak S, Chiang C, et al. Rosiglitazone does not improve cognition or global function when used as adjunctive therapy to AChE inhibitors in mild-to-moderate Alzheimer's disease: two phase 3 studies. Curr Alzheimer Res 2011;8:592-606
    • (2011) Curr Alzheimer Res , vol.8 , pp. 592-606
    • Harrington, C.1    Sawchak, S.2    Chiang, C.3
  • 92
    • 77956090575 scopus 로고    scopus 로고
    • Rosiglitazone monotherapy in mild-to-moderate Alzheimer's disease: Results from a randomized, double-blind, placebo-controlled phase III study
    • Gold M, Alderton C, Zvartau-Hind M, et al. Rosiglitazone monotherapy in mild-to-moderate Alzheimer's disease: results from a randomized, double-blind, placebo-controlled phase III study. Dement Geriatr Cogn Disord 2010;30:131-146
    • (2010) Dement Geriatr Cogn Disord , vol.30 , pp. 131-146
    • Gold, M.1    Alderton, C.2    Zvartau-Hind, M.3
  • 93
    • 58149265311 scopus 로고    scopus 로고
    • Pioglitazone improved cognition in a pilot study on patients with Alzheimer's disease and mild cognitive impairment with diabetes mellitus
    • Hanyu H, Sato T, Kiuchi A, Sakurai H, Iwamoto T. Pioglitazone improved cognition in a pilot study on patients with Alzheimer's disease and mild cognitive impairment with diabetes mellitus. J Am Geriatr Soc 2009;57:177-179
    • (2009) J Am Geriatr Soc , vol.57 , pp. 177-179
    • Hanyu, H.1    Sato, T.2    Kiuchi, A.3    Sakurai, H.4    Iwamoto, T.5
  • 95
    • 78651322583 scopus 로고    scopus 로고
    • A randomized pilot clinical trial of the safety of pioglitazone in treatment of patients with Alzheimer disease
    • Geldmacher DS, Fritsch T, McClendon MJ, Landreth G. A randomized pilot clinical trial of the safety of pioglitazone in treatment of patients with Alzheimer disease. Arch Neurology 2011;68:45-50
    • (2011) Arch Neurology , vol.68 , pp. 45-50
    • Geldmacher, D.S.1    Fritsch, T.2    McClendon, M.J.3    Landreth, G.4
  • 96
    • 84856492410 scopus 로고    scopus 로고
    • The effect of rosiglitazone on LRP1 expression and amyloid beta uptake in human brain microvascular endothelial cells: A possible role of a low-dose thiazolidinedione for dementia treatment
    • Moon JH, Kim HJ, Yang AH, et al. The effect of rosiglitazone on LRP1 expression and amyloid beta uptake in human brain microvascular endothelial cells: a possible role of a low-dose thiazolidinedione for dementia treatment. Int J Neuropsychopharmacol 2012;15:135-142
    • (2012) Int J Neuropsychopharmacol , vol.15 , pp. 135-142
    • Moon, J.H.1    Kim, H.J.2    Yang, A.H.3


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