Correlation between blood enthylenethiourea and thyroid gland disorders among banana plantation workers in the Philippines

Environmental Health Perspectives

Volumn 112, Issue 1, 2004, Pages 42-45

  Panganiban, Lynn R ^a   Cortes Maramba, Nelia ^a   Dioquino, Carissa ^a   Suplido, Maria Lurenda ^a   Ho, Herbert ^a   Francisco Rivera, Ana ^b   Manglicmot Yabes, Ailyn ^a  

^a UNIVERSITY OF THE PHILIPPINES MANILA   (Philippines)

^b Department of Health   (Philippines)

Author keywords

Banana plantations; Biologic monitoring; Blood ethylenethiourea; Environmental monitoring; Ethylenebisthiocarbamate exposure; Thyroid gland disorders

Indexed keywords

2 IMIDAZOLIDINETHIONE; BIOLOGICAL MARKER; THYROTROPIN; N,N' ETHYLENEBIS(DITHIOCARBAMIC ACID) DERIVATIVE;

ADULT; AGRICULTURAL WORKER; ANALYSIS OF VARIANCE; ARTICLE; BANANA; BLOOD LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HEALTH CARE ORGANIZATION; HEALTH SURVEY; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MEDICAL EXAMINATION; OCCUPATIONAL DISEASE; OCCUPATIONAL EXPOSURE; PHILIPPINES; PLANTATION; PRIORITY JOURNAL; RANDOMIZATION; THYROID DISEASE; THYROID FUNCTION TEST; THYROID NODULE; THYROTROPIN BLOOD LEVEL; ULTRASOUND; URINE LEVEL; AGRICULTURE; FRUIT; METABOLISM; MIDDLE AGED;

ADULT; AGRICULTURE; BIOLOGICAL MARKERS; ETHYLENEBIS(DITHIOCARBAMATES); ETHYLENETHIOUREA; FRUIT; HUMANS; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE; PHILIPPINES; THYROID DISEASES;

EID: 0347756692     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.6499     Document Type: Article

References (23)

1. Aprea C, Bette A, Catenacci G, Lotti A, Minoia C, Passini W, et al. 1996. Reference values of urinary ethylenethiourea in four regions of Italy (multicentric study). Sci Total Environ 192:83-93.
2. Aprea C, Sciarra G, Sartorelli P, Mancini R, Di Luca V. 1998. Environmental and biological monitoring of exposure to mancozeb, ETU and dimethoate during industrial formulation. J Toxicol Environ Health 53:263-281.
3. Blackwell-Smith R Jr, Finnegan JK, Larson PS, Sahyoun PF, Dreyfuss ML, Haag HB. 1953. Toxicologic studies on zinc and disodium ethylenebisdithiocarbamates. J Pharmacol Exp Ther 109:159-166.
4. Brucker-Davis F. 1998. Effects of environmental synthetic chemicals on thyroid function. Thyroid 8:827-856.
5. FAO/WHO. 1965. Evaluation of the Toxicity of Pesticide Residues in Food. FAO Meeting Report No. PL:1965/10/1; WHO/Food Add/27.65. Geneva:World Health Organization.
6. FAO/WHO. 1971. 1970 Evaluations of Some Pesticide Residues in Food. ACP 1979/M/12/1; WHO/Food Add/71.42. Geneva:World Health Organization.
7. Greenspan FS. 1994. The thyroid gland. In: Basic and Clinical Endocrinology (Greenspan FS, Baxter JD, eds). Norwalk, CT:Appleton and Lange, 216-217.
8. Houeto P, Bindoula G, Hoffman JR. 1995. Ethylenebisdithiocarbamates and ethylenethiourea: possible human health hazards. Environ Health Perspect 103:568-573.
9. Hurley PM, Hill RN, Whiting RJ. 1998. Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents. Environ Health Perspect 106:437-445.
10. IARC. 1991. Fungicides. ARC Monogr Eval Carcinog Risks Hum 53:403-422.
11. International Programme on Chemical Safety. 1988. Dithiocarbamate Pesticides, Ethylenethiourea, and Propylenethiourea: A General Introduction. Environmental Health Criteria 78. Geneva:World Health Organization. Available: http://www.inchem.org/documents/ehc/ehc/ ehc78.htm [accessed 18 November 2003].
12. Kato Y, Odanaka Y, Teramoto S, Matano O. 1976. Metabolic fate of ethylenethiourea in pregnant rats. Bull Environ Contam Toxicol 16(5):546-555.
13. Kurttio P, Vartiainen T, Savolainen K. 1990a. Environmental and biological monitoring of exposure to ethylenebisdithiocarbamate fungicides and ethylenethiourea. Br J Ind Med 47:203-206.
14. Kurttio P, Vartiainen T, Savolainen K. 1990b. Ethylene thiourea in air and in urine as an indicator of exposure to ethylenebisdithiocarbamate fungicides. Scand J Work Environ Health 16:203-207.
15. Marinovich M, Guizzetti M, Ghilardi F, Viviani B, Corsini E, Galli CL. 1997. Thyroid peroxidase as toxicity target for dithiocarbamates. Arch Toxicol 71:508-512.
16. Newsome WH. 1974. The excretion of ethylenethiourea by rat and guinea pig. Bull Environ Contam Toxicol 11:174-176.
17. 14C-Ethylenethiourea: distribution, excretion, and metabolism in pregnant rats. Teratology 13:263-266.
18. Seifter J, Ehrich WE. 1948. Goitrogenic compounds: pharmacological and pathological effects. J Pharmacol Exp Ther 92:303-314.
19. Smith DM. 1984. Ethylene thiourea: thyroid function in two groups of exposed workers. Br J Ind Med 41:362-366.
20. Steenland K, Cedillo L, Tucker J, Hines C, Sorensen K, Deddens J, et al. 1997. Thyroid hormones and cytogenetic outcomes in backpack sprayers using ethylenebis(dithiocarbamate) (EBDC) fungicides in Mexico. Environ Health Perspect 105:1126-1130.
21. Studer H, Gerber H. 1991. Clinical manifestations and management of non-toxic diffuse and nodular goiter. In: Werner and Ingbar's The Thyroid: A Fundamental and Clinical Test (Braverman LE, Utiger RD, eds). 6th ed. Philadelphia:Lippincott, 1130-1132.
22. U.S. EPA. 2000. EPA Region IX Preliminary Remediation Goal (PRG) Tables. 2000 Update. San Francisco, CA:U.S. Environmental Protection Agency Region 9.
23. Velandria FV, Magbitang JA, Tanchoco CC, Mendoza TS, Orense CL, Tangco JB, et al. 1997. Fourth national nutrition survey, Philippines, 1993. Philipp J Nutr 44:49-65.