Human synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: Increased therapeutic dosage and immunogenicity

FEBS Letters

Volumn 586, Issue 4, 2012, Pages 310-313

  Strotmeier, Jasmin ^a   Willjes, Gesche ^a   Binz, Thomas ^a   Rummel, Andreas ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

BoNT G; Botulinum neurotoxin B; Human synaptotagmin II; Protein receptor; RimabotulinumtoxinB

Indexed keywords

BOTULINUM TOXIN; BOTULINUM TOXIN A; BOTULINUM TOXIN B; BOTULINUM TOXIN G; LEUCINE; PHENYLALANINE; SYNAPTOTAGMIN II; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CHIMPANZEE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; HUMAN; IMMUNOGENICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR AFFINITY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; BOTULINUM TOXINS; CONSERVED SEQUENCE; EVOLUTION, MOLECULAR; HUMANS; KINETICS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PAN TROGLODYTES; PROTEIN STRUCTURE, TERTIARY; RATS; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; SYNAPTOTAGMIN II;

MUS; PAN; RATTUS;

EID: 84857053354     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.12.037     Document Type: Article

References (27)

1. T. Binz, and A. Rummel Cell entry strategy of clostridial neurotoxins J. Neurochem. 109 2009 1584 1595
2. L. Muraro, S. Tosatto, L. Motterlini, O. Rossetto, and C. Montecucco The N-terminal half of the receptor domain of botulinum neurotoxin A binds to microdomains of the plasma membrane Biochem. Biophys. Res. Commun. 380 2009 76 80
3. A. Fischer, D.J. Mushrush, D.B. Lacy, and M. Montal Botulinum neurotoxin devoid of receptor binding domain translocates active protease PLoS Pathog. 4 2008 e1000245
4. M. Montal Botulinum neurotoxin: a marvel of protein design Annu. Rev. Biochem. 79 2010 591 617
5. C.L. Comella The treatment of cervical dystonia with botulinum toxins J. Neural. Transm. 115 2008 579 583
6. C.L. Comella, J. Jankovic, K.M. Shannon, J. Tsui, M. Swenson, S. Leurgans, and W. Fan Comparison of botulinum toxin serotypes A and B for the treatment of cervical dystonia Neurology 65 2005 1423 1429 (Pubitemid 41552774)
7. D. Dressler, and H. Bigalke Botulinum toxin type B de novo therapy of cervical dystonia: frequency of antibody induced therapy failure J. Neurol. 252 2005 904 907 (Pubitemid 41186961)
8. Solstice-Neurosciences-Inc. (2010). Myobloc® (rimabotulinumtoxinB) Injection: prescribing information revised 05/2010 [online]. Available from URL: < http://www.myobloc.com/myobloc/hp-about/PI-5-19-10.pdf > [Accessed 2011 Dec. 8].
9. Allergan-Inc. (2011). BOTOX (Botulinum toxin type A) purified neurotoxin complex: prescribing information revised 08/2011 [online]. Available from URL: < http://www.allergan.com/assets/pdf/botox-pi.pdf > [Accessed 2011 Dec. 8].
10. Hunt, T. (2007). Improved botulinum toxin composition. Available from URL: < http://www.wipo.int/pctdb/en/wo.jsp?wo=2007016018&IA= US2006028603&DISPLAY=DESC >. [Accessed 2011 Dec 8] US Patent application 2007/0025019.
11. J.E. Callaway Botulinum toxin type B (Myobloc): pharmacology and biochemistry Clin. Dermatol. 22 2004 23 28 (Pubitemid 38670100)
12. Y. Humeau, F. Doussau, N.J. Grant, and B. Poulain How botulinum and tetanus neurotoxins block neurotransmitter release Biochimie 82 2000 427 446 (Pubitemid 30391899)
13. C. Montecucco How do tetanus and botulinum toxins bind to neuronal membranes? Trends Biochem. Sci. 11 1986 314 317
14. A. Rummel Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept Proc. Natl. Acad. Sci. USA 104 2007 359 364 (Pubitemid 46068036)
15. M. Dong, D.A. Richards, M.C. Goodnough, W.H. Tepp, E.A. Johnson, and E.R. Chapman Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells J. Cell Biol. 162 2003 1293 1303 (Pubitemid 37210885)
16. T. Nishiki, Y. Kamata, Y. Nemoto, A. Omori, T. Ito, M. Takahashi, and S. Kozaki Identification of protein receptor for Clostridium botulinum type B neurotoxin in rat brain synaptosomes J. Biol. Chem. 269 1994 10498 10503 (Pubitemid 24198248)
17. A. Rummel, T. Karnath, T. Henke, H. Bigalke, and T. Binz Synaptotagmins I and II act as nerve cell receptors for botulinum neurotoxin G J. Biol. Chem. 279 2004 30865 30870 (Pubitemid 38938022)
18. E.R. Chapman Synaptotagmin: a Ca(2+) sensor that triggers exocytosis? Nat. Rev. Mol. Cell. Biol. 3 2002 498 508 (Pubitemid 34733431)
19. T.C. Sudhof Synaptotagmins: why so many? J. Biol. Chem. 277 2002 7629 7632 (Pubitemid 34968204)
20. M. Geppert, B.T. Archer 3rd, and T.C. Sudhof Synaptotagmin II. A novel differentially distributed form of synaptotagmin J. Biol. Chem. 266 1991 13548 13552 (Pubitemid 21907384)
21. M.S. Perin, V.A. Fried, G.A. Mignery, R. Jahn, and T.C. Sudhof Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C Nature 345 1990 260 263
22. Q. Chai, J.W. Arndt, M. Dong, W.H. Tepp, E.A. Johnson, E.R. Chapman, and R.C. Stevens Structural basis of cell surface receptor recognition by botulinum neurotoxin B Nature 444 2006 1096 1100 (Pubitemid 46018532)
23. R. Jin, A. Rummel, T. Binz, and A.T. Brunger Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity Nature 444 2006 1092 1095 (Pubitemid 46018531)
24. T. Nishiki The high-affinity binding of Clostridium botulinum type B neurotoxin to synaptotagmin II associated with gangliosides GT1b/GD1a FEBS Lett. 378 1996 253 257
25. CC-domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interaction Mol. Microbiol. 51 2004 631 643 (Pubitemid 38233933)
26. P. Stenmark, M. Dong, J. Dupuy, E.R. Chapman, and R.C. Stevens Crystal structure of the botulinum neurotoxin type G binding domain: insight into cell surface binding J. Mol. Biol. 397 2010 1287 1297
27. O. Sonnabend, W. Sonnabend, R. Heinzle, T. Sigrist, R. Dirnhofer, and U. Krech Isolation of Clostridium botulinum type G and identification of type G botulinal toxin in humans: report of five sudden unexpected deaths J. Infect. Dis. 143 1981 22 27 (Pubitemid 11152593)