Structural analysis of human KDM5B guides histone demethylase inhibitor development

Nature Chemical Biology

Volumn 12, Issue 7, 2016, Pages 539-545

  Johansson, Catrine ^a   Velupillai, Srikannathasan ^a   Tumber, Anthony ^a,b   Szykowska, Aleksandra ^a   Hookway, Edward S ^a   Nowak, Radoslaw P ^a   Strain Damerell, Claire ^a   Gileadi, Carina ^a   Philpott, Martin ^a   Burgess Brown, Nicola ^a   Wu, Na ^a   Kopec, Jola ^a   Nuzzi, Andrea ^a,b   Steuber, Holger ^c   Egner, Ursula ^c   Badock, Volker ^c   Munro, Shonagh ^a   Lathangue, Nicholas B ^a   Westaway, Sue ^d   Brown, Jack ^d   Athanasou, Nick ^a   Prinjha, Rab ^d   Brennan, Paul E ^a,b   Oppermann, Udo ^a   more..

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c BAYER PHARMA AG   (Germany)

^d GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; GSK 467; GSKJ 1; HISTONE DEMETHYLASE; HISTONE DEMETHYLASE INHIBITOR; HISTONE H3; KDM4 PROTEIN; KDM5 C70; KDM5B PROTEIN; KDM6 PROTEIN; LYSINE; OXIDOREDUCTASE INHIBITOR; OXYGENASE; OXYGENASE INHIBITOR; UNCLASSIFIED DRUG; ENZYME INHIBITOR; KDM5B PROTEIN, HUMAN; NUCLEAR PROTEIN; REPRESSOR PROTEIN;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CATALYSIS; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DETERMINATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; ENZYME ACTIVE SITE; HISTONE METHYLATION; HUMAN; HUMAN CELL; HYBRID; MYELOMA CELL; PRIORITY JOURNAL; PROTEIN FOLDING; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; METABOLISM; MOLECULAR MODEL; MULTIPLE MYELOMA; PATHOLOGY; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HISTONE DEMETHYLASES; HUMANS; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; MODELS, MOLECULAR; MULTIPLE MYELOMA; NUCLEAR PROTEINS; PROTEIN CONFORMATION; REPRESSOR PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84969902813     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.2087     Document Type: Article

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