DNA damage and apoptosis induction by the pesticide Mancozeb in rat cells: Involvement of the oxidative mechanism

Toxicology and Applied Pharmacology

Volumn 211, Issue 2, 2006, Pages 87-96

  Calviello, Gabriella ^a   Piccioni, Elisabetta ^a   Boninsegna, Alma ^a   Tedesco, Beatrice ^a   Maggiano, Nicola ^a   Serini, Simona ^a   Wolf, Federica I ^a   Palozza, Paola ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

8 OHdG; Apoptosis; BCL 2; c MYC; Mancozeb; ROS; Single strand break

Indexed keywords

ALPHA TOCOPHEROL; MANCOZEB; PESTICIDE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BLOOD; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; COMET ASSAY; CONTROLLED STUDY; DATA ANALYSIS; DNA DAMAGE; EVALUATION; FIBROBLAST; GENOTOXICITY; LEUKOCYTE; NERVE DEGENERATION; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PATHOGENESIS; PROTEIN EXPRESSION; RAT;

ALPHA-TOCOPHEROL; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; COMET ASSAY; DEOXYGUANOSINE; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; FUNGICIDES, INDUSTRIAL; HYDROGEN PEROXIDE; IN SITU NICK-END LABELING; LEUKOCYTES, MONONUCLEAR; MANEB; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-MYC; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; TIME FACTORS; VITAMINS; ZINEB;

ANIMALIA; RATTUS NORVEGICUS;

EID: 32544449298     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2005.06.001     Document Type: Article

References (42)

1. P.N. Baligar, and B.B. Kaliwal Induction of gonadal toxicity to female rats after chronic exposure to Mancozeb Ind. Health 39 2001 235 243
2. F. Belpoggi, M. Soffritti, M. Guarino, L. Lambertini, D. Cevolani, and C. Maltoni Results of long-term experimental studies on the carcinogenicity of ethylene-bis-dithiocarbamate (Mancozeb) in rats Ann. N. Y. Acad. Sci. 982 2002 123 136
3. B.B. Bindali, and B.B. Kaliwal Anti-implantation effect of a carbamate fungicide Mancozeb in albino mice Ind. Health 40 2002 191 197
4. M. Bisson, and A. Hontela Cytotoxic and endocrine-disrupting potential of atrazine, diazinon, endosulfan, and Mancozeb in adrenocortical steroidogenic cells of rainbow trout exposed in vitro Toxicol. Appl. Pharmacol. 180 2002 110 117
5. G. Calviello, F. Di Nicuolo, E. Piccioni, M.E. Marcocci, S. Serini, N. Maggiano, K.H. Jones, D.G. Cornwell, and P. Palozza Gamma-tocopheryl quinone induces apoptosis in cancer cells via caspase-9 activation and cytochrome c release Carcinogenesis 24 2003 427 433
6. G. Calviello, F. Di Nicuolo, S. Serini, E. Piccioni, A. Boninsegna, N. Maggiano, F.O. Ranelletti, and P. Palozza Docosahexaenoic acid enhances the susceptibility of human colorectal cancer cells to 5-fluorouracil Cancer Chemother. Pharmacol. 55 2005 12 20
7. R.S. Chhabra, S. Eustis, J.K. Haseman, P.J. Kurtz, and B.D. Carlton Comparative carcinogenicity of ethylene thiourea with or without perinatal exposure in rats and mice Fundam. Appl. Toxicol. 18 1992 405 417
8. F. Di Nicuolo, S. Serini, A. Boninsegna, P. Palozza, and G. Calviello Redox regulation of cell proliferation by pyrrolidine dithiocarbamate in murine thymoma cells transplanted in vivo Free Radical Biol. Med. 31 2001 1424 1431
9. R. Engst, and W. Schnaak Metabolism of the fungicidal ethylenebis (dithiocarbamates), maneb and zineb: I. Identification and fungitoxic activity in a model experiment of synthesized metabolites Z. Lebensm.-Unters. Forsch. 134 1967 216 221
10. L. Fishbein Environmental health aspects of fungicides: I. Dithiocarbamtes J. Toxicol. Environ. Health 1 1976 713 735
11. V.A. Fitsanakis, V. Amarnath, J.T. Moore, K.S. Montine, J. Zhang, and T.J. Montine Catalysis of catechol oxidation by metal-dithiocarbamate complexes in pesticides Free Radical Biol. Med. 33 2002 1714 1723
12. E.J. Freireich, E.A. Gehan, D.P. Rall, L.H. Schmidt, and H.E. Skipper Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man Cancer Chemother. Rep. 50 1966 219 245
13. M. Gonzalez, S. Soloneski, M.A. Reigosa, and M.L. Larramendy Effect of dithiocarbamate pesticide zineb and its commercial formulation, azzurro: IV. DNA damage and repair kinetics assessed by single cell gel electrophoresis (SCGE) assay on Chinese hamster ovary (CHO) cells Mutat. Res. 534 2003 145 154
14. A.R. Greenlee, T.M. Ellis, and R.L. Berg Low-dose agrochemicals and lawn-care pesticides induce developmental toxicity in murine preimplantation embryos Environ. Health Perspect. 112 2004 703 709
15. B. Hellman, H. Vaghef, and B. Bostrom The concepts of tail moment and tail inertia in the single cell gel electrophoresis assay Mutat. Res. 336 1995 123 131
16. A. Iseki, F. Kambe, K. Okumura, T. Hayakawa, and H. Seo Regulation of thyroid follicular cell function by intracellular redox-active copper Endocrinology 141 2000 4373 4382
17. A. Jablonicka, H. Polakova, J. Karelova, and M. Vargova Analysis of chromosome aberrations and sister-chromatid exchanges in peripheral blood lymphocytes of workers with occupational exposure to the Mancozeb-containing fungicide Novozir Mn80 Mutat. Res. 224 1989 143 146
18. H.E. Jarrard, K.R. Delaney, and C.J. Kennedy Impacts of carbamate pesticides on olfactory neurophysiology and cholinesterase activity in coho salmon (Oncorhynchus kisutch) Aquat. Toxicol. 69 2004 133 148
19. R. Kackar, M.K. Srivastava, and R.B. Raizada Studies on rat thyroid after oral administration of Mancozeb: morphological and biochemical evaluations J. Appl. Toxicol. 17 1997 369 375
20. F. Kamel, and J.A. Hoppin Association of pesticide exposure with neurologic dysfunction and disease Environ. Health Perspect. 112 2004 950 958
21. P.K. Khan, and S.P. Sinha Impact of higher doses of vitamin C in modulating pesticide genotoxicity Teratog., Carcinog., Mutagen. 14 1994 175 181
22. P.K. Khan, and S.P. Sinha Ameliorating effect of vitamin C on murine sperm toxicity induced by three pesticides (endosulfan, phosphamidon and Mancozeb) Mutagenesis 11 1996 33 36
23. N. Lin, and V.F. Garry In vitro studies of cellular and molecular developmental toxicity of adjuvants, herbicides, and fungicides commonly used in Red River Valley, Minnesota J. Toxicol. Environ. Health 60 2000 423 439
24. X. Ma, P.A. Buffler, R.B. Gunier, G. Dahl, M.T. Smith, K. Reinier, and P. Reynolds Critical windows of exposure to household pesticides and risk of childhood leukemia Environ. Health Perspect. 110 2002 955 960
25. M. Maroni, C. Colosio, A. Ferioli, and A. Fait Biological monitoring of pesticide exposure: a review. Introduction Toxicology 143 2000 1 118
26. G. Meco, V. Bonifati, N. Vanacore, and E. Fabrizio Parkinsonism after chronic exposure to the fungicide maneb (manganese ethylene-bis-dithiocarbamate) Scand. J. Work, Environ. Health 20 1994 301 305
27. L. Militi, A.S. Costantini, V. Bolejack, A. Veraldi, A. Benvenuti, O. Nanni, V. Ramazzotti, R. Tumino, E. Stagnaro, S. Rodella, A. Fontana, C. Vindigni, and P. Vineis Non-Hodgkin's lymphoma, leukemia, and exposures in agriculture: results from the Italian multicenter case-control study Am. J. Ind. Med. 44 2003 627 636
28. B. Monis, and M.A. Valentich Promoting effects of Mancozeb on pancreas of nitrosomethylurea-treated rats Carcinogenesis 14 1993 929 933
29. S. Pelengaris, and M. Khan The many faces of c-MYC Arch. Biochem. Biophys. 416 2003 129 136
30. M.C. Poirier, R.M. Santella, and A. Weston Carcinogen macromolecular adducts and their measurement Carcinogenesis 21 2000 353 359
31. P. Reynolds, J. Von Behren, R.B. Gunier, D.E. Goldberg, M. Harnly, and A. Hertz Agricultural pesticide use and childhood cancer in California Epidemiology 16 2005 93 100
32. A. Sgambato, R. Ardito, B. Faraglia, A. Boninsegna, F.I. Wolf, and A. Cittadini Resveratrol, a natural phenolic compound, inhibits cell proliferation and prevents oxidative DNA damage Mutat. Res. 496 2001 171 180
33. Y. Shukla, M. Antony, S. Kumar, and N.K. Mehrotra Carcinogenic activity of a carbamate fungicide, Mancozeb on mouse skin Cancer Lett. 53 1990 191 195
34. N.P. Singh, M.T. McCoy, R.R. Tice, and E.L. Schneider A simple technique for quantitation of low levels of DNA damage in individual cells Exp. Cell Res. 175 1988 184 191
35. S. Soloneski, M.A. Reigosa, and M.L. Larramendy Effect of the dithiocarbamate pesticide zineb and its commercial formulation, the azzurro. V. Abnormalities induced in the spindle apparatus of transformed and non-transformed mammalian cell lines Mutat. Res. 536 2003 121 129
36. S. Soloneski, M.A. Reigosa, and M.L. Larramendy Vitamin E prevents ethylene bis(dithiocarbamate) pesticide zineb-induced sister chromatid exchange in Chinese hamster ovary cells Mutagenesis 18 2003 505 510
37. M. Thiruchelvam, B.J. Brockel, E.K. Richfield, R.B. Baggs, and D.A. Cory-Slechta Potentiated and preferential effects of combined paraquat and maneb on nigrostriatal dopamine systems: environmental risk factors for Parkinson's disease? Brain Res. 873 2000 225 234
38. A. Vaccari, P. Saba, I. Mocci, and S. Ruiu Dithiocarbamate pesticides affect glutamate transport in brain synaptic vesicles J. Pharmacol. Exp. Ther. 288 1999 1 5
39. P. Villani, C. Andreoli, R. Crebelli, F. Pacchierotti, A. Zijno, and A. Carere Analysis of micronuclei and DNA single-strand breaks in mouse splenocytes and peripheral lymphocytes after oral administration of tetramethylthiuram disulfide(thiram) Food Chem. Toxicol. 36 1998 155 164
40. World Health Organization Dithiocarbamate pesticides, ethylenethiourea, and propylenethiourea: a general introduction Environ. Health Criter. vol. 78 1988 WHO Geneva
41. A. Yarborough, Y.J. Zhang, T.M. Hsu, and R.M. Santella Immunoperoxidase detection of 8-hydroxydeoxyguanosine in aflatoxin B1-treated rat liver and human oral mucosal cells Cancer Res. 56 1996 683 688
42. Y. Zhou, F.S. Shie, P. Piccardo, T.J. Montine, and J. Zhang Proteasomal inhibition induced by manganese ethylene-bis-dithiocarbamate: relevance to Parkinson's disease Neuroscience 128 2004 281 291