Design, synthesis, and biological evaluation of novel tetramethylpyrazine derivatives as potential neuroprotective agents

Chemical and Pharmaceutical Bulletin

Volumn 65, Issue 1, 2017, Pages 56-65

  Chen, Haiyun ^a   Tan, Guolian ^a   Cao, Jie ^a   Zhang, Gaoxiao ^a   Yi, Peng ^a   Yu, Pei ^a   Sun, Yewei ^a   Zhang, Zaijun ^a   Wang, Yuqiang ^a  

^a JINAN UNIVERSITY   (China)

Author keywords

Caffeic acid; Free radical; Neuroprotection; Nitrone; Permanent middle cerebral artery occlusion; Tetramethylpyrazine

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CAFFEIC ACID; CAFFEIC ACID DERIVATIVE; FREE RADICAL; GLYCOGEN SYNTHASE KINASE 3BETA; LACTATE DEHYDROGENASE; NEUROPROTECTIVE AGENT; NITRONE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; TERT BUTYL HYDROPEROXIDE; TETRAMETHYLPYRAZINE; PYRAZINE DERIVATIVE; SCAVENGER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN EDEMA; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; INJURY SEVERITY; MIDDLE CEREBRAL ARTERY OCCLUSION; MITOCHONDRIAL MEMBRANE POTENTIAL; NERVE CELL LESION; NEUROLOGIC DISEASE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PC12 CELL LINE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; ARTERIAL OCCLUSIVE DISEASES; CELL DEATH; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; NERVE CELL; PATHOLOGY; SYNTHESIS;

ANIMALS; APOPTOSIS; ARTERIAL OCCLUSIVE DISEASES; CELL DEATH; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; FREE RADICAL SCAVENGERS; MOLECULAR STRUCTURE; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PC12 CELLS; PYRAZINES; RATS; TERT-BUTYLHYDROPEROXIDE;

EID: 85007579765     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.c16-00699     Document Type: Article

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