Double anchorage to the membrane and intact inter-chain disulfide bond are required for the low pH induced entry of tetanus and botulinum neurotoxins into neurons

Cellular Microbiology

Volumn 13, Issue 11, 2011, Pages 1731-1743

  Pirazzini, Marco ^a   Rossetto, Ornella ^a   Bolognese, Paolo ^a   Shone, Clifford C ^b   Montecucco, Cesare ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM TOXIN; BOTULINUM TOXIN A; BOTULINUM TOXIN B; BOTULINUM TOXIN C; BOTULINUM TOXIN D; METALLOPROTEINASE; SNARE PROTEIN; SYNAPTOBREVIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; TETANUS TOXIN; UNCLASSIFIED DRUG;

ACIDITY; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL ANCHORAGE; CELL PH; CELL STRAIN; CELL SURFACE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISULFIDE BOND; ENZYME ACTIVITY; EXTRACELLULAR SPACE; NERVE CELL; NERVE CELL MEMBRANE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; RAT; SYNAPSE VESICLE;

ANIMALS; BOTULINUM TOXINS; CELL LINE; CULTURE MEDIA; CYTOLOGICAL TECHNIQUES; DISULFIDES; ENDOCYTOSIS; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; NEURONS; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN TRANSPORT; RADIOMETRY; RATS; SYNAPTIC VESICLES; TEMPERATURE; TETANUS TOXIN;

EID: 80054105849     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2011.01654.x     Document Type: Article

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