Iodine nutritional status and thyroid effects of exposure to ethylenebisdithiocarbamates

Environmental Research

Volumn 154, Issue , 2017, Pages 152-159

  Medda, Emanuela ^a   Santini, Ferruccio ^b   De Angelis, Simona ^a   Franzellin, Fabrizio ^c   Fiumalbi, Carla ^d   Perico, Andrea ^d   Gilardi, Enzo ^a   Mechi, Maria Teresa ^d   Marsili, Alessandro ^b   Citroni, Angela ^d   Leandri, Adaniele ^d   Mantovani, Alberto ^a   Vitti, Paolo ^b   Olivieri, Antonella ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b UNIVERSITY HOSPITAL OF PISA   (Italy)

^c CENTRAL HOSPITAL OF BOLZANO   (Italy)

^d SANTA MARIA ANNUNZIATA HOSPITAL   (Italy)

Author keywords

Ethylenthiourea; Exposure; Iodine; Mancozeb; Thyroid disruptors

Indexed keywords

BIOLOGICAL MARKER; IODINE; MANCOZEB; THIOUREA DERIVATIVE; THYROXINE; 2 IMIDAZOLIDINETHIONE; FUNGICIDE; MANEB; ZINEB;

BIOMARKER; ENDOCRINE DISRUPTOR; EXCRETION; HEALTH STATUS; IODINE; MANCOZEB; NUTRITIONAL STATUS; OCCUPATIONAL EXPOSURE; PESTICIDE APPLICATION; POLLUTION EFFECT; POLLUTION EXPOSURE; SECONDARY METABOLITE; SERUM; VINE;

ADULT; AGED; AGRICULTURE; ARTICLE; CLINICAL EXAMINATION; CONTROLLED STUDY; DIETARY INTAKE; ECHOGRAPHY; ENVIRONMENTAL EXPOSURE; GEOGRAPHIC ORIGIN; HUMAN; IODINE DEFICIENCY; MAJOR CLINICAL STUDY; MALE; NUTRITIONAL STATUS; PRIORITY JOURNAL; RISK FACTOR; SERUM; THYROID FUNCTION; THYROXINE BLOOD LEVEL; URINARY EXCRETION; ADVERSE EFFECTS; AGRICULTURAL WORKER; AGRICULTURAL WORKERS' DISEASES; CASE CONTROL STUDY; CHEMICALLY INDUCED; DEFICIENCY; ITALY; MIDDLE AGED; OCCUPATIONAL EXPOSURE; THYROID DISEASES; THYROID FUNCTION TEST;

BOLZANO; CHIANTI; ITALY; TRENTINO-ALTO ADIGE; TUSCANY;

VITIS;

ADULT; AGED; AGRICULTURAL WORKERS' DISEASES; CASE-CONTROL STUDIES; ETHYLENETHIOUREA; FARMERS; FUNGICIDES, INDUSTRIAL; HUMANS; IODINE; ITALY; MALE; MANEB; MIDDLE AGED; NUTRITIONAL STATUS; OCCUPATIONAL EXPOSURE; THYROID DISEASES; THYROID FUNCTION TESTS; ZINEB;

EID: 85008599119     PISSN: 00139351     EISSN: 10960953     Source Type: Journal    
DOI: 10.1016/j.envres.2016.12.019     Document Type: Article

References (60)

1. Aghini Lombardi, F., Pinchera, A., Antonangeli, L., Rago, T., Chiovato, L., Bargagna, S., Bertucelli, B., Ferretti, G., Sbrana, B., Marcheschi, M., Mild iodine deficiency during fetal/neonatal life and neuropsychological impairment in Tuscany. J. Endocrinol. Invest. 18 (1995), 57–62.
2. Aprea, C., Betta, A., Catenacci, G., Lotti, A., Minoia, C., Passini, W., Pavan, I., Saverio Robustelli della Cuna, F., Roggi, C., Ruggeri, R., Soave, C., Sciarra, G., Vannini, P., Vitalone, V., Reference values of urinary ethylenthiourea in four regions of Italy (multicentric study). Sci. Tot. Environ. 192 (1996), 83–93.
3. Aprea, C., Tumino, R., Saieva, C., Masala, G., Salvini, S., Frasca, G., Giurdanella, M.C., Zanna, I., Decarli, A., Sciarra, G., Palli, D., Twenty-four-hour urinary excretion of ten pesticide metabolites in healthy adults in two different areas of Italy (Florence and Ragusa). Sci. Tot. Environ. 332 (2004), 71–80.
4. Axelstad, M., Boberg, J., Nellemann, C., Kiersgaard, M., Rosenskjold Jacobsen, P., Christiansen, S., Sorig Hougaard, K., Hass, U., Exposure to widely used fungicide mancozeb causes thyroid hormone disruption in rat dams but no behavioural effects in the offspring. Toxicol. Sci. 120 (2011), 439–446.
5. Belpoggi, F., Soffritti, M., Guarino, M., Lambertini, L., Cevolani, D., Maltoni, C., Results of long-term experimental studies on the carcinogenicity of ethylene-bis-dithiocarbamate (Mancozeb) in rats. Ann. N. Y. Acad. Sci. 982 (2002), 123–136.
6. Boas, M., Main, K.M., Feldt-Rasmussen, U., Environmental chemicals and function: an update. Curr. Opin. Endocrinol. Diabetes Obes. 16 (2009), 385–391.
7. Bohme, S.R., EPA's proposed Worker Protection Standard and the burdens of the past. Int. J. Occup. Environ. Health 37 (2015), 161–165.
8. Bradman, A., Whitaker, D., Quiros, L., Castorina, R., Claus Henn, B., Nishioka, M., Morgan, J., Barr, D.B., Harnly, M., Brisbin, J.A., Sheldon, L.S., McKone, T.E., Eskenazi, B., Pesticides and their metabolites in the homes and urine of farmworker children living in the Salinas Valley, CA. J. Expo Sci. Environ. Epidemiol. 17 (2007), 331–349.
9. Brucker-Davis, F., Effects of environmental synthetic chemicals on thyroid function. Thyroid 8 (1998), 827–856.
10. Calviello, G., Piccioni, E., Boninsegna, A., Tedesco, B., Maggiano, N., Serini, S., Wolf, F.I., Palozza, P., DNA damage and apoptosis induction by the pesticide Mancozeb in rat cells: involvement of the oxidative mechanism. Toxicol. Appl. Pharmacol. 211 (2006), 87–96.
11. Chhabra, R.S., Eustis, S., Haseman, J.K., Kurtz, P.J., Carlton, B.D., Comparative carcinogenicity of ethylene thiourea with or without perinatal exposure in rats and mice. Fundam. Appl. Toxicol. 18 (1992), 405–417.
12. Colosio, C., Fustinoni, S., Birindelli, S., Bonomi, I., De Pashale, G., Mammone, T., Tiramani, M., Vercelli, F., Visentin, S., Maroni, M., Ethylenthiourea in urine as an indicator of exposure to mancozeb in vineyard workers. Toxicol. Lett. 134 (2002), 133–140.
13. Colosio, C., Fustinoni, S., Corsini, E., Bosetti, C., Birindelli, S., Boers, D., Campo, L., La Vecchia, C., Liesivuori, J., Pennanen, S., Vergieva, T., Van Amelsvoort, L.G., Steerenberg, P., Swaen, G.M., Zaikov, C., Van Loveren, H., Changes in serum markers indicative for health effects in Vineyard workers following exposure to the fungicide mancozeb: an Italian study. Biomarkers 12 (2007), 574–588.
14. De Angelis, S., Pricci, F., Franzellin, F., Olivieri, A., Effects of environmental chemicals on thyroid function. Marino, M., Mita, D.G., (eds.) The Endocrine Disruptors, 2007, Transworld Research Network, Trivandrum, Kerala, India, 53–66.
15. Delange, F., The disorders induced by iodine deficiency. Thyroid 4 (1994), 107–128.
16. Doerge, D.R., Takazaka, R.S., Mechanism of thyroid peroxidase inhibition by ethylenethiourea. Chem. Res. Toxicol. 3 (1990), 98–101.
17. Domico, L.M., Cooper, K.R., Bernard, L.P., Zeevalk, G.D., Reactive oxygen species generation by the ethylene-bis-dithiocarbamate (EBDC) fungicide mancozeb and its contribution to neuronal toxicity in mesencephalic cells. Neurotoxicology 28 (2007), 1079–1091.
18. EFSA (European Food Safety Authority) Panel on Plant Protection Products and their Residues (PPR), Scientific Opinion on the identification of pesticides to be included in cumulative assessment groups on the basis of their toxicological profile (2014 update). EFSA J. 11:3293 (2013), 1–131, 10.2903/j.efsa.2013.3293 Available online: www.efsa.europa.eu/efsajournal.
19. EUROSTAT. 2012 Available on line at 〈http://ec.europa.eu/eurostat/statistics-explained/index.php/Agri-environmental_indicator_-_consumption_of_pesticides〉 [Accessed 14 July 2016].
20. Fantke, P., Charles, R., de Alencastro, L.F., Friedrich, R., Jolliet, O., Plant uptake of pesticides and human health: dynamic modelling of residues in wheat and ingestion intake. Chemosphere 85 (2011), 1639–1647.
21. Flood, D.E., Fernandino, J.I., Langlois, V.S., Thyroid hormones in male reproductive development: evidence for direct crosstalk between the androgen and thyroid hormone axes. Gen. Comp. Endocrinol. 192 (2013), 2–14.
22. Franzellin, F., Experience with iodine prophylaxis in the province of Bolzano. Ann. Ist. Super. Sanita 34 (1998), 377–381.
23. Freyberger, A., Ahr, H.J., Studies on the goitrogenic mechanism of action of N,N,N,N –tetramethylthiourea. Toxicology 217 (2006), 169–175.
24. Fustinoni, S., Campo, L., Liesivuori, J., Pennanen, S., Vergieva, T., van Amelsvoort, L., Bosetti, C., Van Loveren, H., Colosio, C., Biological monitoring and questionnaire for assessing exposure to ethylenebisditiocarbamates in a multicenter European field study. Hum. Exp. Toxicol. 27 (2008), 681–691.
25. Houeto, P., Bindoula, G., Hoffman, J.R., Ethylenebisdithiocarbamates and ethylenethiourea: possible human health hazards. Environ. Health. Perspect. 103 (1995), 568–573.
26. Hurley, P.M., Hill, R.N., Whiting, R.J., Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents. Env. Health. Pespect. 106 (1998), 437–445.
27. IARC (International Agency for Research on Cancer), 1987. Overall evaluations of carcinogenicity: an updating of IARC Monographs. Vols. 1-42. IARC Monogr. Eval. Carcinog. Risks Hum. Lyon: International Agency for Research on Cancer, Suppl. 7, p 207. Available on line at 〈http://monographs.iarc.fr/ENG/Monographs/suppl7/Suppl7.pdf〉.
28. IARC (International Agency for Research on Cancer), 2001. Some thyrotropic agents. IARC Monogr. Eval. Carcinog. Risks Hum. Lyon: International Agency for Research on Cancer, 79, p 659. Last update: April 2015, available on line at 〈http://monographs.iarc.fr/ENG/Classification/ClassificationsGroupOrder.pdf〉.
29. Iwase, T., Yamamoto, M., Shirai, M., Akahori, F., Masaoka, T., Takizawa, T., Arishima, K., Eguchi, Y., Effect of Ethylene thiourea on cultured rat embryos in the presence of hepatic microsomal fraction. J. Vet. Med. Sci. 59 (1997), 59–61.
30. Kackar, R., Srivastava, M.K., Raizada, R.B., Studies on rat thyroid after oral administration of mancozeb: morphological and biochemical evaluations. J. Appl. Toxicol. 17 (1997), 369–375.
31. Krassas, G.E., Poppe, K., Glinoer, D., Thyroid function and human reproductive health. Endoc. Rev. 31 (2010), 702–755.
32. Kurttio, P., Savolainen, K., Ethylenthiourea in air and in urine as an indicator of exposure to ethylenebisdithiocarbamates. Scand. J. Work Environ. Health. 16 (1990), 203–207.
33. Jones, R.L., Hannan, N.J., Kaitu'u, T.J., Zhang, J., Salamonsen, L.A., Identification of chemokines important for leukocyte recruitment to the human endometrium at the times of embryo implantation and menstruation. J. Clin. Endocrinol. Metab. 89 (2004), 6155–6167.
34. Laurberg, P., Cerqueira, C., Ovesen, L., Banke, Rasmussen, L., Perrild, H., Andersen, S., Pedersen, I.B., Carlé, A., Iodine intake as a determinant of thyroid disorders in populations. Best Pract. Res. Clin. Endocrinol. Metab. 24 (2010), 13–27.
35. Lewandowski, T.A., Peterson, M.K., Chamley, G., Iodine supplementation and drinking-water perchlorate mitigation. Food Chem. Toxicol. 80 (2015), 261–270.
36. Lindh, C.H., Littorin, M., Johannesson, G., Jönsson, B.A.G., Analysis of ethylenethiourea as a biomarker in human urine using liquid chromatography/triple quadrupole mass spectrometry. Rapid Commun. Mass Spectrom. 22 (2008), 2573–2579.
37. Maccherini, D., Antonangeli, L., Leoli, F., Rago, T., Vitti, P., Aghini Lombardi, F., Epidemiology of endemic goiter in Tuscany. Ann. Ist. Super. Sanita 34 (1998), 395–397.
38. Mantovani, A., Endocrine Disruptors and the safety of food chains. Horm. Res. Paediatr, 2015, 10.1159/000441496.
39. Maranghi, F., De Angelis, S., Tassinari, R., Chiarotti, F., Lorenzetti, S., Moracci, G., Marcoccia, D., Gilardi, E., Di Virgilio, A., Eusepi, A., Mantovani, A., Olivieri, A., Reproductive toxicity and thyroid effects in Sprague Dawley rats exposed to low doses of ethylenethiourea. Food Chem. Toxicol. 59 (2013), 261–271.
40. Marinovich, M., Guizzetti, M., Ghilardi, F., Viviani, B., Corsini, E., Galli, C.L., Thyroid peroxidase as toxicity target for dithiocarbamates. Arch. Toxicol. 71 (1997), 508–512.
41. NTP (National Toxicology Program), NTP toxicology and carcinogenesis studies of ethylene thiourea (CAS: 96-45-7) in F344 rats and B6C3F1 mice (Feed Studies). Natl. Toxicol. Program Tech. Rep. Ser. 388 (1992), 1–256.
42. Olivieri, A., Radetti, G., Medda, E., Incidence of congenital hypothyroidism in the Autonomous Province of Bolzano: benefit of increased iodine intake: The Italian Study Group for Congenital Hypothyroidism. J. Endocrinol. Invest. 38 (2015), 185–187.
43. Opitz, R., Schmidt, F., Braunbeck, T., Wuertz, S., Kloas, W., Perchlorate and ethylenethiourea induce different histological and molecular alterations in a non-mammalian vertebrate model of thyroid goitrogenesis. Mol. Cell. Endocrinol. 298 (2009), 101–114.
44. Panganiban, L., Cortes-Maramba, N., Dioquino, C., Suplido, M.L., Ho, H., Francisco-Rivera., Manglicmot-Yabes, A., Correlation between blood ethylenethiourea and thyroid gland disorders among banana plantation workers in the Philippines. Environ. Health Perspect. 112 (2004), 42–45.
45. Park, S.J., Park, S.H., Choi, Y.J., Kim, D.W., Son, E.J., Lee, H.S., Yoon, J.H., Kim, E.K., Moon, H.J., Kwak, J.Y., Interobserver variability and diagnostic performance in US assessment of thyroid nodule according to size. Ultraschall. Med. 33 (2012), E186–E190.
46. Pastorelli, A.A., Stacchini, P., Olivieri, A., Daily iodine intake and the impact of salt reduction on iodine prophylaxis in the Italian population. Eur. J. Clin. Nutr. 69 (2014), 211–215.
47. Resch, U., Helsel, G., Tatzber, F., Sinzinger, H., Antioxidant status in thyroid dysfunction. Clin. Chem. Lab. Med. 40 (2002), 1132–1134.
48. Santini, F., Mantovani, A., Cristaudo, A., Rago, T., Marsili, A., Buselli, R., Mignani, A., Ceccarini, G., Bastillo, R., Taddei, D., Ricco, I., Vitti, P., Pinchera, A., Thyroid function and exposure to styrene. Thyroid 18 (2008), 1065–1069.
49. Senou, M., Khalifa, C., Thimmesch, M., Jouret, F., Devuyst, O., Col, V., Audinot, J.N., Lipnik, P., Moreno, J.C., Van Sande, J., Dumont, J.E., Many, M.C., Colin, I.M., Gérard, A.C., A coherent organization of differentiation proteins is required to maintain an appropriate thyroid function in the Pendred thyroid. J. Clin. Endocrinol. Metab. 95 (2010), 4021–4030.
50. Shankar, S.M., Menon, P.S., Karmarkar, M.G., Gopinath, P.G., Dysgenesis of thyroid is the common type of childhood hypothyroidism in environmentally iodine deficient areas of north India. Acta Paediatr. 83 (1994), 1047–1051.
51. SIVR, Società Italiana Valori di Riferimento 2011. Terza lista dei valori di riferimento per elementi, composti organici e loro metaboliti. Available at site 〈http://fad.saepe.it/approfondimenti/Valori_di_riferimento_LISTA_SIVR_2011.0.pdf〉 [Accessed 10 November 2016].
52. Stanbury, J.B., Delange, F., Ermans, A., Fierro-Benitez, R., The varied manifestations of endemic cretinism. Trans. Am. Clin. Climatol. Assoc. 85 (1974), 6–17.
53. Steenland, K., Cedillo, L., Tucker, J., Hines, C., Soresen, K., Deddens, J., Cruz, V., Thyroid hormones and cytogenetic outcomes in backpack sprayers using ethylenebisdithiocarbamate (EBDC) fungicides in Mexico. Environ. Health Perspect. 105 (1997), 1126–1130.
54. Studer, H., Gerber, H., 1991. Clinical manifestations and management of non-toxic diffuse and nodular goiter. In: Braverman, L.E., Utiger, R.D.(Eds.), Werner and Ingbar's The Thyroid: A Fundamental and Clinical Test. 6th ed. Philadelphia, Lippincott, 1130-1132.
55. US EPA (United States Environmental Protection Agency), 1996. Integrated Risk Information System (IRIS): Ethylene thiourea (ETU) (CASRN 96-45-7). Available at: 〈http://www3.epa.gov/ttn/atw/hlthef/ethyl-th.html〉 [Accessed 14 July 2016].
56. US EPA (United States Environmental Protection Agency). Reregistration Eligibility Decision for Mancozeb, EPA 738‐R‐04‐012 Environmental Protection and Toxic Substances 2005. Available at: http://www3.epa.gov/pesticides/chem_search/reg_actions/reregistration/red_PC-014504_20-Sep-05.pdf.
57. Van Wendel de Joode, B., Mora, A.M., Cordoba, L., Cano, J.C., Quesada, R., Faniband, M., Wesseling, C., Ruepert, C., Oberg, M., Eskenazi, B., Mergler, D., Lindh, C.H., Aerial application of mancozeb and urinary ethylene thiourea (ETU) concentrations among pregnant women in Costa Rica: the Infants’ Environmental Health Study (ISA). Environ. Health Perspect. 122 (2014), 1321–1328.
58. Whiting, P., Rutjes, A.W., Reitsma, J.B., Glas, A.S., Bossuyt, P.M., Kleijnen, J., Sources of variation and bias in studies of diagnostic accuracy: a systematic review. Ann. Intern. Med. 140 (2004), 189–202.
59. World Health Organization 2007. Assessment of iodine deficiency disorders and monitoring their elimination: a guide for programme managers. 3rd ed. Geneva: WHO, 2007. Available on line at: 〈http://www.who.int/nutrition/publications/micronutrients/iodine_deficiency/9789241595827/en/〉 [Accessed 18 November 2016].
60. Zimmermann, M.B., Global iodine nutrition: where do we stand in 2013?. Thyroid 23 (2013), 523–528.