CD8+T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature

PLoS Pathogens

Volumn 12, Issue 12, 2016, Pages

  Swanson, Phillip A ^a   Hart, Geoffrey T ^b   Russo, Matthew V ^a   Nayak, Debasis ^c   Yazew, Takele ^b   Peña, Mirna ^b   Khan, Shahid M ^d   Janse, Chris J ^d   Pierce, Susan K ^b   McGavern, Dorian B ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c INDIAN INSTITUTE OF TECHNOLOGY INDORE   (India)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; CD45 ANTIGEN; GAMMA INTERFERON; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; TIGHT JUNCTION PROTEIN; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN 4;

ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BONE MARROW; BRAIN BLOOD VESSEL; BRAIN HERNIA; BRAIN STEM; BRAIN WATER; CAUSE OF DEATH; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CEREBRAL MALARIA; CONTROLLED STUDY; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; INNATE IMMUNITY; MOUSE; NERVE CELL NECROSIS; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; SURVIVAL RATE; ANIMAL; BLOOD VESSEL; DISEASE MODEL; IMMUNOLOGY; PATHOLOGY; PLASMODIUM BERGHEI; TRANSGENIC MOUSE;

ANIMALS; BLOOD VESSELS; BLOOD-BRAIN BARRIER; BRAIN STEM; CD8-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; MALARIA, CEREBRAL; MICE; MICE, TRANSGENIC; PLASMODIUM BERGHEI;

EID: 85007579359     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1006022     Document Type: Article

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