Ligustrazine phosphate ethosomes for treatment of Alzheimer's disease, in vitro and in animal model studies

AAPS PharmSciTech

Volumn 13, Issue 2, 2012, Pages 485-492

  Shi, Jun ^a,b   Wang, Yiming ^b   Luo, Guoan ^a,b  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b TSINGHUA UNIVERSITY   (China)

Author keywords

Alzheimer's disease; ethosome; ligustrazine phosphate; scopolamine; transdermal delivery

Indexed keywords

ANTIOXIDANT; GLUTATHIONE; MALONALDEHYDE; SCOPOLAMINE; SUPEROXIDE DISMUTASE; TETRAMETHYLPYRAZINE;

ALZHEIMER DISEASE; AMNESIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN LEVEL; CARDIOVASCULAR DISEASE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG PENETRATION; DRUG STRUCTURE; IN VITRO STUDY; LIPID PEROXIDATION; MALE; MAZE TEST; NONHUMAN; PRIORITY JOURNAL; RAT;

ACRYLIC RESINS; ADMINISTRATION, CUTANEOUS; ALZHEIMER DISEASE; AMNESIA; ANIMALS; ANTIOXIDANTS; BEHAVIOR, ANIMAL; BRAIN; CHEMISTRY, PHARMACEUTICAL; DISEASE MODELS, ANIMAL; DRUG CARRIERS; ESCAPE REACTION; ETHANOL; GLUTATHIONE PEROXIDASE; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; MEMORY; MICE; MICE, INBRED ICR; MICE, NUDE; MICROSCOPY, CONFOCAL; PERMEABILITY; PHOSPHATIDYLCHOLINES; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; SCOPOLAMINE HYDROBROMIDE; SKIN; SKIN ABSORPTION; SUPEROXIDE DISMUTASE; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS;

EID: 84862887857     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-012-9767-6     Document Type: Article

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