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Volumn 47, Issue 2, 2017, Pages 327-344

Human B-cell memory is shaped by age- and tissue-specific T-independent and GC-dependent events

Author keywords

Antibodies; B cell development; B cells; Immunoglobulins; Innate immunity

Indexed keywords

IMMUNOGLOBULIN M; INTERLEUKIN 2 RECEPTOR GAMMA; JANUS KINASE 3; RNA;

EID: 85007247376     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201646642     Document Type: Article
Times cited : (48)

References (70)
  • 1
    • 0242495755 scopus 로고    scopus 로고
    • Cutting edge: long-term B cell memory in humans after smallpox vaccination
    • Crotty, S., Felgner, P., Davies, H., Glidewell, J., Villarreal, L. and Ahmed, R., Cutting edge: long-term B cell memory in humans after smallpox vaccination. J. Immunol. 2003. 171: 4969–4973.
    • (2003) J. Immunol. , vol.171 , pp. 4969-4973
    • Crotty, S.1    Felgner, P.2    Davies, H.3    Glidewell, J.4    Villarreal, L.5    Ahmed, R.6
  • 3
    • 77955964086 scopus 로고    scopus 로고
    • AID and somatic hypermutation
    • Maul, R. W. and Gearhart, P. J., AID and somatic hypermutation. Adv. Immunol. 2010. 105: 159–191.
    • (2010) Adv. Immunol. , vol.105 , pp. 159-191
    • Maul, R.W.1    Gearhart, P.J.2
  • 4
    • 39749195560 scopus 로고    scopus 로고
    • Evolution in miniature: selection, survival and distribution of antigen reactive cells in the germinal centre
    • Tarlinton, D. M., Evolution in miniature: selection, survival and distribution of antigen reactive cells in the germinal centre. Immunol. Cell Biol. 2008. 86: 133–138.
    • (2008) Immunol. Cell Biol. , vol.86 , pp. 133-138
    • Tarlinton, D.M.1
  • 5
    • 1842405428 scopus 로고    scopus 로고
    • Evidence for a large compartment of IgM-expressing memory B cells in humans
    • Klein, U., Küppers, R. and Rajewsky, K., Evidence for a large compartment of IgM-expressing memory B cells in humans. Blood 1997. 89: 1288–1298.
    • (1997) Blood , vol.89 , pp. 1288-1298
    • Klein, U.1    Küppers, R.2    Rajewsky, K.3
  • 6
    • 0032476611 scopus 로고    scopus 로고
    • Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells
    • Klein, U., Rajewsky, K. and Küppers, R., Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J. Exp. Med. 1998. 188: 1679–1689.
    • (1998) J. Exp. Med. , vol.188 , pp. 1679-1689
    • Klein, U.1    Rajewsky, K.2    Küppers, R.3
  • 8
    • 84865155904 scopus 로고    scopus 로고
    • Does DNA repair occur during somatic hypermutation?
    • Saribasak, H. and Gearhart, P. J., Does DNA repair occur during somatic hypermutation? Semin. Immunol. 2012. 24: 287–292.
    • (2012) Semin. Immunol. , vol.24 , pp. 287-292
    • Saribasak, H.1    Gearhart, P.J.2
  • 9
    • 84862865669 scopus 로고    scopus 로고
    • Immunoglobulin class-switch DNA recombination: induction, targeting and beyond
    • Xu, Z., Zan, H., Pone, E. J., Mai, T. and Casali, P., Immunoglobulin class-switch DNA recombination: induction, targeting and beyond. Nat. Rev. Immunol. 2012. 12: 517–531.
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 517-531
    • Xu, Z.1    Zan, H.2    Pone, E.J.3    Mai, T.4    Casali, P.5
  • 10
    • 0027932998 scopus 로고
    • The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement
    • Chang, B. and Casali, P., The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement. Immunol. Today. 1994. 15: 367–373.
    • (1994) Immunol. Today. , vol.15 , pp. 367-373
    • Chang, B.1    Casali, P.2
  • 11
    • 0942290440 scopus 로고    scopus 로고
    • Peripheral development of B cells in mouse and man
    • Carsetti, R., Rosado, M. M. and Wardmann, H., Peripheral development of B cells in mouse and man. Immunol. Rev. 2004. 197: 179–191.
    • (2004) Immunol. Rev. , vol.197 , pp. 179-191
    • Carsetti, R.1    Rosado, M.M.2    Wardmann, H.3
  • 12
    • 77956551877 scopus 로고    scopus 로고
    • High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populations
    • Wu, Y. C., Kipling, D., Leong, H. S., Martin, V., Ademokun, A. A. and Dunn-Walters, D. K., High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populations. Blood 2010. 116: 1070–1078.
    • (2010) Blood , vol.116 , pp. 1070-1078
    • Wu, Y.C.1    Kipling, D.2    Leong, H.S.3    Martin, V.4    Ademokun, A.A.5    Dunn-Walters, D.K.6
  • 13
    • 0030786425 scopus 로고    scopus 로고
    • B cell subpopulations separated by CD27 and crucial collaboration of CD27 + B cells and helper T cells in immunoglobulin production
    • Agematsu, K., Nagumo, H., Yang, F. C., Nakazawa, T., Fukushima, K., Ito, S., Sugita, K. et al., B cell subpopulations separated by CD27 and crucial collaboration of CD27 + B cells and helper T cells in immunoglobulin production. Eur. J. Immunol. 1997. 27: 2073–2079.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 2073-2079
    • Agematsu, K.1    Nagumo, H.2    Yang, F.C.3    Nakazawa, T.4    Fukushima, K.5    Ito, S.6    Sugita, K.7
  • 14
    • 34250883267 scopus 로고    scopus 로고
    • Human IgM+CD27+ B cells: memory B cells or ‘memory’ B cells?
    • Tangye, S. G. and Good, K. L., Human IgM+CD27+ B cells: memory B cells or ‘memory’ B cells? J. Immunol. 2007. 179: 13–19.
    • (2007) J. Immunol. , vol.179 , pp. 13-19
    • Tangye, S.G.1    Good, K.L.2
  • 15
    • 84896906323 scopus 로고    scopus 로고
    • Clonal and cellular dynamics in germinal centers
    • Victora, G. D. and Mesin, L., Clonal and cellular dynamics in germinal centers. Curr. Opin. Immunol. 2014. 28: 90–96.
    • (2014) Curr. Opin. Immunol. , vol.28 , pp. 90-96
    • Victora, G.D.1    Mesin, L.2
  • 16
    • 73349114344 scopus 로고    scopus 로고
    • Molecular footprints of a germinal center derivation of human IgM+(IgD+)CD27+ B cells and the dynamics of memory B cell generation
    • Seifert, M. and Kuppers, R., Molecular footprints of a germinal center derivation of human IgM+(IgD+)CD27+ B cells and the dynamics of memory B cell generation. J. Exp. Med. 2009. 206: 2659–2669.
    • (2009) J. Exp. Med. , vol.206 , pp. 2659-2669
    • Seifert, M.1    Kuppers, R.2
  • 17
    • 4043164158 scopus 로고    scopus 로고
    • Human blood IgM ‘memory’ B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire
    • Weller, S., Braun, M. C., Tan, B. K., Rosenwald, A., Cordier, C., Conley, M. E., Plebani, A. et al., Human blood IgM ‘memory’ B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire. Blood 2004. 104: 3647–3654.
    • (2004) Blood , vol.104 , pp. 3647-3654
    • Weller, S.1    Braun, M.C.2    Tan, B.K.3    Rosenwald, A.4    Cordier, C.5    Conley, M.E.6    Plebani, A.7
  • 19
    • 0345269199 scopus 로고    scopus 로고
    • Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen
    • Kruetzmann, S., Rosado, M. M., Weber, H., Germing, U., Tournilhac, O., Peter, H.-H., Berner, R. et al., Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen. J. Exp. Med. 2003. 197: 939–945.
    • (2003) J. Exp. Med. , vol.197 , pp. 939-945
    • Kruetzmann, S.1    Rosado, M.M.2    Weber, H.3    Germing, U.4    Tournilhac, O.5    Peter, H.-H.6    Berner, R.7
  • 20
    • 0942268727 scopus 로고    scopus 로고
    • Development and selection of marginal zone B cells
    • Lopes-Carvalho, T. and Kearney, J. F., Development and selection of marginal zone B cells. Immunol. Rev. 2004. 197: 192–205.
    • (2004) Immunol. Rev. , vol.197 , pp. 192-205
    • Lopes-Carvalho, T.1    Kearney, J.F.2
  • 21
    • 40449137383 scopus 로고    scopus 로고
    • CpG drives human transitional B cells to terminal differentiation and production of natural antibodies
    • Capolunghi, F., Cascioli, S., Giorda, E., Rosado, M. M., Plebani, A., Auriti, C., Seganti, G. et al., CpG drives human transitional B cells to terminal differentiation and production of natural antibodies. J. Immunol. 2008. 180: 800–808.
    • (2008) J. Immunol. , vol.180 , pp. 800-808
    • Capolunghi, F.1    Cascioli, S.2    Giorda, E.3    Rosado, M.M.4    Plebani, A.5    Auriti, C.6    Seganti, G.7
  • 23
    • 84899737512 scopus 로고    scopus 로고
    • Identification of a human splenic marginal zone B cell precursor with NOTCH2-dependent differentiation properties
    • Descatoire, M., Weller, S., Irtan, S., Sarnacki, S., Feuillard, J., Storck, S., Guiochon-Mantel, A. et al., Identification of a human splenic marginal zone B cell precursor with NOTCH2-dependent differentiation properties. J. Exp. Med. 2014. 211: 987–1000.
    • (2014) J. Exp. Med. , vol.211 , pp. 987-1000
    • Descatoire, M.1    Weller, S.2    Irtan, S.3    Sarnacki, S.4    Feuillard, J.5    Storck, S.6    Guiochon-Mantel, A.7
  • 27
    • 78650660388 scopus 로고    scopus 로고
    • TLR ligation triggers somatic hypermutation in transitional B cells inducing the generation of IgM memory B cells
    • Aranburu, A., Ceccarelli, S., Giorda, E., Lasorella, R., Ballatore, G. and Carsetti, R., TLR ligation triggers somatic hypermutation in transitional B cells inducing the generation of IgM memory B cells. J. Immunol. 2010. 185: 7293–7301.
    • (2010) J. Immunol. , vol.185 , pp. 7293-7301
    • Aranburu, A.1    Ceccarelli, S.2    Giorda, E.3    Lasorella, R.4    Ballatore, G.5    Carsetti, R.6
  • 28
    • 80052171651 scopus 로고    scopus 로고
    • Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways
    • Berkowska, M. A., Driessen, G. J. A., Bikos, V., Grosserichter-Wagener, C., Stamatopoulos, K., Cerutti, A., He, B. et al., Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways. Blood 2011. 118: 2150–2158.
    • (2011) Blood , vol.118 , pp. 2150-2158
    • Berkowska, M.A.1    Driessen, G.J.A.2    Bikos, V.3    Grosserichter-Wagener, C.4    Stamatopoulos, K.5    Cerutti, A.6    He, B.7
  • 29
    • 0033711628 scopus 로고    scopus 로고
    • Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities
    • Xu, J. L. and Davis, M. M., Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities. Immunity 2000. 13: 37–45.
    • (2000) Immunity , vol.13 , pp. 37-45
    • Xu, J.L.1    Davis, M.M.2
  • 30
    • 7444256675 scopus 로고    scopus 로고
    • The evolutionary and structural ‘logic’ of antigen receptor diversity
    • Davis, M. M., The evolutionary and structural ‘logic’ of antigen receptor diversity. Semin. Immunol. 2004. 16: 239–243.
    • (2004) Semin. Immunol. , vol.16 , pp. 239-243
    • Davis, M.M.1
  • 31
    • 79959971539 scopus 로고    scopus 로고
    • Post-splenectomy and hyposplenic states
    • Di Sabatino, A., Carsetti, R. and Corazza, G. R., Post-splenectomy and hyposplenic states. Lancet 2011. 378: 86–97.
    • (2011) Lancet , vol.378 , pp. 86-97
    • Di Sabatino, A.1    Carsetti, R.2    Corazza, G.R.3
  • 32
    • 47149099174 scopus 로고    scopus 로고
    • The human spleen is a major reservoir for long-lived vaccinia virus-specific memory B cells
    • Mamani-Matsuda, M., Cosma, A., Weller, S., Faili, A., Staib, C., Gar??on, L., Hermine, O. et al., The human spleen is a major reservoir for long-lived vaccinia virus-specific memory B cells. Blood 2008. 111: 4653–4659.
    • (2008) Blood , vol.111 , pp. 4653-4659
    • Mamani-Matsuda, M.1    Cosma, A.2    Weller, S.3    Faili, A.4    Staib, C.5    Garon, L.6    Hermine, O.7
  • 33
    • 0029127069 scopus 로고
    • Analysis of mutations in immunoglobulin heavy chain variable region genes of microdissected marginal zone (MGZ) B cells suggests that the MGZ of human spleen is a reservoir of memory B cells
    • Dunn-Walters, D. K., Isaacson, P. G. and Spencer, J., Analysis of mutations in immunoglobulin heavy chain variable region genes of microdissected marginal zone (MGZ) B cells suggests that the MGZ of human spleen is a reservoir of memory B cells. J. Exp. Med. 1995. 182: 559–66.
    • (1995) J. Exp. Med. , vol.182 , pp. 559-566
    • Dunn-Walters, D.K.1    Isaacson, P.G.2    Spencer, J.3
  • 34
    • 0032476617 scopus 로고    scopus 로고
    • Identification of functional human splenic memory B cells by expression of CD148 and CD27
    • Tangye, S. G., Liu, Y. J., Aversa, G., Phillips, J. H. and de Vries, J. E., Identification of functional human splenic memory B cells by expression of CD148 and CD27. J Exp Med. 1998. 188: 1691–1703.
    • (1998) J Exp Med. , vol.188 , pp. 1691-1703
    • Tangye, S.G.1    Liu, Y.J.2    Aversa, G.3    Phillips, J.H.4    de Vries, J.E.5
  • 35
    • 84885733691 scopus 로고    scopus 로고
    • Preserved antibody levels and loss of memory B cells against pneumococcus and tetanus after splenectomy: tailoring better vaccination strategies
    • Rosado, M. M., Gesualdo, F., Marcellini, V., Di Sabatino, A., Corazza, G. R., Smacchia, M. P., Nobili, B. et al., Preserved antibody levels and loss of memory B cells against pneumococcus and tetanus after splenectomy: tailoring better vaccination strategies. Eur. J. Immunol. 2013. 43: 2659–2670.
    • (2013) Eur. J. Immunol. , vol.43 , pp. 2659-2670
    • Rosado, M.M.1    Gesualdo, F.2    Marcellini, V.3    Di Sabatino, A.4    Corazza, G.R.5    Smacchia, M.P.6    Nobili, B.7
  • 36
    • 84866033654 scopus 로고    scopus 로고
    • Innate immune functions of macrophage subpopulations in the spleen
    • Den Haan, J. M. M. and Kraal, G., Innate immune functions of macrophage subpopulations in the spleen. J. Innate Immun. 2012. 4: 437–445.
    • (2012) J. Innate Immun. , vol.4 , pp. 437-445
    • Den Haan, J.M.M.1    Kraal, G.2
  • 37
    • 84908080466 scopus 로고    scopus 로고
    • Defects in laterality with emphasis on heterotaxy syndromes with asplenia and polysplenia: an autopsy case series at a single institution
    • Burton, E. C., Olson, M. and Rooper, L., Defects in laterality with emphasis on heterotaxy syndromes with asplenia and polysplenia: an autopsy case series at a single institution. Pediatr. Dev. Pathol. 2014. 17: 250–264.
    • (2014) Pediatr. Dev. Pathol. , vol.17 , pp. 250-264
    • Burton, E.C.1    Olson, M.2    Rooper, L.3
  • 38
    • 0035752146 scopus 로고    scopus 로고
    • Cytokines and immunodeficiency diseases
    • Leonard, W. J., Cytokines and immunodeficiency diseases. Nat. Rev. Immunol. 2001. 1: 200–208.
    • (2001) Nat. Rev. Immunol. , vol.1 , pp. 200-208
    • Leonard, W.J.1
  • 39
    • 0029164841 scopus 로고
    • Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)
    • Macchi, P., Villa, A., Giliani, S., Sacco, M. G., Frattini, A., Porta, F., Ugazio, A. G. et al., Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature 1995. 377: 65–68.
    • (1995) Nature , vol.377 , pp. 65-68
    • Macchi, P.1    Villa, A.2    Giliani, S.3    Sacco, M.G.4    Frattini, A.5    Porta, F.6    Ugazio, A.G.7
  • 40
    • 2542461255 scopus 로고    scopus 로고
    • Molecular defects in human severe combined immunodeficiency and approaches to immune reconstitution
    • Buckley, R. H., Molecular defects in human severe combined immunodeficiency and approaches to immune reconstitution. Annu. Rev. Immunol. 2004. 22: 625–655.
    • (2004) Annu. Rev. Immunol. , vol.22 , pp. 625-655
    • Buckley, R.H.1
  • 41
    • 1542343959 scopus 로고    scopus 로고
    • Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation
    • Roberts, J. L., Lengi, A., Brown, S. M., Chen, M., Zhou, Y. J., O'Shea, J. J. and Buckley, R. H., Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation. Blood 2004. 103: 2009–2018.
    • (2004) Blood , vol.103 , pp. 2009-2018
    • Roberts, J.L.1    Lengi, A.2    Brown, S.M.3    Chen, M.4    Zhou, Y.J.5    O'Shea, J.J.6    Buckley, R.H.7
  • 42
    • 9644295710 scopus 로고    scopus 로고
    • Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways
    • Kovanen, P. E. and Leonard, W. J., Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways. Immunol. Rev. 2004. 202: 67–83.
    • (2004) Immunol. Rev. , vol.202 , pp. 67-83
    • Kovanen, P.E.1    Leonard, W.J.2
  • 44
    • 84255197284 scopus 로고    scopus 로고
    • IL-21 is the primary common?? chain-binding cytokine required for human B-cell differentiation in vivo
    • Recher, M., Berglund, L. J., Avery, D. T., Cowan, M. J., Gennery, A. R., Smart, J., Peake, J. et al., IL-21 is the primary common?? chain-binding cytokine required for human B-cell differentiation in vivo. Blood 2011. 118: 6824–6835.
    • (2011) Blood , vol.118 , pp. 6824-6835
    • Recher, M.1    Berglund, L.J.2    Avery, D.T.3    Cowan, M.J.4    Gennery, A.R.5    Smart, J.6    Peake, J.7
  • 45
    • 0031688707 scopus 로고    scopus 로고
    • Somatic hypermutation of human immunoglobulin heavy chain genes: targeting of RGYW motifs on both DNA strands
    • Dörner, T., Foster, S. J., Farner, N. L. and Lipsky, P. E., Somatic hypermutation of human immunoglobulin heavy chain genes: targeting of RGYW motifs on both DNA strands. Eur. J. Immunol. 1998. 28: 3384–3396.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 3384-3396
    • Dörner, T.1    Foster, S.J.2    Farner, N.L.3    Lipsky, P.E.4
  • 46
    • 0036318945 scopus 로고    scopus 로고
    • Age- and tissue-specific differences in human germinal center B cell selection revealed by analysis of IgVH gene hypermutation and lineage trees
    • Banerjee, M., Mehr, R., Belelovsky, A., Spencer, J. and Dunn-Walters, D. K., Age- and tissue-specific differences in human germinal center B cell selection revealed by analysis of IgVH gene hypermutation and lineage trees. Eur. J. Immunol. 2002. 32: 1947–1957.
    • (2002) Eur. J. Immunol. , vol.32 , pp. 1947-1957
    • Banerjee, M.1    Mehr, R.2    Belelovsky, A.3    Spencer, J.4    Dunn-Walters, D.K.5
  • 47
    • 84875759341 scopus 로고    scopus 로고
    • Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization
    • Klein, F., Diskin, R., Scheid, J. F., Gaebler, C., Mouquet, H., Georgiev, I. S., Pancera, M. et al., Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization. Cell 2013. 153: 126–138.
    • (2013) Cell , vol.153 , pp. 126-138
    • Klein, F.1    Diskin, R.2    Scheid, J.F.3    Gaebler, C.4    Mouquet, H.5    Georgiev, I.S.6    Pancera, M.7
  • 48
    • 84883755842 scopus 로고    scopus 로고
    • Secondary mechanisms of diversification in the human antibody repertoire
    • Briney, B. S. and Crowe, J. E., Secondary mechanisms of diversification in the human antibody repertoire. Front. Immunol. 2013. 4. DOI: 10.3389/fimmu.2013.00042.
    • (2013) Front. Immunol. , vol.4
    • Briney, B.S.1    Crowe, J.E.2
  • 49
    • 84876909725 scopus 로고    scopus 로고
    • Human germline antibody gene segments encode polyspecific antibodies
    • Willis, J. R., Briney, B. S., DeLuca, S. L., Crowe, J. E. and Meiler, J., Human germline antibody gene segments encode polyspecific antibodies. PLoS Comput. Biol. 2013. 9. DOI: 10.1371/journal.pcbi.1003045.
    • (2013) PLoS Comput. Biol. , vol.9
    • Willis, J.R.1    Briney, B.S.2    DeLuca, S.L.3    Crowe, J.E.4    Meiler, J.5
  • 50
    • 58049198443 scopus 로고    scopus 로고
    • Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells
    • Throsby, M., van den Brink, E., Jongeneelen, M., Poon, L. L. M., Alard, P., Cornelissen, L., Bakker, A. et al., Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells. PLoS One 2008. 3. DOI: 10.1371/journal.pone.0003942.
    • (2008) PLoS One , vol.3
    • Throsby, M.1    van den Brink, E.2    Jongeneelen, M.3    Poon, L.L.M.4    Alard, P.5    Cornelissen, L.6    Bakker, A.7
  • 54
    • 65549160139 scopus 로고    scopus 로고
    • Analysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targeting
    • Longo, N. S., Lugar, P. L., Yavuz, S., Zhang, W., Krijger, P. H. L., Russ, D. E., Jima, D. D. et al., Analysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targeting. Blood 2009. 113: 3706–3715.
    • (2009) Blood , vol.113 , pp. 3706-3715
    • Longo, N.S.1    Lugar, P.L.2    Yavuz, S.3    Zhang, W.4    Krijger, P.H.L.5    Russ, D.E.6    Jima, D.D.7
  • 55
    • 27644513686 scopus 로고    scopus 로고
    • Splenic marginal zone B cells in humans: where do they mutate their Ig receptor?
    • Weller, S., Reynaud, C.-A. and Weill, J.-C., Splenic marginal zone B cells in humans: where do they mutate their Ig receptor? Eur. J. Immunol. 2005. 35: 2789–2792.
    • (2005) Eur. J. Immunol. , vol.35 , pp. 2789-2792
    • Weller, S.1    Reynaud, C.-A.2    Weill, J.-C.3
  • 56
    • 0027788044 scopus 로고
    • Structure of the VH and VL segments of polyreactive and monoreactive human natural antibodies to HIV-1 and Escherichia coli beta-galactosidase
    • Harindranath, N., Ikematsu, H., Notkins, A. L. and Casali, P., Structure of the VH and VL segments of polyreactive and monoreactive human natural antibodies to HIV-1 and Escherichia coli beta-galactosidase. Int. Immunol. 1993. 5: 1523–1533.
    • (1993) Int. Immunol. , vol.5 , pp. 1523-1533
    • Harindranath, N.1    Ikematsu, H.2    Notkins, A.L.3    Casali, P.4
  • 58
    • 79957544147 scopus 로고    scopus 로고
    • Switched memory B cells maintain specific memory independently of serum antibodies: the hepatitis B example
    • Rosado, M. M., Scarsella, M., Pandolfi, E., Cascioli, S., Giorda, E., Chionne, P., Madonne, E. et al., Switched memory B cells maintain specific memory independently of serum antibodies: the hepatitis B example. Eur. J. Immunol. 2011. 41: 1800–1808.
    • (2011) Eur. J. Immunol. , vol.41 , pp. 1800-1808
    • Rosado, M.M.1    Scarsella, M.2    Pandolfi, E.3    Cascioli, S.4    Giorda, E.5    Chionne, P.6    Madonne, E.7
  • 63
    • 79952282195 scopus 로고    scopus 로고
    • Different B cell populations mediate early and late memory during an endogenous immune response
    • Pape, K. A., Taylor, J. J., Maul, R. W., Gearhart, P. J. and Jenkins, M. K., Different B cell populations mediate early and late memory during an endogenous immune response. Science 2011. 331: 1203–1207.
    • (2011) Science , vol.331 , pp. 1203-1207
    • Pape, K.A.1    Taylor, J.J.2    Maul, R.W.3    Gearhart, P.J.4    Jenkins, M.K.5
  • 65
    • 84870276111 scopus 로고    scopus 로고
    • Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory
    • Kaji, T., Ishige, A., Hikida, M., Taka, J., Hijikata, A., Kubo, M., Nagashima, T. et al., Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory. J. Exp. Med. 2012. 209: 2079–2097.
    • (2012) J. Exp. Med. , vol.209 , pp. 2079-2097
    • Kaji, T.1    Ishige, A.2    Hikida, M.3    Taka, J.4    Hijikata, A.5    Kubo, M.6    Nagashima, T.7
  • 66
  • 67
    • 84903304241 scopus 로고    scopus 로고
    • Improving access to vaccines through tiered pricing
    • Berkley, S., Improving access to vaccines through tiered pricing. Lancet 2014. 383: 2265–2267.
    • (2014) Lancet , vol.383 , pp. 2265-2267
    • Berkley, S.1
  • 68
    • 84913600066 scopus 로고    scopus 로고
    • Re-evaluation of the immunological big bang
    • Flajnik, M. F., Re-evaluation of the immunological big bang. Curr. Biol. 2014. 24: R1060–R1065.
    • (2014) Curr. Biol. , vol.24 , pp. R1060-R1065
    • Flajnik, M.F.1
  • 70
    • 53649106195 scopus 로고    scopus 로고
    • Next-generation DNA sequencing
    • Shendure, J. and Ji, H., Next-generation DNA sequencing. Nat. Biotechnol. 2008. 26: 1135–1145.
    • (2008) Nat. Biotechnol. , vol.26 , pp. 1135-1145
    • Shendure, J.1    Ji, H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.