Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A

Nature

Volumn 505, Issue 7481, 2014, Pages 108-111

  Benoit, Roger M ^a   Frey, Daniel ^a   Hilbert, Manuel ^a   Kevenaar, Josta T ^b   Wieser, Mara M ^a   Stirnimann, Christian U ^a   McMillan, David ^c   Ceska, Tom ^c   Lebon, Florence ^c   Jaussi, Rolf ^a   Steinmetz, Michel O ^a   Schertler, Gebhard F X ^a,d   Hoogenraad, Casper C ^b   Capitani, Guido ^a   Kammerer, Richard A ^a  

^a PAUL SCHERRER INSTITUTE   (Switzerland)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UCB PHARMA   (Belgium)

^d ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; BOTULINUM TOXIN A; GLYCOPROTEIN; PHENYLALANINE; SYNAPTIC VESICLE PROTEIN 2C; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; NERVE PROTEIN; PEPTIDE FRAGMENT; SV2C PROTEIN, HUMAN;

CRYSTAL STRUCTURE; INHIBITION; MOTILITY; NEUROLOGY; PROTEIN; RESOLUTION; TOXIN;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; HYDROGEN BOND; PRIORITY JOURNAL; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; SYNAPSE VESICLE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; ENDOCYTOSIS; HEK293 CELL LINE; HUMAN; METABOLISM; NEOSTRIATUM; NERVE CELL; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; BOTULINUM TOXINS, TYPE A; CRYSTALLOGRAPHY, X-RAY; ENDOCYTOSIS; HEK293 CELLS; HUMANS; MEMBRANE GLYCOPROTEINS; MODELS, MOLECULAR; NEOSTRIATUM; NERVE TISSUE PROTEINS; NEURONS; PEPTIDE FRAGMENTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84892372004     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12732     Document Type: Article

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