Design, synthesis, and biological activities of novel Ligustrazine derivatives

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 10, 2007, Pages 3315-3320

  Cheng, Xian Chao ^a   Liu, Xin Yong ^a   Xu, Wen Fang ^a   Guo, Xiu Li ^a   Ou, Yang ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Cerebrocardiac vascular activity; Ligustrazine; Ligustrazine derivatives; Synthesis

Indexed keywords

2 (4 BIPHENYLMETHYL 1 PIPERAZINEMETHYL) 3,5,6 TRIMETHYLPYRAZINE; 2 [4 (4 CHLOROPHENYL)PHENYLMETHYL 1 PIPERAZINEMETHYL] 3,5,6 TRIMETHYLPYRAZINE; 2 [4 (4,4' DIFLUORO)BIPHENYLMETHYL 1 PIPERAZINEMETHYL] 3,5,6 TRIMETHYLPYRAZINE; ANTITHROMBOCYTIC AGENT; HYDROGEN PEROXIDE; TETRAMETHYLPYRAZINE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CELL DAMAGE; CELL LINE; CHINESE MEDICINE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION;

ANIMALS; BLOOD PLATELETS; CELL LINE; CHROMATOGRAPHY, THIN LAYER; DRUG DESIGN; ENDOTHELIAL CELLS; HUMANS; HYDROGEN PEROXIDE; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; OXIDANTS; PLATELET AGGREGATION INHIBITORS; PYRAZINES; RABBITS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, INFRARED; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 34047112327     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.03.033     Document Type: Article

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