T Cell Activation by Lipopeptide Antigens

Science

Volumn 303, Issue 5657, 2004, Pages 527-531

  Moody, D Branch ^a   Young, David C ^a,b   Cheng, Tan Yun ^a   Rosat, Jean Pierre ^a   Roura Mir, Carme ^a   O'Connor, Peter B ^b   Zajonc, Dirk M ^e   Walz, Andrew ^c   Miller, Marvin J ^c   Levery, Steven B ^d   Wilson, Ian A ^e   Costello, Catherine E ^b   Brenner, Michael B ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NOTRE DAME   (United States)

^d Univ of New Hampshire   (United States)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BACTERIA; CHEMICAL ACTIVATION; LIPIDS; STRUCTURE (COMPOSITION);

HISTOCOMPATIBLE PROTEINS;

CELLS;

ANTIGEN; DIDEHYDROXYMYCOBACTIN; LIPOPEPTIDE ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN; PEPTIDE; SIDEROPHORE; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; UNCLASSIFIED DRUG;

ANTIGEN; PROTEIN;

ARTICLE; MAJOR HISTOCOMPATIBILITY COMPLEX; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANTIGEN PRESENTATION; ANTIGENS, BACTERIAL; ANTIGENS, CD1; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; HYDROGEN BONDING; HYDROPHOBICITY; HYDROXYLATION; LIPOPROTEINS; LYMPHOCYTE ACTIVATION; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; OXAZOLES; PROTEIN CONFORMATION; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES; TRANSFECTION;

MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 9144251572     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1089353     Document Type: Article

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36. The authors acknowledge C. Ratledge for providing mycobactins and advice, C. A. Debono for bacterial culture, and J. Zajicek for preliminary NMR work. This work is supported by grants from the American College of Rheumatology Research and Education Foundation, the Cancer Research Institute, The Mizutani Foundation for Glycoscience, the Deutsche Forschungsgemeinschaft, and NIH or National Center for Research Resources grants (P20 RR16459 to S.B.L, AI50216 and AR48632 to D.B.M., GM62116 and CA58896 to I.A.W., AI30988 and GM25845 to M.J.M., and P41-RR10888 and 510-RR10493 to C.E.C.).