Bitter taste receptor agonists mediate relaxation of human and rodent vascular smooth muscle

European Journal of Pharmacology

Volumn 740, Issue , 2014, Pages 302-311

  Manson, Martijn L ^a   Säfholm, Jesper ^a   Al Ameri, Mamdoh ^a,b   Bergman, Per ^a,b   Orre, Ann Charlotte ^a,b   Swärd, Karl ^c   James, Anna ^a   Dahlén, Sven Erik ^a   Adner, Mikael ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c LUND UNIVERSITY   (Sweden)

Author keywords

Airway smooth muscle; Human pulmonary artery; Taste physiology; Taste sensing type 2 receptors (TAS2Rs); TP receptor; Vascular smooth muscle

Indexed keywords

CHLOROQUINE; DENATONIUM BENZOATE; DEXTROMETHORPHAN; G PROTEIN COUPLED RECEPTOR; NOSCAPINE; QUATERNARY AMMONIUM DERIVATIVE; QUININE; SACCHARIN;

AGED; AGONISTS; ANIMAL; COLON; DRUG EFFECTS; FEMALE; GUINEA PIG; HUMAN; IN VITRO STUDY; KNOCKOUT MOUSE; MALE; MIDDLE AGED; MOUSE; MUSCLE RELAXATION; PHYSIOLOGY; PULMONARY ARTERY; TASTE; THORACIC AORTA; TRACHEA; VASCULAR SMOOTH MUSCLE;

AGED; ANIMALS; AORTA, THORACIC; CHLOROQUINE; COLON; DEXTROMETHORPHAN; FEMALE; GUINEA PIGS; HUMANS; IN VITRO TECHNIQUES; MALE; MICE; MICE, KNOCKOUT; MIDDLE AGED; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NOSCAPINE; PULMONARY ARTERY; QUATERNARY AMMONIUM COMPOUNDS; QUININE; RECEPTORS, G-PROTEIN-COUPLED; SACCHARIN; TASTE; TRACHEA;

EID: 84906055476     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.07.005     Document Type: Article

References (37)

1. C. Advenier, J. Cerrina, P. Duroux, A. Floch, and A. Renier Effects of five different organic calcium antagonists on guinea-pig isolated trachea Br. J. Pharmacol. 82 1984 727 733 (Pubitemid 14085779)
2. F. Ahmed, R.W. Foster, and R.C. Small Some effects of nifedipine in guinea-pig isolated trachealis Br. J. Pharmacol. 84 1985 861 869 (Pubitemid 15108088)
3. R. Andersson, and E. Mohme-Lundholm Studies on the relaxing actions mediated by stimulation of adrenergic alpha- and beta-receptors in taenia coli of the rabbit and guinea pig Acta Physiol. Scand. 77 1969 372 384
4. A. Bergdahl, and K. Sward Caveolae-associated signalling in smooth muscle Can. J. Physiol. Pharmacol. 82 2004 289 299 (Pubitemid 39093694)
5. C. Brown, M. Fezoui, W.M. Selig, C.E. Schwartz, and J.L. Ellis Antitussive activity of sigma-1 receptor agonists in the guinea-pig Br. J. Pharmacol. 141 2004 233 240 (Pubitemid 38250893)
6. B.F. del Pozo, F. Perez-Vizcaino, E. Villamor, F. Zaragoza, and J. Tamargo Stereoselective effects of the enantiomers, quinidine and quinine, on depolarization- and agonist-mediated responses in rat isolated aorta Br. J. Pharmacol. 117 1996 105 110 (Pubitemid 26030258)
7. D.A. Deshpande, W.C. Wang, E.L. McIlmoyle, K.S. Robinett, R.M. Schillinger, S.S. An, J.S. Sham, and S.B. Liggett Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction Nat. Med. 16 2010 1299 1304
8. J.M. Farley, and P.R. Miles The sources of calcium for acetylcholine-induced contractions of dog tracheal smooth muscle J. Pharmacol. Exp. Ther. 207 1978 340 346 (Pubitemid 9098865)
9. J.A. Garcia-Sainz, and A. Mendoza-Mendoza Chloroquine inhibits alpha1B-adrenergic action in hepatocytes Eur. J. Pharmacol. 342 1998 333 338 (Pubitemid 28149988)
10. S. Grassin-Delyle, C. Abrial, S. Fayad-Kobeissi, M. Brollo, C. Faisy, J.C. Alvarez, E. Naline, and P. Devillier The expression and relaxant effect of bitter taste receptors in human bronchi Respir. Res. 14 2013 134
11. P.M. Hudgins, and G.B. Weiss Differential effects of calcium removal upon vascular smooth muscle contraction induced by norepinephrine, histamine and potassium J. Pharmacol. Exp. Ther. 159 1968 91 97
12. R.A. Jenkin, M.A. Baldi, V. Iwanov, and R.F. Moulds Differences between rat and guinea pig aorta in postreceptor mechanisms of alpha 1-adrenoceptors J. Cardiovasc. Pharmacol. 18 1991 566 573
13. M.J. Jiang, C.F. Chan, and Y.L. Chang Intracellular calcium and myosin light chain phosphorylation during U46619-activated vascular contraction Life Sci. 54 1994 2005 2013 (Pubitemid 24175156)
14. I.R. Kamel, W.W. Wendling, D. Chen, K.S. Wendling, C. Harakal, and C. Carlsson N-methyl-D-aspartate (NMDA) antagonists - S(+)-ketamine, dextrorphan, and dextromethorphan - act as calcium antagonists on bovine cerebral arteries J. Neurosurg. Anesthesiol. 20 2008 241 248
15. R.J. Lee, G. Xiong, J.M. Kofonow, B. Chen, A. Lysenko, P. Jiang, V. Abraham, L. Doghramji, N.D. Adappa, J.N. Palmer, D.W. Kennedy, G.K. Beauchamp, P.T. Doulias, H. Ischiropoulos, J.L. Kreindler, D.R. Reed, and N.A. Cohen T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection J. Clin. Invest. 122 2012 4145 4159
16. A.M. Low, J.C. Loke, C.Y. Kwan, and E.E. Daniel Sensitivity to protein kinase C inhibitors of nicardipine-insensitive component of high K+ contracture in rat and guinea-pig aorta Br. J. Pharmacol. 112 1994 604 610 (Pubitemid 24172907)
17. T.C. Lund, A.J. Kobs, A. Kramer, M. Nyquist, M.T. Kuroki, J. Osborn, D.S. Lidke, S.T. Low-Nam, B.R. Blazar, and J. Tolar Bone marrow stromal and vascular smooth muscle cells have chemosensory capacity via bitter taste receptor expression PLoS One 8 2013 e58945
18. T.E. Mecca, J.T. Elam, C.B. Nash, and R.W. Caldwell Alpha-Adrenergic Blocking Properties of Quinine Hcl Eur. J. Pharmacol. 63 1980 159 166 (Pubitemid 10105505)
19. W. Meyerhof, C. Batram, C. Kuhn, A. Brockhoff, E. Chudoba, B. Bufe, G. Appendino, and M. Behrens The molecular receptive ranges of human TAS2R bitter taste receptors Chem. Senses 35 2010 157 170
20. M. Nikpour, M.B. Urowitz, D. Ibanez, P.J. Harvey, and D.D. Gladman Importance of cumulative exposure to elevated cholesterol and blood pressure in development of atherosclerotic coronary artery disease in systemic lupus erythematosus: a prospective proof-of-concept cohort study Arthritis Res. Ther. 13 2011 R156
21. C. Orsmark-Pietras, A. James, J.R. Konradsen, B. Nordlund, C. Soderhall, V. Pulkkinen, C. Pedroletti, K. Daham, M. Kupczyk, B. Dahlen, J. Kere, S.E. Dahlen, G. Hedlin, and E. Melen Transcriptome analysis reveals upregulation of bitter taste receptors in severe asthmatics Eur. Respir. J. 42 2013 65 78
22. R.G. Parton, and M.A. del Pozo Caveolae as plasma membrane sensors, protectors and organizers Nat. Rev. Mol. Cell Biol. 14 2013 98 112
23. V. Pulkkinen, M.L. Manson, J. Safholm, M. Adner, and S.E. Dahlen The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea Am. J. Physiol. Lung. Cell Mol. Physiol. 303 2012 L956 L966
24. B. Razani, J.A. Engelman, X.B. Wang, W. Schubert, X.L. Zhang, C.B. Marks, F. Macaluso, R.G. Russell, M. Li, R.G. Pestell, D. Di Vizio, H. Hou Jr., B. Kneitz, G. Lagaud, G.J. Christ, W. Edelmann, and M.P. Lisanti Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities J. Biol. Chem. 276 2001 38121 38138
25. K.S. Robinett, D.A. Deshpande, M.M. Malone, and S.B. Liggett Agonist-promoted homologous desensitization of human airway smooth muscle bitter taste receptors Am. J. Respir. Cell Mol. Biol. 45 2011 1069 1074
26. B.I. Rosengren, A. Rippe, C. Rippe, D. Venturoli, K. Sward, and B. Rippe Transvascular protein transport in mice lacking endothelial caveolae Am. J. Physiol. Heart Circ. Physiol. 291 2006 H1371 H1377
27. X.L. Rudner, D.E. Berkowitz, J.V. Booth, B.L. Funk, K.L. Cozart, E.B. D'Amico, H. El-Moalem, S.O. Page, C.D. Richardson, B. Winters, L. Marucci, and D.A. Schwinn Subtype specific regulation of human vascular alpha(1)-adrenergic receptors by vessel bed and age Circulation 100 1999 2336 2343
28. G. Ruiz-Irastorza, M. Ramos-Casals, P. Brito-Zeron, and M.A. Khamashta Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic review Ann. Rheum. Dis. 69 2010 20 28
29. J. Safholm, S.E. Dahlen, I. Delin, K. Maxey, K. Stark, L.O. Cardell, and M. Adner PGE(2) maintains the tone of the guinea pig trachea through a balance between activation of contractile EP(1) receptors and relaxant EP(2) receptors Br. J. Pharmacol. 168 2013 794 806
30. A.S. Shah, Y. Ben-Shahar, T.O. Moninger, J.N. Kline, and M.J. Welsh Motile cilia of human airway epithelia are chemosensory Science 325 2009 1131 1134
31. S. Shibata, K. Hattori, and D. Timmerman Effect of cold storage on the response of guinea-pig taenia coli to certain catecholamines and other agents Eur. J. Pharmacol. 11 1970 321 331
32. T. Sjoberg, and S. Steen The strong contractile effect of the thromboxane receptor agonist U-46619 in isolated human pulmonary arteries and its competitive antagonism by BM-13.505 Acta Physiol. Scand. 136 1989 161 165 (Pubitemid 19155619)
33. G. Suarez-Kurtz, M.L. Garcia, and G.J. Kaczorowski Effects of charybdotoxin and iberiotoxin on the spontaneous motility and tonus of different guinea pig smooth muscle tissues J. Pharmacol. Exp. Ther. 259 1991 439 443
34. X. Tan, and M.J. Sanderson Bitter tasting compounds dilate airways by inhibiting airway smooth muscle calcium oscillations and calcium sensitivity Br. J. Pharmacol. 171 2014 646 662
35. M. Tosun, R.J. Paul, and R.M. Rapoport Role of extracellular Ca++ influx via L-type and non-L-type Ca++ channels in thromboxane A2 receptor-mediated contraction in rat aorta J. Pharmacol. Exp. Ther. 284 1998 921 928 (Pubitemid 28130818)
36. C.H. Zhang, C. Chen, L.M. Lifshitz, K.E. Fogarty, M.S. Zhu, and R. ZhuGe Activation of BK channels may not be required for bitter tastant-induced bronchodilation (author reply) Nat. Med. 18 2012 648 650 (650-641)
37. C.H. Zhang, L.M. Lifshitz, K.F. Uy, M. Ikebe, K.E. Fogarty, and R. Zhuge The cellular and molecular basis of bitter tastant-induced bronchodilation PLoS Biol. 11 2013 e1001501