메뉴 건너뛰기




Volumn 361, Issue 2, 2015, Pages 541-555

Activation of the NLRP3/caspase-1 inflammasome in human dental pulp tissue and human dental pulp fibroblasts

Author keywords

Dental pulp; Fibroblasts; Human; Inflammasome; Innate immune system; NLRP3

Indexed keywords

ADENOSINE TRIPHOSPHATE; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOPOLYSACCHARIDE; MEMBRANE PROTEIN; PANNEXIN 1; POTASSIUM ION; PURINERGIC P2X7 RECEPTOR; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; CARRIER PROTEIN; INTERLEUKIN 1BETA; NLRP3 PROTEIN, HUMAN;

EID: 84938739043     PISSN: 0302766X     EISSN: 14320878     Source Type: Journal    
DOI: 10.1007/s00441-015-2118-7     Document Type: Article
Times cited : (74)

References (45)
  • 1
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • COI: 1:CAS:528:DC%2BD28Xit1Kltb8%3D, PID: 16497588
    • Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124:783–801
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 2
    • 83355174404 scopus 로고    scopus 로고
    • Role of the Nlrp3 inflammasome in microbial infection
    • COI: 1:CAS:528:DC%2BC3MXptVGjsr8%3D, PID: 21687408
    • Anand PK, Malireddi RK, Kanneganti TD (2011) Role of the Nlrp3 inflammasome in microbial infection. Front Microbiol 2:12
    • (2011) Front Microbiol , vol.2 , pp. 12
    • Anand, P.K.1    Malireddi, R.K.2    Kanneganti, T.D.3
  • 3
    • 0033180574 scopus 로고    scopus 로고
    • Role of active oxygen species and NO in plant defence responses
    • COI: 1:CAS:528:DyaK1MXls1Oqu74%3D, PID: 10459001
    • Bolwell GP (1999) Role of active oxygen species and NO in plant defence responses. Curr Opin Plant Biol 2:287–294
    • (1999) Curr Opin Plant Biol , vol.2 , pp. 287-294
    • Bolwell, G.P.1
  • 4
    • 77951911814 scopus 로고    scopus 로고
    • Control of infection by pyroptosis and autophagy: role of TLR and NLR
    • COI: 1:CAS:528:DC%2BC3cXltVyksL0%3D, PID: 20229126
    • Bortoluci KR, Medzhitov R (2010) Control of infection by pyroptosis and autophagy: role of TLR and NLR. Cell Mol Life Sci 67:1643–1651
    • (2010) Cell Mol Life Sci , vol.67 , pp. 1643-1651
    • Bortoluci, K.R.1    Medzhitov, R.2
  • 6
    • 0032150528 scopus 로고    scopus 로고
    • In vitro evaluation of the cytotoxicity and genotoxicity of root canal medicines on human pulp fibroblasts
    • COI: 1:STN:280:DyaK1M7itFGjtg%3D%3D, PID: 9922749
    • Chang YC, Huang FM, Cheng MH, Chou LS, Chou MY (1998) In vitro evaluation of the cytotoxicity and genotoxicity of root canal medicines on human pulp fibroblasts. J Endod 24:604–606
    • (1998) J Endod , vol.24 , pp. 604-606
    • Chang, Y.C.1    Huang, F.M.2    Cheng, M.H.3    Chou, L.S.4    Chou, M.Y.5
  • 7
    • 77955555616 scopus 로고    scopus 로고
    • Inflammation–regeneration interplay in the dentine–pulp complex
    • COI: 1:CAS:528:DC%2BC3cXpvVGqsbc%3D, PID: 20580768
    • Cooper PR, Takahashi Y, Graham LW, Simon S, Imazato S, Smith AJ (2010) Inflammation–regeneration interplay in the dentine–pulp complex. J Dent 38:687–697
    • (2010) J Dent , vol.38 , pp. 687-697
    • Cooper, P.R.1    Takahashi, Y.2    Graham, L.W.3    Simon, S.4    Imazato, S.5    Smith, A.J.6
  • 8
    • 43249125839 scopus 로고    scopus 로고
    • Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
    • COI: 1:CAS:528:DC%2BD1cXltFyis7c%3D, PID: 18403674
    • Dostert C, Petrilli V, Van Bruggen R, Steele C, Mossman BT, Tschopp J (2008) Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 320:674–677
    • (2008) Science , vol.320 , pp. 674-677
    • Dostert, C.1    Petrilli, V.2    Van Bruggen, R.3    Steele, C.4    Mossman, B.T.5    Tschopp, J.6
  • 10
    • 33751224777 scopus 로고    scopus 로고
    • SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes
    • COI: 1:CAS:528:DC%2BD28Xht1OjtLnF, PID: 17085590
    • Fay AJ, Qian X, Jan YN, Jan LY (2006) SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes. Proc Natl Acad Sci U S A 103:17548–17553
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 17548-17553
    • Fay, A.J.1    Qian, X.2    Jan, Y.N.3    Jan, L.Y.4
  • 11
    • 34250835251 scopus 로고    scopus 로고
    • The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes
    • COI: 1:CAS:528:DC%2BD2sXntFars70%3D, PID: 17600714
    • Feldmeyer L, Keller M, Niklaus G, Hohl D, Werner S, Beer HD (2007) The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes. Curr Biol 17:1140–1145
    • (2007) Curr Biol , vol.17 , pp. 1140-1145
    • Feldmeyer, L.1    Keller, M.2    Niklaus, G.3    Hohl, D.4    Werner, S.5    Beer, H.D.6
  • 12
    • 84858677223 scopus 로고    scopus 로고
    • Sensing and reacting to microbes through the inflammasomes
    • COI: 1:CAS:528:DC%2BC38XktFSgsbY%3D, PID: 22430785
    • Franchi L, Muñoz-Planillo R, Núñez G (2012) Sensing and reacting to microbes through the inflammasomes. Nat Immunol 13:325–332
    • (2012) Nat Immunol , vol.13 , pp. 325-332
    • Franchi, L.1    Muñoz-Planillo, R.2    Núñez, G.3
  • 14
    • 0034444553 scopus 로고    scopus 로고
    • Cytokine induction by Streptococcus mutans and pulpal pathogenesis
    • COI: 1:CAS:528:DC%2BD3MXjslCktLw%3D, PID: 11083796
    • Hahn CL, Best AM, Tew JG (2000) Cytokine induction by Streptococcus mutans and pulpal pathogenesis. Infect Immun 68:6785–6789
    • (2000) Infect Immun , vol.68 , pp. 6785-6789
    • Hahn, C.L.1    Best, A.M.2    Tew, J.G.3
  • 15
    • 77749270973 scopus 로고    scopus 로고
    • Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor
    • COI: 1:CAS:528:DC%2BD1MXht1ymtbfK, PID: 19812205
    • Harder J, Franchi L, Munoz-Planillo R, Park JH, Reimer T, Núñez G (2009) Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor. J Immunol 183:5823–5829
    • (2009) J Immunol , vol.183 , pp. 5823-5829
    • Harder, J.1    Franchi, L.2    Munoz-Planillo, R.3    Park, J.H.4    Reimer, T.5    Núñez, G.6
  • 16
    • 77955846410 scopus 로고    scopus 로고
    • CpG oligonucleotides induce an immune response of odontoblasts through the TLR9, MyD88 and NF-kappaB pathways
    • COI: 1:CAS:528:DC%2BC3cXhtVKhurjO, PID: 20655295
    • He W, Yu Q, Zhou Z, Wang P (2010) CpG oligonucleotides induce an immune response of odontoblasts through the TLR9, MyD88 and NF-kappaB pathways. Biochem Biophys Res Commun 399:274–278
    • (2010) Biochem Biophys Res Commun , vol.399 , pp. 274-278
    • He, W.1    Yu, Q.2    Zhou, Z.3    Wang, P.4
  • 17
    • 70349326627 scopus 로고    scopus 로고
    • Roles of TLR2, TLR4, NOD2, and NOD1 in pulp fibroblasts
    • COI: 1:CAS:528:DC%2BD1MXhtlSjtLvP, PID: 19734466
    • Hirao K, Yumoto H, Takahashi K, Mukai K, Nakanishi T, Matsuo T (2009) Roles of TLR2, TLR4, NOD2, and NOD1 in pulp fibroblasts. J Dent Res 88:762–767
    • (2009) J Dent Res , vol.88 , pp. 762-767
    • Hirao, K.1    Yumoto, H.2    Takahashi, K.3    Mukai, K.4    Nakanishi, T.5    Matsuo, T.6
  • 18
    • 0022136309 scopus 로고
    • Predominant obligate anaerobes in human carious dentin
    • COI: 1:STN:280:DyaL2M3ptVagtg%3D%3D, PID: 3861648
    • Hoshino E (1985) Predominant obligate anaerobes in human carious dentin. J Dent Res 64:1195–1198
    • (1985) J Dent Res , vol.64 , pp. 1195-1198
    • Hoshino, E.1
  • 20
    • 34247118826 scopus 로고    scopus 로고
    • Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling
    • COI: 1:CAS:528:DC%2BD2sXltVKjsrY%3D, PID: 17433728
    • Kanneganti TD, Lamkanfi M, Kim YG, Chen G, Park JH, Franchi L, Vandenabeele P, Núñez G (2007) Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling. Immunity 26:433–443
    • (2007) Immunity , vol.26 , pp. 433-443
    • Kanneganti, T.D.1    Lamkanfi, M.2    Kim, Y.G.3    Chen, G.4    Park, J.H.5    Franchi, L.6    Vandenabeele, P.7    Núñez, G.8
  • 21
    • 79956300649 scopus 로고    scopus 로고
    • Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
    • COI: 1:CAS:528:DC%2BC3MXms12rs7w%3D, PID: 21616434
    • Kawai T, Akira S (2011) Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 34:637–650
    • (2011) Immunity , vol.34 , pp. 637-650
    • Kawai, T.1    Akira, S.2
  • 22
    • 39749084641 scopus 로고    scopus 로고
    • Active caspase-1 is a regulator of unconventional protein secretion
    • COI: 1:CAS:528:DC%2BD1cXjs1ait74%3D, PID: 18329368
    • Keller M, Ruegg A, Werner S, Beer HD (2008) Active caspase-1 is a regulator of unconventional protein secretion. Cell 132:818–831
    • (2008) Cell , vol.132 , pp. 818-831
    • Keller, M.1    Ruegg, A.2    Werner, S.3    Beer, H.D.4
  • 23
    • 33846946785 scopus 로고    scopus 로고
    • Irreversible but not reversible pulpitis is associated with up-regulation of tumour necrosis factor-alpha gene expression in human pulp
    • COI: 1:STN:280:DC%2BD2s7gvVGmsg%3D%3D, PID: 17305696
    • Kokkas AB, Goulas A, Varsamidis K, Mirtsou V, Tziafas D (2007) Irreversible but not reversible pulpitis is associated with up-regulation of tumour necrosis factor-alpha gene expression in human pulp. Int Endod J 40:198–203
    • (2007) Int Endod J , vol.40 , pp. 198-203
    • Kokkas, A.B.1    Goulas, A.2    Varsamidis, K.3    Mirtsou, V.4    Tziafas, D.5
  • 24
    • 34247574122 scopus 로고    scopus 로고
    • Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response
    • COI: 1:CAS:528:DC%2BD2sXkvVyqsLw%3D, PID: 17164409
    • Kummer JA, Broekhuizen R, Everett H, Agostini L, Kuijk L, Martinon F, van Bruggen R, Tschopp J (2007) Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response. J Histochem Cytochem 55:443–452
    • (2007) J Histochem Cytochem , vol.55 , pp. 443-452
    • Kummer, J.A.1    Broekhuizen, R.2    Everett, H.3    Agostini, L.4    Kuijk, L.5    Martinon, F.6    van Bruggen, R.7    Tschopp, J.8
  • 25
    • 33845890803 scopus 로고    scopus 로고
    • Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation
    • COI: 1:CAS:528:DC%2BD28XhtlChtL7M, PID: 17186029
    • Mariathasan S, Monack DM (2007) Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Nat Rev Immunol 7:31–40
    • (2007) Nat Rev Immunol , vol.7 , pp. 31-40
    • Mariathasan, S.1    Monack, D.M.2
  • 26
    • 0036246180 scopus 로고    scopus 로고
    • Quantitative microbiological study of human carious dentine by culture and real-time PCR: association of anaerobes with histopathological changes in chronic pulpitis
    • COI: 1:CAS:528:DC%2BD38Xkt1Kgs7g%3D, PID: 11980945
    • Martin FE, Nadkarni MA, Jacques NA, Hunter N (2002) Quantitative microbiological study of human carious dentine by culture and real-time PCR: association of anaerobes with histopathological changes in chronic pulpitis. J Clin Microbiol 40:1698–1704
    • (2002) J Clin Microbiol , vol.40 , pp. 1698-1704
    • Martin, F.E.1    Nadkarni, M.A.2    Jacques, N.A.3    Hunter, N.4
  • 27
    • 77749304032 scopus 로고    scopus 로고
    • Signaling by ROS drives inflammasome activation
    • COI: 1:CAS:528:DC%2BC3cXjtVWktbc%3D, PID: 20201014
    • Martinon F (2010) Signaling by ROS drives inflammasome activation. Eur J Immunol 40:616–619
    • (2010) Eur J Immunol , vol.40 , pp. 616-619
    • Martinon, F.1
  • 28
    • 79960746217 scopus 로고    scopus 로고
    • Roles of dental pulp fibroblasts in the recognition of bacterium-related factors and subsequent development of pulpitis
    • Nakanishi T, Takegawa D, Hirao K, Takahashi K, Yumoto H, Matsuo T (2011) Roles of dental pulp fibroblasts in the recognition of bacterium-related factors and subsequent development of pulpitis. Jpn Dent Sci Rev 47:161–166
    • (2011) Jpn Dent Sci Rev , vol.47 , pp. 161-166
    • Nakanishi, T.1    Takegawa, D.2    Hirao, K.3    Takahashi, K.4    Yumoto, H.5    Matsuo, T.6
  • 29
    • 33747191203 scopus 로고    scopus 로고
    • The Inflammasome: first line of the immune response to cell stress
    • COI: 1:CAS:528:DC%2BD28Xpt1aktbo%3D, PID: 16923387
    • Ogura Y, Sutterwala FS, Flavell RA (2006) The Inflammasome: first line of the immune response to cell stress. Cell 126:659–662
    • (2006) Cell , vol.126 , pp. 659-662
    • Ogura, Y.1    Sutterwala, F.S.2    Flavell, R.A.3
  • 30
    • 0034439008 scopus 로고    scopus 로고
    • The expression of MMP-8 in human odontoblasts and dental pulp cells is down-regulated by TGF-beta1
    • COI: 1:CAS:528:DC%2BD3cXhtVKhsb0%3D, PID: 10690664
    • Palosaari H, Wahlgren J, Larmas M, Ronka H, Sorsa T, Salo T, Tjäderhane L (2000) The expression of MMP-8 in human odontoblasts and dental pulp cells is down-regulated by TGF-beta1. J Dent Res 79:77–84
    • (2000) J Dent Res , vol.79 , pp. 77-84
    • Palosaari, H.1    Wahlgren, J.2    Larmas, M.3    Ronka, H.4    Sorsa, T.5    Salo, T.6    Tjäderhane, L.7
  • 31
    • 34548027736 scopus 로고    scopus 로고
    • Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
    • PID: 17599094
    • Pétrilli V, Papin S, Dostert C, Mayor A, Martinon F, Tschopp J (2007) Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ 14:1583–1589
    • (2007) Cell Death Differ , vol.14 , pp. 1583-1589
    • Pétrilli, V.1    Papin, S.2    Dostert, C.3    Mayor, A.4    Martinon, F.5    Tschopp, J.6
  • 32
    • 5144228220 scopus 로고    scopus 로고
    • The role of Toll-like receptors and Nod proteins in bacterial infection
    • COI: 1:CAS:528:DC%2BD2cXot1Omsrw%3D, PID: 15476921
    • Philpott DJ, Girardin SE (2004) The role of Toll-like receptors and Nod proteins in bacterial infection. Mol Immunol 41:1099–1108
    • (2004) Mol Immunol , vol.41 , pp. 1099-1108
    • Philpott, D.J.1    Girardin, S.E.2
  • 33
    • 0003654039 scopus 로고    scopus 로고
    • Host resistance to infection: genetic control of lipopolysaccharide responsiveness by TOLL-like receptor genes
    • COI: 1:CAS:528:DyaK1MXltVems78%3D, PID: 10431187
    • Qureshi ST, Gros P, Malo D (1999) Host resistance to infection: genetic control of lipopolysaccharide responsiveness by TOLL-like receptor genes. Trends Genet 15:291–294
    • (1999) Trends Genet , vol.15 , pp. 291-294
    • Qureshi, S.T.1    Gros, P.2    Malo, D.3
  • 34
    • 84858688293 scopus 로고    scopus 로고
    • Regulation of inflammasome signaling
    • COI: 1:CAS:528:DC%2BC38XktFShtLc%3D, PID: 22430786
    • Rathinam VAK, Vanaja SK, Fitzgerald KA (2012) Regulation of inflammasome signaling. Nat Immunol 13:333–332
    • (2012) Nat Immunol , vol.13 , pp. 332-333
    • Rathinam, V.A.K.1    Vanaja, S.K.2    Fitzgerald, K.A.3
  • 35
    • 81455139884 scopus 로고    scopus 로고
    • Role of the inflammasome, IL-1β, and IL-18 in bacterial infections
    • COI: 1:CAS:528:DC%2BC3MXhsFagsbzK
    • Sahoo M, Ceballos-Olvera I, del Barrio L, Re F (2011) Role of the inflammasome, IL-1β, and IL-18 in bacterial infections. Sci World J 11:2037–2050
    • (2011) Sci World J , vol.11 , pp. 2037-2050
    • Sahoo, M.1    Ceballos-Olvera, I.2    del Barrio, L.3    Re, F.4
  • 36
    • 77950362382 scopus 로고    scopus 로고
    • The inflammasomes
    • COI: 1:CAS:528:DC%2BC3cXlsVSgu78%3D, PID: 20303873
    • Schroder K, Tschopp J (2010) The inflammasomes. Cell 140:821–832
    • (2010) Cell , vol.140 , pp. 821-832
    • Schroder, K.1    Tschopp, J.2
  • 37
    • 84869088838 scopus 로고    scopus 로고
    • NLRP3 is expressed in human dental pulp cells and tissues
    • COI: 1:CAS:528:DC%2BC3sXmsFOhug%3D%3D, PID: 23146643
    • Song Z, Lin Z, He F, Jiang L, Qin W, Tian Y, Wang R, Huang S (2012) NLRP3 is expressed in human dental pulp cells and tissues. J Endod 38:1592–1597
    • (2012) J Endod , vol.38 , pp. 1592-1597
    • Song, Z.1    Lin, Z.2    He, F.3    Jiang, L.4    Qin, W.5    Tian, Y.6    Wang, R.7    Huang, S.8
  • 40
    • 45149092655 scopus 로고    scopus 로고
    • CCL20 production is induced in human dental pulp upon stimulation by Streptococcus mutans and proinflammatory cytokines
    • COI: 1:CAS:528:DC%2BD1cXptFSlsr0%3D, PID: 18582332
    • Takahashi K, Nakanishi T, Yumoto H, Adachi T, Matsuo T (2008) CCL20 production is induced in human dental pulp upon stimulation by Streptococcus mutans and proinflammatory cytokines. Oral Microbiol Immunol 23:320–327
    • (2008) Oral Microbiol Immunol , vol.23 , pp. 320-327
    • Takahashi, K.1    Nakanishi, T.2    Yumoto, H.3    Adachi, T.4    Matsuo, T.5
  • 45
    • 79957512273 scopus 로고    scopus 로고
    • Effects of leukemia inhibitory factor on proliferation and odontoblastic differentiation of human dental pulp cells
    • PID: 21787496
    • Zhou Y, Qian M, Liang Y, Liu Y, Yang X, Jiang T, Wang Y (2011) Effects of leukemia inhibitory factor on proliferation and odontoblastic differentiation of human dental pulp cells. J Endod 37:819–824
    • (2011) J Endod , vol.37 , pp. 819-824
    • Zhou, Y.1    Qian, M.2    Liang, Y.3    Liu, Y.4    Yang, X.5    Jiang, T.6    Wang, Y.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.