Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes

Diabetologia

Volumn 60, Issue 4, 2017, Pages 656-667

  Marroqui, Laura ^a   Dos Santos, Reinaldo S ^a   Op de beeck, Anne ^a   Coomans de Brachène, Alexandra ^a   Marselli, Lorella ^b   Marchetti, Piero ^b   Eizirik, Decio L ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

Apoptosis; ER stress; IFN ; MHC class I; Pancreatic beta cells; Pancreatic islets; Type 1 diabetes; Type I IFN signalling

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; ALPHA INTERFERON; ALPHA TUBULIN; DYE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; GUANOSINE TRIPHOSPHATASE; HEAT SHOCK PROTEIN 70; HLA ANTIGEN CLASS 1; IMMUNOGLOBULIN; INITIATION FACTOR 2ALPHA; INSULIN; INTERFERON REGULATORY FACTOR 9; INTERLEUKIN 1BETA; MYXOVIRUS RESISTANCE PROTEIN; POLYINOSINIC POLYCYTIDYLIC ACID; PROTEIN KINASE TYK2; PROTEIN TYROSINE PHOSPHATASE; SMALL INTERFERING RNA; STAT1 PROTEIN; STAT2 PROTEIN; STAT3 PROTEIN; X BOX BINDING PROTEIN 1; TRANSCRIPTION FACTOR;

APOPTOSIS; ARTICLE; CELL ACTIVATION; CLINICAL EVALUATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME MECHANISM; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; INFLAMMATION; INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; METABOLISM; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE;

APOPTOSIS; BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; DIABETES MELLITUS, TYPE 1; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; INSULIN-SECRETING CELLS; INTERFERON-ALPHA; INTERLEUKIN-1BETA; REAL-TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 85008517927     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-016-4201-3     Document Type: Article

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