메뉴 건너뛰기




Volumn 106, Issue 8, 1998, Pages 437-445

Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents

Author keywords

5' monodeiodinase activity; Induction of hepatic microsomal enzymes; Iodide pump; Mode of carcinogenic action; Pesticides; Thyroid follicular cell tumors; Thyroid hormone; Thyroid peroxidase activity; Thyroid stimulating hormone

Indexed keywords

(ETHYLHEXYL)NORBORNENEDICARBOXIMIDE; 2 IMIDAZOLIDINETHIONE; AMITROLE; BROMACIL; CARCINOGEN; CHLORBUTOL; CLOFENTEZINE; ETRIDIAZOLE; FENBUCONAZOLE; FIPRONIL; LIOTHYRONINE; MANCOZEB; PENDIMETHALIN; PESTICIDE; PRODIAMINE; PYRIMETHANIL; QUINTOZENE; TERBUTRYN; THIAZOPYR; THYROID PEROXIDASE; THYROTROPIN; THYROXINE; TRIADIMEFON; TRIFLURALIN; UNCLASSIFIED DRUG;

EID: 0031677817     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.98106437     Document Type: Article
Times cited : (292)

References (74)
  • 2
    • 85038539667 scopus 로고
    • Health Effect of Exposure to low Levels of Ionizing Radiation
    • Washington, DC:National Academy Press
    • NRC. Health Effect of Exposure to Low Levels of Ionizing Radiation. BEIR V. Washington, DC:National Academy Press, 1990:281-298.
    • (1990) BEIR V , pp. 281-298
  • 3
    • 85069139530 scopus 로고    scopus 로고
    • International conference sponsored by the International Atomic Energy Agency, the European Commission, and the World Health Organization. One Decade after Chernobyl. Summing Up the Consequences of the Accident, 8-12 April 1996, Vienna, Austria
    • International conference sponsored by the International Atomic Energy Agency, the European Commission, and the World Health Organization. One Decade after Chernobyl. Summing Up the Consequences of the Accident, 8-12 April 1996, Vienna, Austria.
  • 4
    • 0025808743 scopus 로고
    • Relationships between serum thyroid stimulating hormone levels and development of thyroid tumors in rats treated with N-bis-(2-hydroxypropyl) nitrosamine
    • Hiasa Y, Kitahori Y, Kitamura M, Nishioka H, Yane K, Fukumoto M, Ohshima M, Nakaoka S, Nishii S. Relationships between serum thyroid stimulating hormone levels and development of thyroid tumors in rats treated with N-bis-(2-hydroxypropyl) nitrosamine. Carcinogenesis 12:873-877 (1991).
    • (1991) Carcinogenesis , vol.12 , pp. 873-877
    • Hiasa, Y.1    Kitahori, Y.2    Kitamura, M.3    Nishioka, H.4    Yane, K.5    Fukumoto, M.6    Ohshima, M.7    Nakaoka, S.8    Nishii, S.9
  • 5
    • 0031682909 scopus 로고    scopus 로고
    • Recent developments in the investigation of thyroid regulation and thyroid carcinogenesis
    • Hard GC. Recent developments in the investigation of thyroid regulation and thyroid carcinogenesis. Environ Health Perspect 106:427-436 (1998).
    • (1998) Environ Health Perspect , vol.106 , pp. 427-436
    • Hard, G.C.1
  • 6
    • 0024443946 scopus 로고
    • The effects of xenobiotics on the structure and function of thyroid follicular and C-cells
    • Capen CC, Martin SL. The effects of xenobiotics on the structure and function of thyroid follicular and C-cells. Toxicol Pathol 17:266-293 (1989).
    • (1989) Toxicol Pathol , vol.17 , pp. 266-293
    • Capen, C.C.1    Martin, S.L.2
  • 7
    • 0024460524 scopus 로고
    • The significance of hepatic microsomal enzyme induction and altered thyroid function in rats: Implications for thyroid gland neoplasia
    • McClain RM. The significance of hepatic microsomal enzyme induction and altered thyroid function in rats: implications for thyroid gland neoplasia. Toxicol Pathol 17:294-306 (1989).
    • (1989) Toxicol Pathol , vol.17 , pp. 294-306
    • McClain, R.M.1
  • 8
    • 0029563556 scopus 로고
    • Mechanistic considerations for the relevance of animal data on thyroid neoplasia to human risk assessment
    • McClain RM. Mechanistic considerations for the relevance of animal data on thyroid neoplasia to human risk assessment. Mutat Res 333:131-142 (1995).
    • (1995) Mutat Res , vol.333 , pp. 131-142
    • McClain, R.M.1
  • 9
    • 0023920340 scopus 로고
    • Goitrogens and thyroid follicular cell neoplasia: Evidence for a threshold process
    • Paynter OE, Burin GJ, Jaeger RB, Gregorio CA. Goitrogens and thyroid follicular cell neoplasia: evidence for a threshold process. Regul Toxicol Pharmacol 8:102-119 (1988).
    • (1988) Regul Toxicol Pharmacol , vol.8 , pp. 102-119
    • Paynter, O.E.1    Burin, G.J.2    Jaeger, R.B.3    Gregorio, C.A.4
  • 12
    • 0343689150 scopus 로고    scopus 로고
    • Assessment of Thyroid Follicular Cell Tumors
    • EPA/630/R-97/002. Washington, DC:U.S. Environmental Protection Agency
    • U.S. EPA. Assessment of Thyroid Follicular Cell Tumors. Risk Assessment Forum. EPA/630/R-97/002. Washington, DC:U.S. Environmental Protection Agency, 1997.
    • (1997) Risk Assessment Forum
  • 13
    • 0001372175 scopus 로고
    • Guidelines for carcinogen risk assessment
    • U.S. EPA. Guidelines for carcinogen risk assessment Fed Reg 51:33992-34003 (1986).
    • (1986) Fed Reg , vol.51 , pp. 33992-34003
  • 14
    • 0000060569 scopus 로고    scopus 로고
    • Proposed guidelines for carcinogen risk assessment
    • U.S. EPA. Proposed guidelines for carcinogen risk assessment. Fed Reg 61:17960-18011 (1996).
    • (1996) Fed Reg , vol.61 , pp. 17960-18011
  • 15
    • 0000212661 scopus 로고
    • Antithyroid action of 3-amino-1,2,4-triazole
    • Alexander NM. Antithyroid action of 3-amino-1,2,4-triazole. J Biol Chem 234:147-150 (1959).
    • (1959) J Biol Chem , vol.234 , pp. 147-150
    • Alexander, N.M.1
  • 17
    • 0003002818 scopus 로고    scopus 로고
    • Toxic responses of the endocrine system
    • (Klaassen CD, Amdur, MO, Doull J, eds). New York:McGraw-Hill
    • Cepen CC. Toxic responses of the endocrine system. In: Casarett and Doull's Toxicology: The Basic Science of Poisons (Klaassen CD, Amdur, MO, Doull J, eds). New York:McGraw-Hill, 1996;617-640.
    • (1996) Casarett and Doull's Toxicology: the Basic Science of Poisons , pp. 617-640
    • Cepen, C.C.1
  • 18
    • 0025773244 scopus 로고
    • Differences in the effects of piperine and piperonyl butoxide on hepatic drug-metabolizing enzyme system in rats
    • Dalvi RR, Dalvi PS. Differences in the effects of piperine and piperonyl butoxide on hepatic drug-metabolizing enzyme system in rats. Drug Chem Toxicol 14:219-229 (1991).
    • (1991) Drug Chem Toxicol , vol.14 , pp. 219-229
    • Dalvi, R.R.1    Dalvi, P.S.2
  • 19
    • 0014353941 scopus 로고
    • Effect of aminotriazole on thyroid function in the rat
    • Fregley MJ. Effect of aminotriazole on thyroid function in the rat. Toxicol Appl Pharmacol 13:271-286 (1968).
    • (1968) Toxicol Appl Pharmacol , vol.13 , pp. 271-286
    • Fregley, M.J.1
  • 21
    • 0015275224 scopus 로고
    • Effects of short term administration of ethylene thiourea upon thyroid function of the rat
    • Graham SL, Hansen WH. Effects of short term administration of ethylene thiourea upon thyroid function of the rat. Bull Environ Contam Toxicol 7:19-25 (1972).
    • (1972) Bull Environ Contam Toxicol , vol.7 , pp. 19-25
    • Graham, S.L.1    Hansen, W.H.2
  • 23
    • 0028079132 scopus 로고
    • Interaction of lindane and carbaryl on hepatic microsomal enzymes in rats
    • Krechniak J, Englot B, Wrzesniowska EH. Interaction of lindane and carbaryl on hepatic microsomal enzymes in rats. Bull Environ Contam Toxicol 52:927-934 (1994).
    • (1994) Bull Environ Contam Toxicol , vol.52 , pp. 927-934
    • Krechniak, J.1    Englot, B.2    Wrzesniowska, E.H.3
  • 24
    • 0026041447 scopus 로고
    • The effect of structurally divergent herbicides on mouse liver xenobiotic-metabolizing enzymes (P-450-dependent mono-oxygenases, epoxide hydrolases and glutathione S-transferases) and carnitine acetyltransferase
    • Moody DE, Narloch BA, Shull LR, Hammock BD. The effect of structurally divergent herbicides on mouse liver xenobiotic-metabolizing enzymes (P-450-dependent mono-oxygenases, epoxide hydrolases and glutathione S-transferases) and carnitine acetyltransferase. Toxicol Lett 59:175-185 (1991).
    • (1991) Toxicol Lett , vol.59 , pp. 175-185
    • Moody, D.E.1    Narloch, B.A.2    Shull, L.R.3    Hammock, B.D.4
  • 25
    • 0005241688 scopus 로고    scopus 로고
    • Influence of pesticides on UDP-glucuronyltransferase in rat liver microsomes
    • Naydenova Z, Urshev Z, Golovinsky E, Grancharov K. Influence of pesticides on UDP-glucuronyltransferase in rat liver microsomes. Pestic Sci 47:25-30 (1996).
    • (1996) Pestic Sci , vol.47 , pp. 25-30
    • Naydenova, Z.1    Urshev, Z.2    Golovinsky, E.3    Grancharov, K.4
  • 26
    • 0021274060 scopus 로고
    • Goitrogenic effects of ethylene thiourea on rat thyroid
    • O'Neil WM. Goitrogenic effects of ethylene thiourea on rat thyroid. Pastic Biochem Physiol 21:92-101 (1984).
    • (1984) Pastic Biochem Physiol , vol.21 , pp. 92-101
    • O'Neil, W.M.1
  • 27
    • 0014981903 scopus 로고
    • Aminotriazole goiter. Fine structure and localization of thyroid peroxidase activity
    • Strum JM, Karnovsky MJ. Aminotriazole goiter. Fine structure and localization of thyroid peroxidase activity. Lab Invest 24:1-12 (1971).
    • (1971) Lab Invest , vol.24 , pp. 1-12
    • Strum, J.M.1    Karnovsky, M.J.2
  • 28
    • 0016709312 scopus 로고
    • Studies on effects of 3-amino-1,2,4-triazole in rat thyroids
    • Tsuda H. Studies on effects of 3-amino-1,2,4-triazole in rat thyroids. Nagoya Shiritsu Daigaku lgakkai Zasshi 26:87-94 (1975).
    • (1975) Nagoya Shiritsu Daigaku Lgakkai Zasshi , vol.26 , pp. 87-94
    • Tsuda, H.1
  • 29
    • 85069130401 scopus 로고
    • Changes in the thyroid gland of rats given 3-amino-1,2,4-triazole. II. Changes following long term administration
    • Tsuda H, Hirose M, Fukushima A, Takahashi M. Changes in the thyroid gland of rats given 3-amino-1,2,4-triazole. II. Changes following long term administration. Nippon Byori Gakku Kaishi 63:136-192 (1974).
    • (1974) Nippon Byori Gakku Kaishi , vol.63 , pp. 136-192
    • Tsuda, H.1    Hirose, M.2    Fukushima, A.3    Takahashi, M.4
  • 30
    • 0021165705 scopus 로고
    • Amitrole-induced cell transformation and gene mutations in Syrian hamster embryo cells in culture
    • Tsutsui T, Maizumi H, Barrett JC. Amitrole-induced cell transformation and gene mutations in Syrian hamster embryo cells in culture. Mutat Res 140:205-207 (1984).
    • (1984) Mutat Res , vol.140 , pp. 205-207
    • Tsutsui, T.1    Maizumi, H.2    Barrett, J.C.3
  • 31
    • 0002126197 scopus 로고
    • Interactions of methylenedioxyphenyl compounds with cytochrome P-450 and effects on microsomal oxidation
    • (Hodgson D, Bend JR, Philpot RM, eds). New York:Elsevier
    • Wilkinson CF, Murray M, Marcus CB. Interactions of methylenedioxyphenyl compounds with cytochrome P-450 and effects on microsomal oxidation. In: Reviews in Biochemical Toxicology (Hodgson D, Bend JR, Philpot RM, eds). New York:Elsevier, 1984;27-64.
    • (1984) Reviews in Biochemical Toxicology , pp. 27-64
    • Wilkinson, C.F.1    Murray, M.2    Marcus, C.B.3
  • 32
    • 0019964736 scopus 로고
    • Goitrogen-induced thyroid growth in the rat: A quantitative morphometric study
    • Wynford-Thomas D, Stringer BMJ, Williams ED. Goitrogen-induced thyroid growth in the rat: a quantitative morphometric study. J Endocrinol 94:131-140 (1982).
    • (1982) J Endocrinol , vol.94 , pp. 131-140
    • Wynford-Thomas, D.1    Stringer, B.M.J.2    Williams, E.D.3
  • 33
    • 0019903550 scopus 로고
    • Dissociation of growth and function in the thyroid during prolonged goitrogen administration
    • Wynford-Thomas D, Stringer BMJ, Williams ED, Dissociation of growth and function in the thyroid during prolonged goitrogen administration. Acta Endrocrinol 101:210-216 (1982).
    • (1982) Acta Endrocrinol , vol.101 , pp. 210-216
    • Wynford-Thomas, D.1    Stringer, B.M.J.2    Williams, E.D.3    Growth, D.O.4
  • 34
    • 0020360026 scopus 로고
    • Desensitisation of rat thyroid to the growth-stimulating action of TSH during prolonged goitrogen administration
    • Wynford-Thomas D, Stringer BMJ, Williams ED, Desensitisation of rat thyroid to the growth-stimulating action of TSH during prolonged goitrogen administration. Acta Endocrinol 101:562-569 (1982).
    • (1982) Acta Endocrinol , vol.101 , pp. 562-569
    • Wynford-Thomas, D.1    Stringer, B.M.J.2    Williams, E.D.3
  • 35
    • 14244263284 scopus 로고
    • TR No. 388. Research Triangle Park, NC:National Toxicology Program
    • 1 Mice (Feed Studies). TR No. 388. Research Triangle Park, NC:National Toxicology Program, 1992.
    • (1992) 1 Mice (Feed Studies)
  • 37
    • 85069143461 scopus 로고    scopus 로고
    • Research Triangle Park, NC:National Toxicology Program, cited 20 March
    • NTP. Numbers of Chemicals Associated with Site-specific Neoplasia. Research Triangle Park, NC:National Toxicology Program, http://ntp-server.niehs.nih.gov/ htdocs/Sites/PSite_Cnt.html [cited 20 March 1998].
    • (1998) Numbers of Chemicals Associated with Site-specific Neoplasia
  • 38
    • 0018759643 scopus 로고
    • The rat as a model for the study of drug effects on thyroid function: Consideration of methodological problems
    • Döhler KD, Wong CC, von zur Mühlen A. The rat as a model for the study of drug effects on thyroid function: consideration of methodological problems. Pharmacol Ther 5:305-318 (1979).
    • (1979) Pharmacol Ther , vol.5 , pp. 305-318
    • Döhler, K.D.1    Wong, C.C.2    Von Zur Mühlen, A.3
  • 40
    • 0026761261 scopus 로고
    • Thyroid follicular cell carcinogenesis: Results from 343 2-year Carcinogenicity studies conducted by the NCI/NTP
    • McConnell EE. Thyroid follicular cell carcinogenesis: results from 343 2-year Carcinogenicity studies conducted by the NCI/NTP. Regul Toxicol Pharmacol 16:177-188 (1992).
    • (1992) Regul Toxicol Pharmacol , vol.16 , pp. 177-188
    • McConnell, E.E.1
  • 41
    • 0027156736 scopus 로고
    • Correlations between chemically related site-specific carcinogenic effects in long-term studies in rats and mice
    • Haseman JK, Lockhart A-M. Correlations between chemically related site-specific carcinogenic effects in long-term studies in rats and mice. Environ Health Perspect 101:50-54 (1993).
    • (1993) Environ Health Perspect , vol.101 , pp. 50-54
    • Haseman, J.K.1    Lockhart, A.-M.2
  • 42
    • 0028902169 scopus 로고
    • Marketed human pharmaceuticals reported to be tumorigenic in rodents
    • Davies TS, Monro A. Marketed human pharmaceuticals reported to be tumorigenic in rodents. J Am Coll Toxicol 14:90-107 (1995).
    • (1995) J am Coll Toxicol , vol.14 , pp. 90-107
    • Davies, T.S.1    Monro, A.2
  • 44
    • 3543120173 scopus 로고
    • Mechanisms of action of antithyroid compounds
    • (Werner SC, Ingbar SH, eds), New York:Harper and Row
    • Green WL. Mechanisms of action of antithyroid compounds. In: The Thyroid (Werner SC, Ingbar SH, eds), New York:Harper and Row, 1978;77-87.
    • (1978) The Thyroid , pp. 77-87
    • Green, W.L.1
  • 45
    • 0023180555 scopus 로고
    • Hypothyroidism and abnormalities in the kinetics of thyroid hormone metabolism in rats treated chronically with polychlorinated biphenyl and polybrominated biphenyl
    • Byrne JJ, Carbone JP, Hanson EA. Hypothyroidism and abnormalities in the kinetics of thyroid hormone metabolism in rats treated chronically with polychlorinated biphenyl and polybrominated biphenyl. Endocrinology 121:520-527 (1987).
    • (1987) Endocrinology , vol.121 , pp. 520-527
    • Byrne, J.J.1    Carbone, J.P.2    Hanson, E.A.3
  • 46
    • 0024592811 scopus 로고
    • Suicide inactivation of lactoperoxidase by 3-amino-1,2,4-triazole
    • Doerge DR, Niemczura WP. Suicide inactivation of lactoperoxidase by 3-amino-1,2,4-triazole. Chem Res Toxicol 2:100-103 (1989).
    • (1989) Chem Res Toxicol , vol.2 , pp. 100-103
    • Doerge, D.R.1    Niemczura, W.P.2
  • 47
    • 0025335417 scopus 로고
    • Mechanism of thyroid peroxidase inhibition by ethylenethiourea
    • Doerge DR, Takazawa RS. Mechanism of thyroid peroxidase inhibition by ethylenethiourea. Chem Res Toxicol 3:98-101 (1990).
    • (1990) Chem Res Toxicol , vol.3 , pp. 98-101
    • Doerge, D.R.1    Takazawa, R.S.2
  • 48
    • 0030786080 scopus 로고    scopus 로고
    • Studies on rat thyroid after oral administration of mancozeb: Morphological and biochemical evaluations
    • Kackar R, Srivastava MK, Raizada RB. Studies on rat thyroid after oral administration of mancozeb: morphological and biochemical evaluations. J Appl Toxicol 17:369-375 (1997).
    • (1997) J Appl Toxicol , vol.17 , pp. 369-375
    • Kackar, R.1    Srivastava, M.K.2    Raizada, R.B.3
  • 49
    • 0020631983 scopus 로고
    • Evaluation of amitrole (aminotriazole) for potential Carcinogenicity in orally dosed rats, mice, and golden hamsters
    • Steinhoff D, Weber H, Mohr U, Boehme K. Evaluation of amitrole (aminotriazole) for potential Carcinogenicity in orally dosed rats, mice, and golden hamsters. Toxicol Appl Pharmacol 69:161-169 (1983).
    • (1983) Toxicol Appl Pharmacol , vol.69 , pp. 161-169
    • Steinhoff, D.1    Weber, H.2    Mohr, U.3    Boehme, K.4
  • 51
    • 0024418731 scopus 로고
    • 1 mice
    • 1mice. Food Chem Toxicol 27:455-463 (1989).
    • (1989) Food Chem Toxicol , vol.27 , pp. 455-463
  • 52
    • 0025349712 scopus 로고
    • Chronic toxicity/carcinogenicity studies of sulphamethazine in Fischer 344/N rats: Two generation exposure
    • Littlefield NA, Sheldon WG, Allen R, Gaylor DW. Chronic toxicity/carcinogenicity studies of sulphamethazine in Fischer 344/N rats: two generation exposure. Food Chem Toxicol 28:157-167 (1990).
    • (1990) Food Chem Toxicol , vol.28 , pp. 157-167
    • Littlefield, N.A.1    Sheldon, W.G.2    Allen, R.3    Gaylor, D.W.4
  • 53
    • 0015657915 scopus 로고
    • The effects of long-term ingestion of methimazole on the thyroids of rats
    • Owen NV, Worth HM, Kiplinger GF. The effects of long-term ingestion of methimazole on the thyroids of rats. Food Cosmet Toxicol 11:649-653 (1973).
    • (1973) Food Cosmet Toxicol , vol.11 , pp. 649-653
    • Owen, N.V.1    Worth, H.M.2    Kiplinger, G.F.3
  • 54
    • 85069143357 scopus 로고    scopus 로고
    • TR 403. Research Triangle Park, NC:National Toxicology Program
    • 1 Mice (Gavage Studies). TR 403. Research Triangle Park, NC:National Toxicology Program.
    • 1 Mice (Gavage Studies)
  • 55
    • 85069143531 scopus 로고    scopus 로고
    • TR 330. Research Triangle Park, NC:National Toxicology Program
    • 1 Mice (Gavage Studies). TR 330. Research Triangle Park, NC:National Toxicology Program.
    • 1 Mice (Gavage Studies)
  • 56
    • 26844449176 scopus 로고    scopus 로고
    • Mode of action of thyroid tumor formation in the male Long-Evans rat administered high doses of alachlor
    • Wilson AG, Thake DC, Heydens WE, Brewster DW, Hotz KJ. Mode of action of thyroid tumor formation in the male Long-Evans rat administered high doses of alachlor. Fundam Appl Toxicol 33:16-23 (1996).
    • (1996) Fundam Appl Toxicol , vol.33 , pp. 16-23
    • Wilson, A.G.1    Thake, D.C.2    Heydens, W.E.3    Brewster, D.W.4    Hotz, K.J.5
  • 58
    • 0025863054 scopus 로고
    • The effect of hepatic enzyme- Inducing drugs on thyroid hormones and the thyroid gland
    • Curran PG, DeGroot LJ. The effect of hepatic enzyme- inducing drugs on thyroid hormones and the thyroid gland. Endocr Rev 12:135-150 (1991).
    • (1991) Endocr Rev , vol.12 , pp. 135-150
    • Curran, P.G.1    DeGroot, L.J.2
  • 59
    • 85033066793 scopus 로고    scopus 로고
    • Biochemical effects of the mouse hepatocarcinogen oxazepam: Similarities to phenobarbital
    • Griffin RJ, Dudley CN, Cunningham ML. Biochemical effects of the mouse hepatocarcinogen oxazepam: similarities to phenobarbital. Fundam Appl Toxicol 29:147-154 (1996).
    • (1996) Fundam Appl Toxicol , vol.29 , pp. 147-154
    • Griffin, R.J.1    Dudley, C.N.2    Cunningham, M.L.3
  • 60
    • 0024599361 scopus 로고
    • The effects of chronic ingestion of spironolactone on serum thyrotropin and thyroid hormones in the male rat
    • Semler DE, Chengelis CP, Radzialowski FM. The effects of chronic ingestion of spironolactone on serum thyrotropin and thyroid hormones in the male rat. Toxicol Appl Pharmacol 98:263-268 (1989).
    • (1989) Toxicol Appl Pharmacol , vol.98 , pp. 263-268
    • Semler, D.E.1    Chengelis, C.P.2    Radzialowski, F.M.3
  • 62
    • 0026554628 scopus 로고
    • UDP-glucuronosyl transferase inducers reduce thyroid hormone levels in rats by an extrathyroidal mechenism
    • Barter RA, Klaassen CD. UDP-glucuronosyl transferase inducers reduce thyroid hormone levels in rats by an extrathyroidal mechenism. Toxicol Appl Pharmacol 113:36-42 (1992).
    • (1992) Toxicol Appl Pharmacol , vol.113 , pp. 36-42
    • Barter, R.A.1    Klaassen, C.D.2
  • 63
    • 0028095346 scopus 로고
    • Reduction of thyroid hormone levels and alteration of thyroid function by four representative UDP-glucuronosyltransferase inducers in rats
    • Barter RA, Klaassen CD. Reduction of thyroid hormone levels and alteration of thyroid function by four representative UDP-glucuronosyltransferase inducers in rats. Toxicol Appl Pharmacol 128:9-17 (1994).
    • (1994) Toxicol Appl Pharmacol , vol.128 , pp. 9-17
    • Barter, R.A.1    Klaassen, C.D.2
  • 64
    • 0025718621 scopus 로고
    • 4 metabolism and thyroid gland function in rats
    • 4metabolism and thyroid gland function in rats. Toxicol Appl Pharmacol 111:263-278 (1991).
    • (1991) Toxicol Appl Pharmacol , vol.111 , pp. 263-278
  • 66
    • 0025996966 scopus 로고
    • Hepatic UDP-glucuronyltransferase activity toward thyroid hormones in rats: Induction and effects on serum thyroid hormone levels following treatment with various enzyme inducers
    • Saito K, Kaneko H, Sato K, Yoshitake A, Yamada H. Hepatic UDP-glucuronyltransferase activity toward thyroid hormones in rats: induction and effects on serum thyroid hormone levels following treatment with various enzyme inducers. Toxicol Appl Pharmacol 111:99-106 (1991).
    • (1991) Toxicol Appl Pharmacol , vol.111 , pp. 99-106
    • Saito, K.1    Kaneko, H.2    Sato, K.3    Yoshitake, A.4    Yamada, H.5
  • 67
    • 0020578263 scopus 로고
    • Formation of diodotyrosine from thyroxine. Ether-link cleavage, an alternate pathway of thyroxine metabolism
    • Balsam A, Sexton F, Forges M, Ingbar SH. Formation of diodotyrosine from thyroxine. Ether-link cleavage, an alternate pathway of thyroxine metabolism. J Clin Invest 72:1234-1245 (1983)
    • (1983) J Clin Invest , vol.72 , pp. 1234-1245
    • Balsam, A.1    Sexton, F.2    Forges, M.3    Ingbar, S.H.4
  • 69
    • 0019452291 scopus 로고
    • The effect of 3-amino-1,2,4-triazole on hepatic and renal deiodination of L-thyroxine to 3,5,3′-triiodothyronine
    • Scammell JG, Fregly MJ. The effect of 3-amino-1,2,4-triazole on hepatic and renal deiodination of L-thyroxine to 3,5,3′-triiodothyronine. Toxicol Appl Pharmacol 60:45-51 (1981).
    • (1981) Toxicol Appl Pharmacol , vol.60 , pp. 45-51
    • Scammell, J.G.1    Fregly, M.J.2
  • 70
    • 0000488148 scopus 로고
    • Further studies on the chemical nature of compounds which inhibit the function of the thyroid gland
    • Astwood EB, Bissell A, Hughes AM. Further studies on the chemical nature of compounds which inhibit the function of the thyroid gland. Endocrinology 37:56-481 (1945).
    • (1945) Endocrinology , vol.37 , pp. 56-481
    • Astwood, E.B.1    Bissell, A.2    Hughes, A.M.3
  • 71
    • 85069139880 scopus 로고
    • Bioassay of Trimethylthiourea for Possible Carcinogenicity
    • Bethesda, MD: National Cancer Institute
    • NCI. Bioassay of Trimethylthiourea for Possible Carcinogenicity. Technical Rept 129. Bethesda, MD: National Cancer Institute, 1979.
    • (1979) Technical Rept , vol.129
  • 72
    • 0022454761 scopus 로고
    • 1 mice
    • 1mice. J Toxicol Environ Health 18:325-337 (1986).
    • (1986) J Toxicol Environ Health , vol.18 , pp. 325-337
  • 74
    • 85069137966 scopus 로고
    • An Inquiry into the Mechanism of Carcinogenic Action cf FD&C Red No. 3 and Its Significance for Risk Assessment
    • Peer Review Panel. Washington, DC:Food and Drug Administration
    • Peer Review Panel. An Inquiry into the Mechanism of Carcinogenic Action cf FD&C Red No. 3 and Its Significance for Risk Assessment. A Report by the FD&C Red No. 3 Peer Review Panel. Washington, DC:Food and Drug Administration, 1987.
    • (1987) A Report by the FD&C Red No. 3 , vol.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.