BMP restricts stemness of intestinal Lgr5 + stem cells by directly suppressing their signature genes

Nature Communications

Volumn 8, Issue , 2017, Pages

  Qi, Zhen ^a   Li, Yehua ^a   Zhao, Bing ^a   Xu, Chi ^b,c   Liu, Yuan ^a   Li, Haonan ^a   Zhang, Bingjie ^a   Wang, Xinquan ^a   Yang, Xiao ^d   Xie, Wei ^a   Li, Baojie ^e   Han, Jing Dong Jackie ^b   Chen, Ye Guang ^a  

^a TSINGHUA UNIVERSITY   (China)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^d BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

^e SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; BONE MORPHOGENETIC PROTEIN; HISTONE DEACETYLASE 1; SMAD1 PROTEIN; SMAD4 PROTEIN; WNT PROTEIN; G PROTEIN COUPLED RECEPTOR; HISTONE DEACETYLASE; LGR5 PROTEIN, MOUSE; PROTEIN BINDING; SMAD PROTEIN;

BEST MANAGEMENT PRACTICE; CELLS AND CELL COMPONENTS; GENE EXPRESSION; HOMEOSTASIS; INJURY; PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME LOCALIZATION; FEMALE; GENE; GENE INACTIVATION; HOMEOSTASIS; INTESTINAL STEM CELL; INTESTINE EPITHELIUM; LGR5 GENE; MALE; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN FUNCTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; STEM CELL EXPANSION; STEM CELL SELF-RENEWAL; TRANSCRIPTION TERMINATION; ANIMAL; C57BL MOUSE; CELL CYCLE CHECKPOINT; CELL PROLIFERATION; CELL SELF-RENEWAL; CYTOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; INTESTINE; IONIZING RADIATION; METABOLISM; PATHOLOGY; PRECANCER; RADIATION RESPONSE; REGENERATION; STEM CELL; WNT SIGNALING;

ANIMALS; BETA CATENIN; BONE MORPHOGENETIC PROTEINS; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; CELL SELF RENEWAL; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HISTONE DEACETYLASES; HOMEOSTASIS; INTESTINES; MALE; MICE, INBRED C57BL; PRECANCEROUS CONDITIONS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RADIATION, IONIZING; RECEPTORS, G-PROTEIN-COUPLED; REGENERATION; SMAD PROTEINS; STEM CELLS; TRANSCRIPTION, GENETIC; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 85008668724     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms13824     Document Type: Article

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