CD1-restricted T cells at the crossroad of innate and adaptive immunity

Journal of Immunology Research

Volumn 2016, Issue , 2016, Pages

  Pereira, Catia S ^a,b   Macedo, M Fatima ^a,b,c  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c UNIVERSITY OF AVEIRO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

CD1 ANTIGEN; LIPID; CD1B ANTIGEN; CD1C PROTEIN, HUMAN; CD1D ANTIGEN; CD1D PROTEIN, HUMAN; GLYCOPROTEIN; T6 ANTIGEN;

ADAPTIVE IMMUNITY; ANTIGEN BINDING; ANTIGEN EXPRESSION; ANTIGEN STRUCTURE; HUMAN; INNATE IMMUNITY; NATURAL KILLER T CELL; NONHUMAN; REVIEW; T LYMPHOCYTE; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; GENETICS; IMMUNOLOGY;

ADAPTIVE IMMUNITY; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD1; ANTIGENS, CD1D; GLYCOPROTEINS; HUMANS; IMMUNITY, INNATE; NATURAL KILLER T-CELLS;

EID: 85008870052     PISSN: 23148861     EISSN: 23147156     Source Type: Journal    
DOI: 10.1155/2016/2876275     Document Type: Review

References (116)

1. S. Porcelli, M. B. Brenner, J. L. Greenstein, S. P. Balk, C. Terhorst, and P. A. Bleicher, "Recognition of cluster of differentiation 1 antigens by human CD4-CD8-cytolytic T lymphocyte, " Nature, vol. 341, no. 6241, pp. 447-450, 1989.
2. E. M. Beckman, S. A. Porcelli, C. T. Morita, S. M. Behar, S. T. Furlong, and M. B. Brenner, "Recognition of a lipid antigen by CD1-restricted + T cells, " Nature, vol. 372, no. 6507, pp. 691-694, 1994.
3. G. De Libero and L. Mori, "The T-cell response to lipid antigens ofMycobacterium tuberculosis, " Frontiers in Immunology, vol. 5, article 219, p. 1, 2014.
4. L. Mori, M. Lepore, and G. De Libero, "The immunology of CD1-and MR1-restricted T cells, " Annual Review of Immunology, vol. 34, no. 1, pp. 479-510, 2016.
5. S. K. Dougan, A. Kaser, and R. S. Blumberg, "CD1 expression on antigen-presenting cells, " Current Topics inMicrobiology and Immunology, vol. 314, pp. 113-141, 2007.
6. M. Rakhshandehroo, S. M. W. Gijzel, R. Siersbaek et al. , "CD1d-mediated presentation of endogenous lipid antigens by adipocytes requires microsomal triglyceride transfer protein, " The Journal of Biological Chemistry, vol. 289, no. 32, pp. 22128-22139, 2014.
7. J. Y. Huh, J. I. Kim, Y. J. Park et al. , "A novel function of adipocytes in lipid antigen presentation to iNKT cells, " Molecular and Cellular Biology, vol. 33, no. 2, pp. 328-339, 2013.
8. H. De La Salle, S. Mariotti, C. Angenieux et al. , "Assistance of microbial glycolipid antigen processing by CD1e, " Science, vol. 310, no. 5752, pp. 1321-1324, 2005.
9. D. Ly and D. B. Moody, "The CD1 size problem: lipid antigens, ligands, and scaffolds, " Cellular and Molecular Life Sciences, vol. 71, no. 16, pp. 3069-3079, 2014.
10. L. Mori and G. De Libero, "T cells specific for lipid antigens, " Immunologic Research, vol. 53, no. 1-3, pp. 191-199, 2012.
11. T. Batuwangala, D. Shepherd, S. D. Gadola et al. , "The crystal structure of human CD1b with a bound bacterial glycolipid, "The Journal of Immunology, vol. 172, no. 4, pp. 2382-2388, 2004.
12. D. M. Zajonc, M. A. Elsliger, L. Teyton, and I. A. Wilson, "Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2. 15 ? A, " Nature Immunology, vol. 4, no. 8, pp. 808-815, 2003.
13. M. Salio, J. D. Silk, E. Yvonne Jones, andV. Cerundolo, "Biology of CD1-and MR1-restricted T cells, " Annual Review of Immunology, vol. 32, pp. 323-366, 2014.
14. A. Shamshiev, H.-J. Gober, A. Donda, Z. Mazorra, L. Mori, and G. De Libero, "Presentation of the same glycolipid by different CD1 molecules, " Journal of Experimental Medicine, vol. 195, no. 8, pp. 1013-1021, 2002.
15. T.-Y. Cheng, M. Relloso, I. Van Rhijn et al. , "Role of lipid trimming and CD1 groove size in cellular antigen presentation, " EMBO Journal, vol. 25, no. 13, pp. 2989-2999, 2006.
16. M. Relloso, T.-Y. Cheng, J. S. Imet al. , "pH-Dependent interdomain tethers of CD1b regulate its antigen capture, " Immunity, vol. 28, no. 6, pp. 774-786, 2008.
17. L. Scharf, N. S. Li, A. J. Hawk et al. , "The 2. 5 a structure ofCD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation, " Immunity, vol. 33, no. 6, pp. 853-862, 2010.
18. M. Dieudé, H. Striegl, A. J. Tyznik et al. , "Cardiolipin binds to CD1d and stimulates CD1d-restricted T cells in the normal murine repertoire, " Journal of Immunology, vol. 186, no. 8, pp. 4771-4781, 2011.
19. K. S. Wun, G. Cameron, O. Patel et al. , "A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells, " Immunity, vol. 34, no. 3, pp. 327-339, 2011.
20. E. D. Yu, E. Girardi, J. Wang et al. , "Structural basis for the recognition of C20:2-GalCer by the invariant natural killer T cell receptor-like antibody L363, " Journal of Biological Chemistry, vol. 287, no. 2, pp. 1269-1278, 2012.
21. T. Mallevaey, A. J. Clarke, J. P. Scott-Browne et al. , "A molecular basis forNKT cell recognition of CD1d-self-antigen, " Immunity, vol. 34, no. 3, pp. 315-326, 2011.
22. L. F. Garcia-Alles, G. Giacometti, C. Versluis et al. , "Crystal structure of human CD1e reveals a groove suited for lipidexchange processes, " Proceedings of theNational Academy of Sciences of the United States of America, vol. 108, no. 32, pp. 13230-13235, 2011.
23. S.-J. Kang and P. Cresswell, "Calnexin, calreticulin, and ERp57 cooperate in disulfide bond formation in human CD1d heavy chain, " The Journal of Biological Chemistry, vol. 277, no. 47, pp. 44838-44844, 2002.
24. S. Zeissig, S. K. Dougan, D. C. Barral et al. , "Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function, " The Journal of Clinical Investigation, vol. 120, no. 8, pp. 2889-2899, 2010.
25. A. Kaser, D. L. Hava, S. K. Dougan et al. , "Microsomal triglyceride transfer protein regulates endogenous and exogenous antigen presentation by group 1 CD1 molecules, " European Journal of Immunology, vol. 38, no. 8, pp. 2351-2359, 2008.
26. S. K. Dougan, A. Salas, P. Rava et al. , "Microsomal triglyceride transfer protein lipidation and control of CD1d on antigenpresenting cells, "The Journal of ExperimentalMedicine, vol. 202, no. 4, pp. 529-539, 2005.
27. S. Brozovic, T. Nagaishi, M. Yoshida et al. , "CD1d function is regulated by microsomal triglyceride transfer protein, " Nature Medicine, vol. 10, no. 5, pp. 535-539, 2004.
28. Y. Sagiv, L. Bai, D. G. Wei et al. , "A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d, " Journal of Experimental Medicine, vol. 204, no. 4, pp. 921-928, 2007.
29. D. Cox, L. Fox, R. Tian et al. , "Determination of cellular lipids bound to human CD1d molecules, " PLoS ONE, vol. 4, no. 5, Article ID 0005325, 2009.
30. V. Briken, R. M. Jackman, S. Dasgupta, S. Hoening, and S. A. Porcelli, "Intracellular trafficking pathway of newly synthesized CD1b molecules, "TheEMBOJournal, vol. 21, no. 4, pp. 825-834, 2002.
31. M. Sugita, E. P. Grant, E. Van Donselaar et al. , "Separate pathways for antigen presentation by CD1molecules, " Immunity, vol. 11, no. 6, pp. 743-752, 1999.
32. M. Sugita, N. van Der Wel, R. A. Rogers, P. J. Peters, and M. B. Brenner, "CD1c molecules broadly survey the endocytic system, " Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 15, pp. 8445-8450, 2000.
33. M. Sugita, R. M. Jackman, E. Van Donselaar et al. , "Cytoplasmic tail-dependent localization of CD1b antigen-presenting molecules to MIICs, " Science, vol. 273, no. 5273, pp. 349-352, 1996.
34. D. C. Barral, M. Cavallari, P. J. McCormick et al. , "CD1a and MHC class I follow a similar endocytic recycling pathway, " Traffic, vol. 9, no. 9, pp. 1446-1457, 2008.
35. M. Sugita, X. Cao, G. F. M. Watts, R. A. Rogers, J. S. Bonifacino, andM. B. Brenner, "Failure of trafficking and antigen presentation by CD1 in AP-3-deficient cells, " Immunity, vol. 16, no. 5, pp. 697-706, 2002.
36. Y.-H. Chiu, S.-H. Park, K. Benlagha et al. , "Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail-truncated CD1d, " Nature Immunology, vol. 3, no. 1, pp. 55-60, 2002.
37. J. Jayawardena-Wolf, K. Benlagha, Y.-H. Chiu, R. Mehr, and A. Bendelac, "CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain, " Immunity, vol. 15, no. 6, pp. 897-908, 2001.
38. I. Sloma, M.-T. Zilber, T. Vasselon et al. , "Regulation of CD1a surface expression and antigen presentation by invariant chain and lipid rafts, " The Journal of Immunology, vol. 180, no. 2, pp. 980-987, 2008.
39. J. S. Im, P. Arora, G. Bricard et al. , "Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation, " Immunity, vol. 30, no. 6, pp. 888-898, 2009.
40. P. Arora, S. S. Kharkwal, T. W. Ng et al. , "Endocytic pHregulates cell surface localization of glycolipid antigen loaded CD1d complexes, " Chemistry and Physics of Lipids, vol. 191, pp. 75-83, 2015.
41. E. Agea, A. Russano, O. Bistoni et al. , "Human CD1-restricted T cell recognition of lipids from pollens, " The Journal of Experimental Medicine, vol. 202, no. 2, pp. 295-308, 2005.
42. J. E. Gumperz, C. Roy, A. Makowska et al. , "Murine CD1drestricted T cell recognition of cellular lipids, " Immunity, vol. 12, no. 2, pp. 211-221, 2000.
43. A. M. Russano, G. Bassotti, E. Agea et al. , "CD1-restricted recognition of exogenous and self-lipid antigens by duodenal + T lymphocytes, " Journal of Immunology, vol. 178, no. 6, pp. 3620-3626, 2007.
44. I. Van Rhijn, T. Van Berlo, T. Hilmenyuk et al. , "Human autoreactive T cells recognizeCD1b and phospholipids, " Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 2, pp. 380-385, 2016.
45. B. J. Wolf, R. V. V. Tatituri, C. F. Almeida et al. , "Identification of a potent microbial lipid antigen for diverse NKT cells, " Journal of Immunology, vol. 195, no. 6, pp. 2540-2551, 2015.
46. R. V. V. Tatituri, G. F. M. Watts, V. Bhowruth et al. , "Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs, " Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 5, pp. 1827-1832, 2013.
47. S. Zeissig, K. Murata, L. Sweet et al. , "Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity, " Nature Medicine, vol. 18, no. 7, pp. 1060-1068, 2012.
48. R. W. Birkinshaw, D. G. Pellicci, T.-Y. Cheng et al. , " T cell antigen receptor recognition of CD1a presenting self lipid ligands, " Nature Immunology, vol. 16, no. 3, pp. 258-266, 2015.
49. L. M. Fox, D. G. Cox, J. L. Lockridge et al. , "Recognition of lysophospholipids by human natural killer T lymphocytes, " PLoS Biology, vol. 7, no. 10, Article IDe1000228, 2009.
50. M. Blomqvist, S. Rhost, S. Teneberg et al. , "Multiple tissuespecific isoforms of sulfatide activate CD1d-restricted type II NKT cells, " European Journal of Immunology, vol. 39, no. 7, pp. 1726-1735, 2009.
51. A. Shamshiev, A. Donda, T. I. Prigozy et al. , "The T cell response to self-glycolipids shows a novel mechanism of CD1b loading and a requirement for complex oligosaccharides, " Immunity, vol. 13, no. 2, pp. 255-264, 2000.
52. J.-E. Park, D. Y. Wu, M. Prendes et al. , "Fine specificity of natural killer T cells against GD3 ganglioside and identification of GM3 as an inhibitory natural killer T-cell ligand, " Immunology, vol. 123, no. 1, pp. 145-155, 2008.
53. L. Kain, B. Webb, B. L. Anderson et al. , "Theidentification of the endogenous ligands of natural killer t cells reveals the presence of mammalian-linked glycosylceramides, " Immunity, vol. 41, no. 4, pp. 543-554, 2014.
54. S. Rhost, L. Löfbom, B.-M. Rynmark et al. , "Identification of novel glycolipid ligands activating a sulfatide-reactive, CD1drestricted, type II natural killer T lymphocyte, " European Journal of Immunology, vol. 42, no. 11, pp. 2851-2860, 2012.
55. S. Nair, C. S. Boddupalli, R. Verma et al. , "Type II NKTTFH cells against Gaucher lipids regulate B-cell immunity and inflammation, " Blood, vol. 125, no. 8, pp. 1256-1271, 2015.
56. D. Zhou, J. Mattner, C. Cantu III et al. , "Lysosomal glycosphingolipid recognition by NKT cells, " Science, vol. 306, no. 5702, pp. 1786-1789, 2004.
57. X. Long, S. Deng, J. Mattner et al. , "Synthesis and evaluation of stimulatory properties of Sphingomonadaceae glycolipids, " Nature Chemical Biology, vol. 3, no. 9, pp. 559-564, 2007.
58. F. Facciotti, G. S. Ramanjaneyulu, M. Lepore et al. , "Peroxisomederived lipids are self antigens that stimulate invariant natural killer T cells in the thymus, " Nature Immunology, vol. 13, no. 5, pp. 474-480, 2012.
59. M. Lepore, C. de Lalla, S. R. Gundimeda et al. , "A novel selflipid antigen targets human T cells against CD1c+ leukemias, " Journal of Experimental Medicine, vol. 211, no. 7, pp. 1363-1377, 2014.
60. A. de Jong, T.-Y. Cheng, S. Huang et al. , "CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens, " Nature Immunology, vol. 15, no. 2, pp. 177-185, 2014.
61. Y. Kinjo, E. Tupin, D. Wu et al. , "Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria, " Nature Immunology, vol. 7, no. 9, pp. 978-986, 2006.
62. D. B. Moody, B. B. Reinhold, M. R. Guy et al. , "Structural requirements for glycolipid antigen recognition by CD1brestricted T cells, " Science, vol. 278, no. 5336, pp. 283-286, 1997.
63. P. A. Sieling, D. Chatterjee, S. A. Porcelli et al. , "CD1-restrictedT cell recognition of microbial lipoglycan antigens, " Science, vol. 269, no. 5221, pp. 227-230, 1995.
64. J. L. Amprey, J. S. Im, S. J. Turco et al. , "A subset of liver NK T cells is activated during Leishmania donovani infection by CD1d-bound lipophosphoglycan, " Journal of Experimental Medicine, vol. 200, no. 7, pp. 895-904, 2004.
65. D. B. Moody, D. C. Young, T.-Y. Cheng et al. , "T cell activation by lipopeptide antigens, " Science, vol. 303, no. 5657, pp. 527-531, 2004.
66. D. Ly, A. G. Kasmar, T.-Y. Cheng et al. , "CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens, " Journal of ExperimentalMedicine, vol. 210, no. 4, pp. 729-741, 2013.
67. D. B. Moody, T. Ulrichs, W. Mühlecker et al. , "CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection, " Nature, vol. 404, no. 6780, pp. 884-888, 2000.
68. L. F. Garcia-Alles, A. Collmann, C. Versluis et al. , "Structural reorganization of the antigen-binding groove of human CD1b for presentation of mycobacterial sulfoglycolipids, " Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 43, pp. 17755-17760, 2011.
69. D. M. Zajonc, M. D. M. Crispin, T. A. Bowden et al. , "Molecular mechanism of lipopeptide presentation by CD1a, " Immunity, vol. 22, no. 2, pp. 209-219, 2005.
70. C. S. Pereira, C. Sa-Miranda, G. De Libero, L. Mori, and M. F. Macedo, "Globotriaosylceramide inhibits iNKT-cell activation in a CD1d-dependent manner, " European Journal of Immunology, vol. 46, no. 1, pp. 147-153, 2016.
71. G. De Libero and L. Mori, "Novel insights into lipid antigen presentation, " Trends in Immunology, vol. 33, no. 3, pp. 103-111, 2012.
72. S. Freigang, E. Landais, V. Zadorozhny et al. , "Scavenger receptors target glycolipids for natural killer T cell activation, " Journal of Clinical Investigation, vol. 122, no. 11, pp. 3943-3954, 2012.
73. L. León, R. V. V. Tatituri, R. Grenha et al. , "Saposins utilize two strategies for lipid transfer and CD1 antigen presentation, " Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 12, pp. 4357-4364, 2012.
74. F. Winau, V. Schwierzeck, R. Hurwitz et al. , "Saposin C is required for lipid presentation by human CD1b, " Nature Immunology, vol. 5, no. 2, pp. 169-174, 2004.
75. W. Yuan, X. Qi, P. Tsang et al. , "Saposin B is the dominant saposin that facilitates lipid binding to human CD1dmolecules, " Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 13, pp. 5551-5556, 2007.
76. M. Salio, H. Ghadbane, O. Dushek et al. , "Saposins modulate human invariant natural killer t cells self-Reactivity and facilitate lipid exchange with cd1d molecules during antigen presentation, " Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 49, pp. E4753-E4761, 2013.
77. S.-J. Kang and P. Cresswell, "Saposins facilitate CD1d-restricted presentation of an exogenous lipid antigen to T cells, " Nature Immunology, vol. 5, no. 2, pp. 175-181, 2004.
78. N. Schrantz, Y. Sagiv, Y. Liu, P. B. Savage, A. Bendelac, and L. Teyton, "The Niemann-Pick type C2 protein loads isoglobotrihexosylceramide onto CD1d molecules and contributes to the thymic selection of NKT cells, " Journal of Experimental Medicine, vol. 204, no. 4, pp. 841-852, 2007.
79. D. Cala-De Paepe, E. Layre, G. Giacometti et al. , "Deciphering the role of CD1e protein in mycobacterial phosphatidyl-myoinositol mannosides (PIM) processing for presentation byCD1b to T lymphocytes, " Journal of Biological Chemistry, vol. 287, no. 37, pp. 31494-31502, 2012.
80. F. Facciotti, M. Cavallari, C. Angénieux et al. , "Fine tuning by human CD1e of lipid-specific immune responses, " Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 34, pp. 14228-14233, 2011.
81. D. Zhou, C. Cantu III, Y. Sagiv et al. , "Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins, " Science, vol. 303, no. 5657, pp. 523-527, 2004.
82. D. I. Godfrey, S. Stankovic, and A. G. Baxter, "Raising the NKT cell family, " Nature Immunology, vol. 11, no. 3, pp. 197-206, 2010.
83. C. De Lalla, M. Lepore, F. M. Piccolo et al. , "High-frequency and adaptive-like dynamics of human CD1 self-reactive T cells, " European Journal of Immunology, vol. 41, no. 3, pp. 602-610, 2011.
84. M. Gilleron, S. Stenger, Z. Mazorra et al. , "Diacylated sulfoglycolipids are novel mycobacterial antigens stimulating CD1-restricted T cells during infection withMycobacterium tuberculosis, " The Journal of Experimental Medicine, vol. 199, no. 5, pp. 649-659, 2004.
85. T. Ulrichs, D. B. Moody, E. Grant, S. H. E. Kaufmann, and S. A. Porcelli, "T-cell responses to CD1-presented lipid antigens in humans withMycobacteriumtuberculosis infection, " Infection and Immunity, vol. 71, no. 6, pp. 3076-3087, 2003.
86. A. de Jong, V. Peña-Cruz, T.-Y. Cheng, R. A. Clark, I. Van Rhijn, andD. B. Moody, "CD1a-autoreactive T cells are a normal component of the human T cell repertoire, " Nature Immunology, vol. 11, no. 12, pp. 1102-1109, 2010.
87. A. G. Kasmar, I. van Rhijn, T.-Y. Cheng et al. , "CD1b tetramers bind T cell receptors to identify a mycobacterial glycolipidreactive T cell repertoire in humans, " Journal of Experimental Medicine, vol. 208, no. 9, pp. 1741-1747, 2011.
88. I. Van Rhijn, A. Kasmar, A. De Jong et al. , "A conserved human T cell population targets mycobacterial antigens presented by CD1b, " Nature Immunology, vol. 14, no. 7, pp. 706-713, 2013.
89. I. Van Rhijn, N. A. Gherardin, A. Kasmar et al. , "TCR bias and affinity define two compartments of theCD1b-glycolipid-specific T cell repertoire, " Journal of Immunology, vol. 192, no. 9, pp. 4054-4060, 2014.
90. S. P. Berzins, M. J. Smyth, and A. G. Baxter, "Presumed guilty: natural killer T cell defects and human disease, " Nature Reviews Immunology, vol. 11, no. 2, pp. 131-142, 2011.
91. P. J. Brennan, M. Brigl, and M. B. Brenner, "Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions, " Nature Reviews Immunology, vol. 13, no. 2, pp. 101-117, 2013.
92. C. J. Montoya, D. Pollard, J. Martinson et al. , "Characterization of human invariant natural killer T subsets in health and disease using a novel invariant natural killer T cell-clonotypic monoclonal antibody, 6B11, " Immunology, vol. 122, no. 1, pp. 1-14, 2007.
93. M. Kanamori, Y. Tasumi, T. Iyoda, M. Ushida, and K. Inaba, "Sulfatide inhibits β-galactosylceramide presentation by dendritic cells, " International Immunology, vol. 24, no. 2, pp. 129-136, 2012.
94. E. Y. Kim, L. Lynch, P. J. Brennan, N. R. Cohen, and M. B. Brenner, "The transcriptional programs of iNKT cells, " Seminars in Immunology, vol. 27, no. 1, pp. 26-32, 2015.
95. M. G. Constantinides and A. Bendelac, "Transcriptional regulation of the NKT cell lineage, " Current Opinion in Immunology, vol. 25, no. 2, pp. 161-167, 2013.
96. P. T. Lee, K. Benlagha, L. Teyton, and A. Bendelac, "Distinct functional lineages of human V-24 natural killer T cells, " Journal of Experimental Medicine, vol. 195, no. 5, pp. 637-641, 2002.
97. J. E. Gumperz, S. Miyake, T. Yamamura, and M. B. Brenner, "Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining, " Journal of Experimental Medicine, vol. 195, no. 5, pp. 625-636, 2002.
98. V. O'Reilly, S. G. Zeng, G. Bricard et al. , "Distinct and overlapping effector functions of expanded human CD4+, CD8a+ and CD4-CD8a-invariant natural killer T cells, " PLoS ONE, vol. 6, no. 12, Article ID e28648, 2011.
99. M.-L. Michel, A. C. Keller, C. Paget et al. , "Identification of an IL-17-producing NK1. 1 iNKT cell population involved in airway neutrophilia, " Journal of ExperimentalMedicine, vol. 204, no. 5, pp. 995-1001, 2007.
100. J.-M. Doisne, C. Becourt, L. Amniai et al. , "Skin and peripheral lymph node invariant NKT cells are mainly retinoic acid receptor-related orphan receptor t+ and respond preferentially under inflammatory conditions, " The Journal of Immunology, vol. 183, no. 3, pp. 2142-2149, 2009.
101. H. Dai, A. Rahman, A. Saxena et al. , "Syndecan-1 identifies and controls the frequency of IL-17-producing naïve natural killer T (NKT17) cells in mice, " European Journal of Immunology, vol. 45, no. 11, pp. 3045-3051, 2015.
102. M. Monteiro, C. F. Almeida, A. Agua-Doce, and L. Graca, "Induced IL-17-producing invariant NKT cells require activation in presence of TGF-β and IL-1α, " The Journal of Immunology, vol. 190, no. 2, pp. 805-811, 2013.
103. M.-L. Michel, D. Mendes-da-Cruz, A. C. Keller et al. , "Critical role of ROR-t in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation, " Proceedings of the NationalAcademy of Sciences of theUnited States ofAmerica, vol. 105, no. 50, pp. 19845-19850, 2008.
104. A. Enders, S. Stankovic, C. Teh et al. , "ZBTB7B (Th-POK) regulates the development of IL-17-producing CD1d-restricted mouse NKT cells, " Journal of Immunology, vol. 189, no. 11, pp. 5240-5249, 2012.
105. I. Engel, M. Zhao, D. Kappes, I. Taniuchi, and M. Kronenberg, "The transcription factor Th-POK negatively regulates Th17 differentiation in V-14i NKT cells, " Blood, vol. 120, no. 23, pp. 4524-4532, 2012.
106. T. Hu, H. Wang, A. Simmons et al. , "Increased level of E protein activity during invariant NKT development promotes differentiation of invariantNKT2 and invariantNKT17 subsets, " The Journal of Immunology, vol. 191, no. 10, pp. 5065-5073, 2013.
107. T. Takahashi, S. Chiba, M. Nieda et al. , "Cutting edge: analysis of human V-24+CD8+ NKT cells activated by β-galactosylceramide-pulsed monocyte-derived dendritic cells, " Journal of Immunology, vol. 168, no. 7, pp. 3140-3144, 2002.
108. L. Moreira-Teixeira, M. Resende, M. Coffre et al. , "Proinflammatory environment dictates the IL-17-producing capacity of human invariant NKT cells, " Journal of Immunology, vol. 186, no. 10, pp. 5758-5765, 2011.
109. A. Balreira, M. F. Macedo, C. Girão et al. , "Anomalies in conventional T and invariant natural killer T-cell populations in Fabry mice but not in Fabry patients, " British Journal of Haematology, vol. 143, no. 4, pp. 601-604, 2008.
110. M. F. Macedo, R. Quinta, C. S. Pereira, andM. C. SaMiranda, "Enzyme replacement therapy partially prevents invariant Natural Killer T cell deficiency in the Fabry disease mouse model, " Molecular Genetics and Metabolism, vol. 106, no. 1, pp. 83-91, 2012.
111. C. S. Pereira, O. Azevedo, M. L. Maia, A. F. Dias, C. Sa-Miranda, and M. F. Macedo, "Invariant natural killer T cells are phenotypically and functionally altered in Fabry disease, " Molecular Genetics andMetabolism, vol. 108, no. 4, pp. 241-248, 2013.
112. I. Marrero, R. Ware, andV. Kumar, "Type IINKTcells in inflammation, autoimmunity, microbial immunity, and cancer, " Frontiers in Immunology, vol. 6, article 316, 2015.
113. S. Cardell, S. Tangri, S. Chan, M. Kronenberg, C. Benoist, and D. Mathis, "CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice, " Journal of Experimental Medicine, vol. 182, no. 4, pp. 993-1004, 1995.
114. S.-H. Park, A. Weiss, K. Benlagha, T. Kyin, L. Teyton, and A. Bendelac, "Themouse CD1d-restricted repertoire is dominated by a few autoreactive T cell receptor families, " Journal of Experimental Medicine, vol. 193, no. 8, pp. 893-904, 2001.
115. J. Zhao, X. Weng, S. Bagchi, and C.-R. Wang, "Polyclonal type II natural killer T cells require PLZF and SAP for their development and contribute to CpG-mediated antitumor response, " Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 7, pp. 2674-2679, 2014.
116. L. Bai, D. Picard, B. Anderson et al. , "The majority of CD1dsulfatide-specific T cells in human blood use a semiinvariant V-1 TCR, " European Journal of Immunology, vol. 42, no. 9, pp. 2505-2510, 2012.