The Hcc-domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interaction

Molecular Microbiology

Volumn 51, Issue 3, 2004, Pages 631-643

  Rummel, Andreas ^a   Mahrhold, Stefan ^a   Bigalke, Hans ^a   Binz, Thomas ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM TOXIN A; BOTULINUM TOXIN B; CARBOHYDRATE; GANGLIOSIDE; HISTIDINE; TETANUS TOXIN; TYROSINE; BOTULINUM TOXIN; NEUROTOXIN; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOHYDRATE ANALYSIS; CARBOXY TERMINAL SEQUENCE; CLOSTRIDIUM BOTULINUM; COMPLEX FORMATION; CONTROLLED STUDY; MASS SPECTROMETRY; NERVE CELL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; SEROTYPE; ANIMAL; CARBOHYDRATE METABOLISM; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR GENETICS; MOUSE; PHRENIC NERVE; PROTEIN TERTIARY STRUCTURE; RAT; SEQUENCE ALIGNMENT; SEROTYPING; SYNAPTOSOME;

CLOSTRIDIUM; CLOSTRIDIUM BOTULINUM; POSIBACTERIA;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BOTULINUM TOXIN TYPE A; BOTULINUM TOXINS; CARBOHYDRATE METABOLISM; GANGLIOSIDES; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEUROTOXINS; PEPTIDE FRAGMENTS; PHRENIC NERVE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEROTYPING; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SYNAPTOSOMES;

EID: 1242320307     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2003.03872.x     Document Type: Article

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