TLR ligation triggers somatic hypermutation in transitional B cells inducing the generation of IgM memory B cells

Journal of Immunology

Volumn 185, Issue 12, 2010, Pages 7293-7301

  Aranburu, Alaitz ^a   Ceccarelli, Sara ^a   Giorda, Ezio ^a   Lasorella, Rosa ^b   Ballatore, Giovanna ^b   Carsetti, Rita ^a  

^a BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^b S EUGENIO HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; CPG OLIGODEOXYNUCLEOTIDE; IMMUNOGLOBULIN M; TOLL LIKE RECEPTOR;

ARTICLE; BLOOD; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; CPG ISLAND; GENE MUTATION; GENE SEQUENCE; GERM LINE; HUMAN; HUMAN CELL; HYPER IGM SYNDROME; IMMUNE RESPONSE; IN VITRO STUDY; INFANT; MEMORY CELL; MUTATION RATE; PRE B LYMPHOCYTE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOMATIC HYPERMUTATION; SPLEEN; UPREGULATION;

ADJUVANTS, IMMUNOLOGIC; B-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; GERMINAL CENTER; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN M; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGIC MEMORY; OLIGODEOXYRIBONUCLEOTIDES; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; TOLL-LIKE RECEPTOR 9; UP-REGULATION;

EID: 78650660388     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1002722     Document Type: Article

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