Ligustrazine derivatives. Part 6: Design, synthesis and evaluation of novel ligustrazinyl acylguanidine derivatives as potential cardiovascular agents

Medicinal Chemistry

Volumn 8, Issue 5, 2012, Pages 928-933

  Li, Zhenyu ^a   Yu, Fang ^a   Cui, Lei ^b   Zhan, Peng ^a   Wang, Shouxun ^b   Shen, Yuemao ^a   Liu, Xinyong ^a  

^a SHANDONG UNIVERSITY   (China)

^b WEIFANG MEDICAL UNIVERSITY   (China)

Author keywords

Acylguanidines; Cardiovascular disease; Ligustrazine; Synthesis

Indexed keywords

3,5,6 TRIMETHYL N (N METHYLCARBAMIMIDOYL)PYRAZINE 2 CARBOXAMIDE; N [N (3 CHLOROBENZYL)CARBAMIMIDOYL] 3,5,6 TRIMETHYLPYRAZINE 2 CARBOXAMIDE; N [N (3,4 DICHLOROBENZYL)CARBAMIMIDOYL] 3,5,6 TRIMETHYLPYRAZINE 2 CARBOXAMIDE; TETRAMETHYLPYRAZINE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENDOTHELIUM INJURY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; VASCULAR ENDOTHELIUM;

ANTIOXIDANTS; CARDIOVASCULAR AGENTS; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; DRUG DESIGN; ENDOTHELIAL CELLS; GUANIDINES; HUMANS; INHIBITORY CONCENTRATION 50; PYRAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84865785179     PISSN: 15734064     EISSN: 18756638     Source Type: Journal    
DOI: 10.2174/157340612802084243     Document Type: Article

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