Saposins modulate human invariant natural killer t cells self-Reactivity and facilitate lipid exchange with cd1d molecules during antigen presentation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 49, 2013, Pages

  Salio, Mariolina ^a   Ghadbane, Hemza ^a   Shepherd, Dawn ^a   Cypen, Jeremy ^a   Gileadi, Uzi ^a   Aichinger, Michael C ^a   Napolitani, Giorgio ^a   Cerundolo, Vincenzo ^a   Dushek, Omer ^b   Van Der Merwe, P Anton ^b   Qi, Xiaoyang ^c   Cox, Liam R ^d   Wojno, Justyna ^d,e   Veerapen, Natacha ^e   Besra, Gurdyal S ^e   Yuan, Weiming ^f   Cresswell, Peter ^g  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

^d Biochemical Recovery Group   (United Kingdom)

^e UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^f UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^g YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autoreactivity; Inflammation; Innate immunity; Lipid binding proteins

Indexed keywords

CD1D ANTIGEN; PROSAPOSIN; SHORT HAIRPIN RNA; SPHINGOLIPID ACTIVATOR PROTEIN;

ADAPTIVE IMMUNITY; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; BACTERIAL INFECTION; BONE MARROW CELL; GENE SILENCING; HUMAN; IMMUNOMODULATION; INVARIANT NATURAL KILLER T CELL; LIPID TRANSPORT; LISTERIA MONOCYTOGENES; NATURAL KILLER T CELL; PRIORITY JOURNAL;

AUTOREACTIVITY; INFLAMMATION; INNATE IMMUNITY; LIPID BINDING PROTEINS;

ANTIGEN-PRESENTING CELLS; ANTIGENS, CD1D; BACTERIA; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; IMMUNOPRECIPITATION; LIPID METABOLISM; NATURAL KILLER T-CELLS; SAPOSINS; SCINTILLATION COUNTING;

EID: 84889654874     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1310050110     Document Type: Article

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