Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance

Cell Stem Cell

Volumn 20, Issue 2, 2017, Pages 233-246.e7

  Liau, Brian B ^a,b   Sievers, Cem ^a,b   Donohue, Laura K ^a,b   Gillespie, Shawn M ^a,b   Flavahan, William A ^a,b   Miller, Tyler E ^d,e   Venteicher, Andrew S ^a,b   Hebert, Christine H ^a,b   Carey, Christopher D ^c   Rodig, Scott J ^c   Shareef, Sarah J ^a,b   Najm, Fadi J ^a,b   van Galen, Peter ^a,b   Wakimoto, Hiroaki ^a   Cahill, Daniel P ^a   Rich, Jeremy N ^d,e   Aster, Jon C ^c   Suvà, Mario L ^a,b   Patel, Anoop P ^a,b   Bernstein, Bradley E ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d LERNER RESEARCH INSTITUTE   (United States)

^e CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cancer; chromatin; drug resistance; epigenetics; glioblastoma; histone demethylases; KDM6A B; Notch; stem cell

Indexed keywords

DASATINIB; HISTONE; HISTONE DEMETHYLASE; NOTCH RECEPTOR; PHOSPHOTRANSFERASE INHIBITOR; KDM6B PROTEIN, HUMAN; LYSINE; NUCLEAR PROTEIN; PROTEIN BINDING; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; TUMOR MARKER; UTX PROTEIN, HUMAN;

ARTICLE; CELL PLASTICITY; CELL PROLIFERATION; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; DRUG TOLERANCE; EPIGENETICS; GLIOBLASTOMA; GLIOMA STEM CELL; HISTONE METHYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION; ACETYLATION; BRAIN; CANCER STEM CELL; CELL CYCLE; DRUG EFFECTS; DRUG RESISTANCE; ENHANCER REGION; GENETIC TRANSCRIPTION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; METHYLATION; NUCLEOTIDE SEQUENCE; PATHOLOGY; TUMOR CELL LINE;

ACETYLATION; BASE SEQUENCE; BIOMARKERS, TUMOR; BRAIN; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMATIN ASSEMBLY AND DISASSEMBLY; DRUG RESISTANCE, NEOPLASM; ENHANCER ELEMENTS, GENETIC; GLIOBLASTOMA; HISTONE DEMETHYLASES; HISTONES; HUMANS; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; LYSINE; METHYLATION; NEOPLASTIC STEM CELLS; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 85008406243     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2016.11.003     Document Type: Article

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