Novel multi-functional nitrones for treatment of ischemic stroke

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 12, 2012, Pages 3939-3945

  Sun, Yewei ^a   Zhang, Gaoxiao ^a   Zhang, Zaijun ^a   Yu, Pei ^a   Zhong, Haijing ^a   Du, Jing ^a   Wang, Yuqiang ^a  

^a JINAN UNIVERSITY   (China)

Author keywords

Antioxidant; Antiplatelet aggregant; Chemical synthesis; Ischemic stroke; Middle cerebral artery occlusion

Indexed keywords

2 [(1,1 DIMETHYLETHYL)OXIDOIMINO]METHYLQUINOXALINE; 2 [[(1,1 DIMETHYLETHYL)OXIDOIMINO]METHYL] 3 ETHYLPYRAZINE; 2 [[(1,1 DIMETHYLETHYL)OXIDOIMINO]METHYL] 3 PROPYLPYRAZINE; 2 METHYL N,N BIS[(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHYL]PROPAN 2 AMINE; 2,5 [[(1,1 DIMETHYLETHYL)OXIDOIMINO]METHYL] 3,6 TRIMETHYLPYRAZINE; 5 [(1,1 DIMETHYLETHYL)OXIDOIMINO]METHYLQUINOXALINE; ACETYLSALICYLIC ACID; NITRONE DERIVATIVE; TETRAMETHYLPYRAZINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICOAGULATION; ANTIOXIDANT ACTIVITY; BRAIN DAMAGE; BRAIN ISCHEMIA; CONFERENCE PAPER; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; NEUROPROTECTION; NONHUMAN; RAT; THROMBOCYTE AGGREGATION INHIBITION;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; FREE RADICAL SCAVENGERS; MALE; MOLECULAR STRUCTURE; NEURONS; NEUROPROTECTIVE AGENTS; NITROGEN OXIDES; PLATELET AGGREGATION; RATS; RATS, SPRAGUE-DAWLEY; STROKE; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 84861580039     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.04.016     Document Type: Conference Paper

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