CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens

Nature Immunology

Volumn 15, Issue 2, 2014, Pages 177-185

  De Jong, Annemieke ^a,g   Cheng, Tan Yun ^a   Huang, Shouxiong ^a   Gras, Stephanie ^b   Birkinshaw, Richard W ^b   Kasmar, Anne G ^a   Van Rhijn, Ildiko ^a,c   Peña Cruz, Victor ^d   Ruan, Daniel T ^a   Altman, John D ^e   Rossjohn, Jamie ^b,f   Moody, D Branch ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MONASH UNIVERSITY   (Australia)

^c UTRECHT UNIVERSITY   (Netherlands)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e EMORY UNIVERSITY   (United States)

^f CARDIFF UNIVERSITY   (United Kingdom)

^g NewYork Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD1 ANTIGEN; DESONIDE; ESTER DERIVATIVE; LIGAND; SKIN LIPID; SQUALENE; UNCLASSIFIED DRUG; WAX; WAX ESTER;

ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; EPIDERMIS; IMMUNITY; IMMUNOREACTIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEBACEOUS GLAND; SKIN FUNCTION; SKIN SURFACE; T LYMPHOCYTE ACTIVATION;

AMINO ACID SEQUENCE; ANTIGEN PRESENTATION; ANTIGENS, CD1; AUTOANTIGENS; HEK293 CELLS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIPIDS; LYMPHOCYTE ACTIVATION; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RECOMBINANT PROTEINS; SKIN; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES;

EID: 84892799782     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2790     Document Type: Article

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