Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1

Biochemical Journal

Volumn 473, Issue 17, 2016, Pages 2645-2654

  Mahrhold, Stefan ^a   Bergström, Tomas ^b   Stern, Daniel ^c   Dorner, Brigitte G ^c   Åstot, Crister ^b   Rummel, Andreas ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b SWEDISH DEFENCE RESEARCH AGENCY   (Sweden)

^c ROBERT KOCH INSTITUTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM TOXIN A; BOTULINUM TOXIN B; FC RECEPTOR; GLYCAN; GLYCOPROTEIN; N ACETYLGLUCOSAMINE; N559 GLYCAN; SYNAPTIC VESICLE GLYCOPROTEIN 2; UNCLASSIFIED DRUG; AZACITIDINE; DECITABINE; MEMBRANE PROTEIN; PROTEIN BINDING;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; CONTROLLED STUDY; ENDOCYTOSIS; GENE EXPRESSION SYSTEM; GLYCOSYLATION; HUMAN; HUMAN CELL; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SEROTYPE; SURFACE PLASMON RESONANCE; SYNAPSE VESICLE; ANALOGS AND DERIVATIVES; METABOLISM;

AZACITIDINE; BOTULINUM TOXINS, TYPE A; GLYCOSYLATION; MEMBRANE GLYCOPROTEINS; PROTEIN BINDING; SURFACE PLASMON RESONANCE; SYNAPTIC VESICLES;

EID: 85008477339     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BCJ20160439     Document Type: Article

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