Cytomegalovirus-Specific IL-10-Producing CD4+T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence

PLoS Pathogens

Volumn 12, Issue 12, 2016, Pages

  Clement, Mathew ^a   Marsden, Morgan ^a   Stacey, Maria A ^a   Abdul Karim, Juneid ^a   Gimeno Brias, Silvia ^a   Costa Bento, Diana ^a   Scurr, Martin J ^a   Ghazal, Peter ^b   Weaver, Casey T ^c   Carlesso, Gianluca ^d   Clare, Simon ^e   Jones, Simon A ^a   Godkin, Andrew ^a   Jones, Gareth W ^a   Humphreys, Ian R ^a,e  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c University of Alabama at Birmingham   (United States)

^d MEDIMMUNE   (United States)

^e WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR3; GAMMA INTERFERON; INTERFERON; INTERLEUKIN 10; INTERLEUKIN 27; TETRAMER; TRANSCRIPTION FACTOR C MAF; TRANSCRIPTION FACTOR T BET;

ANIMAL CELL; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOMEGALOVIRUS; FLOW CYTOMETRY; HERPESVIRIDAE; IMMUNE RESPONSE; MOUSE; NONHUMAN; PERSISTENT VIRUS INFECTION; PHENOTYPE; PROTEIN EXPRESSION; TRANSCRIPTOMICS; VIRUS LOAD; ANIMAL; C57BL MOUSE; CYTOMEGALOVIRUS INFECTION; DISEASE MODEL; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DISEASE MODELS, ANIMAL; HUMANS; INTERFERON TYPE I; INTERLEUKIN-10; INTERLEUKIN-27; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT;

EID: 85007599850     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1006050     Document Type: Article

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