NLRP3 inflammasome may regulate inflammatory response of human periodontal ligament fibroblasts in an apoptosis-associated speck-like protein containing a CARD (ASC)-dependent manner

International Endodontic Journal

Volumn 50, Issue 10, 2017, Pages 967-975

  Lu, W L ^a   Song, D Z ^a   Yue, J L ^a   Wang, T T ^a   Zhou, X D ^a   Zhang, P ^a   Zhang, L ^a   Huang, D M ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

ASC; human periodontal ligament fibroblasts; inflammasome; inflammation; NLRP3

Indexed keywords

CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 6; NLRP3 PROTEIN, HUMAN; PYCARD PROTEIN, HUMAN; TUMOR NECROSIS FACTOR;

APOPTOSIS; CYTOLOGY; FIBROBLAST; HUMAN; INFLAMMATION; METABOLISM; PERIODONTAL LIGAMENT;

APOPTOSIS; CARD SIGNALING ADAPTOR PROTEINS; FIBROBLASTS; HUMANS; INFLAMMASOMES; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PERIODONTAL LIGAMENT; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85008394055     PISSN: 01432885     EISSN: 13652591     Source Type: Journal    
DOI: 10.1111/iej.12722     Document Type: Article

References (33)

1. Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124, 783–801.
2. Allen IC, Scull MA, Moore CB et al. (2009) The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity 30, 556–65.
3. Bryant C, Fitzgerald KA (2009) Molecular mechanisms involved in inflammasome activation. Trends in Cell Biology 19, 455–64.
4. Doyle SL, Campbell M, Ozaki E et al. (2012) NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components. Nature Medicine 18, 791–8.
5. Franchi L, McDonald C, Kanneganti TD, Amer A, Nunez G (2006) Nucleotide-binding oligomerization domain-like receptors: intracellular pattern recognition molecules for pathogen detection and host defense. The Journal of Immunology 177, 3507–13.
6. Hornung V, Ablasser A, Charrel-Dennis M et al. (2009) AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458, 514–8.
7. Jeon DI, Park SR, Ahn MY, Ahn SG, Park JH, Yoon JH (2012) NOD1 and NOD2 stimulation triggers innate immune responses of human periodontal ligament cells. International Journal of Molecular Medicine 29, 699–703.
8. Jiang W, Lv H, Wang H et al. (2015) Activation of the NLRP3/caspase-1 inflammasome in human dental pulp tissue and human dental pulp fibroblasts. Cell and Tissue Research 361, 541–55.
9. Kanneganti TD, Lamkanfi M, Nunez G (2007) Intracellular NOD-like receptors in host defense and disease. Immunity 27, 549–59.
10. Kim YG, Park JH, Shaw MH, Franchi L, Inohara N, Nunez G (2008) The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 28, 246–57.
11. Kummer JA, Broekhuizen R, Everett H et al. (2007) Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response. Journal of Histochemistry & Cytochemistry 55, 443–52.
12. Lamkanfi M, Mueller JL, Vitari AC et al. (2009) Glyburide inhibits the Cryopyrin/Nalp3 inflammasome. Journal of Cell Biology 187, 61–70.
13. Lee DJ, Du F, Chen SW et al. (2015) Regulation and function of the caspase-1 in an inflammatory microenvironment. Journal of Investigative Dermatology 135, 2012–20.
14. Mariathasan S, Weiss DS, Dixit VM, Monack DM (2005) Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis. Journal of Experimental Medicine 202, 1043–9.
15. Martinon F, Burns K, Tschopp J (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-β. Molecular Cell 10, 417–26.
16. Masumoto J, Taniguchi S, Nakayama J et al. (2001) Expression of apoptosis-associated speck-like protein containing a caspase recruitment domain, a pyrin N-terminal homology domain-containing protein, in normal human tissues. Journal of Histochemistry & Cytochemistry 49, 1269–75.
17. Matsuo T, Ebisu S, Nakanishi T, Yonemura K, Harada Y, Okada H (1994) Interleukin-1α and interleukin-1 β in periapical exudates of infected root canals: correlations with the clinical findings of the involved teeth. Journal of Endodontics 20, 432–5.
18. Morsani JM, Aminoshariae A, Han YW, Montagnese TA, Mickel A (2011) Genetic predisposition to persistent apical periodontitis. Journal of Endodontics 37, 455–9.
19. Nair PN (2006) On the causes of persistent apical periodontitis: a review. International Endodontic Journal 39, 249–81.
20. Ozaki E, Campbell M, Doyle SL (2015) Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives. Journal of Inflammation Research 8, 15–27.
21. Ozkurede VU, Franchi L (2012) Immunology in clinic review series; focus on autoinflammatory diseases: role of inflammasomes in autoinflammatory syndromes. Clinical and Experimental Immunology 167, 382–90.
22. Pandey S, Agrawal DK (2006) Immunobiology of Toll-like receptors: emerging trends. Immunology and Cell Biology 84, 333–41.
23. Parker LC, Prince LR, Sabroe I (2007) Translational mini-review series on Toll-like receptors: networks regulated by Toll-like receptors mediate innate and adaptive immunity. Clinical and Experimental Immunology 147, 199–207.
24. Petrilli V, Dostert C, Muruve DA, Tschopp J (2007) The inflammasome: a danger sensing complex triggering innate immunity. Current Opinion in Immunology 19, 615–22.
25. Qiao Y, Wang P, Qi J, Zhang L, Gao C (2012) TLR-induced NF-kappaB activation regulates NLRP3 expression in murine macrophages. Febs Letters 586, 1022–6.
26. Schroder K, Tschopp J (2010) The inflammasomes. Cell 140, 821–32.
27. Scott MJ, Chen C, Sun Q, Billiar TR (2010) Hepatocytes express functional NOD1 and NOD2 receptors: a role for NOD1 in hepatocyte CC and CXC chemokine production. Journal of Hepatology 53, 693–701.
28. Song Z, Lin Z, He F et al. (2012) NLRP3 is expressed in human dental pulp cells and tissues. Journal of Endodontics 38, 1592–7.
29. Wang Y, Zhai S, Wang H et al. (2013) Absent in melanoma 2 (AIM2) in rat dental pulp mediates the inflammatory response during pulpitis. Journal of Endodontics 39, 1390–4.
30. Yamamoto M, Yaginuma K, Tsutsui H et al. (2004) ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules. Genes to Cells 9, 1055–67.
31. Yang H-H, Jun H-K, Jung Y-J, Choi B-K (2014) Enterococcus faecalis activates caspase-1 leading to increased interleukin-1 beta secretion in macrophages. Journal of Endodontics 40, 1587–92.
32. Yu JW, Wu J, Zhang Z et al. (2006) Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization. Cell Death and Differentiation 13, 236–49.
33. Zhang A, Wang P, Ma X et al. (2015) Mechanisms that lead to the regulation of NLRP3 inflammasome expression and activation in human dental pulp fibroblasts. Molecular Immunology 66, 253–62.