Human autoreactive T cells recognize CD1b and phospholipids

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 2, 2016, Pages 380-385

  Van Rhijn, Ildiko ^a,b   Van Berlo, Twan ^b   Hilmenyuk, Tamara ^c   Cheng, Tan Yun ^a   Wolf, Benjamin J ^a   Tatituri, Raju V V ^a   Uldrich, Adam P ^c   Napolitani, Giorgio ^d   Cerundolo, Vincenzo ^d   Altman, John D ^e   Willemsen, Peter ^f   Huang, Shouxiong ^a,j   Rossjohn, Jamie ^g,h   Besra, Gurdyal S ⁱ   Brenner, Michael B ^a   Godfrey, Dale I ^c   Moody, D Branch ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e EMORY UNIVERSITY   (United States)

^f WAGENINGEN UNIVERSITY   (Netherlands)

^g MONASH UNIVERSITY   (Australia)

^h CARDIFF UNIVERSITY   (United Kingdom)

ⁱ UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^j UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

more..

Author keywords

CD1b; Dendritic cell; Lipid antigen; Self antigen; T cell

Indexed keywords

CD1B ANTIGEN; LYSOPHOSPHATIDIC ACID; N NERVONOYL D ERYTHRO SPHINGOSYLPHOSPHORYLCHOLINE; PHOSPHATIDIC ACID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLGLYCEROL; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLSERINE; PHOSPHOLIPID; SULFOGALACTOSYLSPHINGOSINE; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; TRISIALOGANGLIOSIDE; UNCLASSIFIED DRUG; CD1 ANTIGEN;

ANTIGEN RECOGNITION; ARTICLE; BRUCELLA MELITENSIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; LYMPHOCYTE DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LIPID INTERACTION; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; STAPHYLOCOCCUS AUREUS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; ANTIGEN PRESENTING CELL; CHEMISTRY; GENETIC TRANSFECTION; HEK293 CELL LINE; IMMUNOLOGY; K-562 CELL LINE; LYMPHOCYTE ACTIVATION; MASS SPECTROMETRY; METABOLISM;

ANTIGEN-PRESENTING CELLS; ANTIGENS, CD1; HEK293 CELLS; HUMANS; K562 CELLS; LYMPHOCYTE ACTIVATION; MASS SPECTROMETRY; PHOSPHATIDYLGLYCEROLS; PHOSPHOLIPIDS; T-LYMPHOCYTES; TRANSFECTION;

EID: 84954510509     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1520947112     Document Type: Article

References (38)

1. Dougan SK, Kaser A, Blumberg RS (2007) CD1 expression on antigen-presenting cells. Curr Top Microbiol Immunol 314:113-141.
2. Jackman RM, et al. (1998) The tyrosine-containing cytoplasmic tail of CD1b is essential for its efficient presentation of bacterial lipid antigens. Immunity 8(3):341-351.
3. Porcelli S, Morita CT, Brenner MB (1992) CD1b restricts the response of human CD4-8-T lymphocytes to a microbial antigen. Nature 360(6404):593-597.
4. Moody DB, et al. (1997) Structural requirements for glycolipid antigen recognition by CD1b-restricted T cells. Science 278(5336):283-286.
5. Gilleron M, et al. (2004) Diacylated sulfoglycolipids are novel mycobacterial antigens stimulating CD1-restricted T cells during infection with Mycobacterium tuberculosis. J Exp Med 199(5):649-659.
6. Moody DB, et al. (2004) T cell activation by lipopeptide antigens. Science 303(5657): 527-531.
7. Layre E, et al. (2009) Mycolic acids constitute a scaffold for mycobacterial lipid antigens stimulating CD1-restricted T cells. Chem Biol 16(1):82-92.
8. Kasmar AG, et al. (2011) CD1b tetramers bind αβ T cell receptors to identify a mycobacterial glycolipid-reactive T cell repertoire in humans. J Exp Med 208(9): 1741-1747.
9. Kasmar AG, et al. (2013) Cutting Edge: CD1a tetramers and dextramers identify human lipopeptide-specific T cells ex vivo. J Immunol 191(9):4499-4503.
10. Ly D, et al. (2013) CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens. J Exp Med 210(4):729-741.
11. Van Rhijn I, et al. (2013) A conserved human T cell population targets mycobacterial antigens presented by CD1b. Nat Immunol 14(7):706-713.
12. Van Rhijn I, et al. (2014) TCR bias and affinity define two compartments of the CD1b-glycolipid-specific T Cell repertoire. J Immunol 192(9):4054-4060.
13. Layre E, et al. (2011) A comparative lipidomics platform for chemotaxonomic analysis of Mycobacterium tuberculosis. Chem Biol 18(12):1537-1549.
14. Moody DB, et al. (2000) CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection. Nature 404(6780):884-888.
15. Shamshiev A, et al. (1999) Self glycolipids as T-cell autoantigens. Eur J Immunol 29(5): 1667-1675.
16. Li S, Choi HJ, Felio K, Wang CR (2011) Autoreactive CD1b-restricted T cells: A new innate-like T-cell population that contributes to immunity against infection. Blood 118(14):3870-3878.
17. Vincent MS, Xiong X, Grant EP, Peng W, Brenner MB (2005) CD1a-, b-, and c-restricted TCRs recognize both self and foreign antigens. J Immunol 175(10):6344-6351.
18. De Libero G, et al. (2005) Bacterial infections promote T cell recognition of self-glycolipids. Immunity 22(6):763-772.
19. de Lalla C, et al. (2011) High-frequency and adaptive-like dynamics of human CD1 self-reactive T cells. Eur J Immunol 41(3):602-610.
20. de Jong A, et al. (2010) CD1a-autoreactive T cells are a normal component of the human αβ T cell repertoire. Nat Immunol 11(12):1102-1109.
21. Birkinshaw RW, et al. (2015) αβ T cell antigen receptor recognition of CD1a presenting self lipid ligands. Nat Immunol 16(3):258-266.
22. White DC, Frerman FE (1968) Fatty acid composition of the complex lipids of Staphylococcus aureus during the formation of themembrane-bound electron transport system. J Bacteriol 95(6):2198-2209.
23. Beining PR, Huff E, Prescott B, Theodore TS (1975) Characterization of the lipids of mesosomal vesicles and plasma membranes from Staphylococcus aureus. J Bacteriol 121(1):137-143.
24. Ames GF (1968) Lipids of Salmonella typhimurium and Escherichia coli: Structure and metabolism. J Bacteriol 95(3):833-843.
25. de Jong A, et al. (2007) CD1c presentation of synthetic glycolipid antigens with foreign alkyl branching motifs. Chem Biol 14(11):1232-1242.
26. Grant EP, et al. (2002) Fine specificity of TCR complementarity-determining region residues and lipid antigen hydrophilic moieties in the recognition of a CD1-lipid complex. J Immunol 168(8):3933-3940.
27. Wolf BJ, et al. (2015) Identification of a potent microbial lipid antigen for diverse NKT cells. J Immunol 195(6):2540-2551.
28. Tatituri RV, et al. (2013) Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs. Proc Natl Acad Sci USA 110(5):1827-1832.
29. Ray TK, Skipski VP, Barclay M, Essner E, Archibald FM (1969) Lipid composition of rat liver plasma membranes. J Biol Chem 244(20):5528-5536.
30. Horvath SE, Daum G (2013) Lipids of mitochondria. Prog Lipid Res 52(4):590-614.
31. Morita SY, Terada T (2015) Enzymatic measurement of phosphatidylglycerol and cardiolipin in cultured cells and mitochondria. Sci Rep 5:11737.
32. Yorek MA (1993) Biological distribution. Phospholipid handbook, ed Cevc G (Marcel Dekker, New York), pp 745-775.
33. Epand RF, Savage PB, Epand RM (2007) Bacterial lipid composition and the antimicrobial efficacy of cationic steroid compounds (Ceragenins). Biochim Biophys Acta 1768(10):2500-2509.
34. Heemskerk MH, et al. (2003) Redirection of antileukemic reactivity of peripheral T lymphocytes using gene transfer of minor histocompatibility antigen HA-2-specific T-cell receptor complexes expressing a conserved alpha joining region. Blood 102(10): 3530-3540.
35. Gadola SD, et al. (2002) Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains. Nat Immunol 3(8):721-726.
36. Garcia-Alles LF, et al. (2006) Endogenous phosphatidylcholine and a long spacer ligand stabilize the lipid-binding groove of CD1b. EMBO J 25(15):3684-3692.
37. Uldrich AP, et al. (2013) CD1d-lipid antigen recognition by the γδ TCR. Nat Immunol 14(11):1137-1145.
38. Grogan DW, Cronan JE, Jr (1997) Cyclopropane ring formation in membrane lipids of bacteria. Microbiol Mol Biol Rev 61(4):429-441.