Tetramethylpyrazine inhibits CoCl2-induced neurotoxicity through enhancement of Nrf2/GCLc/GSH and suppression of HIF1α/NOX2/ROS pathways

Journal of Neurochemistry

Volumn 134, Issue 3, 2015, Pages 551-565

  Guan, Dongsheng ^a   Su, Yufei ^b   Li, Yingxia ^a   Wu, Chuanjie ^c   Meng, Yi ^a   Peng, Xin ^a   Cui, Yinglin ^a  

^a HENAN UNIVERSITY OF CHINESE MEDICINE   (China)

^b Emergency Department   (China)

^c THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

Author keywords

Cobalt chloride; GCLc; HIF1 ; Neurotoxicity; Nrf2; Tetramethylpyrazine

Indexed keywords

CASPASE 3; CASPASE 9; COBALT CHLORIDE; CYTOCHROME C; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SUPEROXIDE; TETRAMETHYLPYRAZINE; TRANSCRIPTION FACTOR NRF2; COBALT; CYBB PROTEIN, RAT; GCLC PROTEIN, RAT; HIF1A PROTEIN, RAT; MEMBRANE PROTEIN; NEUROPROTECTIVE AGENT; NFE2L2 PROTEIN, RAT; PYRAZINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BRAIN HYPOXIA; BRAIN MITOCHONDRION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME REGULATION; IN VITRO STUDY; IN VIVO STUDY; LATENT PERIOD; MALE; MEMORY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PC12 CELL LINE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; SPATIAL LEARNING; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; CELL HYPOXIA; CHROMATIN IMMUNOPRECIPITATION; DRUG EFFECTS; GENETIC TRANSFECTION; METABOLISM; WESTERN BLOTTING; WISTAR RAT;

LIGUSTICUM WALLICHII; RATTUS;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL HYPOXIA; CHROMATIN IMMUNOPRECIPITATION; COBALT; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; MEMBRANE GLYCOPROTEINS; NADPH OXIDASE; NEUROPROTECTIVE AGENTS; NF-E2-RELATED FACTOR 2; PC12 CELLS; PYRAZINES; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 84935519692     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.13161     Document Type: Article

References (34)

1. Badr G. A., Zhang J. Z., Tang J., Kern T. S., and, Ismail-Beigi F., (1999) Glut1 and glut3 expression, but not capillary density, is increased by cobalt chloride in rat cerebrum and retina. Brain Res. Mol. Brain Res. 64, 24-33.
2. Bai H., Zhang W., Qin X., Zhang T., Wu H., Liu J., and, Hai C. X., (2015) Hydrogen peroxide modulates the proliferation/quiescence switch in the liver during embryonic development and post-hepatectomy regeneration. Antioxid. Redox Signal. 22, 921-937.
3. Caltana L., Merelli A., Lazarowski A., and, Brusco A., (2009) Neuronal and glial alterations due to focal cortical hypoxia induced by direct cobalt chloride (CoCl2) brain injection. Neurotox. Res. 15, 348-358.
4. Caltana L., Rutolo D., Nieto M. L., and, Brusco A., (2014) Further evidence for the neuroprotective role of oleanolic acid in a model of focal brain hypoxia in rats. Neurochem. Int. 79, 79-87.
5. Cheng X. R., Zhang L., Hu J. J., Sun L., and, Du G. H., (2007) Neuroprotective effects of tetramethylpyrazine on hydrogen peroxide-induced apoptosis in PC12 cells. Cell Biol. Int. 31, 438-443.
6. Correia S. C., Carvalho C., Cardoso S., Santos R. X., Placido A. I., Candeias E., Duarte A. I., and, Moreira P. I., (2013) Defective HIF signaling pathway and brain response to hypoxia in neurodegenerative diseases: not an "iffy" question!. Curr. Pharm. Des. 19, 6809-6822.
7. Dai Y., Li W., Zhong M., Chen J., Liu Y., Cheng Q., and, Li T., (2014) Preconditioning and post-treatment with cobalt chloride in rat model of perinatal hypoxic-ischemic encephalopathy. Brain Dev. 36, 228-240.
8. Daulatzai M. A., (2013) Death by a thousand cuts in Alzheimer's disease: hypoxia-the prodrome. Neurotox. Res. 24, 216-243.
9. Dupuis L., (2014) Mitochondrial quality control in neurodegenerative diseases. Biochimie 100, 177-183.
10. Gan L., and, Johnson J. A., (2014) Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases. Biochim. Biophys. Acta, 1842, 1208-1218.
11. Ho W. K., Wen H. L., and, Lee C. M., (1989) Tetramethylpyrazine for treatment of experimentally induced stroke in Mongolian gerbils. Stroke 20, 96-99.
12. Huang J. B., Liu X. F., and, Chen S. Y., (1994) Effect of tetramethylpyrazine in inhibiting respiratory burst of polymorphonuclears and scavenging oxygen free radicals. Zhongguo Zhong Xi Yi Jie He Za Zhi 14, 607-609.
13. Huang L. E., Gu J., Schau M., and, Bunn H. F., (1998) Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc. Natl Acad. Sci. USA 95, 7892-7987.
14. Ivan M., Kondo K., Yang H., et al,. (2001) HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292, 464-468.
15. Jaakkola P., Mole D. R., Tian Y. M., et al,. (2001) Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292, 468-472.
16. Kao T. K., Chang C. Y., Ou Y. C., Chen W. Y., Kuan Y. H., Pan H. C., Liao S. L., Li G. Z., and, Chen C. J., (2013) Tetramethylpyrazine reduces cellular inflammatory response following permanent focal cerebral ischemia in rats. Exp. Neurol. 247, 188-201.
17. Lando D., Peet D. J., Whelan D. A., Gorman J. J., and, Whitelaw M. L., (2002) Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science 295, 858-861.
18. Luo X. X., Ogata H., Xu X., and, Ishitobi F., (1994) Protective effect of tetramethylpyrazine on ischemic neuronal damage in the gerbil hippocampus. No To Shinkei 46, 841-846.
19. Maiti P., Singh S. B., Muthuraju S., Veleri S., and, Ilavazhagan G., (2007) Hypobaric hypoxia damages the hippocampal pyramidal neurons in the rat brain. Brain Res. 1175, 1-9.
20. Massaad C. A., and, Klann E., (2011) Reactive oxygen species in the regulation of synaptic plasticity and memory. Antioxid. Redox Signal. 14, 2013-2054.
21. Mole D. R., and, Ratcliffe P. J., (2008) Cellular oxygen sensing in health and disease. Pediatr. Nephrol. 23, 681-694.
22. Nakanishi K., Tajima F., Nakamura A., Yagura S., Ookawara T., Yamashita H., Suzuki K., Taniguchi N., and, Ohno H., (1995) Effects of hypobaric hypoxia on antioxidant enzymes in rats. J. Physiol. 489 (Pt 3), 869-876.
23. Paulsen J. S., Nance M., Kim J. I., Carlozzi N. E., Panegyres P. K., Erwin C., Goh A., McCusker E., and, Williams J. K., (2013) A review of quality of life after predictive testing for and earlier identification of neurodegenerative diseases. Prog. Neurobiol. 110, 2-28.
24. Ramanathan L., Gozal D., and, Siegel J. M., (2005) Antioxidant responses to chronic hypoxia in the rat cerebellum and pons. J. Neurochem. 93, 47-52.
25. Semenza G. L., (2001) Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends Mol. Med. 7, 345-350.
26. Sharp F. R., and, Bernaudin M., (2004) HIF1 and oxygen sensing in the brain. Nat. Rev. Neurosci. 5, 437-648.
27. Shih Y. H., Wu S. L., Chiou W. F., Ku H. H., Ko T. L., and, Fu Y. S., (2002) Protective effects of tetramethylpyrazine on kainate-induced excitotoxicity in hippocampal culture. NeuroReport 13, 515-519.
28. Wang G. L. S. G., (1993) Characterization of hypoxiainducible factor 1 and regulation of DNA binding activity by hypoxia. J. Biol. Chem. 268, 21513-21518.
29. Wang G. L., Jiang B. H., Rue E. A., and, Semenza G. L., (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl Acad. Sci. USA 92, 5510-5514.
30. Wu W., Yu X., Luo X. P., Yang S. H., and, Zheng D., (2013) Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway. Behav. Brain Res. 253, 212-216.
31. Xiao X., Liu Y., Qi C., Qiu F., Chen X., Zhang J., and, Yang P., (2010) Neuroprotection and enhanced neurogenesis by tetramethylpyrazine in adult rat brain after focal ischemia. Neurol. Res. 32, 547-555.
32. Yang W. W., Shu B., Zhu Y., and, Yang H. T., (2008) E2F6 inhibits cobalt chloride-mimetichypoxia-induced apoptosis through E2F1. Mol. Biol. Cell 19, 3691-3700.
33. Yuan X., Guo X., Deng Y., Zhu D., Shang J., and, Liu H., (2015) Chronic intermittent hypoxia-induced neuronal apoptosis in the hippocampus is attenuated by telmisartan through suppression of iNOS/NO and inhibition of lipid peroxidation and inflammatory responses. Brain Res. 1596, 48-57.
34. Zhang C., Teng F., Tu J., and, Zhang D., (2014) Ultrasound-enhanced protective effect of tetramethylpyrazine against cerebral ischemia/reperfusion injury. PLoS ONE 9, e113673.